Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Attributable Causes of Liver Cancer Mortality and Incidence in China

  • Fan, Jin-Hu (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Wang, Jian-Bing (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Jiang, Yong (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Xiang, Wang (Department of Epidemiology, School of Public Health, Harvard University) ;
  • Liang, Hao (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Wei, Wen-Qiang (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Qiao, You-Lin (Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College) ;
  • Boffetta, Paolo (The Tisch Cancer Institute, Mount Sinai School of Medicine)
  • Published : 2013.12.31
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Abstract

Objectives: To estimate the proportion of liver cancer cases and deaths due to infection with hepatitis B virus (HBV), hepatitis C virus (HCV), aflatoxin exposure, alcohol drinking and smoking in China in 2005. Study design: Systemic assessment of the burden of five modifiable risk factors on the occurrence of liver cancer in China using the population attributable fraction. Methods: We estimated the population attributable fraction of liver cancer caused by five modifiable risk factors using the prevalence data around 1990 and data on relative risks from meta-analyses, and large-scale observational studies. Liver cancer mortality data were from the 3rd National Death Causes Survey, and data on liver cancer incidence were estimated from the mortality data from cancer registries in China and a mortality/incidence ratio calculated. Results: We estimated that HBV infection was responsible for 65.9% of liver cancer deaths in men and 58.4% in women, while HCV was responsible for 27.3% and 28.6% respectively. The fraction of liver cancer deaths attributable to aflatoxin was estimated to be 25.0% for both men and women. Alcohol drinking was responsible for 23.4% of liver cancer deaths in men and 2.2% in women. Smoking was responsible for 18.7% and 1.0%. Overall, 86% of liver cancer mortality and incidence (88% in men and 78% in women) was attributable to these five modifiable risk factors. Conclusions: HBV, HCV, aflatoxin, alcohol drinking and tobacco smoking were responsible for 86% of liver cancer mortality and incidence in China in 2005. Our findings provide useful data for developing guidelines for liver cancer prevention and control in China and other developing countries.

