• Plant Biotechnology Reports
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• v.3 no.2
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• pp.157-165
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• 2009

Human erythropoietin (EPO) is a leading product in the biopharmaceutical market, but functional EPO has only been produced in mammalian cells, which limits its application and drives up the production costs. Using plants to produce human proteins may be an alternative way to reduce the cost. However, a recent report demonstrated that overexpression of the human EPO gene (EPO) in tobacco or Arabidopsis rendered males sterile and retarded vegetative growth, which raises concern whether EPO might interfere with hormone levels in transgenic plants. In the present study, we demonstrated that overexpressing EPO with additional 5'-His tag and 3' ER-retention peptides in tobacco did not cause any developmental defect compared to GUS plants. With our method, all 20 transgenic plants grew on selective medium and, further confirmed by PCR, were fertile. Most of them grew similarly compared to GUS plants. Only one transgenic plant (EPO2) was shorter in plant height but had twice the life span compared to other transgenic plants. When 11 randomly selected EPO plants, along with the abnormal plant EPO2, were subjected to RT-PCR analysis, all of them had detectable EPO transcripts. However, their protein levels varied considerably; seven of them had detectable EPO proteins analyzed by western blot. Our results indicate that overexpressing human EPO protein in plants does not have detrimental effects on growth and development. Our transformation systems allow us to further explore the possibility of glycoengineering tobacco plants for producing functional EPO and its derivatives.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.29-38
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• 2015

In this paper, scale efficiencies and relative efficiencies of R&D projects in Industrial Technology Program, sponsored by Ministry of Trade, Industry and Energy, Korea, are calculated and compared. For the process, various DEA (Data Envelopment Analysis) models are adopted as major techniques. For DEA, two stage input oriented models are utilized for calculating the efficiencies. Next, the calculated efficiencies are grouped according to their subprograms (Industrial Material, IT Fusion, Nano Fusion, Energy Resources, and Resources Technology) and recipient types (Public Enterprise, Large Enterprise, Medium Enterprise, Small Enterprise, Lab., Univ., and etc.) respectively. Then various subprograms and recipient types are compared in terms of scale efficiencies (CCR models) and relative efficiencies (BCC models). In addition, the correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies is calculated, from which the causal relationship between them can be inferred. Statistical analysis shows that the amount of input, in general, should increase in order to be scale efficient (CCR models) regardless of the subprograms and recipient types, that the 1st and 2nd stage relative efficiencies are different in terms of the programs and recipient types (BCC models), and that there is no significant correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies. However, the results should be used only as reference because the goal each and every subprogram has is different and the situation each and every recipient type faces is different. In addition, the causal link between the 1st stage relative efficiencies and the 2nd relative efficiencies is not considered, which, in turn, is the limitation of this paper.

• Journal of Digital Convergence
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• v.15 no.7
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• pp.159-167
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• 2017

According to the statistics of the National Industrial Security Center under the National Intelligence Service, 209 national technologies have been leaked abroad in the past 5 years. Small and medium-sized enterprises and leakage by insiders accounted for 73% and 80% of them, respectively. This suggests that all the capabilities for preventing leakage of industrial technology should be focused on small and medium-sized enterprises and leakage by insiders. Related studies have been actively conducted on legal consideration of industrial technology leakage crimes, improvement of industrial security policies, and industrial security measures for preventing leakage of industrial technology, but adequate empirical studies have not been carried out on factors of leakage of industrial technology. In particular, there have been few studies on the effect of the experience of industrial technology leakage and enterprise scale(large enterprise, small and medium-sized enterprise) on achieving results in leakage prevention. Therefore, this study extracted factors affecting performance to prevent industrial technology leakage by analyzing previous related papers and to empirically analyze relationships with performance by applying the TAM model after classifying variables into the TOE framework by characterizing these properties.

• KIPS Transactions on Computer and Communication Systems
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• v.11 no.6
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• pp.193-204
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• 2022

In a smart factory environment in a small and medium-sized enterprise (SME) environment, sensors and actuators operating on actual manufacturing lines, programmable logic controllers (PLCs) to manage them, human-machine interface (HMI) to control and manage such PLCs, and consists of operational technology server to manage PLCs and HMI again. PLC and HMI, which are in charge of control automation, perform direct connection with OT servers, application systems for factory operation, robots for on-site automation, and production facilities, so the development of security technology in a smart factory environment is demanded. However, smart factories in the SME environment are often composed of systems that used to operate in closed environments in the past, so there exist a vulnerable part to security in the current environment where they operate in conjunction with the outside through the Internet. In order to achieve the internalization of smart factory security in this SME environment, it is necessary to establish a process according to the IEC 62443-4-1 Secure Product Development Life cycle at the stage of smart factory SW and HW development. In addition, it is necessary to introduce a suitable development methodology that considers IEC 62443-4-2 Component security requirements and IEC 62443-3 System security requirements. Therefore, this paper proposes an application plan for the IEC 62443 based development security process to provide security internalization to smart factories in an SME environment.

