• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1508-1517
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• 2015

Optimal Power dispatch is the short-term decision of the optimal output of a number of power generation facilities, to meet the system demand, with the objective of Power dispatching at the lowest possible cost, subject to transmission lines power loss and operational constraints. The operational constraint includes power balance constraint, generator limit constraint, and emission dispatch constraint and valve point effects. In this paper, Opposition based Differential Evolution Algorithm (ODEA) has been proposed to handle the objective function and the operational constraints simultaneously. Furthermore, the valve point loading effects and transmission lines power loss are also considered for the efficient and effective Power dispatch. The ODEA has unique features such as self tuning of its control parameters, self acceleration and migration for searching. As a result, it requires very minimum executions compared with other searching strategies. The effectiveness of the algorithm has been validated through four standard test cases and compared with previous studies. The proposed method out performs the previous methods.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7317-7323
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• 2014

Banks are preparing the system for the new concept of the 2020's. The framework of the core-banking solution is that various demands must be accommodated. In addition, the development process of new system must solve problems, such as obtaining the economic feasibility and expandability as well as minimizing the risk elements. This study verified the superiority of converging framework by analyzing the framework of new converging core-banking solution that can accommodate the current core-banking solution and future requirements. In addition, the study proposed application methods and the pros & cons of a converging framework. The migration effects and successful elements for changing to a new system are proposed.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1197-1200
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• 2015

Breast cancer metastasis is a major cause of cancer-related death in women. However, markers for diagnosis of breast cancer metastasis are rare. Here, we reported that TET1, a tumor suppressor gene, was downregulated and hypermethylated in highly metastatic breast cancer cell lines. Moreover, silencing of TET1 in breast cancer cells increased the migration and spreading of breast cancer cells. In breast cancer clinical samples, TET1 expression was reduced in LN metastases compared with primary tissues. Besides, the methylation level of the TET1 promoter was increased significantly in LN metastases. Taken together, these findings indicate that promoter hypermethylation may contribute to the downregulation of TET1 and could be used as a promising marker for diagnosis in patients with breast cancer metastasis.

• Korean journal of food and cookery science
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• v.7 no.1
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• pp.1-9
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• 1991

The purpose of this study is to investigate the management of Indigenous fermented foods during the period of economic development starting from 1960 until now, and to specify their correlation, while paying special concern to the variables of social change such as the increase of people's income, ceaseless migration of population, change in the family structure, heightening up of the educational level of women and the resulting increase of chances for getting employment, all of which may affect the management of Indigenous fermerted foods in korean families. The result is as follows. Basic seasonings and dishes such as soy bean sauce, red pepper paste, pickled seafoods, and Kimchi, are inclined to be bought as readymade products or provided by relatives in case of many nuclear families rather than made at home, which is a traditional way of home life. However, Kimchi and basic sauces or redpepper paste still show high rate of being made at home. Social variables which affect such tendency are the number of family members, the age and educational level of housewife, and the type of residence.

• Archives of Pharmacal Research
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• v.29 no.2
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• pp.113-122
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• 2006

Among the effector molecules connected with the group of cell surface receptors, Ras proteins have essential roles in transducing extracellular signals to diverse intracellular events, by controlling the activities of multiple signaling pathways. For over 20 years since the discovery of Ras proteins, an enormous amount of knowledge has been accumulated as to how the proteins function in overlapping or distinct fashions. The signaling networks they regulate are very complex due to their multiple functions and cross-talks. Much attention has been paid to the pathological role of Ras in tumorigenesis. In particular, human tumors very frequently express Ras proteins constitutively activated by point mutations. Up to date, three members of the Ras family have been identified, namely H-Ras, K-Ras (A and B), and N-Ras. Although these Ras isoforms function in similar ways, many evidences also support the distinct molecular function of each Ras protein. This review summarizes differential functions of Ras and highlights the current view of the distinct signaling network regulated by each Ras for its contribution to the malignant phenotypic conversion of breast epithelial cells. Four issues are addressed in this review: (1) Ras proteins, (2) membrane localization of Ras, (3) effector molecules downstream of Ras, (4) Ras signaling in invasion. In spite of the accumulation of information on the differential functions of Ras, much more remains to be elucidated to understand the Ras-mediated molecular events of malignant phenotypic conversion of cells in a greater detail.

• Research in Community and Public Health Nursing
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• v.20 no.1
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• pp.67-74
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• 2009

Purpose: The purpose of this study was to investigate the actual condition of social support and loneliness and to examine of the relation between social support and loneliness in migrant workers. Methods: One hundred and thirty migrant workers were sampled from two churches located at Seoul and Gyeonggi-do in order to collect basic data onmigrant workers from August to December, 2007 using a questionnaire. The collected data were analyzed using mean, standard deviation, t-test and ANOVA test. Results: 1) The average scores of social support and loneliness were $3.73{\pm}0.31$ and $2.57{\pm}0.31$, respectively. 2) With respect to the general characteristics of subjects, there was no statistically significant difference in social support, but there was a significant difference in loneliness according to religion (t=2.586, p=.001). 3) The correlation coefficient between social support and loneliness was not significant (r=-.010, p=.929). Conclusion: Social support should be considered in nursing intervention to decrease the level of loneliness in migrant workers. More studies are needed to identify variables influencing social support and loneliness in migrant workers.

