• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.113-125
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• 2018

Exosomes are membranous vesicles of 30-150 nm in diameter that are derived from the exocytosis of the intraluminal vesicles of many cell types including immune cells, stem cells, cardiovascular cells and tumor cells. Exosomes participate in intercellular communication by delivering their contents to recipient cells, with or without direct contact between cells, and thereby influence physiological and pathological processes. They are present in various body fluids and contain proteins, nucleic acids, lipids, and microRNAs that can be transported to surrounding cells. Theragnosis is a concept in next-generation medicine that simultaneously combines accurate diagnostics with therapeutic effects. Molecular components in exosomes have been found to be related to certain diseases and treatment responses, indicating that they may have applications in diagnosis via molecular imaging and biomarker detection. In addition, recent studies have reported that exosomes have immunotherapeutic applications or can act as a drug delivery system for targeted therapies with drugs and biomolecules. In this review, we describe the formation, structure, and physiological roles of exosomes. We also discuss their roles in the pathogenesis and progression of diseases including neurodegenerative diseases, cardiovascular diseases, and cancer. The potential applications of exosomes for theragnostic purposes in various diseases are also discussed. This review summarizes the current knowledge about the physiological and pathological roles of exosomes as well as their diagnostic and therapeutic uses, including emerging exosome-based therapies that could not be applied until now.

• The Transactions of the Korean Institute of Power Electronics
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• v.9 no.6
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• pp.525-535
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• 2004

In this paper, a two-phase DZRCD(Dual Zero Vector Modes RCD) technique is proposed to develope the problem of a conventional two-phase RCD-PWM (Random Centered Distribution PWM) which gives the power spectra of narrow band range in the high modulation index (M). In the proposed DZRCD technique, the zero vector $V_0$ is selected as $V_0$(111) for M$\geqq$0.8. Also, $V_0$ is selected as $V_0$(000) for the modulation indices < 0.8. For the unplementation of the proposed method, a 16-bit micro-controller Cl67 was used and the experiments were conducted with the 1.5kw induction motor under no load condition. The experimental results show that the voltage / current spectra is spread to a wide band range, and the switching noise of motor is reduced by the proposed method compared to the conventional random operation.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.107-109
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• 2006

The additional matters appear to be considered in several aspects for building up power-quality measuring system of transmission system(high voltage system) compared to distribution system(middle or low voltage system). Like in distribution system, input signals are also received from PT and CT source of voltage and current respectively in transmission system and applied in accordance with a certain rate. In this case, very big error rate can be occurred according to the specification of the measuring system as the applying rate is bigger than in distribution system beyond comparison. In addition, when the abnormal signal occurred such as sag/swell, interruption, transient etc., power quality of other sites linked to the system also should be checked to find the accurate cause of the abnormal power-quality signals from the corresponding site. Accordingly, the accurate diagnosis on the condition of Power quality for the system depends on the way how the synchronization system is brought along for each site. This paper will suggest the solution for the most effective system building focused on how to solve the problem of the error rate and synchronization described in the above when building up the measuring system of power quality for transmission system.

• Transactions on Electrical and Electronic Materials
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• v.16 no.5
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• pp.268-273
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• 2015

While analyzing the specimens before and after the thermal shock test, we found that the power drop rate of the bare cell was 5.08%, while the power drop rate of the ribboned cell was 16.49%. In comparative terms, the efficiency was lower at the ribboned cell than at the bare cell. While analyzing through EL (Electroluminescence) shots and cross sections, we tried to decipher the exact cause of the power drop. Although mere color change of the cell was observed at the surface of the bare cell, no abnormality could be found inside the cell. On the surface of the ribboned cell, the short circuit of gridfinger extended from the front part of the front electrode of the ribboned cells. Therefore, cracks occurred on the surface of the cell. Cracks also appeared inside the cell. While analyzing the I-V curve, we determined an increase in the leakage current and an increase of resistances in series in the bare cell. In the ribboned cell, the resistances in parallel reduced remarkably. An increase of resistances in series could also be verified. Conclusively, we deduced that the power drop rate in the bare cell is a life span of the cell itself; aging is the cause of power drop rate in cells. In case of ribboned cell, the power drop rate was directly influenced by internal cracks and an intermetallic compound layer joining the ribbon at the front electrode.

• Korean Journal of Materials Research
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• v.26 no.10
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• pp.513-520
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• 2016

The effect of NaOH concentration on the properties of electrolytic plasma processing (EPP) coating formed on AZ61A Mg alloy is studied. Various types of EPP were employed on magnesium alloy AZ61A in a silicate bath with different concentrations of NaOH additive. Analysis of the composition and structure of the coating layers was carried out using an X-ray diffractometer (XRD) and a scanning electron microscope (SEM). The results showed that the oxide coating layer mainly consisted of MgO and $Mg_2SiO_4$; its porosity and thickness were highly dependent on the NaOH concentration. The Vickers hardness was over 900 HV for all the coatings. The oxide layer with 3 g/l of NaOH concentration exhibited the highest hardness value (1220 HV) and the lowest wear rate. Potentiodynamic testing of the 3 g/l NaOH concentration showed that this concentration had the highest corrosion resistance value of $2.04{\times}10^5{\Omega}cm^2$; however, the corrosion current density value of $5.80{\times}10^{-7}A/cm^2$ was the lowest such value.

