• Macromolecular Research
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• v.13 no.4
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• pp.277-284
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• 2005

The loss or failure of an organ or tissue can occur because of accident or disease, for which tissue or organ transplantation is a generally accepted treatment. However, this approach is extremely limited due to donor shortage. Tissue engineering is a new and exciting strategy, in which patients who need a new organ or tissue are supplied with a synthetic organ or tissue. In this approach, tissues are engineered using a combination of the patient's own cells and a polymer scaffold. The polymer scaffold potentially mimics many roles of extracellular matrices in the body. Various polymers have been studied and utilized to date in tissue engineering approaches. However, no single polymer has been considered ideal for all types of tissues and approaches. This paper discusses the design parameters of those polymers potentially useful in tissue regeneration.

• Molecules and Cells
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• v.40 no.3
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• pp.195-201
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• 2017

In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3'UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.

• IE interfaces
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• v.8 no.3
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• pp.61-73
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• 1995

As the level of maunfacturing system automation increases, the issues of modeling and simulation of AMS(Automated Manufacturing System) are becoming more important. Proposed in this paper is the JR-Net(Job Resource relation-Net) modeling framework which naturally mimics the process of designing an AMS by FA(Factory Automation) engineers. Its main purpose is to provide a modeling tool which facilitate modeling work of AMS for FA engineers unfamiliar with simulation modeling. The proposed modeling scheme is based on the extensive observation that typical AMSs are built from the set of 'standard' components(or catalog items). As an application of the proposed model, two real examples of FMS('G7'FMS model plant, RPI FMS) are modeled by JR-Net, and in case of FMS model plant, a simulation program development procedure using JR-Net modeling results is explained. Finally, simulation result of FMS model plant is analyzed.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.3
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• pp.105-111
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• 2001

The research presented in this paper focuses on a method for the detection of High Impedance Fault(HIF). The method will use the wavelet transform and neural network system. HIF on the multi-grounded three-phase four-wires primary distribution power system cannot be detected effectively by existing over current sensing devices. These paper describes the application of discrete wavelet transform to the various HIF data. These data were measured in actual 22-9kV distribution system. Wavelet transform analysis gives the frequency and time-scale information. The neural network system as a fault detector was trained to discriminate HIF from the normal status by a gradient descent method. The proposed method performed very well by proving the right state when it was applied staged fault data and normal load mimics HIF, such as arc-welder.

• The Korean Journal of Pain
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• v.26 no.1
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• pp.72-75
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• 2013

Zoster sine herpete (ZSH) is difficult to diagnosis during an acute period due to the absence of the characteristic zosteriform dermatomal rash; therefore, progression to postherpetic neuralgia is more common than typical zoster. In addition, misdiagnosis of other neuropathic pain as ZSH is common in clinical situations. Here, we report a case of spinal arteriovenous malformation that mimics ZSH. This is a rare condition; therefore, high clinical suspicion for a correct diagnosis and proper examination are not easy. However, early diagnosis and definitive treatment are essential to prevent neurologic deficit and mortality.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.221-222
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• 1996

In order to prepare the porous hydroxyapatite (HA) ceramics with different porosity, interconnectivity, mechanical properties, surface chemistry and tissue response, several methods have been developed. Of the different forms of Porous HA ceramics which were prepared by various methods, only the coralline HA has undergone major clinical applications in orthopaedic, maxillofacial and ophthalmic surgery. In this study, totally synthetic macroporous HA ceramics with various pore size distribution were prepared. It is shown that the new reticulate HA ceramics, comprised of interconnected voids surmunded by a web of ceramic, have a morphology which mimics that of human trabecular bone.

• Journal of Chest Surgery
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• v.22 no.3
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• pp.473-477
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• 1989

Pulmonary hamartoma has been considered as rare disease, which consists of lung tumor less than 1 %. Originally described by Albrecht in 1904, hamartoma is tumor like malformation-abnormal mixing of the normal components of organ-and is applied also to tumor found in many organs other than the lung. Lately, the major conclusions are that pulmonary hamartoma is neoplastic rather than developmental error in origin. Because pulmonary hamartoma frequently mimics lung cancer, especially in cancer-risk age groups, its clinical significance is great. Recently, we experienced 1 cases of endobronchial hamartoma which located at the right main stem bronchus. The patient was a 54 year old male who was admitted due to symptoms of fever 4 chilliness and dyspnea. Radiologic studies such as chest x-ray, chest tomogram and chest C-T scan revealed that the nearly total haziness of the right lung was caused by endobronchial tumor. The mass was considered as a benign by bronchoscopic exam, so we removed it surgically by tracheobronchotomy without pulmonary resection. Postoperative chest x-ray revealed satisfactory reexpansion of previous collapsed right lung. The patient discharged uneventfully.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2001.06a
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• pp.265-270
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• 2001

Hip joint simulator which Is an essential device for evaluating the wear of biomaterials (ultrahigh molecular weight polyethylene, Co-Cr alloy, alumina, etc.) used in total hip joint replacement was developed. This hip joint simulator mimics the joint motion and joint loading of human gait by adapting the 4 degree of freedom in kinematic motion (flexing/extension, adduction/abduction, Internal rotation/external rotation) and axial loading, Four stations are operated by 8 servo-motors and harmony drives. Joint leading was imposed by displacement control from a ball screw, LM guide, and spring system. Each kinematic link system operates separately or coupled modes. A heater and a thermocouple were installed for keeping the body temperature in each station.

• Proceedings of the Korea Water Resources Association Conference
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• 2002.05b
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• pp.829-836
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• 2002

The paper presents a multi-objective genetic algorithm approach to the design of a water distribution network. The objectives considered are minimization of network cost and maximization of a reliability measure. In this study, a new reliability measure, called network resilience, is introduced. This measure mimics a designer's desire of providing excess power at nodes and designing reliable loops with practicable pipe diameters. The proposed method produces a set of Pareto-optimal solutions in the search space of cost and network resilience. Genetic algorithms are observed to be poor in handling constraints. To handle constraints in a better way, a constraint handling technique that does not require a penalty coefficient and applicable to water distribution systems is presented. The present model is applied to two example problems, which were widely reported. Pipe failure analysis carried out on some of the solutions obtained revealed that the network resilience based approach gave better results in terms of network reliability.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.135-135
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• 2003

Bisphenol A (BPA) mimics estrogen and its activity is one third to one quarter that of estradiol. BPA, an ubiquitous environmental contaminent has been shown to cause development reproductive toxicity and carcinogenic effect. BPA may do physiological action through ER${\alpha}$ and ER${\beta}$ which are expressed in central nerve system.(omitted)