Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Evaluation of Anti-wrinkle Effects in Oriental Herb Extract

한방 원료 추출물의 주름개선 효과를 통한 화장품 원료로서의 가치 평가

  • Kang, Kum-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Kim, In-Deok (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Kwon, Ryun-Hee (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Heo, Ye-Young (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Oh, Sang-Hoon (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Kim, Min-Ah (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Jung, Hye-Jin (Amaranth Cosmetics) ;
  • Kang, Hwan-Yul (Amaranth Cosmetics) ;
  • Ha, Bae-Jin (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
  • 강금석 (신라대학교 의생명과학대학 제약공학과) ;
  • 김인덕 (신라대학교 의생명과학대학 제약공학과) ;
  • 권륜희 (신라대학교 의생명과학대학 제약공학과) ;
  • 허예영 (신라대학교 의생명과학대학 제약공학과) ;
  • 오상훈 (신라대학교 의생명과학대학 제약공학과) ;
  • 김민아 (신라대학교 의생명과학대학 제약공학과) ;
  • 정혜진 (아마란스 화장품) ;
  • 강환열 (아마란스 화장품) ;
  • 하배진 (신라대학교 의생명과학대학 제약공학과)
  • Published : 2007.08.30
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Abstract

The human skin is constantly exposed to environmental irritants such as ultraviolet, smoke and chemicals. Free radicals and reactive oxygen species caused by them play critical roles in cellular damage. They not only injure the skin structure but also participate in the immensely complex inflammatory reaction. Anti-wrinkle effects of the Oriental herb extracts(OHE) were evaluated by the determination of anti-oxidation, collagenase inhibition and collagen synthesis in normal human fibroblast. OHE showed antioxidative activity as high as vitamin C, trolox and DL-penicillamine. Also OHE showed promotive effect on collagen synthesis and inhibitory effect on collagenase activity. These results demonstrated that OHE could be useful as an anti-wrinkle cosmetic ingredient.

본 연구에서는 ７가지 한방원료(음양곽, 복분자, 오미자, 구기자 , 건지황 l 사상자 , 토사자)의 항산화 효과, collagen 합성 촉진 효과, collagenase 활성 저해 효과를 비교 평가함으로써 주름개선 기능성 화장품 원료로서의 사용 가능성을 검토하였다. 항산화 실험인 DPPH 소거 효과, 리놀산 자동산화 억제 효과, superoxide radical 소거 효과, hydroxyl radical 소거 효과에서는 음양곽, 복분자, 오미자, 구기자가 대체적으로 뛰어난 활성을 보여 항노화 화장품 소재로서의 가능성을 보여주었으며, 주름개선 실험인 collagen 합성 촉진 효과, collagenase 저해 효과에서는 건지황, 사상자, 토사자가 다른 네 가지 물질에 비해 뛰어난 효과를 나타내어 주름개선 화장품 소재로서의 가능성을 보여주었다. 이러한 결과는 7가지 한방원료가 항산화 및 주름개선 효능을 나타내므로 기능성 화장품 소재로 활용될 수 있음을 보여 주었다.

Keywords

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