• Journal of Veterinary Clinics
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• v.28 no.1
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• pp.57-62
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• 2011

The shortage of transplantable kidneys has many efforts to regenerate bioartificial kidneys using transgenic animals and diverse kinds of scaffolds which are important tools for cell seeding. However, there are many limitations for clinical applications so far. Recently, decellularized bioscaffolds using animal organs come into spotlight because of its many superior advantages. In current study, we produced decellularized kidney bioscaffolds of pig which is an attractive animal as a clinical model for human. We decellularized pig kidneys with 1% SDS detergent solution using peristaltic pump systems for 12h. After decellularization process, the kidney bioscaffolds preserved intact 3D morphology including glomerular structure and almost DNA from pig was entirely removed. In addition, this process could preserve micro vascular network which is necessary for cell survival. Although, additional studies for recellularization and transplantation should be required, the decellular vascularized kidney bioscaffolds might have many potentials for kidney regeneration.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.111-111
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• 2018

Aronia (black chokeberry), a species of berries is source to a very large number of bioactive compounds like polyphenols, flavonoids, anthocyanins, and tannins in comparison to any other species. Owing to its antioxidant, anti-carcinogenic, anti-aging and anti-inflammatory properties. Fermentation- a bioconversion process exploiting the biological metabolic reaction of micro-organisms, has several benefits like improving the efficacy and safety of physiologically active substances, generation of new functional material, improving the adsorption rate and many others. Antigens like pathogens, food, pollen etc., generate a protective immune response in body tissues, and the process be referred to as inflammation. However, this when excessive results in a condition referred to as refractory inflammatory disease, whose incidence is increasing in the recent times, especially amongst children. The current study intended to assess the anti-oxidant activity, presence of polyphenols and anti-inflammatory efficacy of Aronia extract fermented by Lactic acid bacteria isolated from fermented sea foods. Aronia fruits collected from Sunchang, Chonbuk were lyophilized for fermentation. So as to maximise the efficacy of the fermented Aronia extract, the quantitative effects of lactic acid bacteria species, composition of extraction solution, influence of temperature and time on antioxidant activity and total polyphenol contents were investigated using an experimental design. Anti-inflammatory activity was evaluated on NO and cytokine ($TNF-{\alpha}$, IL-6) production in LPS activated Raw 264.7 cells. Results indicated that antioxidant effect and total polyphenol contents were best improved in extract of Aronia fermented by P. pentosaceus. In addition, NO and cytokine ($TNF-{\alpha}$, IL-6) levels were decreased significantly after fermentation. Thus, it was found that the anti-inflammatory activity of Aronia greatly increased after fermentation process using P. pentosaceus.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.2
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• pp.174-184
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• 2013

For the successful R&D and deployment of LED-based green energy lighting systems, the real-time power quality measurement of both various non-linear power signals including pulse waveform, spike waveform, etc and the undesired-signals including harmonics, sag, swell, etc is required. In this paper, we propose a low-cost power quality measurement (PQM) method for low- (60Hz-several KHz) to high-frequency (several tens KHz) power signals, which are generated by green-energy lighting systems, and implement a PQM testbed using TI TMS320F28335 MCU. The proposed algorithm is programmed using C in the CCS (Code Composer Studio) 3.3 environment and is verified using test signals generated by an arbitrary signal generator, NF-WF1974. In the implemented testbed, we can measure various non-linear current signals that LED SMPS generates, analyze harmonics by fast Fourier transform, and test sag, swell, and interruption using wavelet transform.

• Clean Technology
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• v.23 no.1
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• pp.90-94
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• 2017

These days much efforts are being dedicated to wind power as a potential source of renewable energy. To maintain effective and uniform generation of energy, defect preservation of turbine blade is essential because it directly takes effects on the efficiency of power generation. For the effective maintenance, early measurements of blade defects are very important. However, current technologies such as ultrasonic waves and thermal imaging inspection methods are not suitable because of long inspection time and non-real time inspection. To supplement the problems, the study introduced a method for real time defect monitoring of a blade surface based on surface wave technology. We examined the effect of various parameters such as micro-cracks and peelings on the propagation of surface wave.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.938-946
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• 2008

This study is on sealing leakage holes where are in landfills to make clay cakes with clay particles, which have a negative surface charge using the method of electrophoresis. Generally, electrophoresis is the motion of charged particles in a colloid under the influence of an electric field; particles with a positive charge go to the cathode and negative to the anode. In this study in order to develop the prevention system of leakages of the leachate in landfills, one-dimensional electrophoresis tests were conducted for determining the properties of the motion of the electrophoresis and cutoff using the method of electrophoresis depending on various the effect factors such as types of clays, concentrations of the clays, and applied electric field. In case of the experiments of determining the optimum clays, Na and Ca-Bentonite, Na and Ca-Montmorillonite, which have greater zeta-potential, cation, exchange capacity as well as ability of cutoff, and Micro-cement inducing cementation were chosen and then the effect of those clays was investigated. Moreover, the properties of the motion and settling of the clays were investigated following electric field varied from 0 to 1V/cm at different concentration of the clays in order to determine both the properties of the motion of the clays and the efficiency of electric field when applying different direct current. Ultimately, the ability of cutoff was examined through measuring the permeability of the clay cakes derived from the one-dimensional electrophoresis tests.