• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.26 no.3
• /
• pp.135-145
• /
• 2023

Antibiotics are frequently administered during pregnancy. Although necessary to address acute infections, their use facilitates antibiotic resistance. Other associations have also been found with the use of antibiotics, such as perturbations of gut bacteria, delays in microbial maturation, and increased risks of allergic and inflammatory diseases. Little is known about how the prenatal and perinatal administration of antibiotics to mothers affects the clinical outcomes of their offspring. A literature search was conducted of the Cochrane, Embase, and PubMed engines. The retrieved articles were reviewed by two authors and verified for relevance. The primary outcome was the effect of pre- and perinatal maternal antibiotic use on clinical outcomes. Thirty-one relevant studies were included in the meta-analysis. Various aspects are discussed, including infections, allergies, obesity, and psychosocial factors. In animal studies, antibiotic intake during pregnancy has been suggested to cause long-term alterations in immune regulation. In humans, associations have been found between antibiotic intake during pregnancy and different types of infections and an increased risk of pediatric infection-related hospitalization. A dose-dependent positive association between pre- and perinatal antibiotic use and asthma severity has been reported in animal and human studies, while positive associations with atopic dermatitis and eczema were reported by human studies. Multiple associations were identified between antibiotic intake and psychological problems in animal studies; however, relevant data from human studies are limited. However, one study reported a positive association with autism spectrum disorders. Multiple animal and human studies reported a positive association between pre- and perinatal antibiotic use by mothers and diseases in their offspring. Our findings have potentially significant clinical relevance, particularly considering the implications for health during infancy and later in life as well as the related economic burden.

• Safety and Health at Work
• /
• v.14 no.1
• /
• pp.17-30
• /
• 2023

The human reproductive system can be affected by occupational exposure to many physical and chemical risk factors. This study was carried out to review the studies conducted on the issue of the pathophysiological effects of occupational physical and chemical risk factors on the reproductive system of females and males. In this systematic review, the databases such as "Google Scholar," "Pub-Med," "Scopus," and "Web of Science" were used. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020), the studies included in our study were published between 2000 and 2021. In order to extract the required data, all sections of the articles were reviewed. Out of 57 articles we reviewed, 34 articles were related to field studies and 23 articles to clinical studies. Among them, 43 studies dealt with the pathophysiological effects of chemical agents, six studies dealt with the pathophysiological effects of physical factors, and 8 studies dealt with the pathophysiological effects of physicochemical factors on the human reproductive system. Physical (noise, heat, and radiofrequency radiation) and chemical (such as carbamate and organophosphate pesticides, benzene, toluene, xylene, formaldehyde, NO2, CS2, manganese, lead, nickel, and n-hexane) risk factors had pathophysiological effects on the human reproductive system. The presence of these risk factors in the workplace caused damage to the human reproductive system. The rate of these negative pathophysiological effects can be reduced by performing appropriate managerial, technical, and engineering measures in work environments.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2021.05a
• /
• pp.75-77
• /
• 2021

A variety of search engines are currently in use. The search engine supports the retrieval of data required by users through three stages: crawling, index generation, and output of search results based on meta-tag information. However, a large number of documents obtained by searching for keywords are often unrelated or scarce. Because of these problems, it takes time and effort to grasp the content from the search results and classify the accuracy. The index of search engines is updated periodically, but the criteria for weighted values and update periods are different from one search engine to another. Therefore, this paper uses the LSTM model, which extracts the relationship between keywords entered by the user and documents instead of the existing search engine, and improves the relationship between keywords and documents by entering keywords that the user wants to find.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2020.06a
• /
• pp.91-91
• /
• 2020

