• 한국운동역학회지
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• 제25권4호
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• pp.475-482
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• 2015

Objective : The purpose of this study was to investigate mean plantar foot pressure, maximum plantar pressure and ground reaction force, and center migration path of pressure according to the type of trekking shoes for the development of shoes. Method : Subjects of the study averaged $22.10{\pm}2.05years$ of age. Their average height was $169.27{\pm}7.62cm$ and their average weight was $64.34{\pm}10.22kg$. The method of this study was administered measuring 50 steps, at once, 3 times at a speed of 4 km/h and using the data of 30 steps. Pedar-X system measured the mean foot pressure, maximum foot pressure, mean maximum force, and center migration path of pressure by subjects' position while walking. Statistical analysis was performed by SPSS 23.0 using a paired t-test. Results : Results of the study showed Nestfit trekking shoes lower foot pressure of both feet in mean foot pressure and maximum foot pressure. Nestfit trekking shoes showed high ground reaction force (p<.001) in the midfoot, and low mean ground reaction force in the rearfoot. The center migration path of pressure showed the Nestfit trekking shoes were more stable than flat insole trekking shoes. Conclusion : It can be concluded that wearing Nestfit trekking shoes spreads pressure efficiently and induces walking stability because Nestfit trekking shoes spread the pressure of the forefoot and rearfoot to the midfoot and the center migration path of pressure shows regularly.

• 지구물리와물리탐사
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• 제5권3호
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• pp.185-192
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• 2002

구조물의 안전진단을 위한 비파괴 검사 분야에 사용되는 지표레이다 자료를 정밀하게 영상화시켜줄 수 있는 3 차원 구조보정기법을 살펴보았다. 이 연구에서는 탄성파 자료처리를 위해 개발된 3차원 Kirchhoff 중합전 심도구조보정기법을 이용하여 구조물 안전진단시 중요대상체인 콘크리트 내의 철근, 균열 등을 3차원적으로 영상화시켰다. 철근과 공동대상체가 동시에 존재하는 경우 물성차이의 구분이 가능토록 영상화되었고, 여러 가지 크기의 철근이 존재하는 경우 XX배열법에 의한 영상이 YY배열법보다 더 높은 분해능을 보여주었다. 따라서 보다 정밀한 정보를 얻기 위해서는 일반적인 YY배열 외에 XX배열법의 영상화 결과를 연계하여 분석하는 것이 필요하다. 마지막으로 주향이 교차하는 두 개의 철근이 다른 심도에 존재하는 경우에는 상부의 철근은 정확하게 영상화되나 철근의 높은 전도도로 인하여 하부의 철근은 실제크기보다 좀 더 크게 영상화되는 한계를 보여주었다.

• 한국융합학회논문지
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• 제9권10호
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• pp.277-283
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• 2018

본 논문은 항공전자 부분품의 기능시험을 위해 사용하는 전용 자동시험체계(ATS)를 범용 자동시험체계로 TPS를 이식하는 연구이다. 항공전자 부분품의 성능시험을 위해 사용하는 전용 자동시험체계는 적게는 수천만원에서 많게는 수백억원에 이르는 고단가로, 항공전자 정비 사업을 영위하는 국내 기업에서는 초기 투자비용에 많은 어려움이 있어 사업 확장의 장애 요인이 되고 있다. 이러한 이유로, 본 논문에서는 전용 자동시험체계를 사용하는 정비대상품인 A항공기에 사용되는 발전기 내의 Wire-Harness를 범용 자동시험체계로 사용하도록 TPS를 이식하는 절차에 대해 연구하였다. 제안한 연구를 통해 전용에서 범용으로 TPS 이식 후 평가 및 검증을 수행한 결과 100% 성능검증을 확인하였으며, 이것은 절차의 표준화를 거쳐 무한한 확장 가능성이 있어 적은 투자로 항공전자 MRO사업의 확장을 원하는 국내 기업들에 큰 도움을 줄 수 있을 것이다.

• Restorative Dentistry and Endodontics
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• 제45권1호
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• pp.2.1-2.7
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• 2020

Objectives: This study aimed to evaluate the cell viability and migration of Endosequence Bioceramic Root Canal Sealer (BC Sealer) compared to MTA Fillapex and AH Plus. Materials and Methods: BC Sealer, MTA Fillapex, and AH Plus were placed in contact with culture medium to obtain sealers extracts in dilution 1:1, 1:2 and 1:4. 3T3 cells were plated and exposed to the extracts. Cell viability and migration were assessed by 3-(4,5-dimethylthiazoyl)-2,5-diphenyl-tetrazolium bromide (MTT) and Scratch assay, respectively. Data were analyzed by Kruskal-Wallis and Dunn's test (p < 0.05). Results: The MTT assay revealed greater cytotoxicity for AH Plus and MTA Fillapex at 1:1 dilution when compared to control (p < 0.05). At 1:2 and 1:4 dilutions, all sealers were similar to control (p > 0.05) and MTA Fillapex was more cytotoxic than BC Sealer (p < 0.05). Scratch assay demonstrated the continuous closure of the wound according to time. At 30 hours, the control group presented closure of the wound (p < 0.05). At 36 hours, only BC Sealer presented the closure when compared to AH Plus and MTA Fillapex (p < 0.05). At 42 hours, AH Plus and MTA Fillapex showed a wound healing (p > 0.05). Conclusions: All tested sealers demonstrated cell viability highlighting BC Sealer, which showed increased cell migration capacity suggesting that this sealer may achieve better tissue repair when compared to other tested sealers.

