• 대한방사선기술학회지:방사선기술과학
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• 제41권5호
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• pp.463-469
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• 2018

Morphological information such as shape and margin of micro lesion is important information for diagnosis of disease in clinical imaging. In this study, we investigated the morphological changes of the micro lesions by comparing the contrast and area in grid suppressed DR images according to grid frequency. In the profile analysis of the image, the mass showed an average intensity variation of 8.6 ~ 72.4 after suppression, The higher the grid frequency, the more the contrast was increased. However, in the images obtained using 103 lp / inch, which is a grid frequency less than the sampling frequency, the contrast of the mass in the vertical direction decreased after suppression. In the binary image, the area change of the mass was also large. As a result, the shape, size, and margin of the mass changed. In the case of very small calcification, the higher the grid frequency is the larger the change in contrast, so that a clear image can be obtained in the post-suppression image. However, we could confirm that the margin of the lesion was blurred and the lesion was lost in some of the images using the 103 lp / inch grid. The higher the frequency of the grid, The change of the contrast of fiber occurred largely and clear boundary was confirmed. The decrease of the number of pixels was small and morphological change was small. In conclusion, when using a grid frequency that is not suitable for the sample frequency, morphological changes or lesion loss of micro lesions in the post- suppression image may give the possibility of misdiagnosis in diagnosis and differentiation of the image.

• 한국전자통신학회논문지
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• 제7권4호
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• pp.881-895
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• 2012

마이크로 로봇은 인간의 다양한 질병과 진단에 있어 유용한 도구로서 활용이 가능한데, 이러한 이유로 현재 세계의 많은 국가들은 마이크로 로봇의 제작과 개발에 관심을 기울이고 있다. 한국정부 역시 이러한 세계적 추세 속에서, 마이크로 로봇 개발에 대한 기술정책을 만들고 많은 노력을 하고 있다. 따라서 본고는 SWOT분석을 통해, 한국의 마이크로 로봇 기술동향과 개발현황을 분석하여 미래 한국의 마이크로 로봇에 대한 가장 합당한 발전방안을 모색한다. 연구결과, '박테리아 기반기술의 마이크로 로봇(C형-2)'과 '무배터리 자체추진기 자율이동 마이크로 로봇(C형-3)'과 같은, 한국에서 관련 최신 특허로 등록받은 마이크로 로봇에 대한 보다 집중적인 지원이 필요하며, 이 양 분야 모두 현재 세계적인 수준으로 성장하고 있으므로 지원 중인 마이크로 로봇 개발에 관한 예산을 더욱 늘리는 한편 보다 적극적으로 관련 기술개발을 추진해야 한다.

• 치위생과학회지
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• 제23권1호
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• pp.60-67
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• 2023

Background: In our study, a silver diamine fluoride (SDF) compound for the treatment of dental caries was synthesized to characterize its remineralization activity upon direct application to deciduous teeth. This study aimed to use microscopic computed tomography (microCT) and nanoindentation to evaluate whether SDF composite application could effectively arrest dental caries in five exfoliated primary molars. Methods: Carious teeth were extracted and visually examined using quantitative photofluorescence devices (Qraycam and QraypenTM). After performing microCT, the SDF composite was applied to the teeth according to the manufacturer's instructions. The researchers exchanged and precipitated the irritant saliva once daily for 1 week. The teeth were sectioned longitudinally through the centers of the mesial and distal surfaces, embedded, polished, and measured using nanoindentation. Thereafter, microCT was repeated. Statistical analyses were performed using GraphPad Prism software. Results: Following SDF composite application, a remineralized layer was observed on microCT images, and the hardness increased when measured using nanoindentation. We found that demineralized enamel presented with an increased number of irregular crystals in the deep carious lesion group compared with those in the shallow carious lesion group, resulting in a rougher surface. Conclusion: The SDF composite may be used for remineralization of early caries and cessation of advanced caries in primary molars.

