• The Journal of the Korea Contents Association
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• v.11 no.12
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• pp.307-316
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• 2011

The objective of this study is to figure out some specific features that were found during the adaptation process of migrant women by marriage to their local community, and also to elicit certain practical implications to facilitate their adaptation, based on the findings. For data collection, in-depth interviews were conducted with eight migrant women by marriage and the interviews were tape-recorded for transcription. For analysis, phenomenological method, particularly, Colaizzi method was adopted, by which meaningful statements in the data were categorized into themes and theme clusters. A total of 7 thematic unts, 17 themes and 47 meanings were elicited from the analysis and these 7 thematic units were "reinforcement of inner capability"; "cultural assimilation"; "to be a limited benefit receiver"; "no human network"; " impossible to be optimistic about future"; "hoping to reside in their local community"; "possible to leave Korea." Finally, this study suggested the implications for social welfare practices to facilitate the adaptation of immigrant women by marriage in their local community.

• Journal of the Economic Geographical Society of Korea
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• v.21 no.4
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• pp.393-408
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• 2018

This study aims to raise our understanding of how memory of a social group is transnationally appropriated and utilized by other subjects. A collective sense of justice for comfort women has been handed to many Koreans either in Korea or in overseas countries since the early 1990s. In the U.S., the first comfort women monument was established in Palisades Park, New Jersey by Korean-Americans and local politicians as they wanted to strengthen the common sense of Korean ethnicity with the symbolic power of the memoryscape. Exploring the diffusion of comfort women memorials in the U.S., this study examines the complexity and multilayered structure of memory politics and its transnational mobility, which are connected to Korean-Americans' struggle for belonging.

• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.113-117
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• 2005

Organosulfur compounds have been shown to exert an anti-cancer activity. In an attempt to develop novel chemopreventive and anti-cancer agents for liver cancer, we synthesized allylthiopyridazine derivatives. We have previously shown that allylthiopyridazine derivatives exert inhibitory effects on proliferation, invasion and migration of SK-Hep-1 hepatocarcinoma cells in vitro. The in vivo anti-tumor effect of 3-methvl-6-allylthiopy-ridazine, named as K6, was also reported. In this study, we further investigated the preclinical anti-cancer efficacy of K6 for hepatocarcinoma using nude mice xenografted with Hep-G2 hepatocellular carcinoma cells. K6(20-100 mg/kg, orally administered everyday for 30 days) markedly decreased the tumor volume of Hep-G2 cell-transplanted nude mice as evidenced by ultrasonographic and plethysmogranhic analyses. The inhibitory effect on tumor volume was lower than that exerted by doxorubicin (2 mg/kg), intravenously injected) which was used as a positive control. This study shows that K6 efficiently suppresses xenograft tumor growth, revealing K6 as apotential anti-cancer agent for suppressing in vivo progression of liver cancer. Given that hepatocarcinoma is among the most prevalent and lethal malignancies and there is no effective treatment to date, our study may contribute to the potential drug development for liver cancer.

• Animal cells and systems
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• v.13 no.1
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• pp.9-15
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• 2009

Eph receptors and their ephrin ligands have been implicated in a variety of cellular processes such as cellular morphogenesis and motility. Our previous studies demonstrated that Odin, one of the Anks family proteins, functions as a scaffolding protein of the EphA8 signaling pathway leading to modulation of cell migration or axonal outgrowth. Here we show that WDR7 is associated with Odin and that it is possibly implicated in the EphA8 signaling pathway. WD40 repeats present in the COOH-terminal region of WDR7 appear to be crucial for its association with Odin, whereas the binding motif of Odin is located in between ankyrin repeats and PTB domain. Co-immunoprecipitation experiments revealed that association of WDR7 with Odin is enhanced by ephrin ligand treatment, possibly through forming large protein complexes including both EphA8 and ephrin-A5. Consistently, immunofluorescence staining experiments suggested that WDR7 constitute a component of the large protein complexes containing Odin, EphA8 and ephrin-A5. Taken together, our results suggest the WDR7-Odin complexes might be involved in the signaling pathway downstream of the EphA8 receptor.

