• Title/Summary/Keyword: Medical AI

검색결과 454건 처리시간 0.035초

Comprehensive Expression Analysis Suggests Functional Overlapping of Human FOX Transcription Factors in Cancer

  • Zhang, Ya-Li;Sun, Feng-Ting;Zhang, Ze;Chen, Xiao-Xu;Liu, Ai-Xiang;Pan, Jing-Jing;Peng, Fei;Zhou, Shuai;Sun, Li-Jun
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권23호
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    • pp.10475-10481
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    • 2015
  • Forkhead-box (FOX) transcription factors comprise a large gene family that contains more than 50 members in man. Extensive studies have revealed that they not only have functions in control of growth and development, but also play important roles in different diseases, especially in cancer. However, biological functions for most of the members in the FOX family remain unknown. In the present study, the expression of 39 FOX genes in 48 kinds of cancer was mined from the Gene Expression Atlas database of European Bioinformatics Institute. The analysis results showed that some FOX genes demonstrate overlapping expression in various cancers, which suggests particular biological functions. The pleiotropic features of the FOX genes make them excellent candidates in efforts aimed to give medical treatment for cancers at the genetic level. The results also indicated that different FOX genes may have the synergy or antagonistics effects in the same cancers. The study provides clues for further functional analysis of FOX genes, especially for the pleiotropic biological functions and crosstalk of FOX genes in human cancers.

Clinical Efficacy of Endoscopic Pancreatic Drainage for Pain Relief with Malignant Pancreatic Duct Obstruction

  • Gao, Fei;Ma, Shuren;Zhang, Ning;Zhang, Yingchun;Ai, Meina;Wang, Bing
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권16호
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    • pp.6823-6827
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    • 2014
  • Objective: This study was conducted to investigate the efficacy of pancreatic drainage for pain relief in advanced pancreatic cancer. Method: Seventy-one patients with pancreatic carcinoma were divided into two groups: dilated and non-dilated pancreatic ducts. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP), endoscopic biliary stenting and pancreatic stenting. Visual Analog Scale (VAS) scores, pain remission rates and survival time were evaluated during follow-up. Results: The post-ERCP VAS score of the dilated group was lower than that of the non-dilated group at 1 and 3 months post-ERCP. There was no difference at 6 months. The pain remission rate in the dilated duct group was significantly higher than that in non-dilated duct group in 1 and 3 months post-ERCP. The median survival times were 8.17 and 8.22 months respectively. Conclusion: Endoscopic pancreatic drainage can relieve pain of advanced pancreatic cancer accompanied by safe dilation of the pancreatic duct.

BRCA1 Promoter Hypermethylation Signature for Early Detection of Breast Cancer in the Vietnamese Population

  • Truong, Phuong Kim;Lao, Thuan Duc;Doan, Thao Phuong Thi;Huyen, Thuy Ai
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권22호
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    • pp.9607-9610
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    • 2014
  • Breast cancer, a leading cause of death among women in most countries worldwide, is rapidly increasing in incidence in Vietnam. One of biomarkers is the disruption of the genetic material including epigenetic changes like DNA methylation. With the aim of finding hypermethylation at CpG islands of promoter of BRCA1 gene, belonged to the tumor suppressor gene family, as the biomarker for breast cancer in Vietnamese population, sensitive methyl specific PCR (MSP) was carried out on 115 samples including 95 breast cancer specimens and 20 normal breast tissues with other diseases which were obtained from Ho Chi Minh City Medical Hospital, Vietnam. The result indicated that the frequency of BRCA1 hypermethylation reached 82.1% in the cases (p<0.001). In addition, the DNA hypermethylation of this candidate gene increased the possibility to be breast cancer with high incidence via calculated odd ratios (p<0.05). In conclusion, hypermethylation of this candidate gene could be used as the promising biomarker application with Vietnamese breast cancer patients.

