• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.33-43
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• 2010

Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications including arthritis treatment, wound healing, ocular surgery, and tissue augmentation. Because of its mucoadhesive property and safety, HA has received much attention as a tool for drug delivery system development. It has been used as a drug delivery carrier in both nonparenteral and parenteral routes. The nonparenteral application includes the ocular and nasal delivery systems. On the other hand, its use in parenteral systems has been considered important as in the case of sustained release formulation of protein drugs through subcutaneous injection. Particles and hydrogels by various methods using HA and HA derivatives as well as by conjugation with other polymer have been the focus of many studies. Furthermore, the affinity of HA to the CD44 receptor which is overexpressed in various tumor cells makes HA an important means of cancer targeted drug delivery. Current trends and development of HA as a tool for drug delivery will be outlined in this review.

• 부모자녀건강학회지
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• 제13권2호
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• pp.95-101
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• 2010

Purpose: This study is intended to identify difference postpartum depression according to delivery mode in the postpartum women. Methods: The subjects were 239 postpartum women in D and A city. Data collected from June 9, 2006 to August 6, 2007 using structured questionnaire surveys and convenience sampling. Measuring instrument was BDI (Beck Depression Inventory) translated By Lee and Song (1991). Collected data was analyzed by $x^2$-test, ANCOVA, Stepwise Multiple Regression with SPSS/PC 14.0. Results: There were significant differences in postpartum period ($x^2$=12.40, p = .002) and sleeping hours ($x^2$=9.09, p = .011) as analysed distribution of the subjects according to delivery mode. As result of analyzing the difference of postpartum depression according to delivery mode using ANCOVA, C-sec women's postpartum depression was higher than vaginal delivery women statistically (F=6.32, p = .013). As a result of Multiple Regression, income was a influencing factor of postpartum depression in vaginal delivery women and support of spouse and sleeping hours were influencing factors in C-sec women. Conclusion: There were differences in postpartum depression and their influencing factors according to delivery mode. Therefore it is necessary to develop and study a concrete nursing intervention and strategies for reducing the postpartum depression according to delivery mode.

• 정보관리연구
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• 제43권4호
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• pp.169-189
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• 2012

이용자의 요구에 의해 타 도서관 소장 자료를 복사해 주는 학술정보센터의 원문복사서비스는 저작권법상 저작권 제한 규정에서 그 법적 근거를 찾을 수 있다. 그러나 정보유통 기술의 발달과 함께 해외 저작물의 디지털 전송에 대한 이용자 요구가 증가하면서 보다 적극적인 정보서비스가 요구되고 있다. 이에 이 연구는 해외 저작물의 원문복사서비스에 대한 법적 근거 검토와 함께, 해외 정보서비스 기관의 저작권 권리처리 사례를 살펴봄으로써 해외 저작물의 디지털 복제 전송이 가능한 저작권 권리처리 방안을 제시하였다. 이를 통해 갈수록 첨예해지고 있는 저작권 분쟁 시대에 저작권자의 권리를 보호하는 한편, 학술정보센터 이용자의 다양한 정보요구를 충족시킬 수 있는 새로운 서비스 모델을 기획할 수 있을 것이다.

• 대한토목학회논문집
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• 제33권6호
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• pp.2575-2582
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• 2013

공공건설공사 발주제도 운영에 있어 기술경쟁을 지향하는 턴키 및 대안방식 등 설계 시공일괄방식의 경우, 시설물의 품질향상 및 건설기술 발전에 기여하였음에도 불구, 계약되는 공사비가 설계 시공 분리발주방식을 적용하는 공사보다 높아 예산낭비 우려가 있다는 지적과 함께 수주독점, 입찰담합, 심의비리 등의 문제가 쟁점이 되고 있다. 그러나 실제 발주방식별 사업성과와 효과에 대해 정밀 비교분석한 사례가 없는 실정이며, 단순히 낙찰률 등 사업의 한정된 일반적 정보만으로 사업효과를 논의하고 판단하는 것은 자칫 오류를 범할 우려가 있다. 이에 공공 건설공사를 대상으로 계약에서 준공에 이르기까지 실제 집행한 공사비 자료를 광범위하게 조사하여 비용의 투입구조 및 변동추세 등 발주방식별 특성을 비교분석하고 공공건설공사 발주제도의 올바른 이해와 효율적 운영을 도모하고자 한다.

• 임상간호연구
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• 제18권1호
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• pp.74-85
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• 2012

Purpose: The purpose of this study was to explore the attitudes of wives and husbands to the husband's presence during labor and delivery. Methods: A total of 264 participants including 132 wives and 132 husbands were surveyed. The participants' attitudes towards the husband's presence during child birth were collected using a questionnaire. The data were analyzed by descriptive analysis, t-test, Mann-Whitney test, ANOVA with post hoc, and Kruskal-Wallis test. Results: 119 husbands participated in all stages of labor. Mean attitude scores were 109.7(13.47) for wives and 108.7(12.60) for husbands. Husbands' attitudes scores were significantly related to marriage satisfaction and family planning. Conclusion: Wives and husbands had positive attitudes to the husband's presence during the labor and delivery. Therefore, husband's presence during labor and delivery could be encouraged.

