• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.343-344
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• 2009

• BioChip Journal
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• v.12 no.4
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• pp.257-267
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• 2018

Inertial microfluidics has attracted significant attention in recent years due to its superior benefits of high throughput, precise control, simplicity, and low cost. Many inertial microfluidic applications have been demonstrated for physiological sample processing, clinical diagnostics, and environmental monitoring and cleanup. In this review, we discuss the fundamental mechanisms and principles of inertial migration and Dean flow, which are the basis of inertial microfluidics, and provide basic scaling laws for designing the inertial microfluidic devices. This will allow end-users with diverse backgrounds to more easily take advantage of the inertial microfluidic technologies in a wide range of applications. A variety of recent applications are also classified according to the structure of the microchannel: straight channels and curved channels. Finally, several future perspectives of employing fluid inertia in microfluidic-based cell sorting are discussed. Inertial microfluidics is still expected to be promising in the near future with more novel designs using various shapes of cross section, sheath flows with different viscosities, or technologies that target micron and submicron bioparticles.

• Mass Spectrometry Letters
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• v.1 no.1
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• pp.21-24
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• 2010

The development of clinical biomarkers involves discovery, verification, and validation. Recently, multiple reaction monitoring (MRM) coupled with stable isotope dilution mass spectrometry (IDMS) has shown considerable promise for the direct quantification of proteins in clinical samples. In particular, multiple biomarkers have been tracked in a single experiment using MRM-based MS approaches combined with liquid chromatography. We report here a highly reproducible, quantitative, and dynamic MRM system for validating multi-biomarker proteins using Nanoflow HPLC-Microfluidics Chip/Triple-Quadrupole MS. In this system, transitions were acquired only during the retention window of each eluting peptide. Transitions with the highest MRM-MS intensities for the five target peptides from colon cancer biomarker candidates were automatically selected using Optimizer software. Relative to the corresponding non-dynamic system, the dynamic MRM provided significantly improved coefficients of variation in experiments with large numbers of transitions. Linear responses were obtained with concentrations ranging from fmol to pmol for five target peptides.

• Journal of the KSME
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• v.50 no.1
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• pp.37-41
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• 2010

최근 미세유체기술(microfluidics)을 기반으로 한 lab on a chip 기술이 기계, 의료, 바이오, 제약, 화학, 환경 분야 등의 다양한 분야에서 각광 받고 있다. 이 글에서는 일회용 고분자 lab on a chip 대량생산의 기반 기술에 해당하는 고분자 미세성형 기술에 대해 소개한다.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.11
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• pp.25-35
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• 2000

• Molecular & Cellular Toxicology
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• v.3 no.sup4
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• pp.37.1-37.1
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• 2007

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.11a
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• pp.373-374
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• 2010

• Journal of Korean Society on Water Environment
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• v.23 no.1
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• pp.33-37
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• 2007

Microelectrodes for measuring nitrogenous compounds (${NH_4}^+$, ${NO_3}^-$) that were applied into the microfluidics chips was investigated, and the effect of temperature was especially examined. In this specific research, microelectrodes were first calibrated to check the function, and then microsensor that was combined microelectrode with microfluidic chip was re-calibrated. Experimental results showed that there are no change in the function between microelectrode and microfluidic chip. The electro motive force (EMF) for the ${NH_4}^+$ microsensor was similar to the one theoretically calculated from Nernst equation, but the EMF for ${NO_3}^-$ showed minor change.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.197-198
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• 2011

• Molecular & Cellular Toxicology
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• v.2 no.4
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• pp.279-284
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• 2006

This paper describes the fabrication methods of a carbon nanotube (CNT) filter and a microdialysis chip. A CNT filter can help perform dialysis on a microfluidic chip. In this study, a membrane type of a CNT filter is fabricated and located in a microfluidic chip. The filter plays a role of a dialysis membrane in a microfluidic chip. In the fabrication process of a CNT filter, individual CNTs are entangled each other by amide bonding that is catalyzed by 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemically treated CNTs are shaped to form a CNT filter using a PDMS film-mold and vacuum filtering. Then, the CNT filter is sandwiched between PDMS substrates, and they are bonded together using a thin layer of PDMS prepolymer as adhesive. The PDMS substrates are fabricated to have a microchannel by standard photo-lithography technique.