• Journal of Nutrition and Health
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• 제38권4호
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• pp.267-278
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• 2005

Postmenopausal women or ovariectomized rats are associated with increased cholesterol levels, which are risk factors of metabolic syndrome and cardiovascular diseases. Increased prevalence of metabolic syndrome after menopause might be associated with estradiol deficiency. Harmful effect of estradiol hampers the casual usage of hormone to prevent the metabolic syndrome. Soy protein has been reported to show several beneficial effects on health, however it is unclear which components of soy protein is responsible for anti-obesity and hypocholesterolemic effects. Soy isoflavones, gem-stein and daizein, are suggested to have anti-obesity and hypocholesterolemic effects but with inconsistency. The present study investigated the effect of supplementation of genistein (experiment I) and soy protein containing isoflavones (experiment II) to high fat diet on body weight gain, food intake, liver and fat tissue weight and the lipid levels in ovariectomized rats. Plasma and hepatic lipid contents and the mRNA levels of genes encoding lipid metabolism related proteins, such as CPT1 and HMGR were measured. Ovariectomy increased body weight, fat tissue weight and plasma and hepatic lipid levels which increase the risk of metabolic syndrome. Soy protein could improve plasma and hepatic lipids levels. Soy protein also increased hepatic CPT1 and HMGR mRNA levels. Plasma and hepatic lipids levels could not be decreased by dietary genistein alone. In contrast, lipids levels could be decreased by isoflavone-fortified soy protein, suggesting that the ingestion of soy protein enriched with isoflavone gives more benefit for protecting postmenopausal women from metabolic syndrome.

• 한국직업건강간호학회지
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• 제29권1호
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• pp.69-77
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• 2020

Purpose: The prevalence of metabolic syndrome (MetS), a cluster of metabolic abnormalities has rapidly increased in Korea. Sleep may play a role in determining its prevalence. However, the relationships between MetS and the duration and quality of sleep are not yet clear. This study aimed to examine the associations between the duration and quality of sleep and the prevalence of MetS. Methods: Study participants included 348 Korean blue-collar workers employed by six small-sized companies in Korea. The data were collected using an interviewer-administered questionnaire, and logistic regression analysis was conducted to estimate the effects of the factors related to MetS. Results: The multiple logistic regression analysis revealed that the independent factors that contributed to the prevalence of MetS were being male (adjusted odds ratio [aOR]=4.87, 95% confidence interval [CI]=1.58~15.0) and lower sleep quality (aOR=5.12, 95% CI=1.90~14.30). Sleep duration was related to the prevalence of some MetS components, but it was not associated with MetS prevalence. Conclusion: Sleep quality was negatively associated with MetS prevalence when covariates, such as sleep duration, were controlled. When developing a MetS risk-reduction program, focus should be given to sleep quality as well as sleep duration in an intervention for Korean blue-collar workers.

• 생명과학회지
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• 제17권12호
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• pp.1744-1753
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• 2007

비만 여중생을 대상으로 하여 12주간 행동수정 프로그램을 포함한 걷기운동을 실시한 결과 비만 여중생의 체조성, 체력, 대사증후군의 유병률 및 대사증후군 위험인자에서 긍정적인 변화를 가져오는 것을 확인하였다. 또한 다중선형회 귀분석 결과 체조성의 상완위팔근육둘레, 허리둘레, 신체발달지수, 체수분, 체지방량의 개선과 체력의 50m달리기 향상이 BMI, WHR, HDL-C, 공복혈당, 수축기혈압, HOMA지수를 개선시킬 수 있는 것으로 나타나 유산소성 걷기운동과 행동수정 프로그램에 의한 식사량조절과 식습관 변화가 비만청소년에 있어서 대사증후군에 의한 심혈관질환과 당뇨병, 심리적 우울증에 효과적인 프로그램이 될 수 있다고 생각된다. 그러나 피험자 수가 적고, 실험기간이 짧아 실험결과를 일반화하기에는 주의가 필요하며, 실험이후에 학생들의 지속적 운동 습관을 유지하기 위한 프로그램의 개발이 필요하다고 생각된다.

• 동의생리병리학회지
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• 제24권3호
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• pp.519-524
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• 2010

This clinical study was done to examine comparison the prevalence of metabolic syndrome and obesity index between patients with silent lacunar infarction and normal controls. We compared the components of metabolic syndrome and obesity index between patients silent lacunar infarction(n=62) and normal controls(n=72). The analysis of the data was done by Frequency Analysis, two sample t-test, Chi-square Test. Hypertension and diabetes mellitus was significantly higher in patients of silent lacunar infarctions. Body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome were higher significantly in patients of silent lacunar infarctions than normal controls. Although statistically insignificant, waist circumference showed relatively higher in patients of silent lacunar infarction. This result emphasizes the importance of managing that hypertension, diabetes, body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome in silent lacunar infarction.