IPCC (Intergovernmental Panel on Climate Change) 5차 평가보고서에 의하면 최근 배출 온실가스의 양은 관측 이래 최고 수준이며 온실가스로 인한 기후변화는 인간계와 자연계에 광범위한 영향을 주고 있다고 보고하였다. 기후변화의 영향은 국제적으로 빙하 감소, 사막화, 해수면 상승 등 뚜렷하게 나타나고 있다. 이러한 기후변화에 대응하기 위해 온실가스 완화 정책과 동시에 새로운 기후변화 환경에 적응하는 것이 필요하다. 기후변화 적응이란 현재 나타나고 있거나 미래에 나타날 것으로 예상되는 기후변화의 파급효과와 영향에 대응할 수 있도록 하는 모든 행동이며 이를 위해서는 기후변화 영향분석이 수반되어야 한다. MOTIVE 연구단에서는 기후변화 적응대책 수립의 지원을 목표로 7개 부문(건강, 물관리, 농업, 산림, 생태, 해양, 수산)에서 "한국형 통합평가 모형"을 개발하고 있다. 각 부문에서 개발하는 프로세스 모델은 시스템에 대한 지식을 가진 상황에서 사용하면 신뢰할 수 있는 예측 결과를 얻을 수 있지만, 부문별 통합을 통한 영향 분석 시 타 분야에 대한 지식이 수반되어야 하는 어려움을 가진다. 이를 위해 본 연구에서는 시스템 내의 물리적 프로세스에 대한 요구 없이 입출력 데이터만을 이용하여 결과를 신속하게 추정하는 데이터 모델링(기계학습)을 이용하였다. 데이터 모델링을 위한 데이터는 다양한 자연 현상에 대한 BANPOL(수질 프로세스 모델) 분석을 통한 자료를 이용하여 학습 자료를 구축하였다. 즉, 데이터 모델링은 BANPOL 모델을 대리하는 메타모델이며, 낙동강 표준유역에 대한 유량 및 수질을 높은 상관성으로 추정하였다. 원 모델보다 정확도는 낮을 수 있으나 메타모델의 개발을 통한 웹 시스템을 개발하여 비전문가의 구동 및 신속한 기후 시나리오를 적용할 수 있는 환경을 개발하였다.

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.2
• /
• pp.120-132
• /
• 2023

Background: To systematically review studies on inhaled corticosteroids (ICS) and lung cancer incidence in chronic airway disease patients. Methods: We conducted electronic bibliographic searches on OVID-MEDLINE, EMBASE, and the Cochrane Database before May 2020 to identify relevant studies. Detailed data on the study population, exposure, and outcome domains were reviewed. Results: Of 4,058 screened publications, 13 eligible studies in adults with chronic obstructive pulmonary disease (COPD) or asthma evaluated lung cancer incidence after ICS exposure. Pooled hazard ratio and odds ratio for developing lung cancer in ICS exposure were 0.81 (95% confidence interval, 0.64 to 1.02; I²=95.7%) from 10 studies and 1.02 (95% confidence interval 0.50 to 2.07; I²=94.7%) from three studies. Meta-regression failed to explain the substantial heterogeneity of pooled estimates. COPD and asthma were variously defined without spirometry in 11 studies. Regarding exposure assessment, three and 10 studies regarded ICS exposure as a time-dependent and fixed variable, respectively. Some studies assessed ICS use for the entire study period, whereas others assessed ICS use for 6 months to 2 years within or before study entry. Smoking was adjusted in four studies, and only four studies introduced 1 to 2 latency years in their main or subgroup analysis. Conclusion: Studies published to date on ICS and lung cancer incidence had heterogeneous study populations, exposures, and outcome assessments, limiting the generation of a pooled conclusion. The beneficial effect of ICS on lung cancer incidence has not yet been established, and understanding the heterogeneities will help future researchers to establish robust evidence on ICS and lung cancer incidence.

• The Journal of Internal Korean Medicine
• /
• v.44 no.3
• /
• pp.285-293
• /
• 2023

Background: Irritable bowel syndrome (IBS) is a digestive disorder characterized by abdominal discomfort or pain accompanied by a change in stool condition. Owing to its complicated mechanisms, a standard treatment for IBS has not yet been established. Yukgunja-tang (YGT) is a Korean herbal medicine known in Asia to be effective in the treatment of gastrointestinal symptoms. In this study, we will conduct a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of YGT in IBS treatment. Methods and analysis: English databases, such as Embase, Medline (via PubMed), Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials, will be searched for articles published up to April 2023. Additional databases, such as five Korean, one Chinese, and one Japanese database, will be included. RCTs and quasi-RCTs will also be included in the assessment of the efficacy of YGT. The overall efficacy rate will be the primary outcome, and data such as IBS quality-of-life measurements, global symptom scores, and adverse events will be the secondary outcomes. Review Manager Version 5.3 will be used for evaluation, and the risk of bias (RoB) will be evaluated using Cochrane Collaboration's RoB tool. The Grading of Recommendations Assessment, Development, and Evaluation approach will be used to score the quality of evidence. Conclusion: This study will demonstrate the efficacy and safety of YGT for treating patients with IBS.

• Korean Journal of Construction Engineering and Management
• /
• v.24 no.1
• /
• pp.61-70
• /
• 2023

Due to economic or environmental reasons, green remodeling projects for old buildings are being actively carried out. Meanwhile, in the process of performing the green remodeling, the plan of green remodeling including passive and active elements has been decided based on the subjective experience and knowledge of engineers currently. Therefore, in this study, an ontology-based green remodeling decision-making support model, which can analyze the properties of old buildings and suggest appropriate remodeling plans, was established. In the developed model, once the basic properties of a building are entered, an appropriate remodeling plan composed of passive and active elements can be provided. By utilizing the results developed through the research, it is expected that it will be possible to support decision-making on more objective and appropriate remodeling alternatives development through web-based meta data search in accordance with the accumulation in remodeling cases.

