• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2333-2340
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• 2015

Background: Due to the strong inhibitory effects of $PPAR{\gamma}$ gene on the growth of cancer cells, the role of Pro12Ala polymorphism in $PPAR{\gamma}$ gene has been extensively investigated in cancer recently. However, the results were inconsistent according to cancer type. The aim of this study was to comprehensively evaluate the $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer susceptibility. Materials and Methods: Search strategies were conducted in Pubmed, Medline (Ovid), Chinese biomedical database (CBM), China national knowledge infrastructure (CNKI), VIP, and Wanfang database, covering all publications, with the last search up to November 01, 2014. The strength of association between $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer risk was assessed by OR with 95%CI. Results: A total of 546 cases and 827 controls in 5 case-control studies were included in this meta-analysis. The results indicated that the variant G allele carriers (CG+GG) had a 2.31 times higher risk for gastric cancer when compared with the homozygote CC (odds ratio (OR)=2.31, 95% confidence interval (CI)=1.67-3.21 for CG+GG vs. CC). In the subgroup analysis by ethnicity, significantly elevated risks were both found in Asians (OR=2.56, 95% CI=1.42-4.64) and Caucasians (OR=2.20, 95% CI=1.48-3.25). Similarly, in the subgroup analysis by H. pylori status, a significantly increased risk was identified in H. pylori (+) populations (OR=3.68, 95%CI=2.07-6.52), but not in H. pylori(-) populations (OR=1.17, 95%CI=0.58-2.39). Conclusions: This pooled analysis suggested that the $PPAR{\gamma}$ Pro12Ala polymorphism could be an independent predictive risk factor for gastric cancer especially in H. pylori infected populations in Asians and Caucasians. Nevertheless, prospectively designed cohort studies are needed to further investigate gene-gene and gene-environment interactions to confirm the combined effects of $PPAR{\gamma}$ Pro12Ala polymorphisms and H. pylori infection on gastric cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4787-4793
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• 2014

Background: Many cancer patients experience poor pain control due to various factors, including misconceptions regarding the use of opioid analgesics. For management of cancer pain, interventions involving education of both patients and physicians have been attempted. Objectives: This review aimed to assess the current evidence of the benefits of education for the management of cancer pain. Methods: We searched the Medline, EMBASE, Cochrane library, and major Korean databases to identify relevant studies. We included most study designs, but excluded case series. The primary outcomes were pain intensity and quality of life (QoL). Two reviewers assessed the risk of bias using the Cochrane's tool for RCT and Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) for non-randomized studies, independently. Results: After extensive searches, 3,324 publications were screened, and 32 studies were selected. The education interventions used in the included studies included a wide variety of education methods, but the most common method was a booklet produced for patients. Regardless of the education method used, the results of the meta-analysis were as follows. The SMDs of the most severe, average, and current pain in the RCTs were significant. The SMD of worst, average, and current pain were -0.34 (-0.55, -0.13), -0.40 (-0.64, -0.15), and -0.79 (-1.35, -0.23). In the non-randomized studies, the effects on average pain were significant, but those on worst and current pain were not. Conclusions: Education intervention reduced the pain of cancer patients. Therefore, patient education could be considered to be an effective method of cancer pain management. However, our data should be interpreted with caution, and studies using standardized protocols are needed to confirm these observations.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7251-7256
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• 2013

Objectives: To estimate the proportion of liver cancer cases and deaths due to infection with hepatitis B virus (HBV), hepatitis C virus (HCV), aflatoxin exposure, alcohol drinking and smoking in China in 2005. Study design: Systemic assessment of the burden of five modifiable risk factors on the occurrence of liver cancer in China using the population attributable fraction. Methods: We estimated the population attributable fraction of liver cancer caused by five modifiable risk factors using the prevalence data around 1990 and data on relative risks from meta-analyses, and large-scale observational studies. Liver cancer mortality data were from the 3rd National Death Causes Survey, and data on liver cancer incidence were estimated from the mortality data from cancer registries in China and a mortality/incidence ratio calculated. Results: We estimated that HBV infection was responsible for 65.9% of liver cancer deaths in men and 58.4% in women, while HCV was responsible for 27.3% and 28.6% respectively. The fraction of liver cancer deaths attributable to aflatoxin was estimated to be 25.0% for both men and women. Alcohol drinking was responsible for 23.4% of liver cancer deaths in men and 2.2% in women. Smoking was responsible for 18.7% and 1.0%. Overall, 86% of liver cancer mortality and incidence (88% in men and 78% in women) was attributable to these five modifiable risk factors. Conclusions: HBV, HCV, aflatoxin, alcohol drinking and tobacco smoking were responsible for 86% of liver cancer mortality and incidence in China in 2005. Our findings provide useful data for developing guidelines for liver cancer prevention and control in China and other developing countries.

