• 셀메드
• /
• 제11권1호
• /
• pp.6.1-6.7
• /
• 2021

In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Transition from sol to gel is contingent on one or a mixture of diverse stimuli, such as transition of pH control of temperature, irradiation by UV, by the occurrence of certain ions or molecules. Such characteristic features may be commonly employed in drug delivery systems for the production of bioactive molecules for continuous delivery vehicles. The technique of in situ gelling has been shown to be impactful in enhancing the potency of local or systemic drugs supplied by non-parenteral pathways, increasing their period of residence at the absorption site. Formulation efficacy is further improved with the use of mucoadhesive agents or the use of polymers with both in situ gelling properties and the ability to bind with the mucosa/mucus. The most popular and common approach in recent years has provided by the use of polymers with different in situ gelation mechanisms for synergistic action between polymers in the same formulation. In situ gelling medicine systems in recent decades have received considerable interest. Until administration, it is in a sol-zone and is able to form gels in response to various endogenous factors, for e.g elevated temperature, pH changes and ions. Such systems can be used in various ways for local or systemic supply of drugs and successfully also as vehicles for drug-induced nano- and micro-particles. In this review we will discuss about various aspects about use of these in situ gels as novel drug delivery systems.

• 정보보호학회논문지
• /
• 제31권3호
• /
• pp.331-340
• /
• 2021

5G를 포함한 통신 산업이 발전함에 따라, 모바일 임베디드 시스템을 위한 특수목적의 초소형 컴퓨터인 SoC (System on Chip)의 개발이 증대되고 있다. 이에 따라, 산업체와 기업들의 기술 설계의 패러다임이 변화하고 있다. 기존의 공정은 기업들이 마이크로 아키텍처를 구매하였다면, 지금은 ISA (Instruction Set Architecture)를 사들여, 기업이 직접 아키텍처를 설계한다. RISC-V는 축소 명령어 집합 컴퓨터 기반의 개방형 명령어 집합이다. RISC-V는 모듈화를 통하여 확장이 가능한 ISA를 탑재했으며, 현재 전 세계적 기업들의 지원을 통하여 ISA의 확장 버전 등이 개발되고 있다. 본 논문에서는 RISC-V에서 국산 블록 암호 ARIA, LEA, PIPO에 대하여 성능 벤치마킹과 분석 결과를 제공한다. 또한, RISC-V의 기본 명령어 집합과 특징을 활용한 구현 방법을 제안하고 성능을 논의한다.

• 한국시뮬레이션학회논문지
• /
• 제30권1호
• /
• pp.75-85
• /
• 2021

본 논문에서는 개인사업자 부도율을 보다 정확하게 예측하기 위한 새로운 방법으로 개인사업자의 기업 신용 및 개인 신용정보를 가공, 분석하여 입력 특성으로 활용하는 심층 신경망기반 예측 모델을 제시한다. 다양한 분야의 모델링 연구에서 특성 선택 기법은 특히 많은 특성을 포함하는 예측 모델에서 성능 개선을 위한 방법으로 활발히 연구되어 왔다. 본 논문에서는 부도율 예측 모델에 이용된 입력 변수인 거시경제지표(거시변수)와 신용정보(미시변수)에 대한 통계적 검증 이후 추가적으로 신용정보 특성 선택 방법을 통해 예측 성능을 개선하는 특성 집합을 확인할 수 있다. 제안하는 신용정보 특성 선택 방법은 통계적 검증을 수행하는 필터방법과 다수 래퍼를 결합 사용하는 반복적·하이브리드 방법으로, 서브 모델들을 구축하고 최대 성능 모델의 중요 변수를 추출하여 부분집합을 구성 한 후 부분집합과 그 결합셋에 대한 예측 성능 분석을 통해 최종 특성 집합을 결정한다.