• Molecules and Cells
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• v.45 no.9
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• pp.631-639
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• 2022

Breast cancer is the leading cause of cancer-related death in women worldwide, despite medical and technological advancements. The RhoBTB family consists of three isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. RhoBTB1 and RhoBTB2 have been proposed as tumor suppressors in breast cancer. However, the roles of RhoBTB3 proteins are unknown in breast cancer. Bioinformatics analysis, including Oncomine, cBioportal, was used to evaluate the potential functions and prognostic values of RhoBTB3 and Col1a1 in breast cancer. qRT-PCR analysis and immunoblotting assay were performed to investigate relevant expression. Functional experiments including proliferation assay, invasion assay, and flow cytometry assay were conducted to determine the role of RhoBTB3 and Col1a1 in breast cancer cells. RhoBTB3 mRNA levels were significantly up-regulated in breast cancer tissues as compared to in adjacent normal tissues. Moreover, RhoBTB3 expression was found to be associated with Col1a1 expression. Decreasing RhoBTB3 expression may lead to decreases in the proliferative and invasive properties of breast cancer cells. Further, Col1a1 knockdown in breast cancer cells limited the proliferative and invasive ability of cancer cells. Knockdown of RhoBTB3 may exert inhibit the proliferation, migration, and metastasis of breast cancer cells by repressing the expression of Col1a1, providing a novel therapeutic strategy for treating breast cancer.

• Women's Studies Review
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• v.26 no.1
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• pp.183-206
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• 2009

This study attempts to explore a phenomenon of an expansion of emotional capitalism in the context of marriage migration. Emphasizing that 'emotion,' 'love,' 'affection,' 'intimacy,' and 'care' are neither materialistic nor a work, and noting that they are social roles attached to natural femininity and that they are separated from the economic realm, modern myth has been challenged by the increase of marriage industry, emotional/service work, and care industry. This study discusses the ways in which individual desires for love and intimacy and her/his economical needs are combined or negotiated. Specifically, this study 1) reviews existing literature on how 'love' and 'intimacy' has been combined with economy under capitalism in general, 2) discusses the ways in which a marriage has been commercially negotiated within the context of South Korea, 3) analyzes combined aspects of 'love' and 'economy' within cross-border marriages and suggests that cross-border marriages, even though they are highly commercially negotiated, may not be fully explained by 'economy' only as other marriages have both aspects of 'love' and 'economy.' An analysis on 'love' and 'economy,' not only separated from each other but also controversial, is essential for understanding 'intimacy' and transitions of Korean families in post-modern era. However, the evaluation criteria for commercial trades in 'love' and 'intimacy' have not developed yet. Whereas a certain trade is inevitable or essential, others may threaten our lives. Developing the ethical and political evaluation criteria on such commercial trades requires future study.

• Journal of Nutrition and Health
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• v.57 no.1
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• pp.43-52
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• 2024

Purpose: Cancer is the leading cause of death in Koreans, with breast cancer being the most common among women. Breast cancer readily metastasizes, and the existing treatment processes impose a significant burden on patients. This study examined whether pomegranate-derived exosome-like nanovesicles (PNVs) have anti-cancer effects by inhibiting cell infiltration and metastasis while increasing apoptosis on breast cancer MDA-MB-231 cells. Methods: Initially, exosome-like nanovesicles were isolated from pomegranate using ultracentrifugation. Subsequently, the size range of these nanovesicles was confirmed using nanoparticle tracking analysis. The ability of breast cancer MDA-MB-231 cells to internalize these natural nanovesicles was assessed with flourescence microscope. The anti-cancer effects of the PNVs were confirmed by applying various concentrations of PNVs (10, 50, 100 ㎍/mL) to MDA-MB-231 cells and systematically assessing their impact on cell viability and migration. Results: The round shape of the lipid bilayer in the PNVs was confirmed, providing crucial insights into their structural properties. We demonstrate that PNVs-associated DiD dye can be efficiently internalized by the MDA-MB-231 cells. The data showed that the PNVs inhibited cell viability, invasion rates, and migration in MDA-MB-231 cells. In addition, PNVs were absorbed into the MDA-MB-231 cells, leading to an increased expression of apoptosis proteins, such as cleaved caspase-3 and phosphorus-JNK, in a concentration-dependent manner. Furthermore, a reduction in cell infiltration and decreased expression of the transition markers MMP-2 and MMP-9 proteins were observed. Conclusion: For the first time, this study suggests that PNVs may be useful in the prevention or treatment of breast cancer by inhibiting the infiltration and metastasis of MDA-MB-231 cells and inducing apoptosis.

• Journal of Chest Surgery
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• v.47 no.2
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• pp.117-123
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• 2014

Background: Implanted venous access devices or permanent central venous access systems (PCVASs) are routinely used in oncologic patients. Complications can occur during the implantation or use of such devices. We describe such complications of the PCVAS and their management. Methods: Our retrospective study included 1,460 cases in which PCVAS was implanted in the 11 years between January 2002 and January 2013, including 810 women and 650 men with an average age of 45.2 years. We used polyurethane or silicone catheters. The site of insertion and the surgical or percutaneous procedure were selected on the basis of clinical data and disease information. The subclavian and cephalic veins were our most common sites of insertion. Results: About 1,100 cases (75%) underwent surgery by training surgeons and 360 patients by expert surgeons. Perioperative incidents occurred in 33% and 12% of these patients, respectively. Incidents (28%) included technical difficulties (n=64), a subcutaneous hematoma (n=37), pneumothoraces (n=15), and an intrapleural catheter (n=1). Complications in the short and medium term were present in 14.2% of the cases. Distortion and rupture of the catheter (n=5) were noted in the costoclavicular area (pinch-off syndrome). There were 5 cases of catheter migration into the jugular vein (n=1), superior vena cava (n=1), and heart cavities (n=3). No patient died of PCVAS insertion or complication. Conclusion: PCVAS complications should be diagnosed early and treated with probable removal of this material for preventing any life-threatening outcome associated with complicated PVCAS.