• The Korean Journal of Pesticide Science
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• v.2 no.2
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• pp.10-15
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• 1998

The bimolecular inhibition rate constants of carbofuran and N-dimethylphosphinothioyl carbofuran(PSC) to acetylcholinesterase(AChE) were $7.7{\times}10^{5}\;M^{-1}{\cdot}min^{-1}$ and $1.2{\times}10^{3}\;M^{-1}{\cdot}min^{-1}$, respectively. These results showed that PSC required a bioactivation process for its toxic action because it didn't inhibit the target enzyme effectively. The potency of PSC as an inhibitor of AChE increased when PSC and AChE were incubated with microsomes fortified with NADPH compared with microsome alone. Piperonyl butoxide(PBO) addition to these coupled systems greatly reduced the inhibition of the target enzyme by blocking the bioactivation process. In vivo inhibition study of mouse brain AChE, $I_{50}$ value for AChE was 28 mg/kg for PSC and the value increased to 57 mg/kg when PBO was pretreated. This result showed that cytochrome $P_{450}$ would also play a role in the bioactivation process of PSC in vivo. And conversioin of carbofuran from PSC was 55 % in a chemical oxidation system using meta-chloroperoxybenzoic acid. The oxidative activation of PSC to carbofuran was shown to be essential for showing its toxicological action and cytochrome $P_{450}$ was identified as an important enzyme which participated in this process.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.2
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• pp.163-176
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• 2010

The representative method to efficiently manage the organization's data is to avoid data duplication through the promotion of sharing and reusing existing data. The systematic structuring of existing data and efficient searching should be supported in order to promote the sharing and reusing of data. Without regard for these points, the data for the system development would be duplicated, which would deteriorate the quality of the data. Data taxonomy provides some methods that can enable the needed data elements to be searched quickly with a systematic order of managing data. This paper proposes that the Origin data taxonomy method can best maximize data sharing, reusing, and consolidation, and it can be used for Meta Data Registry (MDR) and Semantic Web efficiently. The Origin data taxonomy method constructs the data taxonomy structure built upon the intrinsic nature of data, so it can classify the data with independence from business classification. Also, it shows a deployment method for data elements used in various areas according to the Origin data taxonomy structure with a data taxonomic procedure that supports the proposed taxonomy. Based on this case study, the proposed data taxonomy and taxonomic procedure can be applied to real world data efficiently.

• Journal of KIISE:Software and Applications
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• v.35 no.12
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• pp.716-730
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• 2008

In Service-Oriented Architecture (SOA), service providers develop and deploy reusable services on the repositories, and service consumers utilize blackbox form of services through their interfaces. Services are also highly evolvable and often heterogeneous. Due to these characteristics of the service, it is hard to manage the faults if faults occur on the services. Autonomic Computing (AC) is a way of designing systems which can manage themselves without direct human intervention. Applying the key disciplines of AC to service management is appealing since key technical issues for service management can be effectively resolved by AC. In this paper, we present a theoretical model, Symptom-Cause-Actuator (SCA), to enable autonomous service fault management in SOA. We derive SCA model from our rigorous observation on how physicians treat patients. In this paper, we first define a five-phase computing model and meta-model of SCA. And, we define a schema of SCA profile, which contains instances of symptoms, causes, actuators and their dependency values in a machine readable form. Then, we present detailed algorithms for the five phases that are used to manage faults the services. To show the applicability of our approach, we demonstrate the result of our case study for the domain of 'Flight Ticket Management Services'.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.495-500
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• 2015

