• Food Science of Animal Resources
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• v.36 no.4
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• pp.452-457
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• 2016

Lactoferrin is a glycoprotein with various biological effects, with antibacterial activity being one of the first effects reported. This glycoprotein suppresses bacterial growth through bacteriostatic or bactericidal action. It also stimulates the growth of certain kinds of bacteria such as lactic acid bacteria and bifidobacteria. In this study, Asn-Leu-Asn-Arg was selected and chemically synthesized based on the partial sequences of bovine lactoferrin tryptic fragments. Synthetic Asn-Leu-Asn-Arg suppressed the growth of Pseudomonas fluorescens, P. syringae and Escherichia coli. P. fluorescens is a major psychrotrophic bacteria found in raw and pasteurized milk, which decreases milk quality. P. syringae is a harmful infectious bacterium that damages plants. However, synthetic Asn-Leu-Asn-Arg did not inhibit the growth of Lactobacillus acidophilus. It is expected that this synthetic peptide would be the first peptide sequence from the bovine lactoferrin C-lobe that shows antibacterial activity.

• 제어로봇시스템학회:학술대회논문집
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• 1999.10a
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• pp.108-111
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• 1999

In this paper, we develope a composite control law for linear systems with norm-bounded time-varying parameter uncertainties, which consists of a basic linear robust control do-signed so as to generate a desired transient time-response for the worst-case parameter variation and a nonlinear modification term designed so as to reduce cautiousness of the linear robust control in an adaptive manner. The proposed controller is established such that the reduction of cautiousness of the linear robust control is well incorporated into the achievement of a good transient behavior.

• The Korean Journal of Zoology
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• v.37 no.3
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• pp.343-351
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• 1994

The partial nucleotide sequences of 185 ribosomal RNA gene were compared for six cnidarian species (one belongs to class Hvdrozoa: Coryne pusilla. Five belong to class Anthozoa: Beflonella rigida from Octocorallia; Anemonia sulcutu, Anthopfeura kurognne, An thopleura midori from Hexacorallia: Cerianthus filiformis from Ceriantipatharial. The aligned sequence data were used to test the hypothesis on the anthozoan phylosenv by using the distance matrix method and parsimony method. The phvlosenetic inferences resulting from these methods indicate that the anthozoan is a monophvletic group and support the three subclass scheme (Octocorallia, HexBcorallia, Ceriantipatharial within class Anthozoa. The result also indicates that ceriantipatharian is more primitive than the other groups and that family Actiniidae is a monophvletic group within the anthozoan. However, the present analysis does not clearly indicate the phvlogenetic relationships of species among genera.

• Conservation Science in Museum
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• v.6
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• pp.11-16
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• 2005

We conduct the conservation treatment for the plate armour excavated from No. 321 of Tumulus Group of Yangdong-ri, Gimhae and examine its structure in detail. In terms of the treatment of plate armour, we strengthen the quality of material of weakened remains by disassembling the packed plate armour in urethane form and focus on restoring their original form.

• Conservation Science in Museum
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• v.4
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• pp.41-46
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• 2003

Remarkable features, such as neck guard and plate designed the shape of a duck, are identified in the process of conservation for the plate armour excavated from the No. 2 tomb, Daeseong-dong, Gimhae. We considered that should be careful for treating this kind of artifacts, especially when restoring to its original. For this purpose, we thoroughly studied the endurance of materials for restoration and applied the techniques in reference to the traditional method.

• Proceedings of the Korean Institute of Landscape Architecture Conference
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• 2007.10b
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• pp.78-83
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• 2007

The colors have a close to our life and there are many color names derived from plants in Japan. This study aimed to analyze relationship people and plants and investigated what the images of colors derived from plants related to the color names. Surveys on color images of abstract and concrete were conducted with adults who lived in the metropolitan area and in urban areas. The subjects were surveyed about images of similar colors derived from plants(3 type of similar two colors; pink, green and yellow) and asked to select a pair of color names(momo or pink, midori or green, yamabuki or lemon) corresponding to the color. The subjects were simultaneously presented with two similar colors and asked to give their perceptions of each color against 13 polar opposite pairs of terms or phrases using a Semantic Differential Scale, and asked to select the number of the 16 items concerned with life such as clothes and food. With the pink colors, many subjects did not feel opposite abstract images between these two similar colors and felt the same concrete images such as 'cosmetics' and 'clothes', and these color names such as momo and pink are confused. With the green colors and the yellow colors, many subjects felt opposite abstract images between these two similar colors such as 'natural - artificial' and 'rural - urban' and different concrete images such as 'plants' and 'plastics', and these two similar colors are distinguished by the color names such as 'midori - green' and 'yamabuki - lemon'. The results revealed that there are two patterns in the relationship colors derived from plants, color images and color names. In the pattern which images of colors derived from plants are connected with artificial things irrelevant to plants, the color names corresponding to the two similar colors are confused. On the other hand, in the pattern which images of colors derived from plants are connected with plants and artificial things, the two similar colors are distinguished by their color names. So demographics influenced the images of color, younger subjects compared with older tend to obviously distinguish images of colors derived from plants, and there are images of color influenced by the environment as a child. In both patterns, images of colors derived from plants are influenced by artificial things and natural colors are limited among many people. These results indicate that there are a few opportunities to see colors of plants which are full of variety. These results suggest that it is necessary to recognize colors derived from plants in relation to plants and to educate regarding the nature of plants, therefore landscape architecture focused on colors of plants is required.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5681-5685
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• 2012