• Advances in concrete construction
• /
• 제14권2호
• /
• pp.103-113
• /
• 2022

On the basis of fabrication, the utilization of nano material in numerous industrial and technological system, obtained the utmost significance in current decade. Therefore, the current investigation presents a theoretical disposition regarding the flow of electric conducting Williamson nanoliquid over a stretchable surface in the presence of the motile microorganism. The impact of thermal radiation and magnetic parameter are incorporated in the energy equation. The concentration field is modified by adding the influence of chemical reaction. Moreover, the splendid features of nanofluid are displayed by utilizing the thermophoresis and Brownian motion aspects. Compatible similarity transformation is imposed on the equations governing the problem to derive the dimensionless ordinary differential equations. The Homotopy analysis method has been implemented to find the analytic solution of the obtained differential equations. The implications of specific parameters on profiles of velocity, temperature, concentration and motile microorganism density are investigated graphically. Moreover, coefficient of skin friction, Nusselt number, Sherwood number and density of motile number are clarified in tabular forms. It is revealed that thermal radiation, thermophoresis and Brownian motion parameters are very effective for improvement of heat transfer. The reported investigation can be used in improving the heat transfer appliances and systems of solar energy.

• Design & Manufacturing
• /
• 제17권3호
• /
• pp.48-54
• /
• 2023

In this study, an injection mold with ultra-small surface properties was manufactured using nanosecond laser processing. A superhydrophobic characteristic analysis was performed on the PET specimen manufactured through this. To this end, a hydrophobic pattern was defined using the Cassie-Baxter model. The defined features were selected with a spot diameter of 25um and pitch spacing of 30um and 35um. As a result of the basic experiment, it was confirmed that the fine pattern shape had an aspect ratio of 1:1 when the pitch interval was 35um and 20 iterations. Through the determined processing conditions, a hydrophobic pattern was implemented on the core surface of KP4. A specimen with a hydrophobic pattern was produced through injection molding. The height of the molded hydrophobic pattern is 20 ㎛ less than the depth of the core and the contact angle measurement results are 92.1°. This is a contact angle smaller than the superhydrophobic criterion. Molding analysis was performed to analyze the cause of this, and it was analyzed that the molding was not molded due to the lack of pressure in the injection machine.

• 아태비즈니스연구
• /
• 제15권1호
• /
• pp.239-256
• /
• 2024

Purpose - The purpose of this study was to examine the main determinants of the gap between housing demand and house affordability. Design/methodology/approach - This study used the micro-level data of 60,043 households from Korea Housing-Finance Corporation by covering the period 2011 to 2022. Findings - First, the trend of general housing demand showed a higher figure in the future demand than in current demand. And such a tendency showed in all types of households, a relative young, low income, and single households. In the case of current housing demand, it has increased by 2022 from the beginning of 2013, while the future demand has rapidly increased from 2020. Second, although the house affordability showed a higher figure in current housing demand by 2019, its trend changed to be higher in future housing demand from 2020 by a rapid decreasing affordbility in current demand. In the case of young householders, the current house affordability was higher than that of future. The figure of low income householders was below 1 point in both periods, and house affordability of single householders showed a similar level in both periods. which showed over 1 point. Third, financial regulation on housing markets induced th widening of the gap between housing demand and house affordability, and such a trend is much atronger in the future(potential) gap of demand and affordability. More specifically, the strengthen financial regulation leaded to the widening of the gap in all types of households, a relative young, low income, and single households. Research implications or Originality - The effect of financial regulation is necessary to consider under the features of each households.