Background: Published studies have reported relationships between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and lung cancer risk in Chinese population. However, the epidemiological results remained controversial. The objective of this study was to clarify the association of XRCC1 Arg399Gln polymorphism with lung cancer risk in the Chinese population. Materials and Methods: Systematic searches were performed through the database of Medline/Pubmed, Web of Science, Embase, CNKI and WanFang Medical Online. Odds ratios (ORs) with 95% confidence interval (95%CI) were calculated to estimate the strength of the association. Results: Overall, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.36, 95%CI: 1.09-1.71) in the Chinese population on the basis of 19 studies with 5,416 cases and 5,782 controls. We did not observe any association between XRCC1 codon 399 Arg/Gln and Arg/Gln+Gln/Gln polymorphisms and lung cancer risk (OR=1.00, 95%CI: 0.92-1.08 and OR=1.05, 95%CI: 0.97-1.13, respectively). Limiting the analysis to studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.18, 95%CI: 1.01-1.38). When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43). Conclusions: Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population. Larger sample size studies are required to confirm our findings.

• The Journal of Korean Academic Society of Nursing Education
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• v.15 no.1
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• pp.32-43
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• 2009

Purpose: The purpose of this study was to identify the trend of nursing research by analyzing the doctoral dissertations in one college of nursing in Korea. Method: The areas of research, the methodological characteristics, and theories used in the research were explored in all doctoral dissertations (n=120) published from 1989 to 2006. Result: Mainly "Nursing" has been studied (44.9%) among four meta-paradigms of nursing science. The "client" domain (46.7%) and the "practice" domain (41.7%) were most frequently studied in type of nursing knowledge. The main purpose of the thesis was to develop nursing interventions and examine the effectiveness of the practice (40.8%) in quantitative research. Almost all (94.7%) of the qualitative dissertation studies were to explore phenomena in the nursing field. Almost half of the dissertations (43.9%) were an experimental design, 34.7% were a model construction, and 15.8% were a qualitative design. The majority of dissertations (83.3%) were to apply the specific theory and almost half (43.8%) studied borrowed theories from other fields. Conclusion: It is necessary to develop more rigorous and various research designs such a longitudinal design, or randomized controlled trial and this will lead to expanding the body of nursing knowledge.

• Journal of the Korea Concrete Institute
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• v.27 no.1
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• pp.65-73
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• 2015

This study discussed the pozzolanic properties of calcined sewage sludge (CSS) according to calcination and fineness conditions. The chemical and mineralogical analysis of CSS according to calcination temperature and time were carried out and compared with that of the existing pozzolanic materials such as fly-ash, blast furnance slag and meta-kaolin. Various mortars were made by mixing those CSS and $Ca(OH)_2$ (1:1 wt. %), and their compressive strength and hydrates according to experimental factors such as fineness of CSS and curing age were also investigated in detail. The results show clearly the potentiality of calcined sewage sludge (CSS) as an admixture materials in concrete, but the CSS should be controlled by calcination temperature and time, and fineness etc. In this experimental condition, the calcination temperature of $800^{\circ}C$, calcination time of 2 hours and fineness of $5,000cm^2/g$ were optimum conditions in consideration of the mechanical properties and economic efficiency of CSS. The compressive strength of CSS mortars was higher than that of fly-ash mortars and blast furnace slag mortars, especially at the early ages. Then, the utilization of CSS in construction fields was greatly expected.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.850-861
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• 2014

The purpose of this review was to evaluate the effects of simulation-based education on clinical competence and confidence in nursing students and summarize the available evidence on the simulation-based intervention. A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement was conducted. Studies published between 2005 and 2014 were reviewed using the following databases: RISS, KISS, and Google Scholar. The keywords used were nursing and either simulation or simulator. Selected studies were assessed for methodological quality using Quality Assessment Tool for Quantitative Studies. Seventeen studies were identified, including a total of 1,912 nursing students. All the 16 studies found simulation as a valid strategy on clinical competence and confidence in nursing education. This review provides updated evidence for simulation-based learning in nursing education. Further studies are needed to increase generalizability using randomized controlled trials, enough sample size, and longitudinal study design. In addition, valid measurements are needed to assess the main outcomes.