Failure of Mitral Valve Repair in a Dog with Severe Mitral Regurgitation

심한 이첨판 역류를 가진 개에 실시한 이첨판 성형술의 실패 원인

  • Kim, Min-Su (Veterinary Cardiovascular Surgery Unit, Department of Veterinary Surgery, College of Veterinary Medicine, Chonbuk National University)
  • 김민수 (전북대학교 수의과 대학)
  • Accepted : 2012.08.16
  • Published : 2012.10.31

Abstract

A 10-year-old 4-kg spayed female Chihuahua with severe congestive heart failure was referred for surgical treatment. Through several examinations, the dog was diagnosed as severe mitral regurgitation (MR) and moderate TR. Because of the poor prognosis associated with continuation of medical management, surgical repair of the mitral valve was considered as the treatment option for the dog. The mitral valve repair was performed undergoing cardio pulmonary bypass (CPB) circuit. However after mitral repair, the dog was died without recovery from anesthesia. Many risk factors associated with failure of cardiac surgery are included CPB management, hypothermia, organ dysfunction, hemorrhage, hypotension, electrolyte & acid base imbalance, and infection. Although the dog is died from the operation, it is an important to reveal the factors of failure in veterinary clinic. From the case report, causes of failure of mitral valve repair can be considered from the failure of oxygenation and gas exchange by hypothermia and serious hypotension with low heart rate by low cardiac output syndrome (LCOS). Through the several considerations from this case, it is known that coming cardiac surgery for mitral valve repair is required to be more careful for successful operation. Further it can be brought to increase success rate in further operation.

10살령의 4 kg 암컷 치와와가 심한 울혈성심부전의 수술적 치료를 위해서 내원하였다. 여러 가지 진단을 통해 이 환자는 심한 이첨판 폐쇄부전과 중등도의 삼천판 폐쇄부전이 확인되었다. 약물에 대한 치료적인 반응이 여의치 않아, 수술적으로 이첨판을 교정하는 치료방법으로 지시되었다. 체외순환을 이용한 심폐순환기하에서 이첨판교정술이 실시되었다. 하지만 이 환자는 교정 후에 마취에서 회복되지 못하고 사망하였다. 심장수술에 있어 실패를 유발하는 여러 가지 원인들에는 심폐순환기 운용, 저체온증, 장기부전, 출혈, 저혈압, 전해질과 산-염기 불균형, 그리고 감염 등이 있다. 비록 이 환자는 사망하였지만, 그 원인을 밝혀 내는 일은 수의학 분야에서 중요한 일이다. 이 증례의 사망원인을 고찰해 본 결과, 심한 저체온증에 의한 가스환기와 산소공급의 이상 그리고 심장수술과 관련한 저심박출량 증후군으로 인한 낮은 심박동수를 동반한 저혈압으로 사망한 것으로 생각되었다. 이 증례의 원인 규명을 위한 고찰은 이첨판성형술의 성공을 위해서는 좀더 세심한 주의가 요구됨을 알 수 있게 해주었고, 나아가 앞으로의 수술에서 성공률을 높일 수 있는 중요한 계기가 될 것이다.

