• Journal of Ginseng Research
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• v.47 no.4
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• pp.493-505
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• 2023

In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related "ingredients-targets" network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.416-419
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• 2002

There are being two prominent studying for Digital Radiography. Direct and Indirect method of Digital Radiography are announced for producing high quality digital image. The one is using amorphous selenium as photoconductor and the other is using phosphor layer as a light conversion. But each two systems have strength and weakness such as high voltage and blurring effect. In this study, we investigated the electrical characteristic of $multi-layer\left(CaWO_{4}+a-Se \right)$ as a photoconductor according to the changing arsenic composition ratio. This is a basic research for developing of Hybrid digital radiography which is a new type X-ray detector. The arsenic composition ratio of a-Se compound is classified into 7 different kinds which have 0.1%, 0.3%, 0.5%, 1%, 1.5%, 5%, 10% and were made test sample throught thermo-evaporation. The phosphor layer of $CaWO_4$ was overlapped on a-Se using EFIRON optical adhesives. We measured the dark and photo current about the test sample and compared the electrical characteristic of the net charge and signal-to-noise ratio. Among other things, test sample of compound material of 0.3% arsenic showed good characteristic of $2.45nA/cm^2$ dark current and $357.19pC/cm^2/mR$ net charge at $3V/{\mu}m$.

• Nuclear Engineering and Technology
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• v.56 no.8
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• pp.3123-3128
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• 2024

The dicentric chromosome assay is a gold standard method to estimate radiation exposure by calculating the ratio of dicentric chromosomes existing in cells. The objective of this study was to propose an automatic dicentric chromosome discrimination method based on deep convolutional neural networks using radiation exposure patient data. From 45 patients with radiation exposure, conventional Giemsa-stained images of 116,258 normal and 2800 dicentric chromosomes were confirmed. ImageNet was used to pre-train VGG19, which was modified and fine-tuned. The proposed modified VGG19 demonstrated dicentric chromosome discrimination performance, with a true positive rate of 0.927, a true negative rate of 0.997, a positive predictive value of 0.882, a negative predictive value of 0.998, and an area under the receiver operating characteristic curve of 0.997.

• Journal of the Korean Society of Radiology
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• v.84 no.3
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• pp.736-744
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• 2023

Adult-onset Alexander Disease (AOAD) is a rare genetically determined leukoencephalopathy that presents with ataxia, spastic paraparesis, or brain stem signs including speech abnormalities, swallowing difficulties, and frequent vomiting. The diagnosis of AOAD is frequently proposed based on the findings on MRI. We demonstrate two cases (37-year-old female and 61-year-old female) with characteristic imaging findings and changes in follow-up MRI in patients with AOAD, which were confirmed via glial fibrillary acidic protein (GFAP) mutation analysis. On MRI, the typical tadpole-like brainstem atrophy and periventricular white matter abnormalities were noted. The presumptive diagnoses were made based on the typical MRI appearances and, subsequently, confirmed via GFAP mutation analysis. Follow-up MRI demonstrated the progression of atrophy in the medulla and upper cervical spinal cord. Our report could help raise awareness of characteristic MRI findings of AOAD, thus helping clinicians use GFAP analysis for AOAD diagnosis confirmation.

• Journal of The Korea Institute of Healthcare Architecture
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• v.23 no.2
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• pp.27-35
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• 2017

Purpose: This study analyzed the status of general hospitals as an expanded concept of medical resources including medical staff and equipment. The purpose of this study is to provide a basic for the feasibility study of the scale and establishment of facility guidelines at the planning stage of general hospitals. Methods: The subjects of this study were limited to general hospitals. The status of medical resources was based on the data of the Health Insurance Review and Assessment Service. The number of beds, doctors, nursing grades and major medical equipment were surveyed in 335 general hospitals. Results: 1) The characteristic of general hospitals varies depending on the number of inpatient beds. To be concrete, there were differences in the number of medical staffs and equipments in general hospitals based on 300 500 800 1,000 beds. 2) As the number of hospital beds increases, the number of medical staff increases more than medical equipment and facilities. Medical equipment and facilities remain constant, even when the number of beds increases. On the other hand, the number of medical staff increased about 1.5 times in each level. Implications: Architectural plans for medical staff should be considered differently depending on the number of beds. In particular, architectural planning and facility guidelines should be applied differently based on 300 and 500 beds.

