• 대한한방소아과학회지
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• 제15권1호
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• pp.77-104
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• 2001

The effects of the oriental herbal medicine Saenghyetang(SHT, 生慧湯), which consists of Rehmanniae Radix (熟地黃 九蒸: was made by 9th steam) 40g, Corni Fructus(山茱黃) 16g, Polygalae Radix(遠志) 8g, Zizyphi Spinosae Semen(酸棗仁) 2g, Biotae Semen(柏子仁 去油: oil ingredient was removed) 20g, Poria Cocos(茯笭) 12g, Ginseng Radix(人蔘) 12g, Acori Graminei Rhizoma(石菖蒲) 2g, Sinapis Semen(白芥子) 8g, on learning ability and memory were investigated. Hot water extract(HWE) and ethanol extract(EE) from SHT were used for the studies. Learning ability and memory are related to modifications of synaptic strength among neurons that interactive. Enhanced synaptic coincidence detection leads to improved learning ability and memory. If the NMDA receptor, a synaptic coincidence detector, acts as a graded switch for memory formations, enhanced signal detection by NMDA receptors should enhance learning ability and memory. It was shown that NR2B was increased in the forebrains of oriental medicine-administrated mice, leading to enhanced activation of NMDA receptors and facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These HWE-SHT treated mice exhibited that superior ability in learning and memory when performing various behavioral tasks, showing that NR2B is enhanced by HWE-SHT treatment and also is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA receptor-dependent modifications, which were mediated in part by HWE administration, of synaptic efficacy, therefore, represent a mechanism for associative learning ability and memory. Results suggest that oriental medical enhancement of NR2B contributes to increase intelligence and memory in mammals On the other hand, to examine the effects of EE-SHT on the learning ability and memory in experimental mice, EE-SHT was tested on passive and active avoidance responses. The EE-SHT ameliorated the memory retrieval deficit induced by ethanol in mice, but not other memory impairments. EE-SHT(10, 20mg/100 g, p.o.) did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests and the ambulatory activity of normal mice in a normal condition. However, EE-SHT at 20 mg/kg significantly decrease the spontaneous motor activity during the shuttle box test, and also to extend the sleeping time induced by pentobarbital in mice. These results suggest that SHT has an ameliorating effect on memory retrieval impairments and a weak tranquilizing action.

• Clinical and Experimental Reproductive Medicine
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• 제25권2호
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• pp.115-122
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• 1998

The maintenance of a viable pregnancy has long been viewed as an immunological paradox. The deveolping embryo and trophoblast are immunologically foreign to the maternal immune system due to their maternally inherited genes products and tissue-specific differentiation antigens (Hill & Anderson, 1988). Therefore, speculation has arisen that spontaneous abortion may be caused by impaired maternal immune tolerance to the semiallogenic conceptus (Hill, 1990). Loss of recall antigen has been reported in immunosuppressed transplant recipients and is associated with graft survival (Muluk et al., 1991; Schulik et al., 1994). Progesterone $(10^{-5}M)$ has immunosuppressive capabilities (Szekeres-Bartho et al., 1985). Previous study showed that fertile women, but not women with unexplained recurrent abortion (URA), lose their immune response to recall antigens when pregnant (Bermas & Hill, 1997). Therefore, we hypothesized that immunosuppressive doses of progesterone may affect proliferative response of lymphocytes to trophoblast antigen and alloantigen. Proliferative responses using $^3H$-thymidine ($^3H$-TdR) incorporation of peripheral blood mononuclear cells (PBMCs) to the irradiated allogeneic periperal blood mononuclear cells as alloantigen, trophoblast extract and Flu as recall antigen, and PHA as mitogen were serially checked in 9 women who had experienced unexplained recurrent miscarriage. Progesterone vaginal suppositories (100mg b.i.d; Utrogestan, Organon) beginning 3 days after ovulation were given to 9 women with unexplained RSA who had prior evidence of Th1 immunity to trophoblast. We checked proliferation responses to conception cycle before and after progesterone supplementation once a week through the first 7 weeks of pregnancy. All patients of alloantigen and PHA had a positive proliferation response that occmed in the baseline phase. But 4 out of 9 patients (44.4%) of trophoblast antigen and Flu antigen had a positive proliferative response. The suppression of proliferation response to each antigen were started after proliferative phase and during pregnancy cycles. Our data demonstrated that since in vivo progesterone treated PBMCs suppressed more T-lymphocyte activation and $^3H$-TdR incorporation compare to PBMCs, which are not influenced by progesterone. This data suggested that it might be influenced by immunosuppressive effect of progesterone. In conclusion, progesterone may play an important immunological role in regulating local immune response in the fetal-placental unit. Furthermore, in the 9 women given progesterone during a conception cycle, Only two (22%) repeat pregnancy losses occured in these 9 women despite loss of antigen responsiveness (one chemical pregnancy loss and one loss at 8 weeks of growth which was karyotyped as a Trisomy 4). These finding suggested that pregnancy loss due to fetal aneuploidy is not associated with immunological phenomena.