• Computers and Concrete
• /
• v.32 no.6
• /
• pp.577-594
• /
• 2023

Engineered cementitious composites with calcined clay limestone cement (LC³-ECC) as a kind of green, low-carbon and high toughness concrete, has recently received significant investigation. However, the complicated relationship between potential influential factors and LC³-ECC compressive strength makes the prediction of LC³-ECC compressive strength difficult. Regarding this, the machine learning-based prediction models for the compressive strength of LC³-ECC concrete is firstly proposed and developed. Models combine three novel meta-heuristic algorithms (golden jackal optimization algorithm, butterfly optimization algorithm and whale optimization algorithm) with support vector regression (SVR) to improve the accuracy of prediction. A new dataset about LC³-ECC compressive strength was integrated based on 156 data from previous studies and used to develop the SVR-based models. Thirteen potential factors affecting the compressive strength of LC³-ECC were comprehensively considered in the model. The results show all hybrid SVR prediction models can reach the Coefficient of determination (R²) above 0.95 for the testing set and 0.97 for the training set. Radar and Taylor plots also show better overall prediction performance of the hybrid SVR models than several traditional machine learning techniques, which confirms the superiority of the three proposed methods. The successful development of this predictive model can provide scientific guidance for LC³-ECC materials and further apply to such low-carbon, sustainable cement-based materials.

• Hip & pelvis
• /
• v.35 no.2
• /
• pp.73-87
• /
• 2023

The aim of this review is to conduct an analysis of existing literature on outcomes of application of various methods of joint decompression in management of septic arthritis of the hip in children. A search of literature in PubMed, Embase, and Google Scholar was conducted for identification of studies reporting on the outcomes of intervention for septic arthritis of the hip in children. Of the 17 articles selected, four were comparative studies; two of these were randomized controlled trials while the rest were single arm studies. Statistical difference was observed between the proportion of excellent clinical and radiological outcomes in arthrotomy (90%, 95% confidence interval [CI] 81-98%; 89%, 95% CI 80-98%), arthroscopy (95%, 95% CI 91-100%; 95%, 95% CI 90-99%), and arthrocentesis (98%, 95% CI 97-100%; 99%, 95% CI 97-100%), respectively. The highest overall rate of additional unplanned procedures was observed in the arthrocentesis group (24/207, 11.6%). Patients who underwent arthrocentesis had a statistically greater chance of excellent clinical and radiological outcomes, although the highest level of need for additional unplanned surgical intervention was observed in the arthrocentesis group, followed by the arthroscopy group and the arthrotomy group. Future conduct of a prospective multi-centric study focusing on the developed and developing world, along with acquisition of data. such as delay of treatment and severity of disease will enable assessment of the efficacy of one technique over the other by surgeons worldwide.

• Annals of Hepato-Biliary-Pancreatic Surgery
• /
• v.27 no.1
• /
• pp.6-19
• /
• 2023

A systematic review was conducted in compliance with PRISMA statement standards to identify all studies reporting outcomes of laparoscopic resection of benign or malignant lesions located in caudate lobe of liver. Pooled outcome data were calculated using random-effects models. A total of 196 patients from 12 studies were included. Mean operative time, volume of intraoperative blood loss, and length of hospital stay were 225 minutes (95% confidence interval [CI], 181-269 minutes), 134 mL (95% CI, 85-184 mL), and 7 days (95% CI, 5-9 days), respectively. The pooled risk of need for intraoperative transfusion was 2% (95% CI, 0%-5%). It was 3% (95% CI, 1%-6%) for conversion to open surgery, 6% (95% CI, 0%-19%) for need for intra-abdominal drain, 1% (95% CI, 0%-3%) for postoperative mortality, 2% (95% CI, 0%-4%) for biliary leakage, 2% (95% CI, 0%-4%) for intra-abdominal abscess, 1% (95% CI, 0%-4%) for biliary stenosis, 1% (95% CI, 0%-3%) for postoperative bleeding, 1% (95% CI, 0%-4%) for pancreatic fistula, 2% (95% CI, 1%-5%) for pulmonary complications, 1% (95% CI, 0%-4%) for paralytic ileus, and 1% (95% CI, 0%-4%) for need for reoperation. Although the available evidence is limited, the findings of the current study might be utilized for hypothesis synthesis in future studies. They can be used to inform surgeons and patients about estimated risks of perioperative complications until a higher level of evidence is available.