• Safety and Health at Work
• /
• 제11권2호
• /
• pp.136-142
• /
• 2020

Background: Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory arthritis. This meta-analysis was conducted to examine the association between occupational exposure to silica and the risk of developing RA among different workers. Methods: In this meta-analysis, we searched relevant published studies using major electronic databases including Scopus, PubMed, ISI Web of Science, and Google Scholar search engine up to October 2019, and the references of retrieved articles were also checked for further possible sources. A random-effects model was used to account for heterogeneity among the results of the studies using the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The Q-statistic and I² tests were calculated to assess heterogeneity between the studies. Results: The pooled calculation of OR indicated a significant association between occupational exposure to silica and risk of developing RA among different workers (OR = 2.59, 95% CI = 1.73 to 3.45). In addition, the pooled estimates of OR in smokers were statistically significant (OR = 2.49, 95% CI = 1.13 to 3.86). Conclusions: The findings of the present study reveal that occupational exposure to silica may be associated with increased risk of developing RA.

• 한국생물정보학회:학술대회논문집
• /
• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
• /
• pp.245-250
• /
• 2003

There are currently about 6000 bacterial species with validly published names, but scientists assume that these may be less than 1% of bacterial species present on the earth. Microbial resource is one of the most important bioresources in bioinderstry and provides us with high economic values. To find missing ones, the studies of metagenome, metabolome, and proteome about microbes have started recently in developed countries. We construct the information system that integrates information on microbial genome resources and manages the information to support efficient research of microbial genome application, and name this system 'Bio-Meta Information System (Bio-MIS)'. Bio-MIS consists of integrated microbial genome resources database, microbial genome resources input system, integrated microbial genome resources search engine, microbial resources on-line distribution system, portal service and management via internet. In the future, we will include public database connection and implement useful bioinformatics software for analyzing microbial genome resources. The web-site is accessible at http://biomis.probionic.com

• Journal of Microbiology and Biotechnology
• /
• 제16권2호
• /
• pp.178-183
• /
• 2006

Microbes are one of the most important bioresources in bioindustry and provide high economic values. Although there are currently about 6,000 bacterial species with validly published names, microbiologists generally assume that the number may account for less than 1% of the bacterial species present on Earth. To discover the remaining species, studies of metagenomes, metabolomes, and proteomes related to microbes have recently been carried out in various fields. We have constructed an information system that integrates various data on microbial resources and manages bioinformation to support efficient research of microorganisms. We have designated this system 'Bio-Meta Information System (Bio-MIS).' Bio-MIS consists of an integrated microbial resource database, a microbial resource input system, an integrated microbial resource search engine, a microbial resource online distribution system, a portal service, and management via the Internet. In the future, this system is expected to be connected with various public databases. We plan to implement useful bioinformatics software for analyzing microbial genome resources. The Web site is accessible at http://biomis.probionic.com.

• 생물정신의학
• /
• 제25권4호
• /
• pp.89-100
• /
• 2018

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method that delivers 1-2 mA of current to the scalp. Several clinical studies have been conducted to confirm the therapeutic effect of major depressive disorder (MDD) patients with tDCS. Some studies have shown tDCS's antidepressant effect, while the others showed conflicting results in antidepressant effects. Our aim of this review is to understand the biological bases of tDCS's antidepressant effect and review the results of studies on tDCS's antidepressant effect. For the review and search process of MDD treatment using tDCS, the US National Library of Medicine search engine PubMed was used. In this review, we discuss the biological mechanism of tDCS's antidepressant effect and the existing published literature including meta-analysis, systematic review, control trial, open studies, and case reports of antidepressant effects and cognitive function improvement in patients with MDD are reviewed. We also discuss the appropriate tDCS protocol for MDD patients, factors predictive of response to tDCS treatment, the disadvantages of tDCS in MDD treatment, and side effects.