• 사상체질의학회지
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• 제10권1호
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• pp.235-252
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• 1998

1. 연구배경 및 목적 : 태음인(太陰人) 신방법(新定方)의 하나인 청심연자탕(淸心蓮子湯)의 효능(效能)과 활용(活用)에 대한 임상적(臨床的) 연구(硏究)를 통하여 사상체질병증(四象體質病證)의 이해(理解)와 방제(方劑)의 운용(運用)에 도움을 주고자 한다. 2. 방법 : 1997년 3월부터 1998년 2월까지 1년간 동국대학교 분당한방병원 체질의학클리닉에 내원(來院)한 환자를 중 청심연자탕(淸心蓮子湯)이 20점(貼) 이상 투여되고 경과관찰(經過觀察)이 가능(可能)했던 125명(남자 62명, 여자 63명)을 대상으로 청심연자탕(淸心蓮子湯)이 투여된 환자(患者)의 특성(特性), 치료효과(治療效果), 부작용(副作用)등에 관하여 조사하고 분석하였다. 3. 결과 : 태음인(太陰人)의 청심연자탕(淸心蓮子湯)은 남녀(男女) 구별없이 20세 이상의 전 연령층(年齡層)에서 사용되었으며, 대상환자(對象惠者)들의 주소증(主訴症)은 수족비(手足痺), 두통(頭痛), 피로(疲勞) 등 60 종류였다. 치료효과(治療效果)의 분포는 호전(好轉)(60.8%), 우수(優秀)(15.2%), 별무변화(別無變化)(24.0%)였으며 악화(惡化)는 없었다. 전신상태의(全身狀態)의 특징으로는 설태(舌苔)가 백태(白苔) 또는 황태(黃苔)를 띠거나 수면(睡眠)에 장애(障碍)가 있는 경우가 많았다. 처방(處方)을 활용(活用)할 때는 다른 치료법이나 처방의 변경없이 청심연자탕(淸心蓮子湯)만을 사용한 경우가 많았으며 병증(病症)에 따라 2~3 종류(種類)의 약물(藥物)을 가미(加味)하여 사용하였다. 청심연자탕(淸心蓮子湯)의 치료효과(治療效果)에는 질환(疾患)의 이환기간(罹患期間), 치료기간(治療期間), 투여량(投與量)등이 영향(影響)을 미쳤으며 부작용(副作用)으로는 설사(泄瀉), 소화불량(消化不良) 등이 있었다.

• The Journal of Korean Physical Therapy
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• 제16권3호
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• pp.86-96
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• 2004

