Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Genetic Association between ERCC5 rs17655 Polymorphism and Colorectal Cancer Risk: Evidence Based on a Meta-analysis

  • Zeng, Yong (Department of Cardiothoracic Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University) ;
  • Wei, Li (Department of Oncology, the 401 Hospital of PLA) ;
  • Wang, Ya-Jie (Department of Oncology, Changhai Hospital, Second Military Medical University) ;
  • Liu, Chuan (Department of Oncology, Changhai Hospital, Second Military Medical University)
  • Published : 2015.08.03
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Previous studies evaluating the association between the excision repair cross complementing group 5 (ERCC5) gene rs17655 polymorphism and colorectal cancer susceptibility generated controversial results. To generate large-scale evidence on whether the ERCC5 rs17655 polymorphism might indeed be associated with colorectal cancer susceptibility, the present meta-analysis was performed. Materials and Methods: Data were collected from PubMed, Embase and Web of Science, with the last report up to Apr 03, 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Results: A total of nine studies including 5,102 cases and 6,326 controls based on the search criteria were included and significant associations were found between ERCC5 rs17655 polymorphism CG vs GG overall (OR = 1.29, 95% CI =1.18~1.40) and in the dominant model (OR=1.23, 95% CI =1.13~1.33). On subgroup analysis by ethnicity and source of controls, the ERCC5 rs17655 polymorphism was found to correlate with the pathogenesis of colorectal cancer among Asians and Caucasians and with hospital-based populations. Conclusions: This meta-analysis suggests that the ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.

