• Title/Summary/Keyword: Memory Improvement

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Protective effect of Phyllostachys edulis (Carrière) J. Houz against chronic ethanol-induced cognitive impairment in vivo

  • Jiyeon Kim;Ji Myung Choi;Ji-Hyun Kim;Qi Qi Pang;Jung Min Oh;Ji Hyun Kim;Hyun Young Kim;Eun Ju Cho
    • Nutrition Research and Practice
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    • v.18 no.4
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    • pp.464-478
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    • 2024
  • BACKGROUND/OBJECTIVES: Chronic alcohol consumption causes oxidative stress in the body, which may accumulate excessively and cause a decline in memory; problem-solving, learning, and exercise abilities; and permanent damage to brain structure and function. Consequently, chronic alcohol consumption can cause alcohol-related diseases. MATERIALS/METHODS: In this study, the protective effects of Phyllostachys edulis (Carrière) J. Houz (PE) against alcohol-induced neuroinflammation and cognitive impairment were evaluated using a mouse model. Alcohol (16%, 5 g/kg/day for 6 weeks) and PE (100, 250, and 500 mg/kg/day for 21 days) were administered intragastrically to mice. RESULTS: PE showed a protective effect against memory deficits and cognitive dysfunction caused by alcohol consumption, confirmed through behavioral tests such as the T-maze, object recognition, and Morris water maze tests. Additionally, PE attenuated oxidative stress by reducing lipid oxidation, nitric oxide, and reactive oxygen species levels in the mice's brains, livers, and kidneys. Improvement of neurotrophic factors and downregulation of apoptosis-related proteins were confirmed in the brains of mice fed low and medium concentrations of PE. Additionally, expression of antioxidant enzyme-related proteins GPx-1 and SOD-1 was enhanced in the liver of PE-treated mice, related to their inhibitory effect on oxidative stress. CONCLUSION: This suggests that PE has both neuroregenerative and antioxidant effects. Collectively, these behavioral and histological results confirmed that PE could improve alcohol-induced cognitive deficits through brain neurotrophic and apoptosis protection and modulation of oxidative stress.

The Changes of Short-Term Memory and Autonomic Neurocardiac Function after 4-10Hz Sound and Light Stimulation - A Pilot Study - (4-10 Hz 빛과 소리자극 후 단기기억력 및 자율신경심장기능의 변화 - 예비연구 -)

  • Lee, Seung-Hwan;Kim, Jin-Hwan;Park, Joong-Kyu;Lee, Kyung-Uk;Yang, Dae-Hyun;Hong, Keun-Young;Chae, Jeong-Ho
    • Sleep Medicine and Psychophysiology
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    • v.11 no.1
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    • pp.29-36
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    • 2004
  • Objectives: Sound and light (SL) stimulation has been used as a method to induce some useful mental states in the fields of psychology and psychiatry. It is believed that sound and light entrainment device (SLED) has some specific effects through synchronization of EEG in patients who use it. Theta frequency is believed to stimulate deep relaxation and short term memory processing. This study was conducted to evaluate if 4-10 Hz SL stimulation can induce relaxation and improve short term memory function. Methods: Ten medical students with no medical or psychiatric problems participated in this study. Subjects were randomly divided into two groups. One group was applied with real SLED was applied to one group (R group) and pseudo SLED to the other group (P group). The two groups were exposed to SL stimulation with SLED 15 minutes a day for 5 days, and after two days rest the two groups were switched over. The Korean Wechsler Adult Intelligence Scale (K-WAIS), Academic Motivation Tests (AMT), Test Anxiety Scale (TAS), Korean Auditory Verbal Learning Test (K-AVLT), and digit span were used to evaluate short term memory. Spielberger's State-Trait anxiety inventory and heart rate variability (HRV) test were used to evaluate degree of relaxation. Results: Compared with S group, R group showed a significant improvement in K-AVLT and digit span after a single application of SL stimulation. But 5-day long application did not reveal any differences between the two groups. A significant change in HRV was observed in 5-day long application of SL stimulation after being switched over to other SLED. Conclusion: This pilot study suggests that 4-10 Hz SL stimulation has some positive influences on short term memory and relaxation.