Three kinds of survival rates are generally used depending on the purpose of the investigation: overall, cause-specific, and relative. The differences among these 3 survival rates are derived from their respective formulas; however, reports based on actual cancer registry data are few because of incomplete information and short follow-up duration recorded on cancer registration. The aim of this study was to numerically and visually compare these 3 survival rates on the basis of data from the Nagasaki Prefecture Cancer Registry. Subjects were patients diagnosed with cancer and registered in the registry between 1999 and 2003. We calculated the proportion of cause of death and 5-year survival rates. For lung, liver, or advanced stage cancers, the proportions of cancer-related death were high and the differences in survival rates were small. For prostate or early stage cancers, the proportions of death from other causes were high and the differences in survival rates were large. We concluded that the differences among the 3 survival rates increased when the proportion of death from other causes increased.

• Childhood Kidney Diseases
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• v.21 no.1
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• pp.1-7
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• 2017

Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38) and extracellular signal-regulated kinase (ERK) were strongly expressed in the fetal kidney, whereas c-Jun N-terminal kinase (JNK) was detected predominantly in the adult kidney. The inhibition of p38 or ERK in organ culture resulted in reduced nephron formation with or without reduced kidney size. On the other hand, persistent fetal expression pattern of MAPKs, i.e., upregulation of p38 and ERK and downregulation of JNK, was observed in the cyst epithelium of human renal dysplasia, ovine fetal obstructive uropathy, and pcy mice, a model of polycystic kidney disease. Furthermore, activated p38 and ERK induced by cyclic stretch mediated proliferation and $TGF-{\beta}1$ expression in ureteric bud cells, probably leading to cyst formation and dysplastic changes. Inhibition of ERK slowed the disease progression in pcy mice. Finally, ERK and p38 were inactivated in the early embryonic kidney subjected to maternal nutrient restriction, characterized by reduced ureteric branching and nephron number. Thus, MAPKs mediate the development of normal and diseased kidney. Their modulation may result in novel therapeutic strategies against developmental abnormalities of the kidney.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.10
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• pp.4665-4669
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• 2016

Purpose: To evaluate the legitimacy of a diagnosis of ASC-H in 5 cases which were followed up monthly for over 2 years with both cytology and HPV testing. Methods: Some 5 cases out of a total of 25.0 self-sampled Pap test patients diagnosed as ASC-H provided 119 specimens over 2 years, with HPV-DNA testing perormed using a E6 primer. Results: Cases 1, 2 and 3 showed SIL after the ASC-H diagnosis, while cases 4 and 5 showed and maintained NILM. Cases 1, 2 and 3 were further characterized by small atypical compressed binucleated cells, in which HPV was detected by in situ PCR. Case 4 showed a high N/C ratio in cells in sheets with a mild increase in chromatin. Case 5 demonstrated a high N/C ratio in small cells with no increase in chromatin. Conclusion: The finding of a compressed binucleated cells can define the difference between degenerated endocervical columnar cells and small atypical cells suggestive of HSIL. When small compressed binucleated squamous cells are detected, there may be a chance of continuing HPV infection and undetected SIL.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.570-577
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• 2003

The importance of cornified envelope (CE)-bound lipids to epidermal barrier function is increasingly being recognized. In the present study, we intentionally damaged the cornified layer of hairless mice by ultraviolet irradiation and sodium dodecyl sulfate (SDS) treatment, and assessed the changes in epidermal barrier function by measuring Trans Epidermal Water Loss (TEWL). We also measured changes in the amount of CE-bound lipids using thin layer chromatography (TLC). The results showed that both treatments increased TEWL and decreased CE-bound lipids (omega-hydroxy cerami de and omega-hydroxy acid). In addition, investigation of the chronological changes in TEWL revealed an inverse relationship between TEWL and CE-bound lipids, and a correlation between CE-bound lipids and epidermal barrier function. We then measured the amount of CE-bound lipids in the cheek and the medial side of the upper arm in humans. The results showed that because the cheek receives external stimulation on a daily basis, the amount of CE-bound lipids was significantly lower, while the level of TEWL was higher. These observations, together with those from the animal study, indicate that CE-bound lipids are related to epidermal barrier function.