• Journal of Society of Preventive Korean Medicine
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• v.18 no.1
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• pp.23-41
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• 2014

Objective : The purpose of this study was to lay the groundwork for understanding the details and scope of the legal definition of medicinal products, following the changes in the relevant laws and regulations. This will let readers properly understand the origins of the ongoing conflicts on herbal drugs and new drugs from natural products that are present in the medical field and the medical industry. Possible solutions are proposed in the end. Method : I analyzed the changes in definition of medicinal products since 1945 that have been used in relevant laws and regulations(i.e. Pharmaceutical Affairs Act) and drug approval process(i.e. New Drug Application and Investigational New Drug Application). Results : Legal definition of medicinal products has changed in accordance with the changes in the pharmaceutical industry, such as the establishment of dualistic medical and pharmaceutical System and the introduction of the substance patent. Due to those changes, boundaries of Western medicinal products and health food expanded, while those of herbal medicine products relatively downscaled. Conclusion : Legal definition of medicinal products-i.e. Herbal Drugs, Crude Drugs, and New Drugs from Natural Products-should be reestablished according to academic legitimacy and dualistic medical and pharmaceutical System.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.13 no.1
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• pp.63-86
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• 2007

External treatments have various curative effects. So it had been used to cure various patients. But, it has a limited sphere of application in the present South Korea. Therefore we would like to bring out its sphere of application and detailed method in the oriental medicine classics. Especially, we would like to bring out external use of medecal herbs at base of External treatments. And then we have arrived at following conclusions. 238 species herbs have been used externalpreparation. comparatively often used a herbal medicines are Argyi Wormwood Leaf(艾), Realgar(雄黃), Croton Seed(巴豆), Musk(麝香), Cochinchina Momordica Seed(木鱉仁), Glycyrrhiza uralensis(甘草) and Chuanxiong Rhizome(川芎).

• Journal of Korean Medical classics
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• v.37 no.3
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• pp.21-35
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• 2024

Objectives : The aim of this study is to establish foundation for applied research and clinical application of the treatment principle and imperativeness for Korean Medical treatment of recurrent pregnancy loss through the study of classical texts. Methods : The Donguibogam, Yixuerumen, Jingyuequanshu, together with gynecological texts such as the Fuqingzhunuke and the Nukejinglun were studied in terms of treatment, post-miscarriage cultivation methods and prevention for various types of pregnancy loss. Results : For cases of missed miscarriage, Foshousan is applied, while for recovery post surgery, Shenghuatang-based formulas are applied. For cases of imminent miscarriage, prescriptions should be selected based on major symptoms such as stomach pain, lower back pain and bleeding, while for cases of chemical miscarriages, treatment methods that cultivates the Liver and calms qi should be applied. After pregnancy loss, elimination of stagnant blood should be prioritized according to the principle of 'first eliminate blood, then tonify deficiency'. For prevention of pregnancy loss, Jinguidangguisan-based formulas should be applied according to medicinal administration principles of Korean Medicine. Conclusions : For an integrative treatment and prevention of recurrent pregnancy loss, Korean Medical treatment according to clinical representation is required.

• The Korean Journal of Nuclear Medicine
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• v.38 no.1
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• pp.62-73
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• 2004

Purpose: The herpes simplex virus type 1 thymidine kinase gene(HSV1-tk) is an attractive candidate as a reporter gene in noninvasive reporter gene monitoring system. The HSV1-tk gene was chosen as a reporter gene, because it has been extensively studied, and there are appropriate reporter probes, substrates of HSV1-tk gene product, to apply for HSV1-tk gene imaging. We used radiolabeled 5-iodovinyl-2'-deoxyuridine (IVDU) and 5-iodovinyl-2'-fluoro-2'-deoxyuridine (IVFRU) as reporter probes for HSV1-tk gene monitoring system. Materials and Methods: We prepared HSV1-tk gene transduced Morris hepatoma cell line using retroviral vector, MOLTEN containing HSV1-tk gene. And we confirmed the HSV1-tk gene expression by Northern blotting and Western blotting. We compared in vitro uptakes of radioiodinated IVDU and IVFRU to monitor HSV1-tk gene expression in Morris hepatoma cell line (MCA) and HSV1-tk gene tranduced MCA (MCA-tk) cells until 480 minutes. We also peformed correlation analysis between percentage of HSV1-tk gene tranduced MCA cell % (MCA-tk%) and uptakes of radiolabeled IVDU or IVFRU. Results: MCA-tk cell expressed HSV1-tk mRNA and HSV1-TK protein. Two compounds showed minimal uptake in MCA, but increased uptake was observed in MCA-tk. IVDU showed 4-fold higher accumulation than IVFRU at 480 min in MCA-tk (p<0.01). Both IVDU and IVFRU uptake were linearly correlated ($R^2>0.96$) with increasing MCA-tk%. Conclusion: The radiolabeld IVDU and IVFRU showed higher specific accumulation in retrovirally HSV1-tk gene transfected Morris hepatoma cell line. Both IVDU and IVFRU could be used as good substrates for evaluation of HSV1-tk gene expression.