• Journal of Ginseng Research
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• 제43권3호
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• pp.488-495
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• 2019

Background: Timosaponin AIII (TA3) is a steroidal saponin extracted from Anemarrhena asphodeloides. Here, we investigated the anticancer effects of TA3 in MG63 human osteosarcoma cells. TA3 attenuates migration and invasion of MG63 cells via regulations of two matrix metalloproteinases (MMPs), MMP-2 and MMP-9, which are involved with cancer metastasis in various cancer cells. TA3 reduced enzymatic activities and transcriptional expressions of MMP-2 and MMP-9 in MG63 cells. TA3 also inhibited Src, focal adhesion kinase, extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38, ${\beta}-catenin$, and cAMP response element binding signaling, which regulate migration and invasion of cells. TA3 induced apoptosis of MG63 cells via regulations of caspase-3, caspase-7, and poly(ADP-ribose) polymerase (PARP). Then, we tested several ginsenosides to be used in combination with TA3 for the synergistic anticancer effects. We found that ginsenosides Rb1 and Rc have synergistic effects on TA3-induced apoptosis in MG63 cells. Methods: We investigated the anticancer effects of TA3 and synergistic effects of various ginseng saponins on TA3-induced apoptosis in MG63 cells. To test antimetastatic effects, we performed wound healing migration assay, Boyden chamber invasion assays, gelatin zymography assay, and Western blot analysis. Annexin V/PI staining apoptosis assay was performed to determine the apoptotic effect of TA3 and ginsenosides. Results: TA3 attenuated migration and invasion of MG63 cells and induced apoptosis of MG63 cells. Ginsenosides Rb1 and Rc showed the synergistic effects on TA3-induced apoptosis in MG63 cells. Conclusions: The results strongly suggest that the combination of TA3 and the two ginsenosides Rb1 and Rc may be a strong candidate for the effective antiosteosarcoma agent.

• 한국동물위생학회지
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• 제31권1호
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• pp.93-100
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• 2008

This experiment has been investigated in order to examine the effect of ivermectin and doramectin for laval migratory inhibition in rats. Anisakis spp larvae were obtained from the mackerels in fish market in Cheongju. A total of 225 rats were classified with 3 groups with the same number ($3{\times}75$ rats); group I was control divided into 3 subgroups including 25 rats in each one, others (test groups) were treated subcutaneously with ivermectin and doramectin by 3 kinds of concentrations ($200{\mu}g/kg$, 400, 800), respectively. At 15 minutes after treating, 10 larvae were taken orally into each rat of 6 subgroups in test, and 5 rats were necropsied at 0.5, 1, 2, 4 and 8 hours after oral administration. The recovered larvae were used in larval migration inhibition (LMI). Ivermectin is significantly more effective than doramectin. In rats, the inhibitory effect of ivermectin and doramectin is slightly less than in vitro.

• JSTS:Journal of Semiconductor Technology and Science
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• 제11권2호
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• pp.88-94
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• 2011

In this paper, we design a 1-kb OTP (Onetime programmable) memory IP in consideration of BCD process based EM (Electro-migration) and resistance variations of eFuse. We propose a method of precharging BL to VSS before activation of RWL (Read word-line) and an optimized design of read NMOS transistor to reduce read current through a non-programmed cell. Also, we propose a sensing margin test circuit with a variable pull-up load out of consideration for resistance variations of programmed eFuse. Peak current through the non-programmed eFuse is reduced from 728 ${\mu}A$ to 61 ${\mu}A$ when a simulation is done in the read mode. Furthermore, BL (Bit-line) sensing is possible even if sensed resistance of eFuse has fallen by about 9 $k{\Omega}$ in a wafer read test through a variable pull-up load resistance of BL S/A (Sense amplifier).

• Journal of Periodontal and Implant Science
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• 제28권1호
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• pp.145-160
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• 1998

