• Macromolecular Research
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• 제16권8호
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• pp.682-685
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• 2008

The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at $4^{\circ}C$ and at $37^{\circ}C$ were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.

• 동의생리병리학회지
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• 제22권6호
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• pp.1611-1620
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• 2008

This clinical research was conducted to test patients with Atopic Dermatitis by external application with Hwangryeonhaedok-Tang in cosmetics. We gave scores to 31 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung University Jecheon Oriental Medical Hospital from May 15th, 2008 to June 26th. Fifteen patients were treated with the ointment that contain Hwangryeonhaedok-Tang (experimental group) and sixteen patients were treated with normal ointment that doesn't have Hwangryeonhaedok-Tang (control group) for 4 weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinical Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Hwangryeonhaedok-Tang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). After 4 weeks of external application treatment, SCORAD Index in experimental group was significant statistically decreased compared with control group. After 4 weeks of external application treatment, total IgE of both groups were decreased and eosinophil count in control group was decreased but experimental group was unstatistically decreased. Unstatistically, both groups didn't showed significant effect on Skin Temperature. Transepidermal Water Loss(TEWL) in both groups were increased but experimental group was significant decreased compared with control group. Skin Hydration in experimental group was significant statistically increased compared with control group. Statistically, both groups didn't showed significant effect on Skin pH. Only experimental group showed little increase. After 4 weeks of external application treatment, experimental group showed significant effect on global assesment of efficacy. Considering the above results, we can speculate that cosmetics with Hwangryeonhaedok-Tang has some therapeutical effects in mitigating the symptoms of Atopic Dermatitis.

• 한방안이비인후피부과학회지
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• 제37권2호
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• pp.37-57
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• 2024

Objectives : The purpose of this study is to evaluate the efficacy and safety of hair Ampoules with Malva Verticillata Seed Extract in alopecia patients. Methods : This 24-week clinical study enrolled 70 patients with Alopecia. A series of clinical examinations, subjects were evaluated at 0, 8, 16 and 24-week, counting of the number of hairs on the crown, and subject survey after using the Ampoules. Results : The clinical evaluation showed a significantly difference (p<0.05) after 24 weeks of product use compared to the baseline in the change in hair count in the treatment group compared to the control group within and between groups. It showed greater improvement in the treatment group than in the control group in hair count, hair thickness, and hair loss symptoms in the top of the head and forehead. No severe adverse events were observed during the clinical trial. Counclusions : This suggests that this hair ampoules containing Malva Verticillata Seed Extract could help prevent hair loss in alopecia patients without inducing side effects.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.153-158
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• 2004

Background and Objective: Erythema multiforme(EM) is related disorders of skin and mucous membranes which is typically associated with antecedent medications or infections. etc. EM is an erythematous maculopapular cutaneous eruption of variable form. However, the pathophysiology of the EM remains obscure. Treatment at present is symptomatic and supportive. There is no report on EM treated with oriental medical treatment. Methods: We conducted one patient with EM seen at Won-Kwang University Kwang-Ju Oriental Medical Hospital in 2004. We treated EM in a twenty-two years old man by a herbal medicine(Joa-Chang-Bang), a herbal medicine for external use, acupunture, moxa, COTDE-made cosmetics, and P-Tx(carbon). Conclusions. We had a significant results. So we report this case to estimate the efficiency of oriental medical treatment and management on EM.

• 생명과학회지
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• 제17권8호통권88호
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• pp.1147-1151
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• 2007

본 연구에서는 ７가지 한방원료(음양곽, 복분자, 오미자, 구기자 , 건지황 l 사상자 , 토사자)의 항산화 효과, collagen 합성 촉진 효과, collagenase 활성 저해 효과를 비교 평가함으로써 주름개선 기능성 화장품 원료로서의 사용 가능성을 검토하였다. 항산화 실험인 DPPH 소거 효과, 리놀산 자동산화 억제 효과, superoxide radical 소거 효과, hydroxyl radical 소거 효과에서는 음양곽, 복분자, 오미자, 구기자가 대체적으로 뛰어난 활성을 보여 항노화 화장품 소재로서의 가능성을 보여주었으며, 주름개선 실험인 collagen 합성 촉진 효과, collagenase 저해 효과에서는 건지황, 사상자, 토사자가 다른 네 가지 물질에 비해 뛰어난 효과를 나타내어 주름개선 화장품 소재로서의 가능성을 보여주었다. 이러한 결과는 7가지 한방원료가 항산화 및 주름개선 효능을 나타내므로 기능성 화장품 소재로 활용될 수 있음을 보여 주었다.