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2000년도 봄 학술발표논문집 Vol.27 No.1 (B)
• /
• pp.292-294
• /
• 2000

대부분의 검색엔진들이 사용하는 내용 기반 검색 방법은 웹 페이지에 있는 단어의 빈도만을 이용하여 순위를 결정함으로써 비슷한 단어 빈도를 가지고 있는 방대한 양의 검색 결과로부터 참조할만한 가치가 있는 중요한 페이지를 찾아내기가 매우 어렵다. 중요한 페이지를 구분해 내는 한가지 방법은 얼마나 많은 웹 페이지들이 참조하고 있는가 또한 얼마나 많은 사용자들이 그 웹 페이지에 접속하는가를 보는 것이다. 본 논문에서는 링크 빈도와 클릭 빈도를 이용하여 웹 페이지의 중요도를 계산하는 메타 검색엔진의 프로토타입을 구현하였다. 링크 빈도는 검색엔진에 해당 웹 페이지의 URL을 질의로 던져 구하고 클릭 빈도는 servlet을 이용하여 사용자의 클릭 행위를 감시하여 얻어내도록 하였다. 메타 검색엔진은 이 두 값의 가중치 합으로 각 페이지의 중요도를 계산하고 중요도 순으로 검색 결과를 재배열하여 사용자에게 보여 준다.

• 대한한방내과학회지
• /
• 제41권3호
• /
• pp.306-325
• /
• 2020

Objectives: The aim of this study is to investigate the effect of a Dachaihu decoction for hyperlipidemic acute pancreatitis (HLAP) by systematic review and meta-analysis of Chinese clinical studies. Methods: China National Knowledge Infrastructure (CNKI) was utilized as the major search engine. The date of the literature search was March 7, 2020. Randomized controlled trials (RCTs) about using a Dachaihu decoction for HLAP were included in this study. Meta-analysis was performed by synthesizing outcome data, including total effective rate, abdomen pain relief time, first bowel movement time, blood amylase recovery time, and triglyceride (TG) levels (mmol/L). The selected literature was assessed using Cochrane's risk of bias (RoB). Results: Twelve of 44 RCTs met the inclusion criteria. Most studies were evaluated with RoB as having unclear risk. The total effective rate of herbal medicine treatment based on the Dachaihu decoction was significantly higher than that of symptomatic supportive treatment in 10 articles (risk ratio=1.15, 95% CI: 1.08 to 1.21, p<0.00001, I²=0%). Herbal medicine treatment based on a Dachaihu decoction was significantly more effective than symptomatic supportive treatment in terms of reducing abdomen pain relief time (in all articles; mean difference=-1.70, 95% CI: -1.91 to -1.41, p<0.00001, I²=45%), first bowel movement time (in 7 articles; mean difference=-1.46, 95% CI: -1.86 to -1.05, p<0.00001, I²=73%), blood amylase recovery time (in 8 articles; mean difference=-1.48, 95% CI: -2.04 to -0.92, p<0.00001, I²=90%), and TG levels (in 8 articles; mean difference=-1.59, 95% CI: -2.28to -0.91, p<0.00001, I²=90%). Only one article reported side effects of treatment among the intervention group and control group, citing pancreatic ulcer and pancreatic pseudocyst formation. Conclusions: This study suggests that herbal medicine treatment based on a Dachaihu decoction could yield higher efficacy for HLAP than symptomatic supportive treatment alone. However, the results might be somewhat biased because of the poor quality and small sample size of the included RCTs. Well-qualified clinical studies are needed to prove the effectiveness of Dachaihu decoction therapy for HLAP.

• 대한기계학회논문집
• /
• 제15권6호
• /
• pp.2026-2036
• /
• 1991

본 연구에서는 동력전달용 치차설계 전문가 시스템을 구축하기 위한 일단의 연구로서 먼저, 치차의 시험중 또는 사용중에 일어나는 파손에 대하여 파손의 원인탐 색과 대책수립을 위한 전문가 시스템을 개발한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7567-7573
• /
• 2015