A clinical study about painful manifestation on lumbar with regard to movement change of trunk The purpose of this study is to present the basis of low back pain therapy which is close examined of back muscle that is the main reason for that case of back pain when trunk rotation, flexion and extension. Therefore this study, which is based on literature review and clinical experience, has tried to figure out that back pain which is considered to be significant for the most increasing time, posture, motion, painful area, involved muscle have any influence on trunk rotation, flexion and extension This study has done with the patients in oriental rehabilitation clinic, K-oriental hospital, from Jan, 2003 to Dec, 2003. Total cases were 145(male:$39\%$-52 patients, female:$64.1\%$-93 patients) those who complained lumbosacral pain with radiating that makes patient unable to bending or extending the trunk. And they were surveyed retrospect way, checking the medical record and that of therapist. Results are as followings. 1. For sprain patient, $34.5\%$ complained pain on extension, and among them, the most remarkably, patients who did right rotation extension pattern were $20\%$. Herniated disc patient shows greater limit on flexion when trunk moves bending route, but right rotation with extension pattern shows the most limitation on flexion-extension according to the rotation of trunk 2. Cases of morning back pain($60.5\%$) showed high value on right rotation extension pattern($18.6\%$), right rotation flexion pattern($16.3\%$) but did not show big difference on left flexion and extension pattern 3. Patients those who complain pain on sitting position showed highest value each left, right $14.6\%$ of left and right rotation extension pattern 4. Among extension painful patient, there showed highest value of each $32.5\%$ on right rotation extension pattern, and $20.0\%$ on right rotation flexion pattern. 5. Tenderness distribution of quadratus lumborum showed $34.5\%$ on right rotation extension pattern, $20.7\%$ on left rotation extension pattern, and that of iliopsoas muscle at right rotation flexion pattern showed right muscle $20.0\%$, left $50.0\%$ Derived from the results of survey above, for sprain and HIVD patient showed greatest pain on right rotation pattern, for pain plus patient on right rotation extension among those who has extreme pain on sitting in the morning described tenderness on right quadratus lumborum, and those who complain pain on left rotation extension described tenderness on left lumborum the most Decisively, it is possible to figure out the problem muscle that involved when I found the time, position, motion that aggravating and painful area. Therefore this study would be expected to be able to be a useful clinical materials on diagnosis and therapy of low back pain.

• Journal of the Optical Society of Korea
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• 제19권6호
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• pp.700-704
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• 2015

As pH is a widely used index in chemical, medical, and environmental applications, research on pH sensors has been active in recent years. This study obtained RGB values by measuring the reflected light from a liquid sample to detect fine changes in pH, and performed mathematical modeling to investigate the relationship between the detected optical signal and pH value. Also, the trends in pH changes were easily identified by analyzing RGB values and displaying them in the color coordinate for easy visualization of data. This method implemented a user-friendly system that can measure and analyze in real time. This system can be used in many fields such as genetic engineering, environmental engineering, and clinical engineering, because it not only can measure pH but also replaces a colorimeter or turbidimeter.

• 한국임상수의학회지
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• 제29권5호
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• pp.416-421
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• 2012

10살령의 4 kg 암컷 치와와가 심한 울혈성심부전의 수술적 치료를 위해서 내원하였다. 여러 가지 진단을 통해 이 환자는 심한 이첨판 폐쇄부전과 중등도의 삼천판 폐쇄부전이 확인되었다. 약물에 대한 치료적인 반응이 여의치 않아, 수술적으로 이첨판을 교정하는 치료방법으로 지시되었다. 체외순환을 이용한 심폐순환기하에서 이첨판교정술이 실시되었다. 하지만 이 환자는 교정 후에 마취에서 회복되지 못하고 사망하였다. 심장수술에 있어 실패를 유발하는 여러 가지 원인들에는 심폐순환기 운용, 저체온증, 장기부전, 출혈, 저혈압, 전해질과 산-염기 불균형, 그리고 감염 등이 있다. 비록 이 환자는 사망하였지만, 그 원인을 밝혀 내는 일은 수의학 분야에서 중요한 일이다. 이 증례의 사망원인을 고찰해 본 결과, 심한 저체온증에 의한 가스환기와 산소공급의 이상 그리고 심장수술과 관련한 저심박출량 증후군으로 인한 낮은 심박동수를 동반한 저혈압으로 사망한 것으로 생각되었다. 이 증례의 원인 규명을 위한 고찰은 이첨판성형술의 성공을 위해서는 좀더 세심한 주의가 요구됨을 알 수 있게 해주었고, 나아가 앞으로의 수술에서 성공률을 높일 수 있는 중요한 계기가 될 것이다.

