• 한국식품조리과학회지
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• 제15권1호
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• pp.37-41
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• 1999

유색미 수원 415호 쌀가루에 gluten 대체재료로써 10% gluten 및 3% hydroxypropyl methyl cellulose를 첨가하여 제조한 쌀빵의 가공적성을 검토한 결과, 유색미 수원 415호로 성형성이 아주 좋은 쌀빵의 제조가 가능하였다. 유색미 쌀빵의 물성 중 경도와 씹힘성은 3% hydroxypropyl methyl cellulose를 첨가하여 제조한 것이 10% gluten을 첨가하여 제조한 것 보다 낮아 부드러웠으며, 탄력성은 이와 반대의 경향을 나타내었다. 또한 저장에 따른 쌀빵의 노화도는 3% hydroxypropyl methyl cellulose 첨가하여 제조하는 경우 강력분으로 제조한 빵과 비슷한 수준이었다. 관능검사 결과에 의하면, 3% hydroxypropyl methylcellulose를 첨가하여 제조한 쌀빵은 밀가루 빵에 비해서 질감이 부드럽기는 하지만 기공의 균일성은 나쁘게 나타났다. 그러나 빵의 탄력성은 밀가루 빵에 비해서 유의적인 차이가 없었다.

• 환경위생공학
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• 제10권3호
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• pp.16-28
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• 1995

Influences of capsaicin on the activities of cytochrome P45O of liver cell were studied in rats. Rats were provided food and water ad libitum and capsaicin and methylcellulose were gavaged for 6 days. Body weight gain and liver weight/body weight ratio, microsomal protein content and serum HDL- cholesterol content, the activity of cytochrome P450 and erythromycin demethylase, the activities of ethoxyresorufin and pentoxyresorufin O- dealkylase were determined. Capsaicin increased body weight gain but showed no significant changes on liver weight as compared with control group. Capsaicin increased the microsomal protein significantly but decreased the serum HDL- cholesterol. Capsaicin decreased the microsomal cytochrome P4SO significantly and did not show any influences on erythromycin demethylase ( cytochrome P45O III A ). Capsaicin increased the activity of pentoxyresorufin O- dealkylase ( cytochrome P45O II B) and decreased the activity of ethoxyresorufin O-dealkylase ( cytochrome P45O I A). It might be concluded that capsaicin reduced the microsomal cytochrome P45O and induced the CYP III and inhibited the CYP I A. It also might be concluded that capsaicin had no influence on CYP III A and decreased serum HDL- cholesterol. In these results capsaicin can not be used as an anti- atherosclerotic agent by increasing the CYP III A and HDL- cholesterol but it is considered that the more precise study on these theme is necessary.

• Journal of Pharmaceutical Investigation
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• 제22권2호
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• pp.133-137
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• 1992

A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.

• Current Research on Agriculture and Life Sciences
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• 제32권1호
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• pp.18-23
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• 2014

본 연구에서는 유변물성측정기를 이용하여 HPMC 첨가량, 물 양, HPMC 분자량, 셀룰로오스 에테르 치환제 및 치환도가 쌀 반죽의 압축 및 집착 특성에 미치는 영향에 대해 살펴보았다. HPMC 첨가량이 증가함에 띠라 접착강도는 꾸준히 증가하였으나, 압축강도는 2% HPMC 첨가량에서 최대 강도를 보였다. HPMC의 분자량이 증가하거나, 물 양이 감소할수록 쌀 반죽의 압축강도 및 접착강도가 증가하는 결과를 보였다. 이들 인자 외에도, 셀룰로오스 에테르의 치환제 및 치환도도 쌀 반죽의 압축강도 및 접착강도를 결정하는 중요한 인자임을 확인하였다.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.113-117
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• 2007

The aim of this study was to investigate the effect of different wall material on the microencapsulation efficiency of microcapsules containing fish oil. The present work reports on the microencapsulation of fish oil by spray drying using hydroxypropyl methylcellulose (HPMC) 2910, maltodextrin, gelatin, sodium caseinate as wall materials. The emulsion stability was assessed by emulsion stability index value (ESI). The microstructural properties of microcapsules was evaluated by scanning electron microscopy (SEM) and microencapsulation efficiency (ME) was assessed by soxhlet method. The highest ESI and ME were observed in the case of a 1:1 gelatin/sodium caseinate ratio and 1:1 glycerin fatty acid ester/lecithin ratio, and ME of microcapsules was increased with increasing the ESI of emulsion. Thus, the stability of emulsion was a critical factor for the encapsulation of fish oil.