• 보건교육건강증진학회지
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• 제31권1호
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• pp.13-26
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• 2014

Objectives: This study aimed to assess whether metabolic syndrome (MS) is related to osteoporosis and investigate the association between the MS components and bone mineral density (BMD). Methods: We conducted a cross-sectional study for 4,365 women aged over 50 years who completed health examination from 2008 to 2012 in Korea Association of Health Promotion Gangwon Branch. Height, body weight, waist circumference, blood pressure, fasting plasma glucose, serum lipid profiles, and BMD were measured. Results: Obesity measured as body mass index (BMI) was detrimental to all of the MS components but positively correlated with BMD at three skeletal sites (lumbar spine, femoral neck, and total hip). There were no significant differences in the MS prevalence between women without osteoporosis and those with osteoporosis. In age-adjusted analysis, women with MS had significantly higher BMD at three sites when compared to those without MS. After adjusting for BMI and age, these significances disappeared, such that MS was not associated with higher BMD. Conclusions: Our findings indicate that obesity increases the risk of MS whereas underweight increases that of osteoporosis. The association between MS and higher BMD was explained by the higher BMI in those with MS. MS may not be associated with osteoporosis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3873-3877
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• 2012

Objective: Colorectal cancer (CRC) and the metabolic syndrome (MetS) are both on the rise in Malaysia. A multi-centric case-control study was conducted from December 2009 to January 2011 to determine any relationship between the two. Methods: Patients with confirmed CRC based on colonoscopy findings and cancer free controls from five local hospitals were assessed for MetS according to the International Diabetes Federation (IDF) definition. Each index case was matched for age, gender and ethnicity with two controls (140: 280). Results: MetS among cases was highly prevalent (70.7%), especially among women (68.7%). MetS as an entity increased CRC risk by almost three fold independently (OR=2.61, 95%CI=1.53-4.47). In men MetS increased the risk of CRC by two fold (OR=2.01, 95%CI, 1.43-4.56), demonstrating an increasing trend in risk with the number of Mets components observed. Conclusion: This study provides evidence fora positive association between the metabolic syndrome and colorectal cancer. A prospective study on the Malaysian population is a high priority to confirm these findings.

• 농촌의학ㆍ지역보건
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• 제35권1호
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• pp.67-76
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• 2010

광주지역의 한 종합병원 수검자를 대상으로 백혈구 수와 대사증후군과의 관련 요인을 분석하고자 단면 연구를 시행한 결과 대사증후군의 유병률은 남성이 25.2%, 여성은 13.3%로 나타났으며, 연령별 유병률은 남성은 40대에서, 여성은 60세 이상에서 가장 높은 유병률을 보였고 남녀 모두 백혈구수가 증가 할수록 대사증후군의 유병률이 높게 나타났다. 대사증후군과 백혈구수와의 로지스틱 회귀분석의 결과에서는 남, 여 모두 백혈구 수가 증가 할수록 대사증후군의 위험도가 증가하였다. 결론적으로 본 연구에서는 비록 정상범위 일지라도 증가된 백혈구 수는 대사증후군과 연관성이 있다는 것을 확인할 수 있으며, 대사증후군 기준을 충족시키는 항목수가 많을수록 백혈구 수는 증가하는 경향을 보였고, 백혈구 수를 네 개의 군으로 나누었을 때 백혈구 구분수가 증가할수록 대사증후군의 유병률도 증가하고 있었다. 백혈구수와 백혈구 감별계산이 대사증후군을 예측하는 인자로 가치가 있는지는 광범위한 대단위 연구와 시간적 순서에 의해 인과관계를 규명하는 코호트연구가 필요하다고 생각된다.