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Effect of Therapeutic and Educational strategies using music on improvement of auditory information processing and short-term memory skills for children with underachievement (학습부진아의 청각정보처리와 단기기억력 향상을 위한 음악의 치료적·교육적 접근)

  • Chong, Hyun Ju
    • Journal of Music and Human Behavior
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    • v.1 no.1
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    • pp.1-10
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    • 2004
  • Being engaged in the musical tasks needs cognitive skills to perceive musical sound, organize them into meaningful unit, store them in the memory and retrieve them when needed. These skills are also required for academic tasks indicating that there is positive correlation between skills for musical and academic tasks. Based on these findings, the study purported to examine whether the developed sessions can enhance cognitive skills which is composed of auditory information skills, which is composed of perceiving sounds, organizing them into groups based on the existing information or organization pattern, and short-term memory skills. Eighteen elementary students in 4, 5, and 6th grades have participated in the study. The study has administered Music Cognitive Skills Test(MCST) before and after implementing music therapy sessions. The MCST consisted of five parts, first one measuring the rhythm imitating skills, second, measuring the melodic imitation skills, third, measuring discriminative skills in identifying higher pitch, fourth, measuring discriminative skills in identifying identical chords, and lastly, measuring the tone retention skills. The results indicated that there was statistical difference between the pre and post test in rhythm and melody imitation skills. Because reproduction of perceived rhythm patterns requires memory skills, imitating patterns are considered cognitive skills. Also melody is defined adding spatial dimension to the rhythm which is temporal concept. Being able to understand melodic pattern and to reproduce the pattern also requires cognitive skills. The subjects have shown significant improvement in these two areas. In other areas, there were definite increase of scores, however, no significant differences. The study also explores interpretation of these results and also observed consistencies among the participants in completing the musical tasks.

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A Performance Improvement Scheme for a Wireless Internet Proxy Server Cluster (무선 인터넷 프록시 서버 클러스터 성능 개선)

  • Kwak, Hu-Keun;Chung, Kyu-Sik
    • Journal of KIISE:Information Networking
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    • v.32 no.3
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    • pp.415-426
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    • 2005
  • Wireless internet, which becomes a hot social issue, has limitations due to the following characteristics, as different from wired internet. It has low bandwidth, frequent disconnection, low computing power, and small screen in user terminal. Also, it has technical issues to Improve in terms of user mobility, network protocol, security, and etc. Wireless internet server should be scalable to handle a large scale traffic due to rapidly growing users. In this paper, wireless internet proxy server clusters are used for the wireless Internet because their caching, distillation, and clustering functions are helpful to overcome the above limitations and needs. TranSend was proposed as a clustering based wireless internet proxy server but it has disadvantages; 1) its scalability is difficult to achieve because there is no systematic way to do it and 2) its structure is complex because of the inefficient communication structure among modules. In our former research, we proposed the All-in-one structure which can be scalable in a systematic way but it also has disadvantages; 1) data sharing among cache servers is not allowed and 2) its communication structure among modules is complex. In this paper, we proposed its improved scheme which has an efficient communication structure among modules and allows data to be shared among cache servers. We performed experiments using 16 PCs and experimental results show 54.86$\%$ and 4.70$\%$ performance improvement of the proposed system compared to TranSend and All-in-one system respectively Due to data sharing amount cache servers, the proposed scheme has an advantage of keeping a fixed size of the total cache memory regardless of cache server numbers. On the contrary, in All-in-one, the total cache memory size increases proportional to the number of cache servers since each cache server should keep all cache data, respectively.

A Case Report of Non-Motor Symptoms Evaluated Using the Non-Motor Symptom Scale in a Patient with Secondary Parkinsonism Presumed to be Probable Lewy Body Dementia and Improved with Combined Treatment with Herbal Medicine and Acupuncture (루이소체 치매로 추정되는 이차성 파킨슨증 환자의 Non-Motor Symptom Scale(NMSS)로 평가한 비운동성 증상을 한약과 침의 복합치료로 호전시킨 증례보고 1례)

