• 대한한방내과학회지
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• 제13권1호
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• pp.110-116
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• 1992

This study has been carried out to investigate the cause and symptom of Seup-Su(濕嗽) by referring to 23 literatures. The results were as follows; 1. The factors causing Seup-Su(濕嗽) are divided into 3 groups. The 1st inner factor is lung affected by wetness(濕勝肺). The 2nd outer factors are wetness-evil(濕邪), syndrome caused by summer heat and wetness evils(暑濕), clothe after bath, sit down along the long time, symptoms caused by rain. The 3rd non-innwer and outer factor is the pholegm accumulated. 2. The symptom of Seup-Su(濕嗽) is as follows. arthralgia hidrosis difficulity in micturition pregnancy small tense pulse.

• The Korean Journal of Pain
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• 제1권1호
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• pp.80-86
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• 1988

Caudal buprenorphine was investigated as a postoperative analgesic in a randominzed double blind study of 45 patients after abdominal surgery. At the end of surgery, patients were given 0.2 mg of caudal buprenorphine in 20 ml saline(n=30, experimental group) or no injection(n=15, control group). Pain relief was evaluated by the subsequent need for systemic analgesics(pethidine). Arterial blood gas and micturition disturbance were evaluated. In the buprenophine group, use of systemic analgesics was significantly reduced for the first 24 hours postoperatively. Arterial blond gas study values 2 hollers after buprenorphine administration were within normal range. 8 patients of the buprenorphine group developed urinary retention requiring temporary Nelaton catheterization of the bladder. Caudal buprenorphine for postoperative pain control was a good alternate method of postoperative pain management.

• 대한수의학회지
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• 제64권1호
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• pp.8.1-8.5
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• 2024

An 18-year-old miniature Appaloosa stallion presented with 6 months of history of sanguineous crusts on medial hind limbs and discomfort of micturition. Cauliflower-like and small masses were treated with cryotherapy for 6 months, but the regrowth of masses occurred. Subsequently, local excision via laser and topical treatment with 5% 5-fluorouracil for 5 months were followed. However, the horse was euthanized 4 months later due to regrowth of the masses. The mass was diagnosed as penile papilloma with cellular atypia and Equus caballus papillomavirus type 2 (EcPV-2) DNA was detected. This is the first report of equine penile neoplasm with EcPV-2 infection in Asia.

• Clinical and Experimental Pediatrics
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• 제48권4호
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• pp.411-415
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• 2005

목 적 : 방광의 발달과정은 척수배뇨반사에서 척수연수척수반사로의 전환을 특징으로 한다고 알려져 왔다. 향신경인자가 이러한 방광의 발달과정에 관여한다는 동물연구에도 불구하고 인간의 방광 발달과정에도 향신경인자가 역할을 하는지에 관한 연구는 없는 실정이다. 본 연구는 인간의 방광 발달과정에 향신경인자가 관여할 것이라는 가정 하에 방광 발달과정에서 소변의 nerve growth factor(NGF) 변화를 관찰하였다. 방 법 : 배뇨생식기의 선천적 이상을 동반하지 않고 배뇨이상, 요로감염의 증거가 없는 지원자 60명을 대상으로 하였다. 지원자는 출생 후 한달 미만의 신생아, 1년 미만의 유아, 1세, 2세, 3세, 4세의 소아로 분류하였고 각각 10명씩 소변을 채취하였다. 소변의 NGF의 정량은 ELISA 방법을 이용하였고 소아의 연령, 요자제 유무에 따른 NGF의 변화를 NGF/Cr, NGF/total protein 값으로 비교하였다. 결 과 : 연령별로 NGF/Cr은 신생아에서 증가하였다가 유아에 감소하고 1세, 2세에 증가하였다가 3세 때부터 감소하였다. 신생아에서 다른 군과 비교하였을 때 의미있는 증가가 관찰이 되었고(P<0.05) 다른 군에서는 의미있는 차이를 보이지는 않았다. NGF/total protein도 NGF/Cr과 비슷한 양상으로 관찰이 되었다. 자발적 배뇨조절이 가능한 소아는 1세에 2명, 2세에 8명, 3세와 4세에는 10명씩이었다. 1세 이상에서 요자제 유무에 따른 NGF/Cr을 비교하였을 때 요자제가 있는 소아에서 의미있게 감소하였다(P<0.05). 결 론 : 단절배뇨와 높은 방광압력을 특징으로 하는 요자제 이전에 NGF가 증가하였다가 요자제 이후에는 감소하는 것을 확인하였다. 이는 배뇨근-괄약근 협동장애로 인해 증가된 방광조직의 NGF가 역행성 축삭수송을 통해 중추신경계에서 척수반사를 척수연수척수반사로 성숙시키고 이것이 다시 배뇨근-괄약근 성숙을 통해 요자제를 형성하였다고 추정할 수 있다. 이는 인간의 방광 발달과정에도 향신경인자가 방광신경 성장과 배뇨반사의 재구성에 관여함을 시사한다고 생각한다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.31-31
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• 2018

