• 간호행정학회지
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• 제3권1호
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• pp.37-50
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• 1997

The purpose of this study was to identify the gap between need-level and demonstration-level in nursing managerial competencies. In addition, the study proposes solutions to narrow this gap. The results of this study are as follows : 1) The mean score for need-level of each item was 4.0, and for demonstration-level, 3.5. This indicates that military hospital head nurses demonstrate a higher level of managerial competencies than the moderate level on all items. But items which were related to resource/ cost/ information managament, staff development management and professionalism management got relatively low ratings in the need-level. 2) The mean score for need-level of each category was 4.14, and for demonstration-level, 3.53. Categories on the individual dimension got a higher rating than categories on the group or organization dimension in both need-level and demonstration level. 3) The gap between need-level and demonstration-level appeared in all items(p<.05) and categories(p<.001). Although the gap was relatively low, it indicates that it is essential to plan a developmemt program for all nursing management competencies for military hospital head nurses. 4) There were significant differences in the gap between need-level and demonstration-level according to specific characteristics of the subjects. The gap did not appear in many categories on the individual dimension where the number of nursing staff was more than 10, a major grade, ICU head nurse or for head nurses having a long career. 5) Need-level and demonstration-level showed a difference according to specific characteristics of the subjects, because need-level and demonstration-level were higher where the number of nursing staff was more than 10, a major grade, and for ICU or Medical ward head nurses. The categories which showed need-level difference and demonstration-level differences according to specific characteristics of the subjects existed almostly completely in the group and organization dimension. Gap-level differences according to the number of hospital bed existed in only two categories. 6) The general causes of the gap were indicated to be 'Knowledge/ skill/ experience deficit', 'Limitation of rules and systems/ Inappropriate organizational environment' for most items, categories, and dimensions. The results of this study indicate that extensive competency developing strategies must be developed, because a gap was found in all items and categories. Specially, there is a need to concentrate attention on competencies in the group and organizational dimension which had a wider gap level. And it is important to take an individual approach according to the cause for each gap. In order to produce effective competency developing strategies, top managers must have sinsights into the importance of nursing staff development and nursing officer's efforts to develop themselves must be achieved. Further multi-dimensional(education, personnel-policy, nursing/ organizational environment) solutions to the gap must be developed and utilized.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.419-422
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• 2013

Conventional classifications of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are rather unsatisfactory because of the variation in survival within each subgroup. Molecular markers are being found able to predict patient outcome in more and more tumours. The aim of this study was to characterize the expression of the proteins cyclin D1, cyclin E and P53 in GEP-NETs and assess any prognostic impact. Tumor specimens from 68 patients with a complete follow-up were studied immunohistochemically for cyclin D1, cyclin E and P53 expression. High cyclin D1 and cyclin E immunostaining (${\geq}$ 5% positive nuclei) was found in 48 (71%) and 24 (35%) cases, and high P53 staining (${\geq}$ 10% positive nuclei) in 33 (49%). High expression of P53 was more common in gastric neuroendocrine tumors and related to malignant behavior, being associate with a worse prognosis on univariate analysis (RR=1.9, 95%CI=1.1-3.2). High expression of cyclin E was significantly associated with shorter survival in the univariate analysis (RR=2.0, 95%CI=1.2-3.6) and multivariate analysis (RR=2.1, 95%CI=1.1-4.0). We found no significant correlation between the expression of cyclin D1 and any clinicopathological variables. Our study indicated a prognostic relevance for cyclin E and P53 immunoreactivity. Cyclin E may be an independent prognostic factor from the 2010 WHO Classification which should be evaluated in further studies.

• Journal of Gastric Cancer
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• 제8권2호
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• pp.104-109
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• 2008