• Journal of Digital Contents Society
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• v.8 no.2
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• pp.213-225
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• 2007

This study confirms Busan area medium and small enterprises' position and analyzed present condition and actual conditions of swing Korea measure and consumer's attitude about measure in general circumstance that our country medium and small enterprises is placed in information. According to result that analyze Busan area medium and small enterprises' information level, Busan was expose by whole country average low including the electron commercial transaction rate. When consider weight that Busan economy occupies in gross domestic product, information differential of medium and small enterprises of Busan area is subject that must improve urgently and seriousness point is true that information differential of manufacturing industry is main factor more. Therefore, urgent agenda should be the activation of manufacturing industry information assistance measure and extension of current manufacturing technique information assistance business for Busan economy. Also, at problem solution progress, Busan is thought that must come looking for seat role actively.

• Fashion & Textile Research Journal
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• v.20 no.1
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• pp.22-33
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• 2018

The aim of the research study is to carve sustainable business strategies for the fashion communities in Ethiopia and Ukraine which are suffering today due to ever-increasing share of fast fashion consumerism. Fashion houses and international brands propagandize sustainability and consumption for better consumer base, where as originally sustainable local-based craftsmen still stay in the shade. Four communities/local designers are selected from the countries through the method of purposive sampling. Qualitative analysis is the basis of the research as we performed personal interviews and in-depth analysis of the communities to diagnose the problems and subsequently devise the solutions. In this research, we have studied and analyzed the problems faced by hereditary communities and ethnic designers in small and medium scale enterprise sector from two emerging economies. After the grounding the difficulties faced we advised strategies for sustainable future growth to the companies. The current academic literature on small and medium scale enterprises highlights the problems and solutions for general industry sectors. This paper brings attention to fashion communities and designers who promote national heritage and are struggling to survive in emerging economies due to industrialization and globalization. Moreover the comparison of the two geographies is unique in nature.

• Journal of the Korean Society of Food Culture
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• v.32 no.1
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• pp.39-51
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• 2017

The purpose of this study was to analyze the current status relating to food packaging and design for status of small and medium food enterprises. A company survey was conducted from June to October, 2015 and targeted 1300 small and medium domestic food enterprises. Finally, a total of 1300 (recovery rate 100%) useable data were selected. Statistical analyses were performed on the data utilizing the SPSS PASW Statistics 18.0 for Windows, such as descriptive statistics and frequency analysis. According to the results, awareness and importance of food labeling were high, but performance of English inscription of product name was relatively low. The most important reason for food labeling was 'providing correct information on food' 910 (72.8%). Accordingly, a system which can provide the latest information by continuously monitoring mandatory disclosure requirements for types of foods in individual countries is needed.

• Journal of Information Management
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• v.24 no.1
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• pp.21-31
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• 1993

This paper deals with in-house and external information sources available for small and medium enterprises of which information needs become specialized, diversified integrated and massive under circumstance of computer and telecommunication technology. It also presents not only the ways and means of collecting analysing, utilizing various information being aquired from internal and external sources but also adequate condition and application of information, and information system for small and medium enterprises in which resources are relatively short.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.5
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• pp.353-361
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• 2016

Recently, the small shipyard companies have difficulties that causes by depression of shipbuilding industry. The small shipyard companies need some strategies to overcome the slump in shipbuilding industry field. In this paper, we conduct the survey for present condition diagnosis of small shipyard companies, and analyze the production process based on Information Strategy Planning(ISP) method. When analyze based on ISP, we apply IDEF0 and LOVC technique to analyze the production process of small shipyard companies. Also we conduct the gap analysis between the analyzed present condition and the requirements of improvement. Therefore, the most important result of the analysis is to establish a system for enterprise planning and management, which customized for small shipyard companies, with satisfying economic feasibility and usability.

• Journal of the Korea Safety Management & Science
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• v.19 no.1
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• pp.123-129
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• 2017

This study aims to analyze the performance of the beneficiaries of the SMEs(Small and Medium Enterprises) support project that has been handled online on the 'BizOK System', which is the integrated support system for SMEs in Incheon, by comparing before and after receiving support. Various performance indicators can be used, but this study used the rate of increase in sales, exports and employed manpower collected by the 'BizOK System'. Moreover, to analyze the trend of business performance by corporate feature, this study grouped the businesses into 7 categories including sales, business history, number of employees and capital. The results of this study are expected to be used in drawing implications for business support policies by utilizing them as basic data for enhancing efficiency of the support project and establishing corporate policies.