• Journal of Pharmaceutical Investigation
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• 제39권6호
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• pp.437-443
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• 2009

To develop a topical bioadhesive formulation of clotrimazole for enhanced transdermal delivery, hydroxypropyl methylcellulose gel containing permeation enhancer was formulated and permeation studies were carried out. The release characteristics of the drug from the gel formulation were examined according to the receptor medium, drug concentration, and temperature. The rate of drug release from the gel increased with increasing drug concentration and temperature. The activation energy (Ea) of drug permeation, which was calculated from the slope of log P versus 1/T plots, was 14.41kcal/mol for a 1%(w/w) loading dose. The enhancer, such as saturated, unsaturated fatty acids, pyrrolidones, propylene glycol derivatives, glycerides, and non-ionic surfactants, were incorporated onto the gels to increase the amount of drug permeation into the skin. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the highest level of enhancement. These results show that clotrimazole gels containing polyoxyethylene 2-oleyl ether could be used for the enhanced transdermal delivery of clotrimazole.

• 한국임상수의학회지
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• 제28권1호
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• pp.87-93
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• 2011

Upper gastrointestinal contrast studies were performed to compare the quality of images using two different commercialized barium products in 10 healthy beagle dogs of each group; 30% barium suspension in group 1, and 35% dilute barium suspension in group 2. Contrast media were administered through gastric tube at a dose rate of 10 ml/kg in all groups. All procedures were evaluated by three criteria: the quality of the images obtained, the transit time and the distensibility of the bowel. The imaging in group 1 showed good image quality, a rapid transit time, and good distensibility of bowel loop.

• 한국식품조리과학회지
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• 제12권1호
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• pp.92-98
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• 1996

쌀가루(200 mesh)로 만든 슈의 품질을 향상시키기 위하여 가장 효과적인 첨가물의 종류와 첨가비율을 구명하고져 본 실험을 수행하였다. 첨가물로는 lecithin, span 20, span 40, span 80 등의 유화제와, gelatin, arabic pm, methylcellulose, CMC 등의 점증제를 사용하였다. 1. 쌀가루만으로도 슈형성은 가능하였다. 2. 그러나, 유화제를 첨가하면 쌀가루만의 무첨가구 보다 관능평가에서는 유의차가 없었지만 팽화력이 우수하였다. 3. 점증제로는 큰 효과가 없었으며, 오히려 다량첨가시에는 반죽의 경도가 커져서 슈내부에 공동이 형성되지 않았다. 4. 두가지의 유화제나 점증제와의 복합사용은 유화제 단독 사용시보다 효과가 없었다. 5. Lecithin을 0.6%로 첨가할 경우, 슈의 품질이 가장 우수하였다.

• 한국포장학회지
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• 제4권2호
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• pp.45-57
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• 1998

Immature and mature plums(Prunus salicina L.) were coated with calcium-added methylcellulose(CaMC) and hydroxypropylmethyl-cellulose-15(CaHPMC-15). Physicochemical, nutritional and sensory characteristics were compared during the 8-day storage period at $30^{\circ}C$. Irrespective of maturity, pH of plums increased and the titratable acidity decreased during storage. Free sugars such as glucose, fructose, sucrose and sorbitol were eventually decreased during storage, but Ca-added cellulose coatings influenced on the prevention of free sugars from decreasing especially in mature plums. Vitamin C contents in immature and mature plums became decreased during storage, but the coatings took effective on its retention. Changes of malic acid, the major organic acid in plums were appeared the same tendency as vitamin C during storage. Results of sensory evaluation showed the development of red color in peel and the softening of plum tissue, and also showed that the overall eating quality and appearance generally decreased during storage. However, the coated plums either CaMC or CaHPMC-15 exhibited the better sensory characteristics. As though the significant difference in postharvest storage quality were not found between the two coatings, CaMC and CaHPMC-15 coatings significantly contributed to the improvement of overall storage quality, especially the retention of vitamin C and organic acids only on the mature plums.

• 공업화학
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• 제4권1호
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• pp.125-131
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• 1993

두 종류의 변성 셀룰로오즈 막내의 물의 상태를 시차열분석계를 이용하여 분석하였다. 셀룰로오즈막들은 카르복시메틸 셀룰로오즈(CMC)-젤라틴 고분자전해질 복합체막과 아크릴산 가교 메틸셀룰로오즈(MC)전해질막이다. 동결수(자유수)와 비동결수(결합수) 양을 측정하여서 막을 통한 용질들의 투과도와의 관계를 조사하였다. 막내의 물의 상태는 막의 조성, 모폴로지, 그리고 수화도의 영향을 받는 것을 알았다. 수화된 막들을 통한 확산 투과도의 차이를 자유수와 결합수의 차이로 설명하였다.