Benign prostatic hyperplasia (BPH), which is the most common disorder in elderly men, involves androgenic hormone imbalance with chronic inflammation that causes imbalance between cell apoptosis and cell proliferation. As the root cause of the BPH remains unclear and synthetic drugs for treatment of BPH have undesirable side effects, the development of effective alternative medicines has been considered. Chinese Skullcap has been considered natural remedy to treat pyrexia, micturition disorder and inflammation. Although skullcap has effective properties on various diseases, the effects and molecular mechanism of Skullcap on BPH are not fully understood. Therefore, in this study, we evaluated the efficacy of Chinese Skullcap root extract (SRE) in testosterone-induced BPH rats. Compared with the untreated group, the SRE treatment group suppressed pathological alterations, such as prostate growth and increase in serum dihydrotestosterone and $5{\alpha}$-reductase levels. Furthermore, SRE significantly decreased the expression of androgen receptor and proliferating cell nuclear antigen. SRE also restored Bax/Bcl-2 balance. These effect of SRE was more prevalent than commercial $5{\alpha}$-reductase inhibitor, finasteride. Taken together, we propose that SRE suppresses abnormal androgen events in prostate tissue and inhibits the development of BPH by targeting inflammation- and apoptosis-related markers. These finding strengthens that SRE could be used as plant-based $5{\alpha}$-reductase inhibitory alternative.

• 셀메드
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• 제10권3호
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• pp.23.1-23.5
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• 2020

Hasāh al-kuliya (Nephrolithiasis) is a common disease with a worldwide prevalence of about 12%. A 64 years old male patient, who visited the outpatient department of National Research Institute of Unani Medicine for Skin Disorder (NRIUMSD), Hyderabad, presented with complaints of mild dull pain in right flank region and burning micturition for one month. The ultrasonography of whole abdomen confirmed that there was one stone of 5 mm in calyceal region of each kidney. The patient was treated with the Unani regimen comprising of three formulations Majoon, Hajrul Yahood (5 gm), Jawarish Zarooni Sada (5 gm) and Habb-i-Mudir (1000 mg) for 6 months. The patient did not report any acute pain during the therapy. After 6 months of treatment the ultrasonography of whole abdomen showed absence of the stone from each kidney, ureters and bladder. There was no recurrence of the disease during next 6 months of post treatment follow up. This case report documented the successful medical treatment and prevention of recurrence of bilateral nephrolithiasis through Unani medicines. It concluded that the Unani regimen was effective and safe in the management of bilateral nephrolithiasis.

• 한방재활의학과학회지
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• 제26권3호
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• pp.143-151
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• 2016

A 57-year-old male patient was diagnosed as Incomplete cervical spinal cord injury and Neurogenic bladder after falling accident and suffered from tetraplegia and urinary retention. The patient was hospitalized and treated with Complex Korean Medical treatment such as acupuncture, electro-acupuncture, bee venom pharmacopuncture and herbal medication for 13 weeks. International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) was adopted to evaluate the functional recovery and Korean version of Modified Barthel Index (K-MBI) was adopted to evaluate the recovery of activities of daily living (ADL). After treatment, Total scores of ISNCSCI and K-MBI were improved. Also patient's micturition reflex was recovered and symptoms of neurogenic bladder were improved. This result shows that Korean Medical treatment may be an effective treatment option for spinal cord injury and neurogenic bladder patients. Further clinical studies are needed to clarify the effect of Korean Medical treatment on spinal cord injury.

