• 여성건강간호학회지
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• 제3권2호
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• pp.268-281
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• 1997

This study was done for the purpose of analysing the relationship between menopausal syndrome and depression in the pre and post menopausal women's group. Data were collected by a questionnaire from November, 1995 to December, 1996. The subject were 244 midlife women(94 subjects were in pre-menopausal period, 150 subject were in post-menopausal period). The instruments used for this study were the menopausal syndrome scale by Neugarton and depression scale by Zung. Data were analyzed with the SPSS/PC using frequency, t-test, and Pearson correlation coefficients. The results of this study were as follows ; 1. The most serious menopausal symptom in the midlife women was 'back pain and joint pain'. 2. The item of 'Hot flush'(t=-2.78, p<0.01), 'sweating'(t=-2.31, p<0.05) and 'nervousness'(t=-2.13, p<0.05) as menopausal syndromes were statistically significant in the two groups ; Post menopausal group were higher then premenopausal group. 3. Postmenopausal group were a little higher then premenopausal group as depression level. It was none statistically significant in the two groups. 4. The relationship between menopausal syndromes and the level of depression was statistically significant in the group of post-menopausal group(r=0.2083, p<0.01).

• 대한한방부인과학회지
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• 제30권4호
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• pp.175-202
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• 2017

Objectives: This study was conducted towards developing a screening tool for syndrome differentiation in the diagnosis of menopause in menopausal and perimenopausal women. Methods: We conducted a literature review of studies on menopausal diagnosis based on syndrome differentiation, and examined well-founded differentiated syndromes and their respective clinical symptoms. Based on the findings, we created a questionnaire through consultations with Oriental medicine experts in physiology, pathology, and diagnostics. Finally, the research team conducted an expert Delphi study on differentiated syndromes and the associated clinical symptoms. Results: Seven differentiated syndromes were selected, including Liver Depression (肝鬱), Kidney Yin Deficiency (腎陰虛), Kidney Yang Deficiency (腎陽虛), Liver and Kidney Yin Deficiency (肝腎陰虛), Kidney Yin and Yang Deficiency (腎陰陽兩虛), Heart-Kidney Noninteraction (心腎不交), and Dual Deficiency of Heart and Spleen (心脾兩虛); 4 disease locations, including liver (肝), heart (心), spleen (脾), and kidney (腎); and 3 disease natures, including Yin Deficiency (陰虛), Qi Stagnation (氣滯), and Blood Deficiency (血虛). In addition, we added 3 supplemental disease natures, including Yang Deficiency (陽虛), Qi Deficiency (氣虛), and Heat (火熱), in consideration of syndrome differentiation categories that may possibly be added in a follow-up clinical questionnaire. Conclusions: This resulted in a total of 7 differentiated syndromes, 4 disease locations, and 6 disease natures. We translated the clinical symptoms of these 17 categories into Korean Hangeul. After consulting with 5 Oriental medicine experts and a psychology expert, we produced a questionnaire for use in diagnosing menopause based on syndrome differentiation. The calculation of scores for the syndrome differentiation screening tool will be confirmed through clinical research based on the results of a review of existing literature.

• 대한의생명과학회지
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• 제15권3호
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• pp.217-227
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• 2009

