Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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The association Between Occupational Exposure to silica and Risk of Developing Rheumatoid Arthritis: A Meta-Analysis

  • Mehri, Fereshteh (Department of Nutritional Sciences, Nutrition Health Research Center, Hamadan University of Medical Sciences) ;
  • Jenabi, Ensiyeh (Department of Nursing & Midwifery, Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Bashirian, Saeed (Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Shahna, Farshid Ghorbani (Department of Occupational Health, Occupational Health and Safety Research Center, Hamadan University of Medical Sciences) ;
  • Khazaei, Salman (Department of Epidemiology, Research Center for Health Sciences, Hamadan University of Medical Sciences)
  • Received : 2019.12.21
  • Accepted : 2020.02.22
  • Published : 2020.06.30
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Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory arthritis. This meta-analysis was conducted to examine the association between occupational exposure to silica and the risk of developing RA among different workers. Methods: In this meta-analysis, we searched relevant published studies using major electronic databases including Scopus, PubMed, ISI Web of Science, and Google Scholar search engine up to October 2019, and the references of retrieved articles were also checked for further possible sources. A random-effects model was used to account for heterogeneity among the results of the studies using the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). The Q-statistic and I2 tests were calculated to assess heterogeneity between the studies. Results: The pooled calculation of OR indicated a significant association between occupational exposure to silica and risk of developing RA among different workers (OR = 2.59, 95% CI = 1.73 to 3.45). In addition, the pooled estimates of OR in smokers were statistically significant (OR = 2.49, 95% CI = 1.13 to 3.86). Conclusions: The findings of the present study reveal that occupational exposure to silica may be associated with increased risk of developing RA.