• International Neurourology Journal
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• 제22권4호
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• pp.228-236
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• 2018

Neuromodulation was introduced for patients with poor outcomes from the existing traditional treatment approaches. It is well-established as an alternative, novel treatment option for voiding dysfunction. The current system of neuromodulation uses an open-loop system that only delivers continuous stimulation without considering the patient's state changes. Though the conventional open-loop system has shown positive clinical results, it can cause problems such as decreased efficacy over time due to neural habituation, higher risk of tissue damage, and lower battery life. Therefore, there is a need for a closed-loop system to overcome the disadvantages of existing systems. The closed-loop neuromodulation includes a system to monitor and stimulate micturition reflex pathways from the lower urinary tract, as well as the central nervous system. In this paper, we reviewed the current technological status to measure biomarker for closed-loop neuromodulation systems for voiding dysfunction.

• Journal of Acupuncture Research
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• 제39권1호
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• pp.1-9
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• 2022

Lower urinary tract symptoms (LUTS) associated with storage, voiding, and post-micturition reduce quality of life and cause mental health problems. In traditional medicine, Baliao points have been empirically used to treat urinary system diseases. In this review, randomized controlled trials (RCTs) using sacral acupuncture on Baliao points with sham treatment, other remedies, or other acupoints were retrieved from 8 electronic databases up to June 2021. Sixteen RCTs met the inclusion criteria. The quality of the included studies was assessed using a risk-of-bias (ROB) tool. Most of the evaluation indicators used in the included RCTs showed that sacral acupuncture had a significant therapeutic effect compared with the sham control intervention groups, and other remedies. However, all studies using acupoints (other than the Baliao points) as a control intervention had a "high" ROB and only reported secondary processed information, making it difficult to evaluate the efficacy of sacral acupuncture treatment for LUTS. No serious adverse effects were reported for sacral acupuncture, and only a low number of minor side effects were observed. These results suggest that sacral acupuncture could be considered as an alternative to existing treatments, with the added benefit of low cost. Large-scale, long-term RCTs are required in the future.

• 대한예방한의학회지
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• 제20권3호
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• pp.83-91
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• 2016

Objectives : The Levator Ani Muscles Training(LAMT) is one of the well known very effective prevention and treatment method of some specific diseases in the anal organs, digestion system, urinary organs and genital organs, which means LAMT could be considered as an independent exercise. Methods : Chinese databases were searched and found one good source named CNKI(China National Knowledge Infrastructure) where there were downloaded 154 articles, out of which were finally selected 82 used for the introduction of the historical background, health-effectiveness, working mechanism, training methods, etc. Results : LAMT as an independent exercise, is considered very effective for the prevention of diseases in the anal organs, e.g. hemorrhoids, anal fissure, rectal prolapse; urinary organs, e.g. urinary incontinence, frequent micturition; digestion system, e.g. visceroptosis, diarrhea, chronic enteritis; genital organs, e.g. prostatitis, impotence, premature ejaculation, feminine vaginal relaxation, sexual indifference, etc. It is also told LAMT is effective for coronary heart disease, hyperyension and varicose veins of lower extremity to a certain degree. LAMT is also very similar to the Kegel exercise in couple of aspects. They are equally effective for the urinary incontinence and impotence. Conclusions : LAMT as an independent exercise has developed and become more and more health-effective, especially through the combination with the Qigong exercise, and thus many training methods have been introduced. There are not many scientific research and development with very limited accomplishments even in China. It is strongly required to strengthen the research and development activities so that LAMT will become one of the very effective natural healing soonest possible.