• 대한예방한의학회지
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• 제20권1호
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• pp.65-73
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• 2016

Objectives : In this study, we investigated the trends of cohort project in domestic and overseas, and suggested the necessity of cohort on korean medicine and the direction of research. Methods : The papers which include cohort in the title and published by 2015 were searched using PubMed. In order to study the history of cohort in domestic and overseas, research trend was investigated based on the websites of each cohort projects and traditional medicine searching engine named OASIS. Results : Using PubMed, 42,802 papers were searched. Most of the studies over 50 % of total articles, however, were conducted in these 6 years. Nevertheless, cohort studies are being actively proceed, the korean medicine based on cohort studies are nonexistent. Therefore, further discussion about cohort study on korean medicine is necessary to gather physiological index and clinical index of korean medicine consistently. Conclusions : Systematically constructed cohort on korean medicine would be the foundation which collects information, such as gene information, bio information, dietary habit, life style, and Pattern identification (辨證), and integrates them. The analysis of massive clinical materials could suggest the basis of Prevention and treatment of korean medicine considering the difference between personal.

• 대한예방한의학회지
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• 제20권3호
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• pp.67-74
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• 2016

Objectives : The purpose of this study was to analyze the relationship between the Cold-pattern and the quantitative index through the results of an anthropometric method and Bio Impedance Analysis (BIA) of the Haenyeo living in Jeju island. Furthermore, we will examine the effect of Cold-pattern on the quality of life. Methods : BIA indices were acquired directly from Inbody770 and questionnaires were collected by Gallup Korea professional surveyor through face to face interviews. Binary regression analysis and linear regression analysis were used to examine the association between collected data. Results : Total of 175 of people were participated in this study. First, we examined the difference of the indicators in the Cold-pattern group and the non-Cold pattern group by the average comparison of the anthropometry and BIA indices. Most of the non-Cold pattern group showed high quality of life, BIA and anthropometry. In the relationship between Cold-pattern and anthropometry and BIA indices, BMI and PA indices were found to affect the Cold-pattern on a group basis. As the BMI increased by $1kg/m^2$, probability of not being non-Cold pattern was 1.13 times. and as the PA increased by $1^{\circ}$, probability of not being non-Cold pattern was 2.4 times. In the case of EQ5D value, the quality of life of ${\beta}$ was increased by 0.08 in non-Cold pattern (p <.05), EQ5D VAS of ${\beta}$ was also increased by 10.05 (p <.05). Conclusions : This study showed that BMI and PA could be used as a clinical index to evaluate the Cold-pattern as a clinical indicator, and there is a difference in quality of life according to Cold-pattern.

• 동의생리병리학회지
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• 제35권6호
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• pp.267-273
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• 2021

Mibyeong (sub-health) is a concept that represents the sub-health in traditional East Asian medicine. Assuming that the nose sizes and shapes are related to respiratory function, in this study, we hypothesized that the nose size and shape features are related to the self-rated health (SRH) level and self-rated Mibyeong severity, and aimed to assess this relationship using a fully automated image analysis system. The nose size features were evaluated from the frontal and profile face images of 810 participants. The nose size features consisted of five length features, one area feature, and one volume feature. The level of SRH and the Mibyeong severity were determined using a questionnaire. The normalized nasal height was negatively associated with the self-rated health score (SRHS) (partial ρ = -0.125, p = 3.53E-04) and the Mibyeong score (MBS) (partial ρ = -.172, p = 9.38E-07), even after adjustment for sex, age, and body mass index. The normalized nasal volume (ρ = -.105, p = 0.003), the normalized nasal tip protrusion length (ρ = -.087, p = 0.014), and the normalized nares width (ρ = -.086, p = .015) showed significant correlation with the SRHS. The normalized nasal area (ρ = -.118, p = 0.001), the normalized nasal volume (ρ = -.107, p = .002) showed significant correlation with the MBS. The wider, longer, and larger the nose, the lower the SRHS and MBS, indicating that health status can be estimated based on the size and shape features of the nose.

• 동의생리병리학회지
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• 제31권2호
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• pp.145-152
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• 2017

The purpose of this study was to investigate the clinical research of Cold-Heat of pattern identification(PI) focused on quantitative indicators for general people in Korea, through the review of OASIS, KISS, DBpia, NDSL database. Ten clinical researches were analyzed in this study. These research gradually started from 2004 to 2009 but there was no research after 2010. Diagnosis of Cold-Heat PI all was done through a questionnaire, 7 or most researches had not used the intervention methods. Quantitative indicators related to the Cold-Heat PI mentioned in the selected 10 researches are seven, these indicators include heart rate variability(HRV), electroencephalogram, Yangdorak, respiratory index, electrogastrography, acoustic analysis index, western health test index. Related to the HRV were 3 researches, but correlation of significant indicators was a few levels(R=0.026-0.090). So far, studies regarding at the quantitative indicators of the prior the Cold-Heat PI were few, and the results of the study showed that low statistical precision, a lack of biological basis. Refer to the current state, in the future, we expect that research of quantitative indicators of scientific evidence-based through calculated and precise research concerning Cold-Heat PI be regarded as important in Korean Medicine.

