• Applied Microscopy
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• v.10 no.1_2
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• pp.27-32
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• 1980

A case of cutaneous leishmaniasis developed in a 48 year old Korean male who returned from middle east was studied by light and electron microscopic observations. Light microscopically, the lesion consisted of heavy chronic ill-defined granulomatous inflammation involving entire thickness of the dermis, composed of mainly histiocytic and small mononuclear cell infiltrations without evidence of necrosis or giant cell formation. Giemsa staining revealed numerous intracellular micro-organisms within histiocytes, showing dark stained central dot surrounded by light stained cytoplasm. Electron microscopically, the organisms were observed mostly ovoid in shape and frequently binary mitotic features within the host cells. follicle consisted of double unit membranes and microtubules, which are immediately below these membrnae. A long kinetoplast was noted within a very elongated mitochondrion at the center of the organisms and a flagella rose in front of the kineoplast but ended within the cytoplasm. Large numbers of free ribosomes, occasional Golgi complex and SER were also noted, but RER was seldom found. These ultrastructural features corresponded to promastigote stage of Leishmania tropica. In principle, leishmaniasis is a tropical disease and can not be found in temperate zone. However, travel to mideast by many Koreans may contract this disease while they are in endemic regions.

• Journal of KIISE:Information Networking
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• v.31 no.4
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• pp.384-392
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• 2004

Mobile contents service providers have some difficulties to timely and proper service deployment due to rapid development cycle of diverse portable devices with different capabilities. A way to resolve the problem is to introduce a mobile contents service paltform that can adapt original mobile contents to diverse devices dynamically and automatically. In this paper, we propose a mobile contents service platform based on active network mechanisms, called Mobile Content Adaptation Network(MobiCAN). The MobiCAN node provides effective service deployment, execution, and maintenance features and accommodates service layering and service customization capabilities for easy deployment. The basic functional units of the MobiCAN node are micro services with well-defined service interfaces and service layering features. For reliable services among the MobiCAN nodes, we design new distributed and robust Overlay Management Protocols(OMPs). As an example of practical MobiCAN applications, we finally describe Dynamic Contents Customization Proxy(DCCP) service.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.10039-10043
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• 2014

Background: In Pakistan thyroid cancer is responsible for 1.2% cases of all malignant tumors. Ultrasonography (US) is helpful in detecting cancerous thyroid nodules on basis of different features like echogenicity, margins, microcalcifications, size, shape and abnormal neck lymph nodes. We therefore aimed to calculate diagnostic accuracy of ultrasound in detection of carcinoma in thyroid nodules taking fine needle aspiration cytology as the reference standard. Materials and Methods: A cross-sectional analytical study was designed to prospectively collect data from December 2010 till December 2012 from the Department of Radiology in Aga Khan University Hospital, Karachi, Pakistan. A total of 100 patients of both genders were enrolled after informed consent via applying non-probability consecutive sampling technique. Patients referred to Radiology department of Aga Khan University to perform thyroid ultrasound followed by fine-needle aspiration cytology of thyroid nodules were included. They were excluded if proven for thyroid malignancy or if their US or FNAC was conducted outside our institution. Results: The subjects comprised 76 (76%) females and 24 males. Mean age was $41.8{\pm}SD$ 12.3 years. Sensitivity and specificity with 95%CI of ultrasound in differentiating malignant thyroid nodule from benign thyroid nodule calculated to be 91.7% (95%CI, 0.72-0.98) and 78.94% (0.68-0.87) respectively. Reported positive predictive value and negative PV were 57.9% (0.41-0.73) and 96.8% (0.88-0.99) and overall accuracy was 82%. Likelihood ratio (LR) positive was computed to be 4.3 and LR negative was 0.1. Conclusions: Ultrasonography has a high diagnostic accuracy in detecting malignancy in thyroid nodules on the basis of features like echogenicity, margins, micro calcifications and shape.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1563-1567
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• 2012