Keywords

References

  1. Behr L, Chetboul V, Sampedrano CC, Vassiliki G, Pouchelon JL, Laborde F, Borenstein N. Beating heart mitral valve replacement with a bovine pericardial bioprosthesis for treatment of mitral valve dysplasia in a Bull Terrier. Vet Surg 2007; 36: 190-198. https://doi.org/10.1111/j.1532-950X.2007.00259.x
  2. Bizzarri F, Tudisco A, Ricci M, Rose D, Frati G. Different ways to repair the mitral valve with artificial chordae: a systematic review. J Cardiothorac Surg 2010; 5: 22. https://doi.org/10.1186/1749-8090-5-22
  3. Boggs LS, Dewan SJ, Ballard SE. Mitral valve reconstruction in a toy-breed dog. J Am Vet Med Assoc 1996; 209: 1872-1876.
  4. Buchanan JW, Sammarco CD. Circumferential suture of the mitral annulus for correction of mitral regurgitation in dogs. Vet Surg 1998: 27: 182-193. https://doi.org/10.1111/j.1532-950X.1998.tb00117.x
  5. Calafiore AM. Choice of artificial chordae length according to echocardiographic criteria. Ann Thorac Surg 2006; 81: 375-377. https://doi.org/10.1016/j.athoracsur.2004.08.071
  6. Griffiths LG, Orton EC, Boon JA. Evaluation of techniques and outcomes of mitral valve repair in dogs. J Am Vet Med Assoc 224 2004; 224: 1941-1945. https://doi.org/10.2460/javma.2004.224.1941
  7. Griffiths LG. Surgery for cardiac disease in small animals: current techniques. Vet Clin North Am Small Anim Pract 2010; 40: 605-622. https://doi.org/10.1016/j.cvsm.2010.04.001
  8. Kanemoto I, Taguchi D, Yokoyama S, Mizuno M, Suzuki H, Kanamoto T. Open heart surgery with deep hypothermia and cardiopulmonary bypass in small and toy dogs. Vet Surg 2010; 39: 674-679.
  9. Klement P, Feindel CM, Scully HE, Mesher E, Klement G, Del Nido P, Wilson GJ. Mitral valve replacement in dogs. Surgical technique and postoperative management. Vet Surg 1987; 16: 231-237. https://doi.org/10.1111/j.1532-950X.1987.tb00944.x
  10. Kouchoukos NT, Blackstone EH, Doty DB, Hanley FL, Karp RB. Mitral valve disease with or without tricuspid valve disease. In Cardiac surgery, 3th ed. Utah: Churchill Livingstone 2003: 483-553.
  11. Kouchoukos NT, Blackstone EH, Doty DB, Hanley FL, Karp RB. Postoperative care. In Cardiac surgery, 3th ed. Utah: Churchill Livingstone. 2003: 195-253.
  12. Miura T, Eishi K, Yamachika S, Yamachika S, Hashizume K, Yamane K, Tanigushi S, Tanigawa K, Hashimoto W, Odate T, Nakaji S. Mitral valve repair for degenerative disease with leaflet prolapse: to improve long-term outcomes. Gen Thorac Cardiovasc Surg 2009; 57: 10-21.
  13. Orton EC, Hackett TB, Mama K, Boon JA. Technique and outcome of mitral valve replacement in dogs. J Am Vet Med Assoc 2005; 226: 1508-1500. https://doi.org/10.2460/javma.2005.226.1508
  14. Serres F, Chetboul V, Tissier R, Sampedrano CC, Gouni V, Nicolle AP, Pouchelon JL. Chordae tendineae rupture in dogs with degenerative mitral valve disease: prevalence, survival, and prognostic factors (114 cases, 2001-2006) J Vet Intern Med 2007; 21: 258-264.
  15. Sisson D, Kvart C, Darke PGG. In: Textbook of canine and feline cardiology: principle and clinical practice, Philadelphia: WB Saunders. 1988: 536-565.
  16. Takashima K, Soda A, Tanaka R, Yamane Y. Long-term clinical evaluation of mitral valve replacement with porcine bioprosthetic valves in dogs. J Vet Med Sci 2008; 70: 279-283. https://doi.org/10.1292/jvms.70.279
  17. Uechi M. Mitral valve repair in dogs. J Vet Cardiol 2012; 14: 185-192. https://doi.org/10.1016/j.jvc.2012.01.004
  18. Verma S, Mesana TG. Mitral-valve repair for mitral-valve prolapse. N Engl J Med 2009; 36: 2261-2269.
  19. Von Segesser LK. Unusual problems in cardiopulmonary bypass. In Cardiopulmonary bypass: principle and practice, 3th ed. Philadelphia: Lippincot Williams & Wilkins. 2008: 609-613.
  20. White RN, Stepien RL, Hammond RA, Holden DJ, Torrington AM, Milner HR, Cobb MA, Hellens SH. Mitral valve replacement for the treatment of congenital mitral dysplasia in a bull terrier. J Small Anim Pract 1995; 36: 407-410. https://doi.org/10.1111/j.1748-5827.1995.tb02968.x