• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5565-5571
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• 2015

Background: Previous studies evaluating the association between the excision repair cross complementing group 5 (ERCC5) gene rs17655 polymorphism and colorectal cancer susceptibility generated controversial results. To generate large-scale evidence on whether the ERCC5 rs17655 polymorphism might indeed be associated with colorectal cancer susceptibility, the present meta-analysis was performed. Materials and Methods: Data were collected from PubMed, Embase and Web of Science, with the last report up to Apr 03, 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Results: A total of nine studies including 5,102 cases and 6,326 controls based on the search criteria were included and significant associations were found between ERCC5 rs17655 polymorphism CG vs GG overall (OR = 1.29, 95% CI =1.18~1.40) and in the dominant model (OR=1.23, 95% CI =1.13~1.33). On subgroup analysis by ethnicity and source of controls, the ERCC5 rs17655 polymorphism was found to correlate with the pathogenesis of colorectal cancer among Asians and Caucasians and with hospital-based populations. Conclusions: This meta-analysis suggests that the ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6103-6108
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• 2014

Many studies have reported ${\beta}$-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of ${\beta}$-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of ${\beta}$-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of ${\beta}$-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of ${\beta}$-catenin could be a predicative factor of poor prognosis for EC patients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5161-5166
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• 2014

Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC.

• Journal of Korean Academy of Nursing
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• v.34 no.5
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• pp.712-721
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• 2004

Purpose: This investigation examined the effect of PBL on the meta-cognition, critical thinking, and problem solving process. Method: The research design was pre-posttest with a none qui valent control group design. Scenarios for PBL sessions were developed on the basis of textbooks and patients' charts and tested for content validity. Seventy six nursing students who took a 'Nursing Process' course from two nursing schools participated in the experimental group and control group. The experimental group performed PBL during the semester. Meta-cognition and problem solving processes were assessed by questionnaires which were developed using pedagogics. Critical thinking was measured by the CCTST(California Critical Thinking Skill Test) Form 2000. The data was analyzed by repeated measure (pretest-posttest) MANOVA, and correlation analysis. Result: PBL improved the participants' meta-cognition and problem solving process but not critical thinking. The relationship between meta-cognition and the problem solving process was supported but the relationship between critical thinking and problem solving was not supported. Conclusion: These results suggest that PBL has a positive effect on nursing students' educational outcomes. To improve the problem solving ability of nursing students, PBL should be applied to more subjects in the nursing curriculum.

• The Korean Journal of Health Service Management
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• v.10 no.4
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• pp.37-50
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• 2016

Objectives : The aim of this meta-analysis was to draw overall conclusions on the correlation between the organizational effectiveness (OE) of healthcare employees and related factors by summarizing recent studies and to provide a baseline for future research. Methods : A literature search for original articles published from 2005 to 2014 including doctoral theses and KCI journal articles was done in KERIS' RISS, etc. in a systematic manner. From 77 studies which met the inclusion criteria 190 effect sizes (ESs) were calculated for the analysis. A meta-analysis was done with CMA 3 (Biostat company, USA). Results : The overall ES was moderate for all, positively and negatively related factors. For all related factors, job characteristics, group-leader relations, personal and organizational characteristics had a moderate ES. The ES for work experiences was small. Conclusions : Although the results of this study were meaningful it is necessary to perform follow-up analyses (1) based on a longer data period and more articles, (2) including moderating variables with higher explanatory power and (3) adopting a study model with more specific and simplified variables.

• The Journal of Korean Academic Society of Nursing Education
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• v.24 no.4
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• pp.391-405
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• 2018

Purpose: The purpose of this study was to integrate and synthesize findings from qualitative studies exploring male students' experiences of adapting to nursing education programs so as to obtain further understanding of the phenomenon. Methods: The meta-synthesis process was primarily guided by Noblit and Hare's approach, which consists of four stages including searching, appraisal of an individual study's quality, data extraction for analysis, and meta-synthesizing the results. Results: Findings from the literature reviewed were synthesized into six themes: 1) extraordinary choice based on job stability and gender scarcity; 2) unexpected feeling of marginalization as minority far apart from the mainstream; 3) assimilation and negotiation for relational adaptation through perspective shift; 4) fortifying the vision and identity as nursing students by meaning making for adapting to the nursing major; 5) mutual support among colleague male students; and 6) serving in the military as way of hiding out and achieving maturation. Conclusion: The findings illustrate that nursing education programs need practical changes promoting male students' adaptation to the program itself as well as preparation to be a professional nurse in the future.