The present study was set to evaluate the effect of pomegranate extracts on improvement of the menopausal syndromes such as face flushing in ovariectomized rats by carrying out short- and long-term experiments. Pomegranate extracts used to feed rats were prepared from the pulp part which does not contain the rid of the pomegranate, and were dissolved in propylene glycol. From the short-term (16 days) experiment, it was clear that when the 25, 250, 1,250 mg/kg/day concentrations of pomegranate extracts were orally fed to ovariectomized rats, the body temperature of the rats in all the 3 groups were decreased with statistical significance compared to other control groups which were fed with propylene glycol only. Especially, the body temperature decreased by $2.7^{\circ}C$ compared to control groups even when the pomegranate extracts were fed at the low concentration of 25 mg/kg/day implying the usefulness of pomegranate extracts in improving face flushing troubles. In addition, the body weight of the groups fed with pomegranate extracts also decreased when compared to groups fed with only propylene glycol, and the results were also statistically significant. In case of the estradiol level in the blood of rats, the levels were somewhat higher in the groups fed with pomegranate extracts than the control groups, even though the difference was not statistically significant. As found from the results of the short-term experiment, in long-term experiment, the groups fed with pomegranate extracts showed statistically significant decrease in the body temperature and the body weight, whereas the increase of the estradiol levels in blood in each groups were statistically insignificant. During the short- and long-term experiments, no sign of toxicity was found in rats fed with pomegranate extracts indicating no toxic side effects of the pomegranate extracts when orally fed. The concentrations of pomegranate extracts 25, 250, 1250 mg/kg/day treated to ovariectomized rats in this study can be estimated to be 1.5, 15, and 75 g/day when treated to women whose body weight is 60 kg which is average for women with menopausal syndromes. Since even the 75 g/day of high concentration of pomegranate extracts did not show any toxicity in short- and long-term experiments, taking 1.5 g/day concentration of pomegranate extracts would be safe dose for not causing any side effects. Therefore, it can be concluded from the results of this study that taking 1.5 g/day of pomegranate extracts for certain period time will improve the menopausal syndromes including face flushing.

• Journal of Ginseng Research
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• 제27권3호
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• pp.98-102
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• 2003

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-l (tPAI-l) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administration of 6 g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3 months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-l levels in postmenopausal patients with CS were significantly (P<0.001 and P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modem medicine but also by traditional KAMPO medicine.

• 대한예방한의학회지
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• 제24권1호
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• pp.1-14
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• 2020

Objectives : The purpose of this systematic review was to investigate the efficacy and safety of Sanjoin-tang (Suanzaoren decoction, SZRD) for insomnia in menopausal syndromes. Method : We searched the following databases: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Science and Technique Journals Database (VIP), Wanfang, Research Information Service System (RISS), OASIS, Korean studies Information Service System (KISS), and National Digital Science Library (NDSL) databases. Randomized controlled trials (RCTs) or quasi-RCTs that used SZRD for women in menopause were included. The methodological quality of each RCT was assessed using the risk of bias tool. Results : In total, nine RCTs were finally included. The included RCTs had a high risk of bias across their domains. Three RCTs examined the effects of SZRD compared with western medicine (WM) in insomnia. Three RCTs showed favorable effects of SZRD with insomnia. Infrastructure also showed that SZRD resulted in better clinical WM (RR 1.19, 95% CI 1.07 to 1.32, P=0.001, I²=0%). Four RCTs showed favorable effects of Modified SZRD with insomnia. Infrastructure also showed that Modified SZRD resulted in better clinical WM (RR 1.13, 95% CI 1.04 to 1.23, P=0.004, I²=0%). Among the 4 RCTs, three RCTs showed an equivalent effect on the total Pittsburh Sleep Quality Index (PSQI). The meta-analysis also showed that Modified SZRD had a superior effect on the total of PSQI (total of PSQI : MD -2.55, 95% CI -3.72 to -1.37, P<0.0001, I²=85%). Only 2 trials reported adverse events and none reported severe adverse events. Conclusion : SZRD appears to be safe, but there is insufficient evidence to make a definitive conclusion because only a few studies reported adverse events. Due to the poor methodological quality of the included studies and the small number of trials included, the evidence cannot be reproduced and assessed. Well-designed RCTs with a larger sample size are needed in the future.

• 대한한의학방제학회지
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• 제12권1호
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• pp.263-276
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• 2004

Clinical study on one case of climacteric syndrome induced hysterectomy climacteric syndrome is symptoms of physical, mental, physiological in menopausal period. Importance of treatment of climacteric symptoms was on the rise recently. I have treated one patient who has mental depression, anxiety, impatience, impotence, palpitations, facial flushing, abdominal pain in the menopausal period in Dongshin University Oriental Hospital. I took acupunture, moxibustion, cupping, and also I made herbal medicine-gamiguibitang(加味歸脾湯). As a result, I got a good effect through above methods. So I came to write this case report.