• 대한방사선기술학회지:방사선기술과학
• /
• 제36권2호
• /
• pp.149-155
• /
• 2013

대한갑상선학회는 0.5 cm 보다 큰 경우에만 미세침흡인술을 권고하고 있으나, 본원에서는 0.5 cm 이하의 결절에서도 갑상선 유두암이 많이 발견되고 있다. 이 연구는 건강의학센터에서 미세침흡인술을 시행하여 갑상선 유두암으로 확진된 결절을 토대로 크기에 따른 초음파 특징을 분류해 보고자 한다. 결절의 크기를 장경 0.5 cm 이하, 0.5~1 cm, 1 cm 보다 큰 결절의 세 그룹으로 나누어 각각에서의 악성을 시사하는 초음파 소견에 차이가 있는지 알아보았다. 288개의 악성결절 중 0.5 cm 이하 크기는 21.5 % (62/288), 0.5~1 cm 54.9 % (158/288), 1 cm 보다 큰 결절은 23.6 % (68/288)로 나타났다. 앞뒤가 긴모양의 특징은 0.5 cm 이하 그룹 90.3 % (56/62), 1 cm 보다 큰 그룹 48.5 % (33/68)로 나타나 통계적으로 유의한 차이를 보였다(p<0.001). 0.5 cm이하 그룹에서 well defined smooth 결절은 1예도 없었으며, 침상(spiculated) 혹은 불규칙한 경계는 크기가 클수록 빈도가 증가하였다(p=0.024). 내부에코는 0.5 cm 이하 그룹에서 고에코(hyperechogenicity)와 동에코(isoechogenicity)의 결절은 1예도 없었으며, 각 그룹별로 현저한 저에코(marked hypoechogenicity)보다 저에코(hypoechogenicity)가 많았다(p=0.034). 미세 혹은 거대석회화는 0.5 cm 이하에서 77.4 % (48/62)가 관찰되지 않았으며, 0.5 cm 이하 그룹부터 21.0 % (13/62), 48.1 % (76/158), 64.7 % (44/68)로 결절 크기가 증가할수록 관찰빈도가 증가하였다(p<0.001). 초음파에서 0.5 cm 이하의 결절은 앞뒤가 긴 모양과 침상 혹은 불규칙한 경계, 불분명한 경계를 보였고, 저에코 혹은 현저한 저에코가 많았다. 그러나 미세 혹은 거대석회화는 없는 것이 특징적이었다. 따라서 0.5 cm 이하의 작은 크기의 결절에서 악성을 시사하는 초음파적 특징은 미세침흡인 술이나 추적검사에 대한 유용한 지침을 제공할 수 있을 것으로 사료된다.

• 박물관보존과학
• /
• 제15권
• /
• pp.78-95
• /
• 2014

국립중앙박물관 소장 고려시대 칠기 6점을 대상으로 엑스선 ^X-ray 촬영과 현미경 조사, SEM-EDS 분석 등 과학적인 조사를 실시하여 고려시대 칠기의 재질 및 제작기법의 특징을 연구하였다. 조사 결과 칠제합 ^{덕수 4123}을 제외한 나머지 고려시대의 칠기 유물은 목심 ^木心 표면에 직물 ^織物을 입혀 옻칠을 한 목심저피칠기 ^{木芯紵皮漆器} 양식으로 만들어졌음이 밝혀졌다. 화형합과 송엽형합의 목심은 뚜껑의 천판 ^天板 이나 몸체 바닥판의 외각에 두께가 얇은 띠 모양의 목재를 돌려 감아 기벽을 만들었다. 또한 꽃모양 칠제배 ^{덕수 4124}는 권태 ^捲胎 양식 ^樣式과 유사하게 띠 모양의 목재를 나선형으로 감아올려 기벽을 형성한 후 바닥을 판재로 막고 굽을 달아 칠기 잔의 형태를 만든 것으로 나타났다. 현미경을 이용한 광학적 조사에서는 목재나 직물심 위에 골분 ^骨粉을 혼합한 골회 ^骨灰 옻칠을 먼저 하고, 그 위에 다시 옻칠을 중첩하여 바르는 칠기법이 공통적으로 확인되었다. SEM-EDS 및 μ-XRF ^{미소부 형광X-ray} 분석 결과 꽃모양 칠제배 ^{덕수 4124} 표면에는 진사 ^{辰砂: HgS}를 섞은 주칠 ^朱漆이 사용된 것으로 나타났다. 또한 뚜껑에 반점 무늬가 있는 송엽형 칠제합 ^{덕수 4190}은 석황 ^{石黃: As₂S₃}을 섞은 황색 칠을 도장하고 그 위에 연매 ^煙煤를 혼합한 흑색칠로 불규칙한 반점을 찍어 독특한 무늬를 표현한 것으로 조사되었는데 이 칠제합의 측면에 발라진 주칠에는 진사와 연단 ^{鉛丹: Pb₃O₄}을 혼합한 옻칠이 사용된 것으로 나타났다.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2009년도 하계학술대회 논문집
• /
• pp.311-311
• /
• 2009