• Korean Journal of Occupational Health Nursing
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• v.14 no.1
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• pp.71-82
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• 2005

Purpose: This study analyzed domestic articles that studied job-stress of nurses using Meta Analysis to evaluate the responses resulted from job-stress and the factors affecting them. Method: To conduct this study, data were collected primarily from database of "richis" and additionally from 8 nursing journals and 5 theses for a degree on job-stress of clinical nurses. Result: As a result of Meta Analysis casual factor of job-stress, the result represented that two reasons; personal factor was the age, occupational factor were ward, duration of employment and position. By the result of analysis of effect of job-stress, satisfaction of the job, exhaustion, health status and immersion of the job were strongly related to job-stress. According to the general solution against job-stress that referred from job-stress related theses, there are several; Imagination Therapy, Assertive Training and Value Clarification Training could bring significant result. Conclusion: This study showed that because job-stress of clinical nurses had nothing to do with personal factors, job-stress management plans for nurses are needed to focus on occupational factors. Also the study suggested that various coping skills that proved to be effective are needed to be used to relieve job-stress and that's responses on nurses.

• The Korean Journal of Emergency Medical Services
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• v.21 no.1
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• pp.17-44
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• 2017

Purpose: This study aimed to identify the effects of cardiopulmonary resuscitation (CPR) training using a meta-analysis by effect size. Methods: The effect sizes for each variable and the overall effect size for the collected data were identified. The homogeneity verification of the effect size and the difference among the average effect sizes for each mediation variable were determined. Results: The overall average effect size for CPR training was 1.747. Homogeneity verification of the overall effect size was a Q-value of 3716.962, which was statistically significant (p=.000) when${\alpha}=.05$. CPR training showed statistically significant differences depending on age (p=.002), sex (p=.006), number of trainees (p=.000), research design (p=.000), training method (p=.027), and practical training tools (p=.000). Conclusion: CPR training can effectively improve knowledge, skills, and attitudes about CPR. The results of this meta-analysis contribute to the development of more effective educational guidelines for future CPR training and the advancement of the CPR education field.

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.5
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• pp.397-411
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• 2021

This systematic review aimed to assess the effect of premedication on postoperative pain after root canal treatment in vital teeth. Five electronic databases were searched for randomized clinical trials, and two independent reviewers selected eligible studies, extracted data, and assessed the quality of studies using the Cochrane Risk of Bias tool. Meta-analysis was conducted using the random-effects model, and the pooled effect estimate of the standardized mean difference (SMD) between premedication and placebo was calculated. Subgroup analysis was conducted based on the class and route of the drug. Studies with a high risk of bias were excluded from the sensitivity analysis. Ten trials satisfied the inclusion criteria, of which eight were included in the meta-analysis. Premedication was more effective in reducing postoperative pain than placebo at 6 hours (SMD = -1.00; 95% confidence interval [CI] = -1.33 to -0.66), 12 hours (SMD = -0.80; 95% CI = -1.05 to -0.56), and 24 hours (SMD = -0.72; 95% CI = -1.02 to -0.43). The results of the sensitivity analysis confirmed the findings of the primary analysis. Based on these results, it can be concluded that premedication is effective in reducing postoperative pain in teeth with irreversible pulpitis. However, additional quality studies are required for further validation.

• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.3
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• pp.300-311
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• 2019

Purpose: The purpose of this study was to review and synthesize the existing literature on the experience of nursing students in simulation. Methods: A systematic review was undertaken using meta-ethnography. Eight databases were searched up to January 2014 for peer-reviewed studies, written in Korean and English, that reported primary data, used identifiable and interpretative qualitative methods, and offered a valuable contribution to the synthesis. Results: Nine studies were identified, with quality appraisal undertaken. Three key concepts were generated: ambivalence of simulation practice, learning by reflection, and building up of the competency as a future nurse. Six sub-concepts emerged: double sidedness of simulation setting; feeling ambivalence of simulation; learning from others; learning from self-reflection; improvement of confidence by role experience; and internalization of nursing knowledge. A line of argument has been developed based on the themes generated. Conclusion: The findings from this qualitative synthesis and other related literature indicated the importance of capability of educator and extension of the simulation system to facilitate effective simulation-based education.