To investigate the relationship between serum miRNA-21 (miR-21) expression in esophageal squamous cell carcinomas (ESCCs) and its clinicopathologic features, a 1:1 matched case-control study including 21 patients with ESCC and 21 age- and gender-matched healthy controls was carried out. Serum specimens were taken from all subjects. Total RNA was extracted and the stem-loop real time polymerase chain reaction was used to measure serum miR-21 in both groups. Clinical parameters were assessed to determine associations with serum miR-21 concentrations. Serum miR-21 expression in ESCC samples was significantly higher than in paired cancer-free samples (P<0.05). Metastasis was associated with mir-21 expression in serum (P<0.05), ESCC patients with metastasis having 8.4-fold higher serum miR-21 concentrations than healthy controls. There were no statistically significant associations between miR-21 expression and clinicopathologic parameters, such as gender (P>0.05), age (P>0.05), tumor location (P>0.05), cell differentiation (P>0.05), TNM staging (P>0.05), whether chemo/radiotherapy had been administered (P>0.05), or whether surgery had been performed (P>0.05). These findings suggest that the detection of microRNA-21 in serum might serve as a new tumor biomarker in diagnosis and assessment of prognosis of ESCCs.

• Korean Journal of Head & Neck Oncology
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• v.20 no.2
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• pp.147-155
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• 2004

Objectives: Head and neck squamous cell carcinoma (HNSCC) is the most common head and neck malignant tumor. The molecular genetic changes involving both oncogenes and tumor suppressor genes are known to be involved in head and neck squamous cell carcinogenesis, but the roles of the known tumor suppressor genes in carcinogenesis are not fully elucidated. The objectives of this study are to demonstrate the genetic alterations including the loss of heterozygosity (LOH) , amplification, and microsatellite instability of known tumor suppressor genes in HNSCC and to evaluate the relationship between genetic alterations of tumor suppressor genes and clinicopathologic features. Materials and Methods: Genetic alterations of 10 micro satellite markers of the 6 known tumor suppressor genes (APC, EXT1, DPC4, p16, FHIT, and PTEN) were analysed by DNA-PCR in paraffin-embedded histologically confirmed HNSCC specimens. Results: The genetic alterations of tumor suppressor genes were found frequently. Among the genetic alterations, LOH was most frequently found one. LOH was found frequently in APC (45.4%), EXT1 (36.4%), DPC4 (54.5%), and p16 (50%), but not found in FHIT. Also, the author found that abnormalities of APC gene was related to cervical lymph node metastasis and recurrence and that abnormalities of EXT1 gene were coexisted with those of APC gene or DPC4 gene. But these coexistences had no correlation with clinical features. Conclusion: These results suggested that APC, EXT1, p16, and DPC4 genes might play important roles and multiple tumor suppressor genes may participate dependently or independently in the carcinogenesis of HNSCC. These results also suggested that APC gene might relate to prognosis.

• Journal of the Korean Society of Costume
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• v.22
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• pp.23-44
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• 1994

The purpose of this study was to clarify the cultural characteristic of dress and adornments by examining articles on dress adornments and related items in Korean newspaper over periods historically and objectively by means of content analysis. This study attempted to at-tain a macro-cultural view by analysing to at-tain a macro-cultural view by analysing closely the cultural characteristics of dress and adornments as a micro-cultural system through culturally based model suggested by hamilton. The two-hundreds and eighty articles on dress and adornments were selected from newspapers(most by form Chosun Ilbo and partly from Maeil Shinbo) pulished between 1920 and 1990. The results were as follows: 1. The culture of dress and adornment received much attention during the 1930's and 1960's and little during 1950's. 2. Various cultural characteristics of dress and adornments appeared on and after 1960's: reporting more foreign news items showing foreign-oriented and future-oriented features showing cultural relativism. In the 1920's and 1970's the contents of news items on dress and adornments show the most common- mass- oriented character. Foreign-oriented cultural tendencies in cloth-ing were increasing during from 1960's to 1970's but the tendencies were turned to rather tradition-oriented features on and after 1980's compare with 1960's-1970's. Advisory critical articles on dress and adornments were small in number and insignificant but compare with other periods these received much atten-tion during the 1920's and 1980's. 3. Ideological components received much at-tention on and after 1920's to 1990. Techo-nological components received much attention during 1920's and little during 1960's. The social structural components received a little attention on and after 1920's-1940's and 1990. 4. News items on women's dress and adornments received much attention from the 1920's to 1960's and news items on both men's and women's dress and adorments were in-creasing and received much attention on and after the 1970's. 5. The pragmatic cultures were mostly re-lated to techonological components and evaluative-normative culture were mostly re-lated to ideological and social structural components. In the light of these results dress and adorments as a cultural sub-system comprise a dynamic inteacting system that articulated directly with the macro-cultural system.