Carbon nanotubes (CNTs) belong to an ideal material for field emitters because of their superior electrical, mechanical, and chemical properties together with unique geometric features. Several applications of CNTs to field emitters have been demonstrated in electron emission devices such as field emission display (FED), backlight unit (BLU), X-ray source, etc. In this study, we fabricated a CNT cathode by using filtration processes. First, an aqueous CNT solution was prepared by ultrasonically dispersing purified single-walled CNTs (SWCNTs) in deionized water with sodium dodecyl sulfate (SDS). The aqueous CNT solution in a milliliter or even several tens of micro-litters was filtered by an alumina membrane through the vacuum filtration, and an ultra-thin CNT film was formed onto the alumina membrane. Thereafter, the alumina membrane was solvated by acetone, and the floating CNT film was easily transferred to indium-tin-oxide (ITO) glass substrate in an area defined as 1 cm with a film mask. The CNT film was subjected to an activation process with an adhesive roller, erecting the CNTs up to serve as electron emitters. In order to measure their luminance characteristics, an ITO-coated glass substrate having phosphor was employed as an anode plate. Our field emitter array (FEA) was fairly transparent unlike conventional FEAs, which enabled light to emit not only through the anode frontside but also through the cathode backside, where luminace on the cathode backside was higher than that on the anode frontside. Futhermore, we added a reflecting metal layer to cathode or anode side to enhance the luminance of light passing through the other side. In one case, the metal layer was formed onto the bottom face of the cathode substrate and reflected the light back so that light passed only through the anode substrate. In the other case, the reflecting layer coated on the anode substrate made all light go only through the cathode substrate. Among the two cases, the latter showed higher luminance than the former. This study will discuss the morphologies and field emission characteristics of CNT emitters according to the experimental parameters in fabricating the lamps emitting light on the both sides or only on the either side.

• 대한치과보철학회지
• /
• 제42권2호
• /
• pp.192-209
• /
• 2004

Purpose : The purpose of this study was to evaluate the machining accuracy and consistency of implant/abutment/screw combination or internal connection type. Material and methods: In this study, each two randomly selected internal implant fixtures from ITI, 3i, Avana, Bicon, Friadent, Astra, and Paragon system were used. Each abutment was connected to the implant with 32Ncm torque value using a digital torque controller or tapping. All samples were cross-sectioned with grinder-polisher unit (Omnilap 2000 SBT Inc) after embeded in liquid unsaturated polyester (Epovia, Cray Valley Inc). Then optical microscopic and scanning electron microscopic(SEM) evaluations of the implant-abutment interfaces were conducted to assess quality of fit between the mating components. Results : 1) Generally, the geometry of the internal connection system provided for a precision fit of the implant/abutment into interface. 2) The most precision fit of the implant/abutment interface was provided in the case of Bicon System which has not screw. 3) The fit of the implant/abutment interface was usually good in the case of ITI, 3I and Avana system and the amount of fit of the implant/abutment interface was similar to each other. 4) The fit of the implant/abutment interface was usually good in the case of Friadent, Astra and Paragon system. The case of Astra system with the inclined contacting surface had the most Intimate contact among them. 5) Amount of intimate contact in the abutment screw thread to the mating fixture was larger in assembly with two-piece type which is separated screw from abutment such as Friadent, Astra and Paragon system than in that with one-piece type which is not seperated screw from abutment such as ITI, 3I and Avana system. 6) Amount of contact in the screw and the screw seat of abutment was larger in assembly of Friadent system than in asembly of Astra system of Paragon system. Conclusion: Although a little variation in machining accuracy and consistency was noted in the samples, important features of all internal connection systems were the deep, internal implant-abutment connections which provides intimate contact with the implant walls to resist micro-movement, resulting in a strong stable interface. From the results of this study, further research of the stress distribution according to the design of internal connection system will be required.