목적: 국내 위 점막하 종양의 임상병리학적 양상과 치료방법에 대해 파악하고자 전국조사를 실시하였다. 대상 및 방법: 국내 47개 병원에서 2005년부터 2006년까지 위 점막하 종양으로 수술 받은 환자 878명의 자료를 수집하여, 진단명, 증상, 위치, 수술법, 사망률, 종양의 크기, 악성도 등을 조사하였다. 결과: 위 점막하 종양의 수술 후 진단으로는 위장관 간질 종양(Gastrointestinal stromal tumor, GIST)이 586명(66.8%)으로 가장 많았고, 평활근종(Leiomyoma) 97명(11.1%), 신경초종(schwannoma) 70명(8.0%), 이소성 췌장(Ectopic pancreas) 68명(7.8%), 유암종(carcinoid) 16명(1.8%) 순이었다. 환자의 평균 나이는 56.0세, 남녀 비는 1:1.18이었으며, 50.9%의 환자가 증상 없이 발견되었다. 위 상부 1/3에 위치한 위 점막하 종양이 가장 흔했으며(n=449, 52.0%), GIST의 55.4% (n=319), 평활근종의 84.5% (n=82)가 위 상부 1/3에 위치하였다. 복강경적 접근이 전체 환자의 44.2% (n=388)에서 시행되었으며, 수술방법으로는 쐐기 절제술(n=726, 82.8%)이 가장 빈번히 시행되었다. 전체 환자 중 1명(0.1%)만이 수술 후 30일 이내에 사망하였다. GIST 환자 중 115명(21.1%, 115/544)이 고위험도의 악성도를 가졌고, 41명(8.3%, 45/495)에서 수술 후 imatinib mesylate 항암 치료를 하였다. 결론: 조사된 국내 점막하 종양의 약 2/3가 GIST였으며, 약 1/2에서 복강경하 절제술이 이루어졌다. 향후 이 보고가 위점막하 종양의 진료 및 연구의 참고자료로 활용되기를 기대한다.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.372-378
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• 2020

4차 산업에서 가장 높은 성장세를 보이는 드론은 그 분야가 확장됨에 따라 활용도 역시 높아지면서 재난대응분야에서도 활용되고 있다. 실제 재난이 발생하면 지자체에서는 재난대응을 위해 13가지 협업기능을 수행하며 재난의 피해를 최소화하고 있다. 그러나 사람이 접근하기 어려운 지역이나 상황파악이 어려운 곳에서는 현장정보 수집 및 대응지원 등 여러 어려움을 겪고 있다. 이에 재난분야에서 그 활용도가 증가하고 있는 드론 영상을 바탕으로 각 시도별 재난안전대책본부의 13개 협업기능에 활용 가능한 방안을 도출하여 지자체의 재난관리 및 대응 기능을 제고하고자 하였다. 해외에서 활용되는 드론의 활용방안을 문헌연구를 통해 우선적으로 확인하고 산림청, 문화재청, 관세청, 경찰청, 해양경찰청, 해양수산부, 소방청, 국립재난안전연구원, 환경부 등 국내의 11개 부처에서 현재 사용되고 있는 드론 활용분야를 분석함으로써 재난안전대책본부의 13개 협업기능 중 총 10개(재난상황관리, 긴급생활안정지원, 응급복구, 재난자원지원, 교통대책, 의료 및 방역 서비스, 재난현장 환경정비, 사회질서유지, 수색·구조·구급)의 협업기능 활용방안을 도출하였다. 본 연구는 재난안전대책본부의 13개 협업기능별 드론 영상 활용방안을 제시함으로써 재난대응의 효율성을 제고하고자 하였다.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.201-209
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• 2020

본 연구에서는 최근 수가계약 과정에서 논란이 되고 있는 기준연도 변경과 관련된 이슈를 살펴보았다. 이와 관련하여 기준연도 변경이 유형별 환산지수에 미치는 영향과 관련해 민감도분석을 실시하였다. 그리고 기준연도변경이 특정유형에 미치는 유리하거나 불리한 상황을 분석하였다. 또한 단일 환산지수 체계라고 가정하는 경우 기준연도 변경에 따른 환산지수 변동도 고찰하였다. 본 연구의 주요한 결론은 다음과 같다. 첫째, 기준연도를 현재시점에 가깝게 변경하는 경우 병원의 환산지수에는 유리한 효과가 발생한다. 둘째, 기준연도를 현재 시점에 가깝게 변경하는 경우 약국과 의원의 환산지수에는 불리한 효과가 발생하며 의원의 경우 불리한 효과가 크다. 셋째, 유형 전체에 단일 환산지수를 일괄적으로 적용한다고 가정하면 기준연도를 현재 시점에 가깝게 변경하는 경우 모든 유형에 유리한 효과가 발생한다. 기준연도 변동은 보험자와 의료공급자, 의료공급자 사이에 이해충돌을 가지고 올 수 있다. 따라서 자원 배분의 합리적인 근거를 바탕으로 상호 합의에 추진되어야 하며 손실이 초래되는 유형에 대해서는 한시적 보상을 위한 인센티브를 제시할 필요가 있다.