• 대한디지털의료영상학회논문지
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• 제16권2호
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• pp.25-29
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• 2014

The full-field digital mammography (FFDM), which has been known as a digital breast imaging system, carries out more outstanding performance than the screen-film mammography in overall image quality, skin & nipple, description of pectoral muscle and expression of micro-calcification. Thus, in this thesis, I perform experiments for both the enhancement of image quality and accurate estimation of the result in question, when detecting the very tiny-sized lesions in mammography. The image of digital breast X-rays is the important diagnostic tool for detecting early breast cancer and micro calcification lesion. The experiment of how much compression rate has an effect on the result of diagnosis in the case of microcalcification lesion, with JPEG2000 40:1 compression and over 50% enlargement led to obscure or definitely unacceptable diagnostic results is performed. And in another study of assessment of PSNR degree. I recognized the importance of standardized management system in mammography, where not to mention the accurate reading of the image has the most crucial role in diagnosis

• 대한소아치과학회지
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• 제36권3호
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• pp.394-403
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• 2009

인접면 초기 우식병소에 대하여 레진 접착제를 도포하는 최소 침습적 개념의 therapeutic sealing은 치질 삭제가 불필요하다는 점에서 의미있는 술식으로 인정된다. 그러나 이 방법이 초기 우식병소의 법랑질 내 침투 깊이와 무관하게 여전히 유효할 것인지에 대해 의문이 들어 이번 연구는 그 유효성을 평가해 보기 위해 시도되었다. 인접면에 초기 우식병소를 보이는 발거된 소구치 21개를 대상으로 하고, micro-CT 촬영을 통해 병소의 깊이에 따라 분류하였다. 전체 시편을 병소가 법랑질 외층에 국한된 시편의 표면 절반에 접착제를 도포한 1군과 하지 않은 2군, 병소가 법랑질 내층까지 진행된 시편의 표면 절반에 접착제를 도포한 3군과 하지 않은 4군, 비와동성 초기 병소가 법랑-상아 경계까지 진행된 시편의 표면 절반에 접착제를 도포한 5군과 하지 않은 6군으로 분류하였다. 열순환 후 2주간 인공 우식을 유발하고 분류과정과 동일한 평면을 찾아 micro-CT를 촬영하고 병소의 방사선 밀도 변화를 관찰하여 다음과 같은 결과를 얻었다. 1. 인접면 초기 우식병소의 침투 깊이가 증가할수록 병소 본체의 방사선 밀도는 낮아지는 것이 관찰되었다. 2. 병소의 깊이에 무관하게, 레진 접착제를 도포한 모든 실험군에서 처리하지 않은 대조군에 비하여 인공 우식 처리 전후의 방사선 밀도 변화 가 작게 나타났다(p<0.05). 3. 병소가 법랑-상아 경계에 도달한 5군에서도 레진 접착제를 도포하고 인공 우식 처리시, 실험 전후의 유의한 방사선 밀도 변화가 나타나지 않았다(p<0.05).

• Restorative Dentistry and Endodontics
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• 제33권1호
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• pp.28-38
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• 2008

본 연구는 3차원 유한요소 분석법적 연구를 통해 쐐기형 비우식성 치경부병소의 복합레진 수복물에서 다른 탄성계수를 가진 복합레진의 수복과 와동의 형태와 응력의 방향에 따른 응력분포의 영향에 대해 알아보고자 하였다. 발거된 상악 제2소구치를 Micro-CT로 스캔한 후 3D-DOCTOR로 3차원유한요소 모형을 제작하였다. 제작된 소구치 모형에 쐐기형 와동과 변형시킨 와동을 형성하고 각 와동을 탄성계수가 서로 다른 혼합형 복합레진 또는 흐름성 복합레진으로 수복하였다. 수복 전, 후 협측교두와 설측교두에 500N의 하중을 가한 후 응력분포를 ANSYS 프로그램을 이용하여 주 응력 분석법으로 평가한 바 다음과 같은 결과를 얻었다. 1. 수복 전 응력은 근심측 백악법랑경계와 와동저 선각부에 집중되었으며 최대응력은 근심협측우각부에서 나타났다. 2. 와동수복 후 와동저 선각의 응력은 현저히 감소했으나 치경부측 변연의 응력은 수복전보다 증가하였다. 3. 쐐기형태의 병소의 수복 시 와동저 선각부는 탄성계수가 높은 재료가 유리하고 치경부측 변연은 탄성계수가 낮은 재료가 유리하였다. 4. 와동저 선각부를 둥글게 변화시키는 것은 압축응력은 감소시키지 않으나 인장응력은 감소시켰다.

