• Journal of the Korean Chemical Society
• /
• v.47 no.6
• /
• pp.663-666
• /
• 2003

• Journal of Environmental Science International
• /
• v.15 no.8
• /
• pp.799-809
• /
• 2006

Hydrobromic acid salts of new N, N, O tridentate ligands containing phenol, 2-[(2-Methylamino- ethyl- amino)-methyl]-phenol(H-MMP. 2HBr), 5-Bromo-2-[(2-Methylamino-ethylamino)-methyl]-phenol (Br- MMP. 2HBr), 5-Chloro-2-[(2-Methylamino-ethylamino)-methyl]-phenol(Cl-MMP. 2HBr), 5-Methyl-2-[(2-Methylamino-ethylamino)-methyl]-phenol(Me-MMP. 2HBr), 5-Methoxy-2-I(2-Methylamino-ethylamino)- methyl]-phenol(MeO- MMP. 2HBr) and. 1-[(2-Methylamino-ethylamino)- methyl]-naphthalen-2-ol(Nap- MMP. 2HBr) were synthesized. The synthesized ligands were confirmed by C. H. N. atomic analysis, UV-visible and IR spectroscopies, $^1$H NMR, $^{13}$C NMR and mass analysis. The potentiometry study revealed that the proton dissociation constants(logK$_n^H$) of the synthesized ligands and stability constants (logK$_{ML}$, logK$_{LM2}$) of transition metal complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Pb(II) ions occurred in three steps and the order of the calculated overall proton dissociation constants(log$\beta_p$) and stability constants (logK$_{ML}$) of ligands was Br-MMP. 2HBr < Cl-MMP 2HBr < H-MMP. 2HBr < Nap-MMP. 2HBr < Me-MMP. 2HBr < MeO-MMP. 2HBr. The order showed a similar trend to that of Hammett substituent constants($\delta_p$). The synthesized ligands usually form 2:1(ML$_2$) complexes with transition metal ions. The order of the stability constants of each transition metal ions was Co(II) < Ni(II) < Cu(II) ;> Zn(II) ;> Cd(II) ;> Pb(II).

• Bulletin of the Korean Chemical Society
• /
• v.34 no.5
• /
• pp.1371-1377
• /
• 2013

A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee.

• Bulletin of the Korean Chemical Society
• /
• v.22 no.11
• /
• pp.1243-1247
• /
• 2001

The water-soluble poly(aminoaryloxy-methylamino phosphazene) has been synthesized and investigated as a polymeric carrier species for the covalent attachment of biologically active agents. The cyclic trimeric model systems were utilized for the synthesis of polymeric analogues containing bioactive side groups. The sodium salt of 4-acetamidophenol was first allowed to react with (NPCl2)3 or (NPCl2)n and was then treated with excess methylamine to yield derivatives of type [NP(NHCH3)x(OArNHCOCH3)y]3 or [NP(NHCH3)x(OArNHCOCH3)y]n. The 4-acetamido groups were then hydrolyzed to 4-aminophenoxy units with potassium tert-butoxide. Coupling reactions between amino group and N-acetylglycine was accomplished with the use of dicyclohexylcarbodiimide. Their properties and structural characterization are discussed.

• The Journal of Natural Sciences
• /
• v.7
• /
• pp.165-167
• /
• 1995

3'-Methylamino pyrimidine 3 was prepared from deoxy pyrimidine via the following 8 step reaction sequences; silyl protection, mesylation, cyclization, azide substitution, hydrogenation, t-Boc protection, methylation, and deprotection in 23% overall yield as a potential anti-AIDS agents.

• Membrane Journal
• /
• v.24 no.4
• /
• pp.268-275
• /
• 2014

The water-insoluble poly(phenoxy-methylamino)phosphazene has been synthesized and investigated as the new type of diagnostic membrane for the measurements of blood glucose level. Final absorbances at 680 nm through activated polyphosphazene membranes were measured at various concentration of glucose in blood. The end-point results of varing absorbance values according to time (K/S) were used to obtain glucose concentration. The effects of substitution rates with hydrophilic methylamino groups and hydrophobic phenoxy groups on the measurements of glucose concentration were studied. Dose-response slope (DRS) values between glucose concentration and K/S values increased as the hydrophilic substitution rates increased. However, in less than 5% of the hydrophilic substitution rates, DRS values are too low, and in more than 25% of the hydrophilic substitution rates, because DRS increased rapidly, it was difficult to measure exact concentration level of glucose.

• The Journal of Natural Sciences
• /
• v.9 no.1
• /
• pp.95-104
• /
• 1997

We synthesized the following series of 3', 5'hydroxy modified thymidine analogs to check the potential asymmetric catalytic effects. 3'-monomethylammino and dimethylaminothymidine was synthesized from thymidine via 8 step and 7 step in 38%, 20% overall yields respectively. 5'Acetyl-3'-dimethylamino thymidine was prepared from thymidine via 8 step in 40% overall yield. 5‘-TBS-3'-up-t BOC methylamino thymidine was prepared from thymidine via 6 step in 30% overall yield. 3'-acetyl-5'-t BOC amino thymidine was prepared from thymidine via 7 step in 31% overall yield.

• Bulletin of the Korean Chemical Society
• /
• v.21 no.6
• /
• pp.650-652
• /
• 2000

• Bulletin of the Korean Chemical Society
• /
• v.11 no.2
• /
• pp.85-88
• /
• 1990

The electron paramagnetic resonance (EPR) spectrum of the copper (II) complex with the 2-methylamino-1-cyclo-pentene-1-dithiocarboxylate (acdc) anion, $Cu(N-CH_3acdc)_2$ has been studied in the diamagnetic host lattices afforded by the corresponding divalent nickel, zinc, cadmium and mercury complexes. EPR parameters of the complex support the exclusive use of sulfur atoms by the ligand in metal binding. A combination of host lattice structure and covalency effects can be account for the observed spin-Hamiltonian parameters.

• Bulletin of the Korean Chemical Society
• /
• v.16 no.11
• /
• pp.1074-1079
• /
• 1995

Poly(dichlorophosphazene) having low molecular weight (M&bar;w∼104) was synthesized by the thermal reaction of hexachlorocyclotriphosphazene in the presence of excess AlCl3 (>2%) as catalyst. Using the poly(dichlorophosphazene), poly[bis(ethylglycino)phosphazene], poly[bis(glycinemethylamido)phosphazene], and poly[(glycinemethylamido)(methylamino)phosphazene] were prepared. Diammineplatinum(Ⅱ) complex cation was introduced into these derivatized phosphazene polymers, and the resultant polymers containing the platinum(Ⅱ) moiety were charaterized by means of elemental analysis, IR and NMR spectroscopies, and then subjected to in vitro and in vivo assays of antitumor activity.