• 사상체질의학회지
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• 제29권3호
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• pp.248-261
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• 2017

Objectives The purpose of this study is to analyze the decision making process of prescribing Yeoldahanso-tang and Taeeumjowi-tang Choweseuncheng-tang using decision tree. Methods We used collected the prospective clinical data of TE type from September 2012 to July 2015. In this study, we used gender, BMI, blood pressure, pulse and clinical symptoms (digestion, sweat, defecation, urination, sleep, physical status, emotion, heat-coldness, water consumption, facial color) as variables. Decision trees were analyzed using open source R version 3.3.2. Results & Conclusions We found that the decision trees differed among institutions. However, in all institutions, it was found that stool type (ordinary symptom), urine frequency (ordinary and present symptom) and anxiety (ordinary symptom) were important in the decision of prescription. Besides, clinical informations such as sex, Body Mass Index and blood pressure affected the prescription decision.

• Korean Journal of Acupuncture
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• 제40권2호
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• pp.44-53
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• 2023

Objectives : This study was conducted to reveal the relationship between multiple factors of traditional Korean Medicine diagnosis and consider the further probabilities of treating people with physical and mental problems not defined as diseases, which is called 'Mibyeong' in traditional Korean Medicine. Methods : 40 healthy participants were included in the observational clinical trial. The participants were asked to complete health questionnaires (e.g. State-Trait Anxiety Inventory, Pittsburgh Sleep Quality Index, Stress Response Inventory) and they went through a traditional diagnosis process, including four stages of diagnosis (looking, listening/smelling, inquiring, and pulse taking), by a Korean Medicine doctor. Both the Korean Medicine doctor and an artery tonometry device performed the pulse diagnosis. Results : Although all participants were healthy people with no history of disease, more than half of participants had a problem related with severe level of fatigue (n=19), sleep disturbance (n=26) and stress (n=27) status according to the related questionnaires. Participants diagnosed with phlegm syndrome by the Korean Medicine doctor showed significantly greater score in phlegm pattern questionnaires than participants who were not. However, there was little agreement between the doctor's pulse diagnosis and radial artery tonometry results. Conclusions : We conducted a pulse diagnosis and measured health-related information along with the traditional Korean Medicine diagnose procedure, including four stages of diagnosis, and we found a linkage between diagnosis of phlegm and the phlegm pattern questionnaire score. The results suggest that a number of healthy participants, with no disease diagnosed, have Mibyoung symptoms which need further clinical management. Thus, we suggest that Mibyoung management programs based on qualified diagnosis tools and traditional Korean medicine diagnosis procedures be developed, and that future research using various diagnostic tools be carried out on a large population.

• 한방비만학회지
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• 제22권2호
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• pp.136-146
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• 2022

Objectives: The objective of this study is to evaluate weight change and analyze adverse events in overweight and obese women with polycystic ovary syndrome (PCOS) who were prescribed with Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted for medical records of patients with PCOS, who were administered with Gamitaeeumjowee-tang for a period of 12 weeks between January 2019 and December 2021. Outcomes were total weight loss/weight loss rate, the percentage of patients who lost more than 5% and 10% of their baseline weight. Adverse events (AEs) reported by patients were evaluated by severity, causality and system-organ classes. Results: A total of sixty-seven patients were included (mean±standard deviation, Age 28.78±5.25 years, weight 76.78±12.84 kg, body mass index 29.2±4.26 kg/m²). The average total weight loss in PCOS patients was 6.57±3.07 kg and the average weight loss rate was 8.55±3.65%. The percentage of patients with more than 5% and 10% weight loss compared to their baseline weight was 86.56% and 25.37% respectively. The analysis of adverse events are as follows: Causality assessment with World Health Organization-Uppsala Monitoring Centre of AEs showed 'Unlikely' was the most common (71.7%) and severity evaluations with Common Terminology Criteria for Adverse Events showed almost all symptoms were mild (98.9%). Conclusions: Gamitaeeumjowee-tang helps to lose weight of PCOS patients, which is overweight or obese, and no serious adverse events have occurred. Additional well-designed clinical studies are recommended.