• 대한간호학회지
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• 제39권4호
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• pp.574-583
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• 2009

Purpose: This paper analyzed alternative methods of calculating the conversion factor for nurse-midwife's delivery services in the national health insurance and estimated the optimal reimbursement level for the services. Methods: A cost accounting model and Sustainable Growth Rate (SGR) model were developed to estimate the conversion factor of Resource-Based Relative Value Scale (RBRVS) for nurse-midwife's services, depending on the scope of revenue considered in financial analysis. The data and sources from the government and the financial statements from nurse-midwife clinics were used in analysis. Results: The cost accounting model and SGR model showed a 17.6-37.9% increase and 19.0-23.6% increase, respectively, in nurse-midwife fee for delivery services in the national health insurance. The SGR model measured an overall trend of medical expenditures rather than an individual financial status of nurse-midwife clinics, and the cost analysis properly estimated the level of reimbursement for nurse-midwife's services. Conclusion: Normal vaginal delivery in nurse-midwife clinics is considered cost-effective in terms of insurance financing. Upon a declining share of health expenditures on midwife clinics, designing a reimbursement strategy for midwife's services could be an opportunity as well as a challenge when it comes to efficient resource allocation.

• International Journal of Oral Biology
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• 제32권1호
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• pp.7-11
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• 2007

It is difficult to introduce DNA in non-invasive manner into oral cancer cells as well as primary cells for gene manipulation and expression in vivo. So far, several methods for a gene delivery have been performed to solve this problem. Magnetofection is one of the recent methods for gene transfer, and nanoparticles are applied under a magnetic field for DNA delivery. We investigated whether the magnetofection increases the efficiency of a gene delivery into several oral cell lines. By using a plasmid coding the green fluorescent protein (GFP), the efficiency of gene transfer by magnetofection was compared with those by using the calcium phosphate and the commercial transfection agent. Indeed, the magnetofection increased the green fluorescent signal in cells, suggested that this method apparently enhance the efficiency of gene delivery without any defects in various oral cancer cell lines. Finally, we have shown that magnetofection can be a useful technique for gene delivery to difficult-to-transfect cells to perform a functional study of genes in vivo.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권1호
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• pp.141-156
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• 2011

In this paper we develop a link cost function for data delivery in sensor network. Usually most conventional methods determine the optimal coefficients in the cost function without considering the surrounding environment of the node such as the wireless propagation environment or the topological environment. Due to this reason, there are limitations to improve the quality of data delivery such as data delivery ratio and delay of data delivery. To solve this problem, we derive a new cost function using the concept of Partially Connected Neural Network (PCNN) which is modeled according to the input types whether inputs are correlated or uncorrelated. The correlated inputs are connected to the hidden layer of the PCNN in a coupled fashion but the uncoupled inputs are in an uncoupled fashion. We also propose the training technique for finding an optimal weight vector in the link cost function. The link cost function is trained to the direction that the packet transmission success ratio of each node maximizes. In the experimental section, we show that our method outperforms other conventional methods in terms of the quality of data delivery and the energy efficiency.

• Korean Journal of Acupuncture
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• 제29권2호
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• pp.200-215
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• 2012

Objectives : The purpose of this study is to investigate the differences of pulse wave parameter between the non delivery group (single women with no childbirth experience) and the delivery group (married women who gave birth(s) in delivery). Methods : Sixty one healthy (non delivery) nulliparous women and fifty three delivery women participated in this study. We used 3 dimensional pulse analyser(3D MAC, DAEYOMEDI co., Korea), which measures radial pulse waveform non-invasively by way of tonometry method at 5 different applied pressure levels. From 114 subjects enrolled, pulse wave parameters were measured on the six locations of Chon, Kwan and Cheok of each hands. Results : Delivery group's pulse showed larger values in the following pulse wave parameters (Energy, Ap, RAI, As, Aw, h1, h2, h4, h4/h1, t, t1, t2, t4, Wm, Wm/t). Non delivery group's pulse indicated larger values in the pulse wave parameters such as Energy of left Chon, difference pulse energy between left and right hand, Ad, h5, h5/h1, t5. Conclusions : According to the analysis result, delivery group's pulse has bigger values in most part of pulse wave parameters, especially in Kwan and Cheok which correspond to Liver, Kidney, and Myeong-mun. We interpret these results that delivery women are more mature and stable in reproductive organs than non delivery group, as they have experienced delivery(deliveries) and child-caring through married life.

• 대한안전경영과학회지
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• 제15권2호
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• pp.193-204
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• 2013

The growing logistics strategy of a company is to optimize their vehicle route scheduling in their supply chain system. It is very important to analyze for continuous pickups and delivery vehicle scheduling. This paper is a computational study to investigate the effectiveness of continuous pickups and delivery vehicle routing problems. These scheduling problems have 3 subproblems; Inbound Vehicle Routing Problem with Makespan and Pickup, Line-haul Network Problem, and Outbound Vehicle Routing Problem with Delivery. In this paper, we propose 5 heuristic Algorithms; Selecting Routing Node, Routing Scheduling, Determining Vehicle Type with Number and Quantity, and Modification Selecting Routing Node. We apply these Algorithms to S vehicle company. The results of computational experiments demonstrate that proposed methods perform well and have better solutions than other methods considering the basic time and due-date.