• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2006년도 추계학술대회
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• pp.545-559
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• 2006

The function of product design has been an important part for success on new product development We deeply studied 'Chocolate-Phone' case which is considered as a representative of adopting design-oriented new product development strategy. According to this study, we found three contextual factors and nine key success factors for design-oriented new product development. The contextual factors consist of the strong needs for innovative product development, customer's needs for the emotional value, competitive situation for the new product launching. The key success factors consist of design, development marketing, overall sides. The key success factors of design side are to select talented designers and take an insight for market and communication skill. The key success factors of development side are to possess high technological abilities, to do divergence with removing or giving up some function management's strong support. The key success factors of marketing side are to bring core marketers from outside, capacity to gather ideas from outside. The key success factors of overall side are to share design-oriented principle with other parts and to change member's mind from engineer-oriented to market-oriented.

• BMB Reports
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• 제48권8호
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• pp.473-478
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• 2015

The NEK6 (NIMA-related kinases 6) is reported to play po-tential roles in tumorigenesis. Although it is suggested to function in several cellular pathways, the underlying mechanism in tumorigenesis is still largely unknown. In the present study, we discovered interaction of NEK6 with Smad4, a key member of transforming growth factor beta (TGFβ) pathway. Over-expression of NEK6 in hepatocellular carcinoma (HCC) cell lines suppresses TGFβ-mediated transcription activity in a kinase activity-dependent manner. In addition, NEK6 suppresses the cell growth arrest induced by TGFβ. Mechanically, NEK6 blocks nuclear translocation of Smad4, which is essential for TGFβ function. Moreover, we identified that NEK6 could be regulated by TGFβ and hypoxia. Our study sheds new light on the roles of NEK6 in canonical TGFβ/Smad pathway and tum-origenesis. [BMB Reports 2015; 48(8): 473-478]

• 한국기계가공학회지
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• 제13권2호
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• pp.55-63
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• 2014

Fractures and wrinkles are two major defects frequently found in the sheet metal forming process. The process has several noise factors that cannot be ignored when determining the optimal process conditions. Therefore, without any countermeasures against noise, attempts to reduce defects through optimal design methods have often led to failure. In this study, a new and robust design methodology that can reduce the possibility of formation of fractures and wrinkles is presented using decision-making theory. A two-attribute value function is presented to form the design metric for the sheet metal forming process. A modified complex method is adopted to isolate the optimal robust design variables. One of the major limitations of the traditional robust design methodology, which is based on an orthogonal array experiment, is that the values of the optimal design variables have to coincide with one of the experimental levels. As this restriction is eliminated in the complex method, a better solution can be expected. The procedure of the proposed method is illustrated through a robust design of the sheet metal forming process of a side member of an automobile body.

• Steel and Composite Structures
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• 제33권6호
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• pp.767-776
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• 2019

In this article, a simple and robust multi-objective assessment method to control design angles and node positions connected among steel outrigger truss members is proposed to approve both structural safety and economical cost. For given outrigger member layouts, the present method utilizes general-purpose prototypes of outrigger members, having resistance to withstand lateral load effects directly applied to tall buildings, which conform to variable connecting node and design space deposition. Outrigger layouts are set into several initial design conditions of height to width of an arbitrary given design space, i.e., variable design space. And then they are assessed in terms of a proposed multi-objective function optimizing both minimal total displacement and material quantity subjected to design impact factor indicating the importance of objectives. To evaluate the proposed multi-objective function, an analysis model uses a modified Maxwell-Mohr method, and an optimization model is defined by a ground structure assuming arbitrary discrete straight members. It provides a new robust assessment model from a local design point of view, as it may produce specific optimal prototypes of outrigger layouts corresponding to arbitrary height and width ratio of design space. Numerical examples verify the validity and robustness of the present assessment method for controlling prototypes of outrigger truss members considering a multi-objective optimization achieving structural safety and material cost.

• 농촌지도와개발
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• 제23권1호
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• pp.27-37
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• 2016

This paper estimated the demand function of the cuts of pork by using the consumer panel and the weather data from the Korea Meteorological Administration with a log-log model and AIDS model. The results show that the price elasticity of demand for cuts of pork is high in the sequence of arm shoulder, leg, special cuts, tenderloin, blade shoulder. In contrast, spare rib, belly and loin are classified as low price elasticity of demand. The income elasticities of demand for leg and blade shoulder are 11% and 7.6% respectively. The loin is classified as inferior goods, because demand decreases when income increases. The results also demonstrate show that the demand increases highly in the sequence of loin, arm shoulder, spare rib, belly if housewife is older, and the demand of belly increases when family number increases. Belly substitutes every cut except spare rib, and tenderloin substitutes special cuts. Spare rib, on the other hand, does not substitute other cuts. In addition, job status, family member, husband job, purchasing place, consumer characteristic, eating-out times, purchasing time, and weather are statistically significant.