• 대한한방부인과학회지
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• 제30권4호
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• pp.114-134
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• 2017

Objectives: This study aims to investigate the changes of women's postpartum symptoms, including their weights, edema index and quality of life (QOL) over the first six weeks after childbirth. Methods: The study participants were 31 postpartum women treated in the Dept. of Obstetrics & Gynecology, at Woo-Suk University Korean Medicine Hospital, from May 20th to August 5th, 2016. In the first 2 weeks of the postpartum period, the main data collection method was to interview each patient and write down all of their complaints, and additionally referring to each participant's PHR (Personal Health Records). At the 3rd, 4th, 5th and 6th week, the researcher interviewed participants by phone once a week. The participants' weight, edema index (ECW/TBW) and the quality of life (by EQ-VAS) were measured at 1st and 2nd week after childbirth. And, EQ-VAS was assessed once more at the 6th week after childbirth. As a last step, the participants responded to a survey on satisfaction regarding their postpartum care with Korean Medicine. Results: 1. In the 1st one week after childbirth, edema was the most frequent complaint. It was about joint pain of the upper limbs in the 2nd and 3rd weeks, sweating in the 4th week, and joint pain of the upper limbs in the 5th and the 6th weeks. 2. In the 1st two weeks of the postpartum period, the weight of the participants decreased from $66.33{\pm}9.30kg$ to $62.60{\pm}8.92kg$ (p<0.001) and the edema index ECW/TBW decreased from $0.399{\pm}0.010$ to $0.385{\pm}0.0 4$ (p<0.001). The EQ-VAS significantly improved from $61.77{\pm}17.72$ to $73.51{\pm}14.67$ (p<0.001). In the last 4-weeks of the postpartum period, the EQ-VAS decreased from $74.30{\pm}14.25$ to $73.63{\pm}13.35$, but this difference was not statistically significant (p=0.749). 3. Regarding the satisfaction with postpartum care with Korean Medicine, 60% of the participants responded that it was 'Excellent' and 40% said it was 'Good'. Conclusion: Over the entire postpartum period, the most frequent complaints were about musculoskeletal symptoms. Postpartum care with Korean Medicine treatments in the early postpartum period improves various postpartum symptoms and the quality of life for postpartum women.

• 대한한의학회지
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• 제41권3호
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• pp.22-31
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• 2020

Objectives: The purpose of this study was to investigate the association between sleep status and weight loss among adult women with obesity administered with Gamitaeeumjowee-tang. Methods: We retrospectively reviewed the medical records of 137 patients who were were administered with Gamitaeeumjowee-tang for 3 months for the purpose of weight loss. We divided subjects according to sleep duration and sleep quality. We conducted an independent t-test to compare the differences of weight loss between two groups. Also, a regression analysis was applied to determine which factors affected weight loss. Results: There was no significant difference in weight loss between patients who sleep more than 7 hours regularly and patients who sleep less than 7 hours. There was no significant difference between good sleepers and poor sleepers. Initial body mass index and the number of visits to the clinic were the significant factors in weight loss in 2-4 weeks. Initial weight loss was the significant factor in weight loss in 10-12 weeks. There was no significant correlation of sleep duration and sleep quality in weight loss in 2-4 weeks and 10-12 weeks. Conclusions: This study suggests that weight loss may not be affected by sleep status during Gamitaeeumjowee-tang intervention. ostachys japonicus, THP-1, acute myeloid leukemia, apoptosis, autophagy.

• 동의신경정신과학회지
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• 제27권3호
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• pp.169-184
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• 2016

Objectives: To investigate the neurophysiological effect of acupuncture treatment on insomnia patients using quantitative electroencephalography (QEEG) and standardized Low Resolution Brain Electromagnetic Tomography method (sLORETA).Background: Insomnia is one of the commonly encountered symptoms in primary medical care. Recent studies of acupuncture for insomnia reported that the acupuncture groups showed significant improvements compared with the control groups. However, the neurophysiological mechanism of acupuncture in the treatment of insomnia has not been revealed and a few studies have measured the effect of acupuncture treatment using QEEG.Methods: Participants who had some problems in initiating or maintaining sleep, or had non-restorative sleep for more than 3 days a week and ISI scores above 8 and below 21 were treated by acupuncture for 2 weeks (3 times a week, total 6 times). We assessed the effectiveness of acupuncture for insomnia by the PSQI (Pittsburgh Sleep Quality Index) at baseline and at 2 weeks after the end of treatment (4th week). Also, we performed EEG and analysed the EEG data at baseline and at the end of treatment (2nd week) on the linked ears montage using the Neuroguide software program and sLORETA.Results: Thirty-two participants were enrolled and 2 participants dropped out because of personal reasons. Among the 30 participants, EEGs of 12 participants were included in the analysis of QEEG and sLORETA. Total score on the ISI and PSQI was significantly decreased after acupuncture treatment. The number of electrodes exceeding the range of 90% (±1.65) or 95% (±1.96) in the z scored absolute power of beta was significantly decreased after acupuncture treatment. There was no significant change in brain activation between pre- and post-acupuncture using sLORETA.Conclusions: The deviation of absolute power compared to the normative database was significantly decreased after acupuncture treatment in the alpha and beta ranges. Therefore, we suggest that acupuncture treatment for insomnia might be effective through the central nervous system especially in the brain. There are many limitations to drawing any conclusion. Further studies are needed in the future to overcome these limitations.