  • Roh, Min-yeong;Lee, Ji-hyun;Han, Yang-hee;Leem, Jung-tae
    • The Journal of Internal Korean Medicine
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    • v.42 no.5
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    • pp.833-845
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    • 2021
  • Parkinson's syndrome is a degenerative brain disease that presents characteristic motor symptoms of tremor, rigidity, and gait disturbance. In addition to these motor symptoms, Parkinson's syndrome also presents non-motor symptoms (NMSs) such as sleep disturbance and cognitive decline. NMSs reduce patient's quality of life and psychosocial functioning and cause economic burden on the patient, so appropriate evaluation and treatment are required. Lewy body dementia is one of the several diseases belonging to Parkinson's syndrome. Its symptoms such as cognitive function, memory impairment, and hallucinations occur with Parkinsonism. Although drug therapy is being used with drug treatment to treat non-motor symptoms, it has limitations such as side effects, which stimulated interest in other complementary treatment methods such as oriental medicine treatment, dance, and yoga. The patient in this case complained of tremor in the right upper extremity, muscle hypertension and pain, and persistent vision, memory, and cognitive decline. The patient was diagnosed with probable Lewy body dementia. The patient was hospitalized for 4 months and received acupuncture and herbal medicines. After treatment, the patient's NMS scale scores decreased from 90 to 63, and the Unified Parkinson's Disease Rating Scale scores (summed I, II, and III) decreased from 17 points to 8 points. The Beck Depression Inventory score decreased from 22 points to 13 points. In addition, the patient's subjective evaluation revealed improvement. In this case, a patient diagnosed with probable Lewy body dementia who did not respond to the standard treatment and did not want to take medications showed improvement in not only motor symptoms but also NMSs after integrative Korean medicine treatment.

Digitization & Popularization of Printing Woodblocks of the Tripitaka Koreana and Miscellaneous Buddhist Scriptures, Memory of the World (세계기록유산 고려대장경 및 제경판의 디지털화와 대중화)

  • Kang, Soon-Ae
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.22 no.1
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    • pp.27-46
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    • 2011
  • The present paper is focused on Korea's inscribed heritages, digitization of the Tripitaka Koreana & miscellaneous buddhist scriptures, and public uses of the digital properties in order to describe the Digitization & Popularization of Printing Woodblocks of the Tripitaka Koreana and Miscellaneous Buddhist Scriptures, Memory of the World. The Goryeo Daejanggyeong or the Tripitaka Koreana and miscellaneous Buddhist sculptures refer to printing woodblocks of the Tripitaka(National Treasure No.32), and repositories (National Treasure No.52) where the woodblocks are stored. The woodblocks numbers 1,514 types/81,350 blocks/162,700 pages. Haein temple has worked the digital Tripitaka project 2009-2010 and The project for 2010 will focus on DB correction and modification, improvement of homepage that was made in 2009. For this, the focus was especially put on investigating current status and development plans of the digital Tripitaka project. In popularization of the digital Tripitaka, this study examined the Korea's utilization policy and current situation of knowledge resources about culture, successful cases of digital Tripitaka projects, and popularization strategies. This research can contribute to digitization of other cultural heritages and related researches in the future.

Development of the Meta-heuristic Optimization Algorithm: Exponential Bandwidth Harmony Search with Centralized Global Search (새로운 메타 휴리스틱 최적화 알고리즘의 개발: Exponential Bandwidth Harmony Search with Centralized Global Search)

  • Kim, Young Nam;Lee, Eui Hoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.2
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    • pp.8-18
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    • 2020
  • An Exponential Bandwidth Harmony Search with Centralized Global Search (EBHS-CGS) was developed to enhance the performance of a Harmony Search (HS). EBHS-CGS added two methods to improve the performance of HS. The first method is an improvement of bandwidth (bw) that enhances the local search. This method replaces the existing bw with an exponential bw and reduces the bw value as the iteration proceeds. This form of bw allows for an accurate local search, which enables the algorithm to obtain more accurate values. The second method is to reduce the search range for an efficient global search. This method reduces the search space by considering the best decision variable in Harmony Memory (HM). This process is carried out separately from the global search of the HS by the new parameter, Centralized Global Search Rate (CGSR). The reduced search space enables an effective global search, which improves the performance of the algorithm. The proposed algorithm was applied to a representative optimization problem (math and engineering), and the results of the application were compared with the HS and better Improved Harmony Search (IHS).