• Korean Journal of Acupuncture
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• 제24권1호
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• pp.79-94
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• 2007

Objectives : Ulcerative colitis and Crohn's disease are chronic inflammatory disease of the gastrointestinal tract was identified mainly for diarrhea, stomachache, hemafecia. The source and pathologic mechanism about ulcerative colitis and crohn's disease are still unknown but stress, infection, a genetic factor, environmental factors etc. may be the cause of chronic inflammatory disease of the gastrointestinal tract recently. The purpose of the present study is to evaluate the effects of herbal acupuncture with Artemisiae Argyi for the treatment to intestinal disease in the rat with 2, 4, 6 - trinitrobenzenesulfonic acid (TNBS) induced colitis. Methods : Artemisiae Argyi Herbal acupunctures were infected in HapGok (LI4) which is used to treat for intestinal disease in clinic. All animals were subjected to the injection of saline (300 ${\mu}l$, 500 ${\mu}l$) for a study control and TNBS (300 ${\mu}l$, 500 ${\mu}l$) into the lumen of the colon, 8cm proximal to the anus through the intestine. Artemisiae Agryi' Herbal (20 mg/ml, 0.4 ml) acupunctures were injected to the LI4 (both hands) at the secondary injection time of TNBS in rats. And body weight, RBC count, WBC count, total protein, Paw edema rate, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels were observed to study the effects of Artemisiae Argyi' Herbal acupuncture in HapGok (Ll4). Results : Artemisiae Argyi' Herbal acupuncture in HapGok (Ll4) on TNBS-induced colitis inhibit the body weight lose rate but not RBC and WBC count. Furthermore, it inhibited the reduction of total protein concentration, paw edema, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels. Conclusions : Herbal acupuncture with Artemisiae Argyi helps recover the TNBS-induced colonic damage and may be an important method for treatment of the colitis.

• 농촌의학ㆍ지역보건
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• 제42권3호
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• pp.155-167
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• 2017

이 연구는 서울시 강북구 건강마을 사업에 대한 문헌고찰과 운영주체를 대상으로 한 심층면접을 통해 주민운동의 관점에서 사업의 성과와 한계를 살펴보고, 기존 건강증진 사업과의 차별성을 찾아 향후 건강증진 사업의 새로운 방향성을 모색하는 것을 목적으로 하였다. 연구 결과 빈곤층의 비율이 높고, 물리적 환경이 열악한 지역사회 주민들의 건강불평등을 완화하기 위한 건강친화 마을 만들기 사업은 주민조직화의 원리를 적용한 것으로 기존 건강증진사업과 다음과 같은 방법론적 차별성과 성과가 있었다. 첫째, 주민 스스로 지역보건의료 계획을 수립하고 주민의 성장을 통한 건강증진사업이 이루어졌다. 둘째, 기존 건강증진사업에서는 볼 수 없었던 주민활동가가 팀을 이루어 보건소 및 전문가, 주민 간 긴밀한 협력을 위해 매개자로 활동하였다. 셋째, 병의원이나 보건소가 아닌 대안적 주민참여 건강증진 공간인 건강카페를 통한 건강증진 구심점이 마련되어 다양한 프로그램이 활성화되었다. 넷째, 건강의 사회적 결정요인을 고려한 접근을 통한 건강증진 프로그램이 활성화 되었다. 따라서 향후 건강친화 마을 만들기와 같은 지역사회 건강불평등 완화를 위한 사업을 실시할 때 이 연구에서와 같은 방법론적 접근을 고려해볼 필요가 있다. 하지만 다양한 사업주체들이 모인만큼 이해관계와 역할분담과 관련된 어려움이 발생한 점과 시범사업의 성과와 한계를 사전에 명확히 예상하기 못해 갈등이 유발되었던 점 등의 한계가 있었던 만큼 향후 유사한 사업의 계획 시 이 연구에서 나타난 한계점 등을 고려한 내용이 반영되어야 할 것이다. 주민건강운동의 관점에서 건강마을사업 확산 된다면 사회 전체에 건강증진 효과를 만들 것이다.