Background: Catastrophic effects of mustard gas as a chemical warfare agent have always been a major problem for those exposed to this agent. In this meta-analysis it was tried to evaluate carcinogenesis, ocular, cutaneous and respiratory complications of mustard gas exposure among Iranians who had been exposed to this agent during the Iran-Iraq war. Materials and Methods: In this meta-analysis, the required data were collected using keywords "mustard gas", "sulfur mustard", "cancer", "neoplasm", "respiratory complications", "ocular complications", "lung disease", "chronic complication", "eye", "skin", "cutaneous complication", "carcinogenesis" and their combination with keywords "Iran", "Iranian", "prevalence", "mortality" and their Farsi equivalent terms from the databases of SID, Iranmedex, Magiran, Pubmed, Science Direct, Google Search engine, Gray Literature and Reference of References. To determine the prevalence of each complication and perform meta-analysis, CMA: 2 (Comprehensive Meta-Analysis) software with a randomized model was used. Results: Of the 542 articles found, 7 national articles, consistent with the aims of this study were selected. Meta-analysis of seven papers revealed that cancer risk, especially cancer of the respiratory system was elevated, so that the relative risk (RR) of cancer role of mustard gas was inconsistent from 2/1 to 4 in this survey. Also prevalence of delayed skin disorders due to sulfur mustard was 94.6%, pulmonary complications 94.5% and ocular complications 89.9%. The incidence of various cancers in victims exposed to mustard gas was 1.7% worldwide where the rate was 2.2% in Iranian victims of the Iraq-Iran war. Conclusions: Based on present study the prevalence of delayed mustard gas related cutaneous, pulmonary and ocular complications is above 90% and risk of carcinogenesis is higher in comparison to worldwide statistics. This may suggest need for long-term and persistent follow-up and rehabilitation procedures for populations exposed to this agent.

• 한국시뮬레이션학회논문지
• /
• 제19권4호
• /
• pp.59-66
• /
• 2010

이 논문에서는 온톨로지로 표현한 트랜잭션으로부터 연관 규칙을 생성하고 이를 기반으로 추론을 수행하여 개인화 의류 추천을 제공하는 시스템을 제안한다. Onto-Apriori 알고리즘을 이용한 연관 규칙 생성은 유행에 따른 구매성향 변동을 능동적으로 분석할 수 있다. 생성된 규칙은 온톨로지에 메타 노드로 표현하고 이를 기반으로 추론함으로써 사용자의 질의에 맞는 추천 항목을 찾아낼 수 있다. 시스템을 평가하기 위하여 추론 소요시간과 추천 정확도 2가지 요소를 기준으로 시뮬레이션을 수행하여 유효성을 증명하였다.

• 한국정보과학회논문지:데이타베이스
• /
• 제37권5호
• /
• pp.258-266
• /
• 2010

메타 블로그에 등록된 RSS(Really Simple Syndication)의 수는 수십만 개 또는 수백만 개에 이른다. 따라서 이들에 대한 갱신 확인을 수행하는 것은 상당히 긴 시간과 네트워크 자원을 필요로 한다. 메타 블로그나 블로그 검색엔진은 제한된 자원을 가지고 있기 때문에 하루에 방문할 수 있는 블로그의 수가 제한적이다. 하지만 블로그 검색엔진의 성능향상을 위해 새로운 데이터를 최대한 수집하는 것이 필요하기 때문에, 우리는 이 논문에서 수집 효율을 높이기 위한 새로운 방법을 제안한다. 제안하는 방법은 블로그의 포스팅 성향을 분석하여 그것을 토대로 향후 갱신 가능성에 대해 예측하고 갱신 가능성이 높은 시점에만 갱신 확인을 수행한다. 이 연구는 블로그의 입장에서는 분산 서비스 거부 공격(DDoS Attack: Distributed Denial-of-Service Attack)만큼이나 빈번한 갱신확인을 줄이는데 도움이 되고, 인터넷 전체로 보아서는 트래픽을 감소시키는데 기여할 수 있다. 본 논문에서는 블로거들의 포스팅이 이루어지는 요일과 시간에 특정한 패턴이 존재할 것이라는 가정을 하고, 15119개의 실제 블로그에 작성된 포스트에 대해 요일과 시간의 선호도를 분석하였다. 그리고 과거의 포스팅 이력과 요일에 대한 선호도를 바탕으로 갱신 가능성을 예측하기 위한 방법을 제안하고, 12115개의 실제 블로그에 적용하여 그 정확도를 확인하였다. 성능평가를 통해 약 93.06%의 블로그에서 0.5 이상의 정확도를 가짐을 확인하였다.