• 한국산학기술학회논문지
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• 제19권3호
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• pp.309-316
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• 2018

연구목적: 본 연구는 한국 청소년의 대사증후군 유병률 및 대사증후군과 관련이 있는 요인을 확인하기 위한 서술적 조사연구이다. 연구방법: 2015년도 국민건강영양조사 원시자료 중 건강설문조사와 건강검진에서 결측치가 없는 만 12~18세의 청소년 404명을 대상으로 하였다. 청소년의 대사증후군 진단기준으로 National Cholesterol Education Program의 Adult Treatment Panel III에서 제시한 기준을 청소년에게 맞게 변형한 Ford의 방법을 이용하고, SPSS WINDOW 23.0 Program을 활용하여 complex sampling method로 기술통계, t-test, $x^2$-test, logistic regression으로 분석하였다. 연구결과: 한국 청소년의 대사증후군 유병률은 6.5%(소년 6.5%, 소녀 6.4%)이고, 대사증후군 구성요소 중 유병률이 가장 높은 것은 혈압 상승(28.8%)이며 다음은 중성지방 상승(21.3%), 복부둘레 과다(14.1%), 고밀도지단백 콜레스테롤 저하(11.5%), 혈당 상승(7.8%)의 순이었다. 소년과 소녀 모두에서 대사증후군과 관련이 있는 유일한 요인은 체질량지수이고, 체질량지수가 증가할수록 대사증후군에 이환될 가능성은 1.6~2.3배 증가하였다(Adjusted OR=1.552~2.313, p=.001)이었다. 결론: 연구결과를 바탕으로, 한국 청소년의 대사증후군을 예방 및 관리하기 위하여 체질량지수를 정상 범위로 유지하기 위한 중재 프로그램이 개발 및 제공되어야 할 것이다.

• 대한임상검사과학회지
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• 제50권2호
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• pp.155-163
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• 2018

빌리루빈은 내인성 항산화제로서 항염작용이 있으며, 고혈압, 당뇨병, 대사증후군 및 인슐린 저항성과 역상관 관계에 있다고 보고된다. 그러나 간 특이적 지표와 비교하여 빌리루빈과 대사증후군간의 관련성을 평가한 연구는 부족하다. 본 연구에서는 건강검진을 실시한 한국 성인남녀를 대상으로 ALT, GGT와 비교하여 총 빌리루빈과 대사증후군 유병률 사이의 관련성을 조사하고자 하였다. 이 횡단면 연구에는 2015년 3월부터 2018년 2월까지 경기도 소재 종합병원에서 건강검진을 실시한 20세 이상 성인남녀 22,568명이 포함되었다. American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI)의 지침에 따라 대사증후군을 진단하였다. 남녀 모두에서 대사증후군 위험요인이 없는 군보다 대사증후군 진단군에서 간 효소치가 높았으며, 총 빌리루빈과 직접 빌리루빈치는 낮게 나타났다. 남녀 모두에서 혈청 총 빌리루빈은 복부비만(r=-0.066 vs r=-0.055), 중성지방(r=-0.127 vs r=-0.136)과 약한 역상관 관계를 보였으며, 이는 ALT와 GGT보다 약한 관련성이었다. 또한 남녀 모두에서 ALT와 GGT뿐만 아니라 총 빌리루빈은 대사증후군 발생 가능성을 예측하는 지표는 아닌 것으로 나타났다.

• Journal of Nutrition and Health
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• 제46권6호
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• pp.531-539
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• 2013

The prevalence of metabolic syndrome (MetS) in Korea has been increasing in adults, as well as in adolescents. Recently the prevalence of MetS in children has been reported to strongly link that of MetS in parents. Families are known to share similar food environment so that eating habits of parents closely resemble that of the children's. Therefore, the aim of this study to examine metabolic risk factors and dietary intake in children by with respect to mother's metabolic syndrome, based on the data from Korean National Health and Nutrition Examination Survey (KNHANES) 2007-2010. Using the household variable and the eldest child per household, 1,341 pairs of mothers and children were selected. The mothers were defined by MetS criteria, and then the children were classified into the following three groups in accordance to the mothers' MetS; children whose mothers had none, 1-2, and 3 or more components of MetS. All dietary data were evaluated using the data from a food frequency questionnaire. The mean age was $42.6{\pm}4.2$ years for the mothers, and $14.9{\pm}2.0$ years for the children. Children whose mothers had 3 or more components of MetS showed a significantly higher prevalence of overweight and higher level of fasting triglyceride; conversely, they showed a lower level of serum HDL-cholesterol compared to the other two groups. Regarding an agreement of food consumption between the mothers and children, most food groups showed high agreement, except in the category of beverages. Regarding the dietary habits and family meals, children whose mothers had 3 or more components of MetS were more likely to skip breakfast and less likely to have family meals at breakfast or snack. In conclusion, the children's metabolic risk factors and dietary factors were different with respect to the status of mothers' MetS. Further studies are necessary to examine the causal effect of family environment in children's health status.