• 대한지역사회영양학회지
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• 제11권5호
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• pp.661-672
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• 2006

This study was performed to determine the dietary risk factors associated with hypertension. The hypertensive group were composed of 112 hypertensive patients (male 53, female 59) who first visited the hypertension clinic and had been diagnosed as having primary hypertension ($SBP{\ge}140mmHg\;or\;DBP{\ge}90mmHg$). The regular visitors or the subjects on special diets or medical therapies were excluded. The normal group consisted of as subjects (male 41, female 54) matched with age and socioeconomic levels. The subjects having higher intakes (above the 75 percentile) in energy, protein, iron, vitamin A or C showed significantly higher hypertension risk estimated with odds ratio after the covariance factors (age, sex and BMI) were adjusted. More than 2400 mg of sodium (6 g of salt) intake was associated with significantly higher risk of hypertension (odds ratio: 1.773, CI: 1.014-3.014 for $SBP{\ge}140mmHg$; odds ratio: 2.373, CI: 1.359-4.215 for $DBP{\ge}90mmHg$). Hypertensive group showed significantly increased intakes of vegetables and fish and shell fish compared to the normal group. When the vegetable intakes were classified into Kimchi, fresh vegetables and cooked vegetables with seasoning, the hypertensive group was observed as having higher intakes of Kimchi and cooked vegetables with seasoning. The intakes of highest quartile for vegetables (${\ge}327g/day$) (odds ratio: 3.164, CI: 1.740-5.752), fish and their products (${\ge}102g/day$) (odds ratio: 2.756, CI: 1.486-5.109), grains(${\ge}311g/day$) (odds ratio 2.393, CI: 1.186-4.832), meats and their product (${\ge}106g$) (odds ratio: 2.210, CI: 1.225 - 3.987) compared to the lower were significantly associated with the higher risk of hypertension estimated with DBP (${\ge}90mmHg$) after covariance factors were adjusted. In conclusion, our findings confirm that higher intake of energy or sodium are associated with the increased risk of hypertension. Because increased intake of vegetable or fish was associated with the higher risk of hypertension, in contrast with the finding of western countries, choosing or preparation of vegetables or fish with reduced salt is recommended.

• 한국보건간호학회지
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• 제18권1호
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• pp.80-89
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• 2004

This study focused on individual health education for people with hypertension who were being seen in public health centers. The program was an adjusted intervention program that considered the characteristics of each individual and reflected the individual's will to change. Each individual had a different lifestyle with different characteristics and habits so the study considered these individual's characteristics. A comparison was done of knowledge related to hypertension, self-efficacy, and self-care in these individuals. In order to determine the effectiveness of education given by the nurses the variables were measured before and after the individual health education program. The participants in this study were 85 people with hypertension who were seen at a public health center in G city. They were assigned to an experimental group (43) and a control group (42). A tool developed by Park Young-Im (1994) was used to measure knowledge related to hypertension and self-efficacy. A tool developed by Lee Young-Whee (1994) was used for self-care. Data collection was done for 10 weeks from March 24 to May 31, 2003 using interviews with questionnaires. The following is a summary of the results of the study. Hypothesis 1, 'the experimental group which had the individual health education will have higher knowledge scores on hypertension than the control group that did not have the individual health education' was supported (t=4.17, P=0.00). Hypothesis 2, 'the experimental group which had the individual health education will have higher self-efficacy scores than the control group that did not have the individual health education' was supported (t=4.06, P=0.00). Hypothesis 3, 'the experimental group which had the individual health education will have better self-care ability than the control group that did not have the individual health education' was supported (t=4.94, P=0.00). Based on the results of this study, the public health centers should develop an educational program that uses a variety of visual aids and assess the effects of the education on patients with different chronic diseases. After the development of an inclusive education program which will standardize health education effectively and provide a variety of teaching methods, study is needed to measure changes in lifestyle after education and to determine how much knowledge related to hypertension, self-efficacy, and self-care increase