• 한국식품저장유통학회지
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• 제19권5호
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• pp.744-750
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• 2012

안전한 천연물을 이용한 천연항산화제 개발 연구에 대한 관심이 고조되는 가운데, 지유, 진피, 천련자, 천문동, 청피, 편축, 하고초 7종의 천연 약용식물 추출물을 통해 항산화 활성을 측정하였다. 추출물의 총 페놀 함량은 지유가 열수추출물과 40% ethanol 추출물에서 각각 31.5 mg/g, 32.7 mg/g으로 가장 높게 나타났다. 추출물의 수용성 물질에 대한 항산화 효과는 DPPH radical 소거능이 지유, 진피, 천련자, 천문동, 청피, 편축, 하고초 7종의 천연 약용식물의 열수 추출물과 ethanol 추출물에서 80% 이상의 높은 소거활성을 나타내었다. ABTS radical cation decolorization을 측정한 결과, 7종의 천연 약용식물의 열수 추출물과 ethanol 추출물에서 85% 이상의 높은 저해율을 나타내어 매우 우수한 항산화 효과를 가지고 있음을 입증하였다. 지용성 물질에 대한 항산화 효과를 측정하기 위해 Antioxidant Protection Factor(PF)를 측정한 결과, 천련자 열수 추출물에서 1.65 PF로 대조구인 vitamin C 보다 높은 수준을 나타내어 지용성 물질에 대한 항산화 활성이 높음을 확인하였다. TBARs 생성 저해율을 측정한 결과 지유, 천련자, 청피, 편축, 하고초의 열수 추출물과 ethanol 추출물에서 99%에 가까운 높은 저해율을 나타내어 대조구인 vitamin C보다 지용성 물질에 대한 항산화 활성이 매우 높은 것으로 확인되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제19권5호
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• pp.389-399
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• 2015

Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc ($Zn^{2+}$) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc's critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of $Zn^{2+}$ activity has been presumed to parallel the degree of calcium's participation in cellular processes. Whole body and cellular $Zn^{2+}$ levels are largely regulated by metallothioneins (MTs), $Zn^{2+}$ importers (ZIPs), and $Zn^{2+}$ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion channels that play a pivotal role in controlling cardiac contractility are common targets of $Zn^{2+}$. However, these regulatory actions of $Zn^{2+}$ are not limited to the function of the heart, but also extend to numerous other organ systems, such as the central nervous system, immune system, cardiovascular tissue, and secretory glands, such as the pancreas, prostate, and mammary glands. In this review, the regulation of cellular $Zn^{2+}$ levels, $Zn^{2+}$-mediated signal transduction, impacts of $Zn^{2+}$ on ion channels and mitochondrial metabolism, and finally, the implications of $Zn^{2+}$ in health and disease development were outlined to help widen the current understanding of the versatile and complex roles of $Zn^{2+}$.

• 디지털융복합연구
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• 제18권3호
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• pp.259-266
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• 2020

본 논문은 병원행정직원의 조직시민행동과 관련된 융복합적인 요인을 찾아보고자 시도되었다. 설문조사는 무기명 자기기입식 설문지를 사용하여 임의로 선정된 J지역 22개 병원의 행정직원 274명에 대하여 시행되었다. 설문조사 기간은 2019년 7월 1일부터 7월 31일까지 약 한 달간 소요되었다. 위계적 다중회귀분석 결과, 조직공정성의 하위영역인 절차공정성이 높을수록, 집단내신뢰가 높을수록, 조직헌신도가 높을수록 조직시민행동이 높았으며, 이들의 설명력은 41.9%이었다. 이러한 분석결과를 볼 때, 병원행정직원의 조직시민행동을 높이기 위해서는 조직공정성의 하위영역인 절차공정성 및 분배공정성을 높이고, 집단내신뢰를 높이고, 조직헌신도를 높이는 노력이 필요하다. 이상의 결과는 병원행정직원의 조직시민행동을 높이는 의료기관의 인적자원관리 및 산업보건교육에 활용이 기대된다. 추후연구에서는 병원행정직원의 조직시민행동에 영향을 미치는 구조방정식 모형의 수립이 필요하다.