• Journal of radiological science and technology
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• v.7 no.1
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• pp.79-84
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• 1984

• Journal of the Korean Operations Research and Management Science Society
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• v.37 no.4
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• pp.153-160
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• 2012

This study investigates how discrete choice analysis can be applied to health care operations. Discrete choice analysis helps to understand the complex decision-making process of purchasing expensive medical equipments by identifying relative weights that decision makers impose on each attribute through simple virtual choice experiments. We also verified the usefulness of applying discrete choice analysis to the purchase of medical equipments with empirical evidence.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2005.11a
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• pp.29-29
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• 2005

• Korean Medical Education Review
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• v.16 no.1
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• pp.1-6
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• 2014

The teaching and learning environment in medical schools is significantly different from that of other academic fields. An educational information system specifically designed for medical education could be an important solution for the unique context of medical education. In this study, the concept of the educational information system has been reviewed, and how such a system can be utilized effectively for medical education has also been explored. This paper also addresses how learning management systems for online learning could be made more effective through educational information systems. The application of flipped learning, which has been developing rapidly to improve teaching and learning, for medical education was also investigated. In conclusion, it was found that educational information systems could be a solution to various teaching and learning issues in medical schools. In particular, given that high performing students tend to enter medical schools, using educational information systems to improve the teaching and learning environment in medical school should be investigated further.

• Journal of Oriental Neuropsychiatry
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• v.18 no.3
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• pp.15-21
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• 2007

This study was done to review problems in terms of statistical description and statistical application and analysis. Methods; The authors reviewed 42 statistical clinical study papers excluding 12 Overview papers, 75 Descriptive papers, 48 Animal studies out of 177 papers in the Journal of Oriental Neuropsychiatry in the 5 years from 2002 to 2006. Results : 1) 3 papers(7.1%) had no description of statistical method, only P-values, 25 papaers(59.5%) had tables without description of statistical method, 1 paper (2.3%) had no description of statistical method in study method. 2) 10 papers(23.8%) contained problems in terms of statistical application and analysis. 6papers (6/23, 26.0%) for Student t-test, 2 papers(2/7 28.6%)for $X^2$- test, 1 paper(1/15 6.7%) for the analysis of variance, 1 paper(1/6 16.7%) for Pearson correlation contained statistical problems. Conclusion : It was suggested that consultation of investigators with statisticians and more extensive statistical refereeing, the form of the guidelines for description and application of statistics are needed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.212-221
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• 2007

Objectives : This study was conducted to test patients with Atopic Dermatitis by external application with Gynostemma Pentaphyllum MAKINO in cosmetics. Methods : We gave scores to 59 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Daegu Hanny Oriental Medical Center from July 1st, 2005 to December 31th. We checked the clinic index score(extent. intensity : the degree of erythema, induration or papulation, puritus, excorination, lichenification, scaling or dryness, erosion or oozing or weeping. the degree of itching), Eosinophil count and IgE. Results : There are 46 patients we could check by clinic index score, and 44 patients by laboratory. 1. In the 46 cases clinic index score was significantly decreased between the before- and afterexternal application treatment periods(P<0.01). 2. The 46 cases was devided into two types (moist heat type and blood dryness type) by intensity. External application of Gynostemma Pentaphyllum MAKINO in cosmetics did not significant change by two types. 3. In the 44 laboratory cases, the number of eosinophil counts was decreased but the number of IgE was significantly increased. Conclusions : Considering the above results, we have concluded that cosmetics with Gynostemma Pentaphyllum MAKINO have the remedical effect for Atopic Dermatitis.