• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.721-722
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• 2013

• Polymer(Korea)
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• v.37 no.3
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• pp.393-398
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• 2013

Two types of polymeric micro-needles with 250 and $750{\mu}m$ lengths were prepared by a micromolding process. The geometry of dissolving micro-needles with minoxidil was investigated and the mechanical property of polymer micro-needles was also evaluated. Water dissolving micro-needles containing minoxidil were successfully inserted into skin and delivered minoxidil to the skin layer after 30 min of insertion. The observed hair growth was less when the minoxidil treatment was not applied or used without the micro-needles than that the minoxidil was applied by micro-needles. Histologically, these hair follicles became bigger, and the hair papillae were totally encircled by the hair bulbs. In this feasibility test, we show the successful delivery of minoxidil, and effective treatment of hair loss can be possible by using dissolving micro-needles with minoxidil.

• Korean Chemical Engineering Research
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• v.58 no.1
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• pp.122-126
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• 2020

In this study, we produced the micropatterned channel system using polydimethylsiloxane (PDMS) and micromolding in capillaries (MIMIC) technology and evaluated cellular polarity signals through high-resolved imaging at the single-cell level. In cells treated with platelet-derived growth factor (PDGF), three types of key signals in cell migration; phosphoinositide 3-kinase (PI3 K), Rac, and Actin, were strongly activated in the front area compared to the rear region, whereas myosin light chain (MLC) showed no notable activity in the front and rear areas. Our results will, therefore, provide important information and methodology for studying the correlation between cell polarity signals and cell migration under the newly defined microenvironment.

• Korean Chemical Engineering Research
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• v.56 no.6
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• pp.826-831
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• 2018

This study presents fabrication of bi-compartmental particles labeled by multiple fluorescence. To compartmentalize fluorescent expression at the particle, two fluorescent dyes with less overlap of the excitation and emission spectra are selected. To ensure the fluorescence stability, the fluorescent dyes contain acrylate functional groups in the molecules so that they can be cross-linked together with monomers constituting the particle. Strong fluorescent expression and compartmentalization were observed at the particle fabricated using the selected fluorescent dyes through confocal microscopy. Furthermore, long-term fluorescence stability was verified by measuring fluorescent expression and intensity for 4 weeks. We anticipate that the bi-compartmental particles labeled by multiple fluorescence can be widely used for multi-target drug delivery system, analysis of 3 dimensional Brownian motion, and investigation of 3 dimensional complex self-assembled morphologies.

• Tribology and Lubricants
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• v.29 no.5
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• pp.304-309
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• 2013

Shark skin has functionalities such as self-cleaning and antifouling; it also exhibits excellent drag reduction owing to a hierarchical structure of microgrooves and nanometer-long chain mucus drag reduction interfaces around the shark body. In this study, the wettability of a shark skin surface and its replicas are evaluated. First, a shark skin template is taken from a real shark. Then, shark skin replicas are produced directly from a shark skin template, using a micromolding technique. The quantitative replication precision of the shark skin replicas is evaluated by comparing the geometry of the shark skin template to the replica using 2D surface profiles. Contact angles at the solid-air-water interfaces are evaluated for the shark skin template and its replicas under two conditions: with and without hydrophobic coating. The results show that the microriblets on shark skin improve the hydrophobic feature and play a critical role in self-cleaning.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.10a
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• pp.200-203
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• 2001

Micromolding methods such as micro-injection molding and micro-compression molding are most suitable for mass production of plastic micro-optics with low cost. In this study, plastic micro-optical components, such as refractive microlenses and diffractive optical elements(DOEs) with various grating patterns, were fabricated using micro-compression molding process. The mold inserts were made by ultrapricision mechanical machining and silicon etching. A micro compression molding system was designed and developed. Polymer powders were used as molded materials. Various defects found during molding were analyzed and the process was optimized experimentally by controlling the governing process parameters such as histories of mold temperature and compression pressure. Mim lenses of hemispherical shape with $250{\mu}m$ diameter were fabricated. The blazed and 4 stepped DOEs with $24{\mu}m$ pitch and $5{\mu}m$ depth were also fabricated. Optical and geometrical properties of plastic molded parts were tested by interferometric technique.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1021-1024
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• 2003

In this work, we fabricated various 2D metallic and polymeric nanopatterns with the feature resolution of sub-micrometer scale by using the method of microcontact printing ($\mu$ P) based on soft lithography. Silicon masters for the micromolding were made by e-beam lithography. Composite poly(dimethylsiloxane) (PDMS) molds were composed of a thin, hard layer supported by soft PDMS layer. Finally, monodisperse metal or polymer particles could be obtained in the prepared pattern for the application of electronic devices.

• Proceedings of the KSME Conference
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• 2000.11a
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• pp.743-746
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• 2000

Plastic microlenses play an important role in reducing the size, weight, and the cost of the systems in the fields of optical data storage and optical communication. In the present study, plastic microlens arrays were fabricated using micro-compression molding process. The design and fabrication procedures for mold insert were simplified by using silicon instead of metal. A simple but effective micro compression molding process, which uses polymer powder, were developed for microlens fabrication. The governing process parameters were temperature and pressure histories and the micromolding process was controlled such that the various defects developing during molding process were minimized. The radius and magnification ratio of the fabricated microlens were $125{\mu}m$ and over 3.0, respectively.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.8
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• pp.1242-1245
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• 2001

Plastic microlenses play an important role in reducing the size, weight, and the cost of the systems in the fields of optical data storage and optical communication. In the present study, plastic microlens arrays were fabricated using micro-compression molding process. The design and fabrication procedures for mold insert were simplified by using silicon instead of metal. A simple but effective micro compression molding process, which uses polymer powder, were developed for microlens fabrication. The governing process parameters were temperature and pressure histories and the micromolding process was controlled such that the various defects developing during molding process were minimized. The radius and magnification ratio of the fabricated microlens were 125$\mu\textrm{m}$ and over 3.0, respectively.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.299-302
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• 2007

We propose a soft-lithographic patterning method for producing a multi-domain liquid crystal (LC) alignment. The LC alignment polyimide layers are periodically patterned in the pixel boundaries by a micromolding-in-capillaries method. In our structure, the initially homeotropic LC orientations in the pixel areas are changed to axially symmetric LC domains due to the symmetric pretilt of LC molecules on the pixel boundaries.