• 한국정보시스템학회지:정보시스템연구
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• 제19권1호
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• pp.35-61
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• 2010

The Internet marketing of hospital is being considered as a strategic requirement that can satisfy the customers. Therefore, it is very important to understand the effects of the medical information on the Internet on the actual consumers. In this study, the paths through which the attitude and satisfaction of the medical information consumers that visit hospital web site are formed for the medical information through the quality of the medical information on the Internet and usability of hospital web site were examined respectively according to the medical examination and treatment subjects that respectively deal with medical acts and cosmetic acts through light metabolism recovery. The usability of hospital web site, rather than medical information quality, had positive effects on the attitudes toward the medical information distributed in the corresponding web site and the satisfaction of use of hospital web site in the case of visitors of the hospital web site for the medical examination and treatment subjects of essential medical examination and treatment and emergency medical treatment, and, on the other hand, the result of analyzing the path of the medical examination and treatment subjects of cosmetics and functional improvement revealed that the medical information quality had positive effects on the medical information attitudes and the usage satisfaction of hospital web site. Accordingly, the attitudes toward the medical information distributed through the web site by the visitors of hospital web site is formed from the quality of medical information and web site usability, and, ultimately, they become generally satisfied with the hospital web site. Such process is revealed different1y according to the medical examination and treatment subjects for which consumers desire to obtain information.

• 한국융합학회논문지
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• 제8권11호
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• pp.439-445
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• 2017

본 연구는 최근 화장품 유해성분에 관한 이슈를 끊임없이 제기되면서 네일 제품에서 발생할 수 있는 유해물질 인체 노출 저감을 위한 안전관리 방안 마련을 목적으로 국내외 문헌고찰을 통해 네일 제품의 안전 표시 기준 현황을 비교 분석하고, 네일 제품 내 유해물질 허용 기준치 초과 사례를 파악하였다. 연구 결과 국내 유통된 인조 손톱 접착제와 네일팁에서 각각 톨루엔 40.3배, 클로로포름 22.8배, 안티몬 15.4배 초과 검출되었다. 선진국은 다양한 정책연구 및 법제화를 통해 작업장 물질안전보건자료 제공 및 환기 장치 설치 등을 의무화하고 있으나 국내에서는 별도의 안전 기준이 없어 네일 제품을 통한 유해물질 인체 노출이 심각한 상황이다. 따라서 네일 제품 작업환경 종사자 소비자 각각의 특성에 맞게 세부 네일 유해물질 안전관리 규정이 우선적으로 정립되어야 하고, 이에 따른 다양한 교육 프로그램 개발 및 보급을 통해 유해물질 화장품에 대한 인지도를 제고한다면 국민의 질병예방 및 건강증진의 융복합적 차원에 기여할 수 있을 것이다.

• 대한화장품학회지
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• 제45권3호
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• pp.277-285
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• 2019

본 연구는 바코드나 큐알코드를 활용하는 데이터베이스를 개발하여 화장품 제조에 필요한 원료를 효과적으로 칭량하고 벌크 제조를 관리하는 시스템을 구축하기 위하여 수행하였다. 원료 라벨과 벌크 제조를 위한 칭량 라벨은 데이터베이스에 입력된 정보를 활용하여 Medi&Co의 프린트 컴포넌트인 ScriptX를 이용하여 웹 상에서 발행하였다. 칭량과 투입 과정을 스캐너와 태블릿, PC 등을 이용하여 확인하여 화장품 벌크 생산시 가장 많은 오류 원인인 오칭량이나 오투입에 의한 제품 이상 발생을 감소시킬 수 있었다. 결론적으로 바코드와 큐알코드를 활용하는 데이터베이스를 화장품 제조에 적용하면 공정 중에서 발생하는 여러 가지 문제점을 감소시켜 화장품의 품질관리와 생산성 효율을 증대시킬 수 있다.