Improving Haskell GC-Tuning Time Using Divide-and-Conquer (분할 정복법을 이용한 Haskell GC 조정 시간 개선)

  • An, Hyungjun;Kim, Hwamok;Liu, Xiao;Kim, Yeoneo;Byun, Sugwoo;Woo, Gyun
    • KIPS Transactions on Computer and Communication Systems
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    • v.6 no.9
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    • pp.377-384
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    • 2017
  • The performance improvement of a single core processor has reached its limit since the circuit density cannot be increased any longer due to overheating. Therefore, the multicore and manycore architectures have emerged as viable approaches and parallel programming becomes more important. Haskell, a purely functional language, is getting popular in this situation since it naturally supports parallel programming owing to its beneficial features including the implicit parallelism in evaluating expressions and the monadic tools supporting parallel constructs. However, the performance of Haskell parallel programs is strongly influenced by the performance of the run-time system including the garbage collector. Though a memory profiling tool namely GC-tune has been suggested, we need a more systematic way to use this tool. Since GC-tune finds the optimal memory size by executing the target program with all the different possible GC options, the GC-tuning time takes too long. This paper suggests a basic divide-and-conquer method to reduce the number of GC-tune executions by reducing the search area by one-quarter for every searching step. Applying this method to two parallel programs, a maximally independent set and a K-means programs, the memory tuning time is reduced by 7.78 times with accuracy 98% on average.

Performance Enhancement Architecture for HLR System Based on Distributed Mobile Embedded System (분산 모바일 임베디드 시스템 기반의 새로운 위치정보 관리 시스템)

  • Kim Jang Hwan
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.12B
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    • pp.1022-1036
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    • 2004
  • In mobile cellular network the ever-changing location of a mobile host necessitates the continuous tracking of its current position and efficient management of location information. A database called Home Location Register(HLR) plays a major role in location management in this distributed environment, providing table management, index management, and backup management facilities. The objectives of this paper are to identify the p개blems of the current HLR system through rigorous analysis, to suggest solutions to them, and to propose a new architecture for the HLR system. In the HLR system, a main memory database system is used to provide real-time accesses and updates of subscriber's information. Thus it is suggested that the improvement bemade to support better real-time facilities, to manage subscriber's information more reliably, and to accommodate more subscribers. In this paper, I propose an efficient backup method that takes into account the characteristics of HLR database transactions. The retrieval speed and the memory usage of the two-level index method are better than those of the T-tree index method. Insertion md deletion overhead of the chained bucket hashing method is less than that of modified linear hashing method. In the proposed backup method, I use two kinds of dirty flags in order to solve the performance degradation problem caused by frequent registration-location operations. Performance analysis has been performed to evaluate the proposed techniques based on a system with subscribers. The results show that, in comparison with the current techniques, the memory requirement is reduced by more than 62%,directory operations, and backup operation by more than 80%.

Comparative assessment of frost event prediction models using logistic regression, random forest, and LSTM networks (로지스틱 회귀, 랜덤포레스트, LSTM 기법을 활용한 서리예측모형 평가)

  • Chun, Jong Ahn;Lee, Hyun-Ju;Im, Seul-Hee;Kim, Daeha;Baek, Sang-Soo
    • Journal of Korea Water Resources Association
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    • v.54 no.9
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    • pp.667-680
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    • 2021
  • We investigated changes in frost days and frost-free periods and to comparatively assess frost event prediction models developed using logistic regression (LR), random forest (RF), and long short-term memory (LSTM) networks. The meteorological variables for the model development were collected from the Suwon, Cheongju, and Gwangju stations for the period of 1973-2019 for spring (March - May) and fall (September - November). The developed models were then evaluated by Precision, Recall, and f-1 score and graphical evaluation methods such as AUC and reliability diagram. The results showed that significant decreases (significance level of 0.01) in the frequencies of frost days were at the three stations in both spring and fall. Overall, the evaluation metrics showed that the performance of RF was highest, while that of LSTM was lowest. Despite higher AUC values (above 0.9) were found at the three stations, reliability diagrams showed inconsistent reliability. A further study is suggested on the improvement of the predictability of both frost events and the first and last frost days by the frost event prediction models and reliability of the models. It would be beneficial to replicate this study at more stations in other regions.