• 한국강구조학회 논문집
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• 제18권6호
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• pp.707-716
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• 2006

본 논문에서는 고등해석과 유전자 알고리즘을 이용한 반강접 강뼈대 구조물의 직접설계시스템의 최적화를 수행하였다. 고등해석은 접합부의 비선형, 기하학적 비선형 및 재료적 비선형을 고려한다. 기하학적 비선형은 안정함수를 사용하여 고려하였으며, 재료적 비선형은 CRC 접선 탄성계수와 포물선 함수를 사용함으로서 고려하였다. 접합부의 비선형은 Kishi와 Chen이 제안한 3가지 매개변수를 가지는 파워모델을 사용하여 고려하였다. 최적화 기법으로는 유전자 알고리즘을 사용하였다. 목적함수는 구조물의 중량을 사용하였으며, 제약조건식은 구조시스템의 하중-저항능력, 처짐, 층간 수평변위 및 연성요구 조건을 고려하였다. 제안된 방법에 의한 설계결과를 기존의 방법들과 비교하였다.

• 한국강구조학회 논문집
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• 제9권3호통권32호
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• pp.457-465
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• 1997

형상최적화는 단면최적화에 비하여 구조물의 중량과 경비를 줄일 수 있다. 많은 양의 애매한 정보가 최적설계 문제의 제약조건에 존재할 수도 있다. 상대적으로 중요한 퍼지정도를 포함한 여러개의 기준을 묘사하고 다루는 것은 매우 어렵고 때로는 애매하다. 본 논문에서는 ${\alpha}$-절단법에 의한 퍼지 구조계의 다목적 형상최적화에 대한 가중치방법을 제안한다. 본 연구의 알고리즘을 2부재 트러스 구조물에 적응하여 그 결과가 검토되었다. 그 결과는 ${\alpha}$-절단법과 체적과 변위에 관한 가중치에 따른 최적해를 얻음으로써 설계자는 실제에 적합한 하나의 해를 택할 수 있음을 보여준다.

• 천문학회보
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• 제43권1호
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• pp.61.3-61.3
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• 2018

To understand the assembly of the galaxy population in clusters today, it is important to first understand the impact of previous environments prior to cluster infall, namely preprocessing. We use 15 cluster samples from hydrodynamic zoom-in simulation YZiCS to determine the significance of preprocessing focusing primarily on the tidal mass loss of dark matter halos. We find ~48% of the cluster member halos were once satellites of another host. The preprocessed fraction is not a clear function of cluster mass. Instead, we find it is related to each individual cluster's recent mass growth history. We find that the total mass loss is a clear function of time spent in a host. However, two factors can considerably increase the mass loss rate. First, if the satellite mass is approaching the mass of its host. Second, when the halo suffers tidal mass loss at a higher redshift. The preprocessing provides an opportunity for halos to experience tidal mass loss for a more extended period of time than would be possible if they simply fell directly into the cluster, and at earlier epochs when hosts were more destructive to their satellites.

• Steel and Composite Structures
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• 제25권5호
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• pp.617-624
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• 2017

In this study, a new empirical method is presented to obtain Dynamic Increase Factor (DIF) in nonlinear static analysis of structures against sudden removal of a gravity load-bearing element. In this method, DIF is defined as a function of minimum ratio of difference between maximum moment capacity ($M_u$) and moment demand ($M_d$) to plastic moment capacity ($M_p$) under unamplified gravity loads of elements. This function determines the residual strength of a damaged building before amplified gravity loads. For each column removal location, a nonlinear dynamic analysis and a step-by-step nonlinear static analysis are carried out and the modified empirical DIF formulas are derived, which correspond to the ratio min $[(M_u-M_d)/M_p]$ of beams in the bays immediately adjacent to the removed column, and at all floors above it. Therefore, the new DIF can be used with nonlinear static analysis instead of nonlinear dynamic analysis to assess the progressive collapse potential of a moment frame structure. The proposed DIF formulas can estimate the real residual strength of a structure based on critical member.

• 생명과학회지
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• 제11권5호
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• pp.415-422
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• 2001

Many secreted proteins have disulfide bonds that are important for their structure and function. Protein disulfide isomerase (PDI, EC 5.3.1.4.), an enzyme that catalyzes the formation and rearrangement of thiol/disulfide exchange reactions, is a resident of the endoplasmic reticulum (ER). The subcellular localization and its function as catalyst of disulfide bond formation in the biosynthesis of secretory and cell membrane proteins suggest that PDI plays a key role in the secretory pathway. We have isolated a cDNA encoding protein disulfide isomerase from Bombyx mori(bPDI). It has been characterized under ER stress conditions (dominantly induced by calcium ionophore A23187, tunicamycin and DTT), which is known to cause an accumulation of unfolded proteins in the ER. Furthermore, It has also been examined for tissue distribution(pronounced at the fat body), hormonal regulation (juvenile hormone, insulin and juvenile +transferrin; however, it is not effected by transferrin alone), and the effect of exogenous bacteria (peak at 16 h after infection) on the bPDI mRNA expression. The results suggest that bPDI is a member of the ER stress protein group, and it may play an important role in exogenous bacterial infection in fat body, and that homones regulate its expression.