• 한국임상수의학회지
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• 제35권5호
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• pp.229-232
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• 2018

A 9-year-old intact female Poodle (weighing 3.6 kg) was presented for the treatment of a partial and full thickness burn that covering 45% of body including bilateral thigh and sacrolumbar region. Autologous platelet-rich plasma (PRP) stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. On the unrecovered right thigh of the dog, autologous PRP was injected into the lesion after application of micro-needles. For macroscopic evaluation digital, photographs were taken from wounds at days 0, 3, 5, 13, 21, and 28. On the $3^{rd}$ day after PRP application, epithelialization was accelerated. Application of autologous PRP accelerated wound-healing rate and healing time in full thickness burns as well as secondary complications originating from unrecovered wounds. The delayed lesion was completely healed on the $28^{th}$ day by autologous PRP treatment. In human, PRP was increasingly used in the treatment of a variety of soft tissue in the management of chronic non-healing wounds. This study has shown that PRP treatment can be a valuable and effective aid on intractable wound healing in the dog with burns.

• 대한의용생체공학회:의공학회지
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• 제12권1호
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• pp.1-7
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• 1991

This paper describes and discusses the employment of HMG pattern analysis to provide upper-motor-neuron paraplegics with patient-responsive control of FES ( functional electrical stimulation) for the purpose of walker-supported walking. The use of above-lesion EMG signals as a solution to the control problem is considered. The AR(autoregressive)parameters are identified by time-varying nonstationary Kalman filler algorithm using DSP chip and classified by fuzzy theory. The control and stimuli part of the below-lesion are based on micro-processor(8031). The designed stimulator is a 4-channel version. The experiments described above have only attempted to discriminate between standing function and sit-down function A further advantge of the this system Is applied for motor rehabilitation of social readaption of paralyzed humans.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.521-522
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• 2006

Occlusal loading is considered as the main factor of noncarious cervical lesions. The goal of this study is to identify stress distribution using three dimensional finite element analysis, when occlusal loading is applied on the cervical lesion of human tooth. A finite element model was constructed from micro-CT image and three kinds of static force(500 N) were assumed. In all cases stress concentrates on the same area in the cement-enamel junction. This finding is consistent with published experimental results.

• Biomolecules & Therapeutics
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• 제23권2호
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• pp.195-200
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• 2015

We tested the hypothesis that micro-computed tomography (micro-CT) analysis provides a better quantitative readout of the therapeutic potential of methotrexate (MTX) for treating collagen-induced arthritis (CIA) in rats and compared to conventional histopathological examination. Rats were divided into three groups: Group 1 (G1) was treated with 0.9% saline, whereas groups 2 (G2) and 3 (G3) were boosted with type II collagen at days 0 and 7. Following the first collagen immunization, rats in G1 and G2 were treated with 0.9% saline and those in G3 were treated with 1.5 mg/kg MTX from day 14 to 28. All rats were sacrificed on day 28, at which point and all hind knee joints were analyzed by micro-CT and histopathological examination. Micro-CT analyses showed that bone volume and trabecular number were significantly decreased in G2 and G3 compared to G1 (p<0.01), as was percent bone volume (p<0.05 and p<0.01, respectively). However, bone surface/bone volume was significantly increased in G2 and G3 compared to G1 (p<0.05 and p<0.01, respectively). Trabecular separation was significantly increased in G3 compared to G1 (p<0.05). Histopathological examination showed that knee joints of rats in G2 and G3 showed severe joint destruction with inflammatory cell infiltration. However, cartilage destruction was slightly reduced in G3 compared to G2. Taken together, these results suggest that MTX treatment reduced cartilage destruction in rats with CIA, and micro-CT analyses made it possible to quantify arthritic bony lesion.