• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.104-105
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• 1998

To minimize the Y2K (year 2000) date aware problem of medical devices, we are developing a database that keeps the data such as equipment type, specification, serial number, model number, acquisition date, vendor, manufacturer of the device as well as the names of departments that installed and that is currently responsible for the management of the medical device. The database also keeps the information as to whether the device awares the date, whether it is affected by the Y2K problem or not, how to solve the problem, reference home page address, and so on. The data was collected via internet search of the FDA web site and related of manufacturers homepages. To manage the Y2K problem effectively, the database should be updated regularly to include recent information.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.301-307
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• 2005

We introduce a new multimedia telemedicine system which is called Telemedicine for Real-time Emergency Multi-consultation(TREM), based on multiple connection between medical specialists. Due to the subdivision of medical specialties, the existing one-to-one telemedicine system needs be modified to a simultaneous multi-consulting system. To facilitate the consultation the designed system includes following modules: high-quality video, video conferenceing, bio-signal transmission, and file transmission. In order to enhance the operability of the system in different network environment, we made it possible for the user to choose appropriate data acquisition sources of multimedia data and video resolutions. We have tested this system set up in three different places: emergency room, radiologist's office, and surgeon's office. All three communicating systems were successful in making connections with the multi-consultation center to exchange data simultaneously in real-time.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.106-107
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• 1998

To minimize the failure rate of medical devices, the maintenance records for general X-ray, R/F X-ray, mobile X-ray, artificial dialyzer, ventilator, and automatic chemistry analyzer was analysed with regard to the cause of the failure. The parts responsible for the most frequent system failure was then worked intensively during the preventive maintenance. After this procedure, the faliure of the systems in a month decreased from 1.8 on average to 0.3.

• Journal of Communications and Networks
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• v.13 no.2
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• pp.149-159
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• 2011

In this paper, we study the problem of how to design a medical-grade wireless local area network (WLAN) for healthcare facilities. First, unlike the IEEE 802.11e MAC, which categorizes traffic primarily by their delay constraints, we prioritize medical applications according to their medical urgency. Second, we propose a mechanism that can guarantee absolute priority to each traffic category, which is critical for medical-grade quality of service (QoS), while the conventional 802.11e MAC only provides relative priority to each traffic category. Based on absolute priority, we focus on the performance of real-time patient monitoring applications, and derive the optimal contention window size that can significantly improve the throughput performance. Finally, for proper performance evaluation from a medical viewpoint, we introduce the weighted diagnostic distortion (WDD) as a medical QoS metric to effectively measure the medical diagnosability by extracting the main diagnostic features of medical signal. Our simulation result shows that the proposed mechanism, together with medical categorization using absolute priority, can significantly improve the medical-grade QoS performance over the conventional IEEE 802.11e MAC.

• The Korean Journal of Ceramics
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• v.4 no.4
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• pp.372-376
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• 1998

Using calcium-phosphate-powder targets with the Ca/P ratios of 1.0-1.67, hydroxyapatite ($Ca_{10}(PO_4)_6(OH)_2$, HAp) thin films with 4-7㎛ thickness were prepared on titanium metal plates by r.f. magnetron sputtering, followed an annealing at $200^{\circ}C$ for 24 hr under a high water vapor pressure using an autoclave. All the specimens were systematically characterized by XRD, FT-IR, SEM and EDS analyses. The post-annealed films were confirmed to be a nonstoichiometric oxyhydroxyapatite by XRD and FT-IR measurements.

• BMB Reports
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• v.57 no.1
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• pp.60-65
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• 2024

The CRISPR-Cas9 system has significantly advanced regenerative medicine research by enabling genome editing in stem cells. Due to their desirable properties, mesenchymal stem cells (MSCs) have recently emerged as highly promising therapeutic agents, which properties include differentiation ability and cytokine production. While CRISPR-Cas9 technology is applied to develop MSC-based therapeutics, MSCs exhibit inefficient genome editing, and susceptibility to plasmid DNA. In this study, we compared and optimized plasmid DNA and RNP approaches for efficient genome engineering in MSCs. The RNP-mediated approach enabled genome editing with high indel frequency and low cytotoxicity in MSCs. By utilizing Cas9 RNPs, we successfully generated B2M-knockout MSCs, which reduced T-cell differentiation, and improved MSC survival. Furthermore, this approach enhanced the immunomodulatory effect of IFN-r priming. These findings indicate that the RNP-mediated engineering of MSC genomes can achieve high efficiency, and engineered MSCs offer potential as a promising therapeutic strategy.

• Proceedings of the Korea Information Processing Society Conference
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• 2016.04a
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• pp.890-892
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• 2016

본 연구는 초음파 센서를 사용하여 사용자와 모니터 사이의 거리측정을 통해 거북목 증후군 예방 시스템 개발에 대한 기초연구로 수행하였다. 자세는 바른 자세, 중간 자세, 거북목 유발 자세 총 3가지로, 각 피험자의 역치값을 통해 자세를 구분하였다. 피험자는 총 4명으로 실험을 통해 설정해 놓은 역치값 이상의 신호가 들어왔을 때, LED를 켜서 사용자의 현재 자신의 자세에 대해 피드백을 주도록 구성하였다. 본 연구의 결과를 바탕으로 향후 거북목 증후군 예방과 관련된 다양한 연구에 도움이 될 것으로 사료된다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2012.07a
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• pp.409-410
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• 2012

본 논문에서는 스마트케어 서비스를 위해, Android 운영체제를 기반으로 하는 Device에서 ADK를 이용해 혈압계를 제어하는 방법을 제안한다. 이 방법은 소프트웨어와 하드웨어를 결합한 kit인 ADK를 사용하여 Hardware를 잘 모르는 사람들도 Android에서 Hardware의 GPIO에 좀 더 쉽게 접근하고 제어할 수 있어 보다 다양한 기능을 구현할 수 있다. 또한 이 방법으로 얻은 혈압계 데이터를 Database에 저장하여 데이터통신망을 통해 전문의에게 Feedback을 받음으로써 굳이 병원을 방문하지 않더라도 개인의 건강을 보다 편리하게 관리할 수 있어 한 단계 수준 높은 진단을 받을 수 있다.

• BMB Reports
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• v.49 no.10
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• pp.548-553
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• 2016

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2006.08a
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• pp.156-156
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• 2006