• Journal of Korean Medical classics
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• v.22 no.1
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• pp.61-70
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• 2009

The five viscera[五藏], one of the key concepts from Traditional Oriental Medicine in understanding the nature of human body, endows the characteristic of five phases[五行] on the five representative organs, based on the five phases theory[五行論]. Although the theory from "Geummun-Sangseo(今文尙書)" which states the order of 'liver-mok[肝木] heart-hwa[心火] pancreas-to[脾土] lung-geum[肺金] kidney-su[腎水]' is now widely approved by present-day academics concerning arrangement of five changes and the five viscera, there are some other less-known theories of arrangement. "Gomun-Sangseo[古文尙書]" had suggested the order of 'pancreas-mok[脾木] lung-hwa[肺火] heart-to[心土] liver-geum[肝金] kidney-su[腎水]', which was never practiced, and "Dong-uisusebowon(東醫壽世保元)" of Ijema(李濟馬) expressed the theory of 'lung-mok[肺木] pancreas-hwa[脾火] heart-to[心土] liver-geum[肝金] kidney-su[腎水]'.

• Journal of The Korea Institute of Healthcare Architecture
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• v.11 no.2
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• pp.55-62
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• 2005

This study is to suggest the proper standards of the pediatric facilities. We need to have the medical treatment standard focusing to the architectural concept because the living and medical treatment level and the demand of citizen is increasing. The way of research is mainly referring to USA's hospitals and the patients. This study is for the psychological stability of child. We found the form decisive elements and the basic form characteristic with analysing cases. This elements are emerging to the sociality, privacy, control, recognition and territoriality. We have to improve the satisfaction of the patient through this element. In the future, the role of the improved medical environment will have to be emphasized.

• Korean Journal of Head & Neck Oncology
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• v.5 no.1
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• pp.15-20
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• 1989

There is a difficulty in complete removal of tumor developing at the parapharyngeal space or infratemporal space where they are just under the skull base. We have experienced 3 cases of malignant tumors and 5 cases of benign tumors arising from the parapharyngeal spaces and/or infratemporal space since 1976. We hereby present 8 cases of primary tumors arising in these spaces with a review of anatomical relationship between above spaces, the characteristic symptoms, diagnostic technics, and surgical approaches which should be considered in their management.

• The Korean Journal of Cytopathology
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• v.8 no.1
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• pp.52-56
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• 1997

Oxyphilic (Hurthle) cells have abundant eosinophilic granular cytoplasms and occur in both benign and malignant neoplasms of the thyroid gland. Most published studies described mainly oxyphilic tumors of follicular type, and reports on oxyphilic papillary thyroid carcinomas are rare. The oxyphilic variant of papillary carcinoma differs from the classic papillary carcinoma in its more aggressive biological behavior. We report a case of oxyphilic papillary carcinoma exhibiting exclusively oxyphilic cells in a follicular pattern without papillary structures. The pattern of papillary carcinoma was confirmed by fine needle aspiration material and lymph nodal metastasis, both of which revealed typicaled papillary structures with characteristic nuclear features, psammoma bodies, and oxyphilic cytoplasm.

• The Korean Journal of Nuclear Medicine
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• v.26 no.1
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• pp.155-159
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• 1992

Sternocostoclavicular hyperostosis (SCCH) is a chronic, nonsuppurative inflammatory disease involving sternum, clavicle, upper ribs and its adjacent soft tissue. It is a relatively newly described syndrome, characterized by ossification in the region between the clavicle and the first rib, and hyperostosis of the medial end of the clavicle with simultaneous involvement of the sternum and juxtasternal ribs. We experienced one case of sternocostoclavicular hyperostosis, diagnosed by pinhole bone scintigraphy. This paper describes characteristic pinhole scintigraphic findings of SCCH, with comparative study with radiographic and pathologic findings.