Keywords

References

  1. Bartolucci R, Wei J, Sanchez JJ, et al (2009). XPG mRNA expression levels modulate prognosis in resected non-smallcell lung cancer in conjunction with BRCA1 and ERCC1 expression. Clin Lung Cancer, 10, 47-52. https://doi.org/10.3816/CLC.2009.n.007
  2. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101 https://doi.org/10.2307/2533446
  3. Bordignon V, Cordiali-Fei P, Rinaldi M, et al (2012). Evaluation of antigen specific recognition and cell mediated cytotoxicity by a modified lysispot assay in a rat colon carcinoma model. J Exp Clin Cancer Res, 31, 9. https://doi.org/10.1186/1756-9966-31-9
  4. Canbay E, Cakmakoglu B, Zeybek U, et al (2011). Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population. Curr Med Res Opin, 27, 1295-302. https://doi.org/10.1185/03007995.2011.573544
  5. Center MM, Jemal A, Ward E (2009). International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev, 18, 1688-94. https://doi.org/10.1158/1055-9965.EPI-09-0090
  6. Cheng L, Sturgis EM, Eicher SA, et al (2002). Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. Cancer, 94, 393-7 https://doi.org/10.1002/cncr.10231
  7. Dahm CC, Keogh RH, Spencer EA, et al (2010). Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J Natl Cancer Inst, 102, 614-26. https://doi.org/10.1093/jnci/djq092
  8. Du H, Zhang X, Du M, et al (2014). Association study between XPG Asp1104His polymorphism and colorectal cancer risk in a Chinese population. Sci Rep, 4, 6700. https://doi.org/10.1038/srep06700
  9. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in metaanalysis detected by a simple graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  10. Emmert S, Schneider TD, Khan SG, et al (2001). The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms. Nucleic Acids Res, 29, 1443-52. https://doi.org/10.1093/nar/29.7.1443
  11. Ferlay J, Parkin DM, Steliarova-Foucher E (2010). Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer, 46, 765-81. https://doi.org/10.1016/j.ejca.2009.12.014
  12. Gil J, Ramsey D, Stembalska A, et al (2012). The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. Mol Biol Rep, 39, 527-34. https://doi.org/10.1007/s11033-011-0767-5
  13. Goode EL, Ulrich CM, Potter JD (2002). Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev, 11, 1513-30
  14. Haggar FA, Boushey RP (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg, 22, 191-7 https://doi.org/10.1055/s-0029-1242458
  15. Jiricny J, Marra G (2003). DNA repair defects in colon cancer. Curr Opin Genet Dev, 13, 61-9. https://doi.org/10.1016/S0959-437X(03)00004-2
  16. Joshi AD, Corral R, Siegmund KD, et al (2009). Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis, 30, 472-9. https://doi.org/10.1093/carcin/bgn260
  17. Koeppel F, Poindessous V, Lazar V, et al (2004). Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells. Clin Cancer Res, 10, 5604-13. https://doi.org/10.1158/1078-0432.CCR-04-0442
  18. Li P, Wang L, Liu L, et al (2014). Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk. Tumour Biol, 35, 6581-5. https://doi.org/10.1007/s13277-014-1900-6
  19. Liu D, Wu HZ, Zhang YN, et al (2012). DNA repair genes XPC, XPG polymorphisms: relation to the risk of colorectal carcinoma and therapeutic outcome with Oxaliplatin-based adjuvant chemotherapy. Mol Carcinog, 51, 83-93. https://doi.org/10.1002/mc.21862
  20. Markowitz SD, Bertagnolli MM (2009). Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med, 361, 2449-60. https://doi.org/10.1056/NEJMra0804588
  21. Masutani M, Nakagama H, Sugimura T (2003). Poly(ADPribose) and carcinogenesis. Genes, Chromosomes Cancer, 38, 339-48. https://doi.org/10.1002/gcc.10250
  22. Minelli C, Thompson JR, Abrams KR, et al (2008). How should we use information about HWE in the meta-analyses of genetic association studies? Int J Epidemiol, 37, 136-46. https://doi.org/10.1093/ije/dym234
  23. Munafo MR, Clark TG, Flint J (2004). Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry Res, 129, 39-44. https://doi.org/10.1016/j.psychres.2004.06.011
  24. Ogino S, Stampfer M (2010). Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst, 102, 365-7. https://doi.org/10.1093/jnci/djq031
  25. Pardini B, Naccarati A, Novotny J, et al (2008). DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic. Mutat Res, 638, 146-53. https://doi.org/10.1016/j.mrfmmm.2007.09.008
  26. Paszkowska-Szczur K, Scott RJ, Gorski B, et al (2015). Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population. Mol Biol Rep, 42, 755-64. https://doi.org/10.1007/s11033-014-3824-z
  27. Peltomaki P (2003). Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol, 21, 1174-9. https://doi.org/10.1200/JCO.2003.04.060
  28. Petraki C, Youssef YM, Dubinski W, et al (2012). Evaluation and prognostic significance of human tissue kallikreinrelated peptidase 10 (KLK10) in colorectal cancer. Tumor Biol, 33, 1209-14. https://doi.org/10.1007/s13277-012-0368-5
  29. Rawson JB, Manno M, Mrkonjic M, et al (2011). Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. Carcinogenesis, 32, 741-7. https://doi.org/10.1093/carcin/bgr020
  30. Shields PG, Harris CC (2000). Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J Clin Oncol, 18, 2309-15
  31. Siegel R, Ma J, Zou Z, et al (2014). Cancer statistics, 2014. CA Cancer J Clin, 64, 9-29. https://doi.org/10.3322/caac.21208
  32. Stang A (2010). Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 25, 603-5. https://doi.org/10.1007/s10654-010-9491-z
  33. Steck SE, Butler LM, Keku T, et al (2014). Nucleotide excision repair gene polymorphisms, meat intake and colon cancer risk. Mutat Res Fundam Mol Mech Mutagen, 762, 24-31. https://doi.org/10.1016/j.mrfmmm.2014.02.004
  34. Sun K, Gong A, Liang P (2015). Predictive impact of genetic polymorphisms in DNA repair genes on susceptibility and therapeutic outcomes to colorectal cancer patients. Tumour Biol, 36, 1549-59. https://doi.org/10.1007/s13277-014-2721-3
  35. Sutton AJ, Duval SJ, Tweedie RL, et al (2000). Empirical assessment of effect of publication bias on meta-analysis. BMJ, 320, 1574-7. https://doi.org/10.1136/bmj.320.7249.1574
  36. Wang CJ, Franbergh-Karlson H, Wang DW, et al (2013). Clinicopathological significance of BTF3 expression in colorectal cancer. Tumor Biol, 34, 2141-6. https://doi.org/10.1007/s13277-013-0745-8
  37. Wang L, Jing F, Su D, et al (2015). Association between CTLA-4 rs231775 polymorphism and risk of colorectal cancer: a meta analysis. Int J Clin Exp Med, 8, 650-7.
  38. Zhang H, Ma H, Xu Y, et al (2013). Association of SMAD7 rs12953717 polymorphism with cancer: a meta-analysis. PLoS One, 8, 58170. https://doi.org/10.1371/journal.pone.0058170
  39. Zhang M, Mo R (2014). Association of hOGG1 Ser326Cys polymorphism with colorectal cancer risk: an updated metaanalysis including 5235 cases and 8438 controls. Tumour Biol, 35, 12627-33. https://doi.org/10.1007/s13277-014-2586-5
  40. Zintzaras E, Ioannidis JP (2005). Hegesma: Genome search meta-analysis and heterogeneity testing. Bioinformatics, 21, 3672-3. https://doi.org/10.1093/bioinformatics/bti536
  41. Zintzaras E, Ioannidis JP (2005). Heterogeneity testing in metaanalysis of genome searches. Genet Epidemiol, 28,123-37. https://doi.org/10.1002/gepi.20048

Cited by

  1. The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis vol.8, pp.7, 2017, https://doi.org/10.1038/ctg.2017.35
  2. The association between XPG polymorphisms and cancer susceptibility vol.96, pp.32, 2017, https://doi.org/10.1097/MD.0000000000007467