• Annual Conference of KIPS
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• 2022.11a
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• pp.144-146
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• 2022

차량 환경에서 발생하는 계산 집약적인 태스크가 증가하면서 모바일 엣지 컴퓨팅(MEC, Mobile Edge Computing)의 필요성이 높아지고 있다. 하지만 지상에 존재하는 MEC 서버는 출퇴근 시간과 같이 태스크가 일시적으로 급증하는 상황에 유동적으로 대처할 수 없으며, 이러한 상황을 대비하기 위해 지상 MEC 서버를 추가로 설치하는 것은 자원의 낭비를 불러온다. 최근 이 문제를 해결하기 위해 UAV(Unmanned Aerial Vehicle)기반 MEC 서버를 추가로 사용해 엣지 서비스를 제공하는 연구가 진행되고 있다. 그러나 UAV MEC 서버는 지상 MEC 서버와 달리 한정적인 배터리 용량으로 인해 서버 간 로드밸런싱을 통해 에너지 사용량을 최소화 하는 것이 필요하다. 본 논문에서는 UAV MEC 서버의 에너지 사용량을 고려한 마이그레이션 기법을 제안한다. 또한 GRU(Gated Recurrent Unit) 모델을 활용한 트래픽 예측을 바탕으로 한 마이그레이션을 통해 지연시간을 최소화할 수 있도록 한다. 제안 시스템의 성능을 평가하기 위해 MEC의 마이그레이션 시점을 결정하는 기준점와 차량의 밀도에 따라 실험을 진행하고, 서버의 로드 편차, UAV MEC 서버의 에너지 사용량 그리고 평균 지연 시간 측면에서 성능을 분석한다.

• Journal of the Korea Society of Computer and Information
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• v.22 no.4
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• pp.17-24
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• 2017

In this paper, we propose an efficient dynamic workload balancing strategy which improves the performance of high-performance computing system. The key idea of this dynamic workload balancing strategy is to minimize execution time of each job and to maximize the system throughput by effectively using system resource such as CPU, memory. Also, this strategy dynamically allocates job by considering demanded memory size of executing job and workload status of each node. If an overload node occurs due to allocated job, the proposed scheme migrates job, executing in overload nodes, to another free nodes and reduces the waiting time and execution time of job by balancing workload of each node. Through simulation, we show that the proposed dynamic workload balancing strategy based on CPU, memory improves the performance of high-performance computing system compared to previous strategies.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.141-142
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• 2015

저출산 고령화 시대에 지역인재의 균형적 육성은 지역경쟁력과 직결되는 시급한 사안이라는 점에 착안하여 대구광역시에서 서울의 K대학교로 진학한 20대~40대의 남성 10명을 대상으로 현 시점에서 기획 실행되고 있는 관련 정책의 체감도 및 효과성과 지역인재육성에 대한 인식을 고찰함으로써 지역인재의 유출을 방지하고 지역경쟁력 향상에 기여할 수 있는 교육정책을 지역인재 양성 차원과 활용 차원, 인프라 차원으로 구분하여 고등학교 진로지도 개선, 지역대학 육성, 지역인재 우선채용, 지역산업 맞춤형 학과개편, 지역인적자원개발센터(RHRD) 운영 개선 및 조례제정, 지역주민참여 등 정책을 정교화하기 위한 개선방안을 제시한다.

• BMB Reports
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• v.44 no.7
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• pp.423-434
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• 2011

A female hormone, estrogen, is linked to breast cancer incidence. Estrogens undergo phase I and II metabolism by which they are biotransformed into genotoxic catechol estrogen metabolites and conjugate metabolites are produced for excretion or accumulation. The molecular mechanisms underlying estrogen-mediated mammary carcinogenesis remain unclear. Cell proliferation through activation of estrogen receptor (ER) by its agonist ligands and is clearly considered as one of carcinogenic mechanisms. Recent studies have proposed that reactive oxygen species generated from estrogen or estrogen metabolites are attributed to genotoxic effects and signal transduction through influencing redox sensitive transcription factors resulting in cell transformation, cell cycle, migration, and invasion of the breast cancer. Conjuguation metabolic pathway is thought to protect cells from genotoxic and cytotoxic effects by catechol estrogen metabolites. However, methoxylated catechol estrogens have been shown to induce ER-mediated signaling pathways, implying that conjugation is not a simply detoxification pathway. Dual action of catechol estrogen metabolites in mammary carcinogenesis as the ER-signaling molecules and chemical carcinogen will be discussed in this review.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1877-1880
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• 2012

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.

• Perspectives in Nursing Science
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• v.6 no.1
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• pp.1-20
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• 2009

This research examines, based on nursing's point of view, the current status and problems of the healthcare-related multi-cultural policy which is one of the major issues of contemporary Korea. Today, Korean society is facing a drastic increase of migrant workers and marriage for migration in Korea that leads to the transition to multiculturalism. Each field of society is providing prevalent supports to solve the problems of multicultural families and to promote adoption to Korean society. The activities and researches for multicultural families in nursing area were found and analyzed. 11 researches and 2 books were published. Among these 13 publications, 10 were on the marriage with immigrant women. 8 researches out of 11 (72.7%) were defined as the descriptive surveys, and 3 researches (27.3%) were defined as quasi-experimental studies. Although Korea Nurses Association (KNA) led various activities, more researches and activities by nurses and nursing scholars are required to contribute in improving the health of multicultural families.