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References

  1. Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis. Klareskog L, Malmstrom V, Lundberg K, Padyukov L, Alfredsson L, editors. Semin Immunol 2011. Elsevier.
  2. Cooper GS, Gilbert KM, Greidinger EL, James JA, Pfau JC, Reinlib L, Richardson BC, Rose NR. Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect 2008;116(6):695-702. https://doi.org/10.1289/ehp.11092
  3. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000;43(1):30-7. https://doi.org/10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B
  4. Olsson AR, Skogh T, Axelson O, Wingren G. Occupations and exposures in the work environment as determinants for rheumatoid arthritis. Occup Environ Med 2004;61(3):233-8. https://doi.org/10.1136/oem.2003.007971
  5. Blanc PD, Trupin L, Yelin EH, Schmajuk G. Occupational exposure to coal and silica dust and risk of rheumatoid arthritis in Appalachia. Am J Respir Crit Care Med 2018;197.
  6. Parks CG, Conrad K, Cooper GS. Occupational exposure to crystalline silica and autoimmune disease. Environ Health Perspect 1999;107(Suppl. 5):793-802.
  7. Yassin A, Yebesi F, Tingle R. Occupational exposure to crystalline silica dust in the United States, 1988-2003. Environ Health Perspect 2004;113(3):255-60. https://doi.org/10.1289/ehp.7384
  8. Blanc P, Andersson L, Bryngelsson L. Risk of rheumatoid arthritis in a cohort of silica-exposed Swedish foundry workers. European Respiratory Society; 2016.
  9. Vihlborg P, Bryngelsson L, Andersson L, Graff P. Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. BMJ Open 2017;7(7):e016839. https://doi.org/10.1136/bmjopen-2017-016839
  10. Turner S, Cherry N. Rheumatoid arthritis in workers exposed to silica in the pottery industry. Occup Environ Med 2000;57(7):443-7. https://doi.org/10.1136/oem.57.7.443
  11. Costenbader KH, Feskanich D, Mandl LA, Karlson EW. Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 2006;119(6):503 e1-. e9. https://doi.org/10.1016/j.amjmed.2005.09.053
  12. Stolt P, Kallberg H, Lundberg I, Sjogren B, Klareskog L, Alfredsson L. Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study. Ann Rheum Dis 2005;64(4):582-6. https://doi.org/10.1136/ard.2004.022053
  13. Kallberg H, Ding B, Padyukov L, Bengtsson C, Rönnelid J, Klareskog L, Alfredsson L, EIRA Study Group. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis 2011;70(3):508-11. https://doi.org/10.1136/ard.2009.120899
  14. Stolt P, Yahya A, Bengtsson C, Kallberg H, Ronnelid J, Lundberg I, Klareskog L, Alfredsson L, EIRA Study Group. Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis 2010;69(6):1072-6. https://doi.org/10.1136/ard.2009.114694
  15. Hoovestol RA, Mikuls TR. Environmental exposures and rheumatoid arthritis risk. Curr Rheumatol Rep 2011;13(5):431. https://doi.org/10.1007/s11926-011-0203-9
  16. Blanc PD, Jarvholm B, Toren K. Prospective risk of rheumatologic disease associated with occupational exposure in a cohort of male construction workers. Am J Med 2015;128(10):1094-101. https://doi.org/10.1016/j.amjmed.2015.05.001
  17. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009;6(7):e1000100. https://doi.org/10.1371/journal.pmed.1000100
  18. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2009 September 15; 2017. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
  19. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons; 2011.
  20. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ: Br Med J 1997;315(7109):629-34. https://doi.org/10.1136/bmj.315.7109.629
  21. Too CL, Muhamad NA, Ilar A, Padyukov L, Alfredsson L, Klareskog L, Murad S, Bengtsson C, My EIRA Study Group. Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study. Ann Rheum Dis 2016;75(6):997-1002. https://doi.org/10.1136/annrheumdis-2015-208278
  22. Jiang X, Bengtsson C, Kallberg H, Klareskog L, Alfredsson L. Amount of smoking, duration of smoking cessation, and their interaction with silica exposure in the risk of rheumatoid arthritis: results from the Swedish epidemiological investigation of rheumatoid arthritis study. Arthritis Rheumatol 2014;66. S1262-S.
  23. Noonan CW, Pfau JC, Larson TC, Spence MR. Nested case-control study of autoimmune disease in an asbestos-exposed population. Environ Health Perspect 2006;114(8):1243-7. https://doi.org/10.1289/ehp.9203
  24. Stolt P, Padyukov L, Kallberg H, Lundberg I, Klareskog L, Alfredsson L. Silica exposure is associated with increased risk of a restricted sub-group of rheumatoid arthritis linked to antibodies to cyclic citrullinated peptides. Arthritis Rheum 2005;52(9). S404-S.
  25. Olsson AR, Skogh T, Wingren G. Occupational determinants for rheumatoid arthritis. Scand J Work Environ Health 2000;63:243-9. https://doi.org/10.5271/sjweh.538
  26. Trupin L, Yelin EH, Schmajuk G, Blanc P. Occupational exposure to coal and silica dust is associated with elevated risk of rheumatoid arthritis in coal mining areas of US. Arthritis Rheumatol 2018;70. https://doi.org/10.1002/art.39811
  27. Klockars M, Koskela R, Jarvinen E, Kolari P, Rossi A. Silica exposure and rheumatoid arthritis: a follow up study of granite workers 1940-81. Br Med J (Clin Res Ed). 1987;294(6578):997-1000. https://doi.org/10.1136/bmj.294.6578.997
  28. Yahya A, Bengtsson C, Larsson P, Too CL, Mustafa AN, Abdullah NA, Muhamad NA, Klareskog L, Murad S, Alfredsson L. Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study. Mod Rheumatol 2014;24(2):271-4. https://doi.org/10.3109/14397595.2013.854076
  29. Khuder SA, Peshimam AZ, Agraharam S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-15.
  30. Pollard KM. Environment, autoantibodies, and autoimmunity. Front Immunol 2015;6:60. https://doi.org/10.3389/fimmu.2015.00060
  31. Jayapal M, Bhattacharjee RN, Melendez AJ, Hande MP. Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins. Int J Biochem Cell Biol 2010;42(2):230-40. https://doi.org/10.1016/j.biocel.2009.10.007
  32. Pollard KM. Gender differences in autoimmunity associated with exposure to environmental factors. J Autoimmun 2012;38(2-3):J177-86. https://doi.org/10.1016/j.jaut.2011.11.007
  33. Brown JM, Pfau JC, Pershouse MA, Holian A. Silica, apoptosis, and autoimmunity. J Immunotoxicol 2005;1(3-4):177-87. https://doi.org/10.1080/15476910490911922
  34. Silman AJ, Pearson JE. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res Ther 2002;4(S3):S265. https://doi.org/10.1186/ar578
  35. Ollier W, Thomson W. Population genetics of rheumatoid arthritis. Rheum Dis Clin N Am 1992;18(4):741-59. https://doi.org/10.1016/S0889-857X(21)00149-6
  36. Kiyohara C, Otsu A, Shirakawa T, Fukuda S, Hopkin JM. Genetic polymorphisms and lung cancer susceptibility: a review. Lung Canc 2002;37(3): 241-56. https://doi.org/10.1016/S0169-5002(02)00107-1
  37. Zeng P. Occupational factors and risk of rheumatoid arthritis: studies on silica, physical workload and cold work environment. Institutet for miljomedicin/Institute of Environmental Medicine; 2017.
  38. Karlson EW, Chang S-C, Cui J, Chibnik LB, Fraser PA, De Vivo I, Costenbader KH. Geneeenvironment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. Ann Rheum Dis 2010;69(1):54-60. https://doi.org/10.1136/ard.2008.102962
  39. Steenland K, Brown D. Mortality study of gold miners exposed to silica and nonasbestiform amphibole minerals: An update with 14 more years of followup. Am J Ind Med 1995;27(2):217-29. https://doi.org/10.1002/ajim.4700270207

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