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue which has been lost due to destructive periodontal disease, and numerous kinds of materials and techniques have been developed to achieve this goal. Bone grafts include autografts, allografts, xenografts and synthetic grafts. Among the synthetic grafts, bioactive glass has been used in dentistry for more than ten years and Fetner reported improved new bone formation and more amount of new attachment after grafting PerioGlas, a kind of bioactive glass, in 2-wall defects of monkeys in 1994. It Is well known that 1-wall defects have less osteogenic potential and more epithelial migration, so we need to study the erect of bioactive glass in 1-wall dejects in dogs. The present study evaluates the effect of bioactive glass on the epithelial migration, alveolar bone regeneration, cementum formation and gingival connective tissue attachment in intrabony detects of dogs. Four millimeter deep and four millimeter wide 1-wall defects were surgically cheated in the mesial aspects of premolars. The test group received bioactive glass with a flap procedure and the control underwent flap procedure only. Histologic analysis after 8 weeks of healing revealed the following results: 1. The height of gingival margin was 1.30{\pm}0.73mm$ above CEJ in the control and $1.40{\pm}0.78mm$ in the test group. There was no statistically significant difference between the two group. 2. The length of epithelial growth (the distance from CEJ to the apical end of JE) was $1.74{\pm}0.47mm$ in the control and $1.12{\pm}0.36mm$ in the test group. These was a statistically significant difference between the two groups (P<0.01). 3. The length of new cementum was $2.06{\pm}0.73mm$ in the control and $2.62{\pm}0.37mm$ in the test group. There was no statistically significant difference between the two groups. 4. The length of new bone was $1.83{\pm}0.74mm$ in the control and $2.39{\pm}0.59mm$ in the test group. There was no statistically significant difference between the two groups. These results suggest that the use of bioactive glass 1-wall intrabony defects has significant effect on the prevention of junctional epithelium migration, but doesn't have any significant effect on new bone and new cementum formation.

• 한국포장학회지
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• 제24권3호
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• pp.97-106
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• 2018

국내 및 EU의 이행실험 방법에 따라 장기보관 조건 및 고온 가열을 가정한 실험조건을 설정하여 총 이행량 및 특정 이행량 실험을 통해 EU에서 종이 포장재 및 고체시뮬란트에 적용되고 있는 Tenax®의 적합성 및 국내 도입 가능성을 검토하였다. 종이와 PE 시료를 대상으로 surrogates를 각각 10종, 5종씩 선정하여 표준시료를 제작하였다. $Tenax^{(R)}$를 이용한 LDPE 필름 시료에서의 총이행량 실험 결과 EU에서 현재 고체 시뮬란트용 추출용매로 공식 사용 중인 에테르로의 추출량이 $1.318mg/dm^2$로서 다른 용매들에서보다 유의적으로 추출 능력이 뛰어남을 확인할 수 있었다. 또한 접촉시간이 길어질수록, 그리고 온도가 높아질수록 총 이행량이 증가하는 경향을 보였다. $Tenax^{(R)}$의 사용량 검토 실험에서는 EU의 $Tenax^{(R)}$ 실험 방법에 제시된 $4mg/dm^2$가 적합한 양임을 확인할 수 있었다. 또한, petri dish의 밀폐 여부에 따른 총이행량 실험 결과 $Tenax^{(R)}$를 이용한 총 이행량 실험시 petri dish를 알루미늄 필름으로 충분히 밀봉하는 방법이 가장 우수한 결과를 나타냄을 확인할 수 있었다. $Tenax^{(R)}$를 이용한 특정 이행량 실험의 적합성 실험결과, 필름과 종이제시료에서의 시뮬란트 별 surrogates의 특정 이행량은 상이한 경향을 나타냈는데 이는 각 물질의 흡착성, 용해도, 분산성 등 다양한 특성에 좌우된 것으로 판단된다. 일반적으로 n-heptane은 $Tenax^{(R)}$와 일부 surrogates에서 유사한 이행량 수준을 보였으며, $Tenax^{(R)}$가 실제 식품에서의 보다 유의적으로 높은 수준의 특정 이행량 값이 나타났다. 이러한 결과들을 감안하면 $Tenax^{(R)}$가 전분, 탈지분유, 설탕과 같은 장기보존 건조 식품류 및 종이제에 대한 고체 시뮬란트로 사용될 수 있는 가능성이 있다고 사료되었다. 그러나, 그러나, 본 연구는 종이제와 PE 필름, 그리고 특정 두께의 시료를 대상으로 제한적인 실험 조건하에서 이루어진 결과이므로, 최종적으로 $Tenax^{(R)}$를 국내에서 액체 시뮬란트를 대체하기 위해서는 보다 다양한 식품류, 이행 조건, 포장재질, 그리고 상이한 물리적 특성을 지닌 surrogates에 대한 특정 이행 양상을 조사하는 연구들이 수행될 필요성이 요구된다.

• 한국환경성돌연변이발암원학회지
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• 제17권2호
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• pp.71-77
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• 1997

The single cell gel electrophoressis(SCGE) assay, also known as the comet assay, is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakage in mammalian cells. The SCGE or comet assay is a promising test for the detection of DNA damage and repair in individnal cells. It has widespread potential applications in DNA damage and repair studies, genotoxicity testing and biomonitoring. In this microgel electrophoresis technique, cells are embedded in agarose gel on microscope slides, iysed and electrophoresed under alkaline conditions. Cells with increased DNA damage display increased migration of DNA from the nucleus towards the anode. The length of DNA migration indicates the amount of DNA breakage in the cell. The comet assay is also capable of identifying apoptotic cells which contain highly fragmented DNA. Here we review the development of the SCGE assay, existing protocols for the detection and analysis of comets, the relevant underlying principles determining the behaviour of DNA and the potential applications of the technique.