• 대한예방한의학회지
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• 제23권1호
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• pp.15-26
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• 2019

Background and Aim : Health care and cosmetics as well as quality of life is now a matter of concern and many categories of complementary and alternative medicine fall into the territory of the medical practice of Korean medicine. Accordingly, penalties are being taken for unlicensed medical practices of Korean medicine in so called complementary and alternative medicine area. There is a possibility of violating the law for the public part because it is not clearly stipulated in the law as to what is a licensed medical practice. Materials and Method : The significance of the Medical Service Act and the Act on Special Measures for the Control of Public Health Crimes were reviewed, and the related supreme court cases were discussed upon the legal aspect of processing the unlicensed medical practice of Korean medicine. The legal information was provided from the National Law Information Center of the Ministry of Government Legislation, and the information websites of the Supreme Court and the Constitutional Court. Results : The concept of medical practice, which is essential in judging the case of unlicensed medical practice, is 'prevention and treatment of diseases through diagnosis, examination, prescribing, medication, or surgical procedures based on medical expertise', and the 'acts that may result in harm and injury of health unless performed by a medical person'. With respect to the medical practice of Korean medicine, the concept includes 'prevention and treatment of diseases using the principle of traditional Korean Medicine'. Conclusions : The concept of medical practice should be clearly stipulated in the law for the control over the unlicensed medical practices of Korean medicine. And it is important to move from the current concept of medical person-oriented medical practice emerging from the national system of healthcare control, to a concept that can accept the era of health managing-oriented medical environment and the co-governance of the healthcare providers and consumers for the future.

• 대한화장품학회지
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• 제30권2호
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• pp.227-233
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• 2004

자외선이 피부에 지속적으로 조사되면 썬번, 염증, 광노화와 같은 다양한 부작용이 생기게 된다. 따라서 광손상에 대한 보호작용은 점점 중요성이 인식되고 있으며, 천연 식물추출물에서 자외선에 대한 광보호효과가 있는 안전하고 효과적인 물질개발에 대한 연구가 진행되고 있다. 본 연구는 자외선에 의해 유도된 피부손상에 대한 보호효과가 우수한 천연식물추출물에 대한 것이다. 향나무, 능소화, 비자추출물에서 자외선에 의해 생성되는 라디칼에 대한 항산화효과, MMP 발현 및 활성 저해, 염증관련 사이토카인인 인터루킨 1알파, 6, 프로스타글란딘 E$_2$ 생성저해효과 등으로 피부세포보호 효과를 연구하였다. 실험결과 천연추출물 중 향나무추출물과 능소화추출물이 프리라디칼 및 슈퍼옥사이드 라디칼 소거효과가 우수하게 나타났으며 피부 콜라겐과 같은 메트릭스를 분해하는 효소인 MMP-1의 활성 및 발현 저해효과는 섬유아세포에서 UVA 조사에 의한 실험에서 우수하게 나타났으며, 피부세포 배양액에 대해 zymography를 실시하여 활성이 감소됨을 확인하였다. 피부 각질형성세포에서 자외선에 의해 유도된 염증관련 사이토카인인 인터루킨 6의 발현량 실험에서도 무처리군에 비해 향나무추출물이 인터루킨 6을 30% 정도 저해효과가 나타났으며, 염증반응 중 cyclooxygenase(COX)에 의한 경로에서 생성되는 프로스타글란딘 E$_2$의 생성량도 감소시켰다. 사람피부에서 SLS (0.5%) 첩포로 유발된 자극성 피부염의 항염증 효과 평가 시 SLS에 의해 유발되는 자극정도가 피검자의 피부상태에 따라 다양하게 나타났으며, 향나무 추출물 함유 에멀젼 제품 도포 실험에서는 피부 홍반 완화 효과와 피부장벽 회복효과가 우수하게 나타났다. 이상의 결과로 향나무추출물은 자외선 조사 및 SLS에 의한 피부손상에 대한 피부세포보호작용이 우수하여 광노화에 대응하는 자극완화 소재로서의 화장품 응용 가능성을 확인하였다.