• Applied Microscopy
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• v.42 no.2
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• pp.95-103
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• 2012

The cell surface sculpture of the plant epidermis has received great interest recently. It has also been an active area of research, as the biological microstructures of the surface, such as papillae and waxes, exhibit several unique properties, including self-cleaning character; namely the "Lotus effect" first described in the leaves of the lotus, Nelumbo nucifera. The Lotus effect is the phenomenon in which the super-hydrophobic and water-repellent nature of lotus leaves allow water drops to run off easily on the surface in a rolling and sliding motion thereby facilitating the removal of dirt particles. It is well-known that surface roughness on the micro- and nanoscale is a primary characteristic allowing for the Lotus effect. This effect is common among plants and is of great technological importance, since it can be applied industrially in numerous fields. In the present study, Nelumbo nucifera leaf and stem epidermal surfaces have been examined with a focus on the features of papillae and wax crystalloids. Both young and mature Nelumbo nucifera leaf epidermis demonstrated the Lotus effect on their entire epidermal surface. The central area of the upper epidermis, in particular, formed extremely papillose surfaces, with an additional wax layer, enabling greater water repellency. Despite the presence of wax crystalloids, epidermal surfaces of the lower leaf and stem lacking papillae, were much more easily wetted.

• The Journal of Advanced Prosthodontics
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• v.11 no.6
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• pp.341-349
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• 2019

PURPOSE. A novel retentive type of implant prosthesis that does not require the use of cement or screw holes has been introduced; however, there are few reports examining the biomechanical aspects of this novel implant. This study aimed to evaluate the biomechanical features of cementless fixation (CLF) implant prostheses. MATERIALS AND METHODS. The test groups of three variations of CLF implant prostheses and a control group of conventional cement-retained (CR) prosthesis were designed three-dimensionally for finite element analysis. The test groups were divided according to the abutment shape and the relining strategy on the inner surface of the implant crown as follows; resin-air hole-full (RAF), resin-air hole (RA), and resin-no air hole (RNA). The von Mises stress and principal stress were used to evaluate the stress values and distributions of the implant components. Contact open values were calculated to analyze the gap formation of the contact surfaces at the abutment-resin and abutment-implant interfaces. The micro-strain values were evaluated for the surrounding bone. RESULTS. Values reflecting the maximum stress on the abutment were as follows (in MPa): RAF, 25.6; RA, 23.4; RNA, 20.0; and CR, 15.8. The value of gap formation was measured from 0.88 to 1.19 ㎛ at the abutment-resin interface and 24.4 to 24.7 ㎛ at the abutment-implant interface. The strain distribution was similar in all cases. CONCLUSION. CLF had no disadvantages in terms of the biomechanical features compared with conventional CR implant prosthesis and could be successfully applied for implant prosthesis.

• Journal of KIISE
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• v.43 no.9
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• pp.1008-1014
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• 2016

Data such as Twitter, Facebook, and customer reviews belong to the informal document group, whereas, newspapers that have grammar correction step belong to the formal document group. Finding consistent rules or patterns in informal documents is difficult, as compared to formal documents. Hence, there is a need for additional approaches to improve informal document analysis. In this study, we classified Twitter data, a representative informal document, into ten categories. To improve performance, we revised and expanded features based on LDA(Latent Dirichlet allocation) word distribution. Using LDA top-ranked words, the other words were separated or bundled, and the feature set was thus expanded repeatedly. Finally, we conducted document classification with the expanded features. Experimental results indicated that the proposed method improved the micro-averaged F1-score of 7.11%p, as compared to the results before the feature expansion step.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.19 no.1 s.71
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• pp.27-37
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• 2006

A Metropolis genetic algorithm (MGA) is developed and applied for the structural design optimization. In MGA, favorable features of Metropolis criterion of simulated annealing (SA) are incorporated in the reproduction operations of simple genetic algorithm (SGA). This way, the MGA maintains the wide varieties of individuals and preserves the potential genetic information of early generations. Consequently, the proposed MGA alleviates the disadvantages of premature convergence to a local optimum in SGA and time consuming computation for the precise global optimum in SA. Performances and applicability of MGA are compared with those of conventional algorithms such as Holland's SGA, Krishnakumar's micro GA, and Kirkpatrick's SA. Typical numerical examples are used to evaluate the computational performances, the favorable features and applicability of MGA. The effects of population sizes and maximum generations are also evaluated for the performance reliability and robustness of MGA. From the theoretical evaluation and numerical experience, it is concluded that the proposed MGA Is a reliable and efficient tool for structural design optimization.