• 대한한의학원전학회지
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• 제26권4호
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• pp.267-280
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• 2013

Objective : One of the unique syndromes in Asian traditional medicine named 'heat entering the blood chamber(熱入血室, HEBC)' first appeared in Shanghanlun(傷寒論) and Jinguiyaolue(金匱要略) written by Zhangzhongjing(張仲景) who is the most famous doctor in ancient China. Method : Through comparison between Huangdineijing(黃帝內經), Shanghanlun(傷寒論), Jinguiyaolue(金匱要略) and other medical texts, the correct meaning, causes and mechanisms of HEBC can be analysed and organized to suggest new view of HEBC in modern society. Result : This syndrome is usually occurred in women during catching cold and menstruation, accompanying alternation of chillness and fever, pseudo-malaria, delirium, raveled chest(結胸), uterine hemorrhage, etc. The main sign of this syndrome, delirium belongs to the category of liver disease and fever in Huangdineijing(黃帝內經) which is a document more early published than Shanghanlun. Although there are still many other comprehensions about what blood chamber is, it could be the same as uterus according to Huangdineijing, it is relevant to the control of menstruation and emotions, and the function of liver and thoroughfare vessel(衝脈). Conclusion : HEBC is a syndrome exclusive to women, caused by their unique physical and psychological characteristics. It's beginning can be found in Huangdineijing, and by Shanghanlun and Jinguiyaolue, its concept as a single disease pattern becomes established. In other words, HEBC is a complex disease related to menstruation and its related hormonal dysfunctions, closely related to PMS, menopausal syndrome of today. Physical symptoms accompanied by psychological anxiety and fear is characteristic of this condition. Therefore gynecological approaches as well as socio-cultural issues related to women in modern society must be adopted when dealing with HEBC.

• 정신신체의학
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• 제23권1호
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• pp.57-65
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• 2015

연구목적 급격한 호르몬 변화가 발생하는 월경과 폐경 시기에 기분증상 및 신체증상이 나타난다는 공통된 임상적 특징과 생물학적 기전의 유사성을 바탕으로 하여 월경전 증후군/월경전 불쾌장애와 폐경기 증상의 연관성이 제기되었으나 아직까지 일관된 결론이 내려지지 않고 있다. 따라서 본 연구는 폐경기 여성에서 각각의 폐경 단계에 따라 월경 전 증후군의 과거력과 대표적인 폐경기 증상 중의 하나인 혈관운동증상의 연관성에 대해 조사해보고자 하였다. 방 법 한국건강관리협회 전국 16개 지사에 건강검진을 목적으로 방문한 361명의 폐경주위기 여성과 693명의 폐경후기 여성을 대상으로 단면연구를 시행하였다. 모든 대상자는 혈관운동증상과 월경전 증후군 과거력 및 여러 요인(연령, 결혼, 수입, 교육 수준, 음주, 운동, 흡연, 폐경에 대한 태도, 우울, 스트레스)에 대한 자가보고식 설문지를 작성하였다. 결 과 전기 폐경주위기를 제외한 후기 폐경주위기, 전기 폐경후기, 후기 폐경후기에서 월경전 증후군/월경전 불쾌장애의 과거력이 있는 여성에서 중등도 이상의 혈관운동증상을 호소하는 비율이 유의하게 높았다(전기 폐경주위기, p=0.824 ; 후기 폐경주위기, p=0.001 ; 전기 폐경후기, p=0.001 ; 후기 폐경후기, p=0.01). 후기 폐경주위기와 전기 폐경후기에서 PSST score와 혈관운동증상의 심각도가 유의한 양의 상관관계가 관찰되었다(후기 폐경주위기, r=0.213, p=0.010 ; 전기 폐경후기, r=0.246, p<0.001). 우울, 폐경에 대한 태도, 스트레스, 생활습관요인 등의 관련된 요인들을 통제하였을 때, 후기 폐경주위기와 전기 폐경후기에서 월경전 증후군/월졍전 불쾌장애의 과거력이 중등도 이상의 혈관운동증상을 예측하는 유의한 인자로 나타났다(후기 폐경주위기, OR=5.197, p=0.005 ; 전기 폐경후기, OR=3.017, p=0.010). 결 론 본 연구는 폐경 단계에 따라 월경전 증후군/월경전 불쾌장애와 혈관운동증상의 연관성이 차별적으로 나타남을 시사한다. 본 연구에서 나타난 결과를 규명하기 위한 추가적인 대단위의, 전향적인 연구가 필요할 것으로 사료된다.