• 한국지역사회생활과학회지
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• 제16권1호
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• pp.149-163
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• 2005

Family has emerged as a key concept for health, and it has been identified as one of the most important conditions. The relationship between health habit and its management is different depending on family. The odd pair family, mostly rural lower income class, worry to have poor health because of no spouse and small family size. One thousand eight hundred and seventy(1870) subjects were collected in 9 provinces through the sampling of Probability Proportional to Size (PPS). Questionnaire method was conducted on health checking, bath states, alcohol consumption, cigarette smoking, and the prevalence of farmer's health related problems. The main results were as follows: 1) The characteristics of odd pair families are that the head of household is female(77% ), the size of family is small(1.76 persons), the education level is low(7.5 years for male, 3.1 years for female) and the age group is old (male: 89.78 year old, female: 73.69 year old). 2) For the odd pair family, the frequency of health checking is quite low with one or two times per year(l0.2%) and the rate of no-health checking is much higher(35.8%) .3) Bathing utility is not available 29.6% of the odd pair family and only cold water is supplied at home for the 11.5 % of them. However, for the paired family, 9.8 % of them has no bathing utility and the rate of the family supplied with only cold water is just 7.9%. 4) The bathing frequency score of odd pair family is l.74points for male and 1.25 points for female. 5) The rate of smoking habits for odd pair family is 68.5 % and specially it is 7.6% for female, which is higher comparing with that of pair family. 6) The smoking frequency score of odd pair family is 1.57 points. 7) Alcohol drinking frequency score of odd pair family is 1.79 points for male, and 3.24points for female. 8) Farmers' syndrome(FS) revealed 38.7% of odd pair family and it is lower than that of pair family(57.3%). Special pain of FS was huckle bone and muscle(28.4%) and articular pain(24.l %). The pain rate of huckle bone and muscle(43.l %) and articular pain(33.5%) were higher in a year in odd pair family were lower than those of pair family: farming machine caused accidents(6.5%) and pesticide poisoning(5.7%). l0) The odd pair family use more frequently medical clinic or public health center for the treatment of FS(74.7%) and pesticide poisoning(62.5%) than the pair family for FS(69.0%) and for pesticide poisoning(.53.6%). The score of FS treatment is 5.70 points for odd pair family and it is not significantly different from 5.62 points of the paired family. The result of pesticide poisoning treatment score is as same as that of FS.

• 간호행정학회지
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• 제10권4호
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• pp.495-513
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• 2004

As this study is the descriptive research study that tries to present the basic data aiming to establish a role of nurses for the Community Welfare Center, by surveying the role expectation and the degree of role performance towards nurses for the Community Welfare Center that nurses for the Community Welfare Center and social workers recognize, it carried out the Questionnaire research targeting nurses who are working for the Community Welfare Center located in Seoul and social workers of institutions where nurses are working, and then analyzed the results, and the study results are as follows. Both the group of nurses and the group of social workers were highly recognizing the necessity and the importance of nurses for the Community Welfare Center, and expected that more effective services will be possible to be offered by means of that nurses do work for the Community Welfare Center. However, compared to the degree that social workers recognize a nurses specialty, the nurses thought that their specialty is not acknowledged in the Community Welfare Center, and even in case of duty friction between groups being felt while social workers and nurses are working together, nurses were experiencing further friction of duties. While nurses are well recognizing their roles, they are statistically and significantly recognizing the degree of role performance lower than expected, thus the difference between the role expectation and the role performance could be seen. Also, the group of nurses showed the higher role expectation towards nurses than the group of social workers, and in relation to roles of a counselor, referral resource, an advocator, an educator, a case manager, a and a coordinator, the degree of role expectation by the group of nurses is statistically and significantly higher than the group of social workers, thus it could be seen that there is difference in the expectation degree between both groups, as to a role of nurses for the Community Welfare Center. In particular, as to a role of universally medical services, the expectations between nurses and social workers showed mutual agreement, but in relation to a role of nurses for community in the more expanded sphere, social workers did not show a receptive attitude, thus it was indicating that there exists an element of role conflict. In relation to the role performance of nurses for the Community Welfare Center, nurses were feeling the disorder degree more than social workers, in all items of disorder factors, and there was difference in recognition between nurses and social workers, as to the priority of disorder factors. Because of, through this study, having been found the difference in recognition of role expectation, the degree of role performance, and a disorder factor between nurses and social workers, as to the nurses for the Community Welfare Center, it is required a study with a more diversified method on a role of nurses for the Community Welfare Center.