Journal of agricultural medicine and community health (농촌의학ㆍ지역보건)

Korean Society for Rural Medicine and Community Health (한국농촌의학지역보건학회)
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Relationship between White Blood Cell Counts and the Metabolic Syndrome

백혈구 수와 대사증후군과의 관련성

  • Seo, Hyun-Sook (Department of Laboratory Medicine, Gwangju Veterans Hospital) ;
  • Yun, Yong-Woon (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Sohn, Seok-Joon (Department of Preventive Medicine, Chonnam National University Medical School)
  • 서현숙 (광주보훈병원 진단검사의학과) ;
  • 윤용운 (전남대학교 의과대학 예방의학교실) ;
  • 손석준 (전남대학교 의과대학 예방의학교실)
  • Received : 2010.01.20
  • Accepted : 2010.02.10
  • Published : 2010.03.31
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Abstract

Objectives: This study was attempted to identify the relationship between white blood cell counts and the metabolic syndrome. Methods: This study included 394 adults who visited the medical checkup center placed in Gwangju, January 1, 2008 to December 31, 2008. Index of blood test and physical checkup were performed on the study such as triglyceride, HDL-cholesterol, fasting sugar and white blood cell counts. Logistic regression analysis was used to evaluate the association between white blood cell counts, white blood cell differential count and metabolic syndrome with an adjustment age and smoking status. Results: The prevalence rate of metabolic syndrome was 25.3% among males and 13.3% among females, and was particularly high among males in their 40s. The increase in white blood cell counts lead to high prevalence of metabolic syndrome for both males and females. As white blood cell counts increased, the values of body mass index and cardiovascular risk factors were increased significantly. The odds ratio for elevated white blood cell counts increased significantly in the subjects with each components of the metabolic syndrome compared to the subjects without them. The lymphocyte counts in the white blood cell differential counts were higher in patients with metabolic syndrome than in those without. Conclusions: High level of white blood cell counts in normal range can be used as indicator in chronic inflammation. Increased white blood cell counts were significantly associated with metabolic syndrome.

광주지역의 한 종합병원 수검자를 대상으로 백혈구 수와 대사증후군과의 관련 요인을 분석하고자 단면 연구를 시행한 결과 대사증후군의 유병률은 남성이 25.2%, 여성은 13.3%로 나타났으며, 연령별 유병률은 남성은 40대에서, 여성은 60세 이상에서 가장 높은 유병률을 보였고 남녀 모두 백혈구수가 증가 할수록 대사증후군의 유병률이 높게 나타났다. 대사증후군과 백혈구수와의 로지스틱 회귀분석의 결과에서는 남, 여 모두 백혈구 수가 증가 할수록 대사증후군의 위험도가 증가하였다. 결론적으로 본 연구에서는 비록 정상범위 일지라도 증가된 백혈구 수는 대사증후군과 연관성이 있다는 것을 확인할 수 있으며, 대사증후군 기준을 충족시키는 항목수가 많을수록 백혈구 수는 증가하는 경향을 보였고, 백혈구 수를 네 개의 군으로 나누었을 때 백혈구 구분수가 증가할수록 대사증후군의 유병률도 증가하고 있었다. 백혈구수와 백혈구 감별계산이 대사증후군을 예측하는 인자로 가치가 있는지는 광범위한 대단위 연구와 시간적 순서에 의해 인과관계를 규명하는 코호트연구가 필요하다고 생각된다.

Keywords

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