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References

  1. Baan R, Grosse Y, Straif K, et al (2009). A review of human carcinogens--Part F: chemical agents and related occupations. Lancet Oncol, 10, 1143-4. https://doi.org/10.1016/S1470-2045(09)70358-4
  2. Boffetta P, Hashibe M, La Vecchia C, et al (2006). The burden of cancer attributable to alcohol drinking. Int J Cancer, 119, 884-7. https://doi.org/10.1002/ijc.21903
  3. Calle EE, Rodriguez C, Walker-Thurmond K, et al (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med, 348, 1625-38. https://doi.org/10.1056/NEJMoa021423
  4. Chen ZM, Liu BQ, Boreham J, et al (2003). Smoking and liver cancer in China: case-control comparison of 36, 000 liver cancer deaths vs. 17, 000 cirrhosis deaths. Int J Cancer, 107, 106-12. https://doi.org/10.1002/ijc.11342
  5. Chen WQ (2009). Estimation of cancer incidence and mortality in China in 2004-2005. Chin J Oncol, 31, 664-8.
  6. Chen JG, Zhang SW, Chen WQ (2010). Analysis of liver cancer mortality in the national retrospective sampling survey of death causes in China, 2004-2005. Zhonghua Yu Fang Yi Xue Za Zhi, 44, 383-9.
  7. Chuang SC, La Vecchia C, Boffetta P (2009). Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett, 286, 9-14. https://doi.org/10.1016/j.canlet.2008.10.040
  8. Danaei G, Vander Hoorn S, Lopez AD, et al (2005). Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet, 366, 1784-93. https://doi.org/10.1016/S0140-6736(05)67725-2
  9. Darrow LA, Steenland NK (2011). Confounding and bias in the attributable fraction. Epidemiology, 22, 53-8. https://doi.org/10.1097/EDE.0b013e3181fce49b
  10. de Martel C, Ferlay J, Franceschi S, et al (2012). Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol, 13, 607-15. https://doi.org/10.1016/S1470-2045(12)70137-7
  11. Ezzati M, Hoorn SV, Rodgers A, et al (2003). Estimates of global and regional potential health gains from reducing multiple major risk factors. Lancet, 362, 271-80. https://doi.org/10.1016/S0140-6736(03)13968-2
  12. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  13. Ge KY (1997). Body mass index of young Chinese adults. Asia nPacific J Clin Nutr, 6, 175-9.
  14. Gu D, Kelly TN, Wu X, et al (2009). Mortality attributable to smoking in China. N Engl J Med, 360, 150-9. https://doi.org/10.1056/NEJMsa0802902
  15. Inoue M, Sawada N, Matsuda T, et al (2012). Attributable causes of cancer in Japan in 2005--systematic assessment to estimate current burden of cancer attributable to known preventable risk factors in Japan. Ann Oncol, 23, 1362-9. https://doi.org/10.1093/annonc/mdr437
  16. International Agency for Research on Cancer, Academie des Sciences-Institut de France, Academie de Medecine, Federation Nationale des Centres de Lutte contre le Cancer (2007). IARC Working Group Reports, Vol 3, Attributable Causes of Cancer in France in the Year 2000. Lyon: IARC Press.
  17. Lai SW, Chen PC, Liao KF, et al (2012). Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study. Am J Gastroenterol, 107, 46-52. https://doi.org/10.1038/ajg.2011.384
  18. Levin ML (1953). The occurrence of lung cancer in man. Acta Unio Int Contra Cancrum, 9, 531-41.
  19. Liang X, Bi S, Yang W, et al (2009). Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine, 27, 6550-7. https://doi.org/10.1016/j.vaccine.2009.08.048
  20. Liang H, Wang J, Xiao H, et al (2010). Estimation of cancer incidence and mortality attributable to alcohol drinking in China. BMC Public Health, 10, 730. https://doi.org/10.1186/1471-2458-10-730
  21. Liu BQ, Peto R, Chen ZM, et al (1998). Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ, 317. 1411-22. https://doi.org/10.1136/bmj.317.7170.1411
  22. Liu Y, Chang CC, Marsh GM, et al (2012). Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis. Eur J Cancer, 48, 2125-36. https://doi.org/10.1016/j.ejca.2012.02.009
  23. Lu PX, Wang JB, Zhang QN, et al (2010). Longitudinal study of aflatoxin exposure in the development of primary liver cancer in patients with chronic hepatitis. Zhonghua Yi Xue Za Zhi, 90, 1665-9.
  24. Ministry of Health of the People's Republic of China (2008). Report of the Third National Retrospective Survey of Death Causes in China. Beijing: Chinese Academy of Medical Sciences & Peking Union Medical College Press.
  25. Olsen JH, Andersen A, Dreyer L, et al (1997). Summary of avoidable cancers in the Nordic countries. APMIS Suppl, 76, S141-6.
  26. Omer RE, Kuijsten A, Kadaru AM, et al (2004). Populationattributable risk of dietary aflatoxins and hepatitis B virus infection with respect to hepatocellular carcinoma. Nutr Cancer, 48, 15-21. https://doi.org/10.1207/s15327914nc4801_3
  27. Pan XR, Yang WY, Li GW, et al (1997). Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care, 20, 1664-9. https://doi.org/10.2337/diacare.20.11.1664
  28. Parkin DM, Boyd L, Walker LC (2011). 16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer, 105, S77-81. https://doi.org/10.1038/bjc.2011.489
  29. Pei GJ, Fu L, Cui YL (2008). Meta-analysis on the association of hepatocellular carcinoma with alcohol drinking among Chinese people. Xian Dai Yu Fang Yi Xue, 35, 2626-7.
  30. Polesel J, Zucchetto A, Montella M, et al (2009). The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma. Ann Oncol, 20, 353-7.
  31. PRC National Blood Pressure Survey Cooperative Group (1995). Alcohol Consumption and Blood Pressure: A Nation-wide Survey of in 1991 in China. Chin J Hypert, 3, 50-4.
  32. Rothman KJ (2012). Epidemiology: An introduction. 2nd edition. New York: Oxford University Press.
  33. Shin A, Park S, Shin HR, et al (2011). Population attributable fraction of infection-related cancers in Korea. Ann Oncol, 22, 1435-42. https://doi.org/10.1093/annonc/mdq592
  34. Wang JB, Jiang Y, Wei WQ, et al (2010). Estimation of cancer incidence and mortality attributable to smoking in China. Cancer Causes Control, 21, 959-65. https://doi.org/10.1007/s10552-010-9523-8
  35. Wang JB, Jiang Y, Liang H, et al (2012a). Attributable causes of cancer in China. Ann Oncol, 23, 2983-9. https://doi.org/10.1093/annonc/mds139
  36. Wang C, Wang X, Gong G, et al (2012b). Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer, 130, 1639-48. https://doi.org/10.1002/ijc.26165
  37. Weng XZ, Hong ZG, Chen DY (1987). Smoking prevalence in Chinese aged 15 and above. Chin Med J, 100, 886-92.
  38. Wu HC, Wang Q, Yang HI, et al (2009). Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev, 18, 846-53. https://doi.org/10.1158/1055-9965.EPI-08-0697
  39. Xia GL, Liu CB, Cao HL, et al (1996). Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992. Int Hepatol Commun, 5, 62-73. https://doi.org/10.1016/S0928-4346(96)82012-3
  40. Xiang W, Shi JF, Li P, et al (2011). Estimation of cancer cases and deaths attributable to infection in China. Cancer Causes Control, 22, 1153-61. https://doi.org/10.1007/s10552-011-9791-y
  41. Yang G, Fan L, Tan J, et al (1999). Smoking in China: findings of the 1996 National Prevalence Survey. JAMA, 282, 1247-53. https://doi.org/10.1001/jama.282.13.1247
  42. Yang WS, Va P, Bray F, et al (2011). The role of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence and prognosis: a meta-analysis of prospective cohort studies. PLoS One, 6, e27326. https://doi.org/10.1371/journal.pone.0027326
  43. Yao HY, Yang NN, Fang Y, et al (2002). A comprehensive analysis on the risk factors of lung cancer, liver cancer and breast cancer. Zhongguo Zhong Liu, 11, 695-6.
  44. Yu MC, Yuan JM (2004). Environmental factors and risk for hepatocellular carcinoma. Gastroenterology, 127, S72-8. https://doi.org/10.1016/j.gastro.2004.09.018
  45. Zhou XY, Fang JQ (2002). The application of Gibbs sampling in meta-analysis for case-control studies of HBV, HCV and dual infection in primary hepatocelluar carcinoma. Zhongshan Yi Ke Da Xue Xue Bao, 23, 165-7.

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