Development of a position sensitive CsI(Tl) crystal array

  • Shi, Guo-Zhu;Chen, Ruo-Fu;Chen, Kun;Shen, Ai-Hua;Zhang, Xiu-Ling;Chen, Jin-Da;Du, Cheng-Ming;Hu, Zheng-Guo;Fan, Guang-Wei
    • Nuclear Engineering and Technology
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    • 제52권4호
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    • pp.835-840
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    • 2020
  • A position-sensitive CsI(Tl) crystal array coupled with the multi-anode position sensitive photomultiplier tube (PS-PMT), Hamamatsu H8500C, has been developed at the Institute of Modern Physics. An effective, fast, and economical readout circuit based on discretized positioning circuit (DPC) bridge was designed for the 64-channel multi-anode flat panel PSPMT. The horizontal and vertical position resolutions are 0.58 mm and 0.63 mm respectively for the 1.0 × 1.0 × 5.0 ㎣ CsI(Tl) array, and the horizontal and vertical position resolutions are 0.86 mm and 0.80 mm respectively for the 2.0 × 2.0 × 10.0 ㎣ CsI(Tl) array. These results show that the CsI(Tl) crystal array with low cost could be applied in the fields of medical imaging and high-resolution gamma camera.

Sol-Gel Transition in Di-(2-ethylhexyl) phthalate-Plasticized Poly(vinyl chloride)

  • Lee, Chang-Hyung;Nah, Jae-Woon;Cho, Kil-Won;Kim, Seong-Hun;Hahn, Ai-Ran
    • Bulletin of the Korean Chemical Society
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    • 제24권10호
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    • pp.1485-1489
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    • 2003
  • The gelation for di-(2-ethylhexyl) phthalate (DEHP)-plasticized poly(vinyl chloride) was studied by measuring time-resolved small-angle X-ray scattering (SAXS) and a flow of the solutions in test tube. It was found that for the gelation there were three regimes. At Regime I, the solution rapidly changed to a gel, and the SAXS intensity showed a peak and the peak intensity increased, keeping the peak angle constant. Applying the SAXS intensity to the kinetic analysis of the liquid-liquid phase separation, it was revealed that the spinodal decomposition proceeded to develop a periodic length of 29.9 nanometer in size, a hydrogen-bonding-type association in polymer rich phase followed, and then it induced fast gelation rate. At Regime II, the gelation slowly occurred and the SAXS intensity was not observed, suggesting that a homogeneous gel network was formed by a hydrogen-bonding. At regime III, the solution was a homogeneous sol.

물체의 3-D 형상 복원을 위한 삼각측량 시스템 (A Study on the 3-D Information Abstraction of object using Triangulation System)

  • 김국세;이정기;조애리;배일호;이준
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2003년도 춘계학술발표논문집 (상)
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    • pp.409-412
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    • 2003
  • The 3-D shape use to effect of movie, animation, industrial design, medical treatment service, education, engineering etc... But it is not easy to make 3-D shape from the information of 2-D image. There are two methods in restoring 3-D video image through 2-D image; First the method of using a laser; Second, the method of acquiring 3-D image through stereo vision. Instead of doing two methods with many difficulties, I study the method of simple 3-D image in this research paper. We present here a simple and efficient method, called direct calibration, which does not require any equations at all. The direct calibration procedure builds a lookup table(LUT) linking image and 3-D coordinates by a real 3-D triangulation system. The LUT is built by measuring the image coordinates of a grid of known 3-D points, and recording both image and world coordinates for each point; the depth values of all other visible points are obtained by interpolation.

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A study on improvement of elderly welfare service focusing on the user of AI and the IoT

  • QUAN, Zhixuan;KANG, Minsoo
    • 식품보건융합연구
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    • 제7권5호
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    • pp.1-7
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    • 2021
  • The aging of the population has a fundamental impact on the national economy, including decline in productive population, atrophy of available funds, slowdown of technological innovation, slowdown of economic growth, and decrease in vitality of society as a whole. Increase of elderly population would lead to increase in elderly welfare consumers, which would also lead to increase the demand for elderly welfare services. However, due to the continuation of the low birth rate, there is a great shortage of human resources who can handle this. In such a situation, the main goal of the elderly welfare system in the future should aim to actively try to design effective policies, prepare systems, and implement services for the problems of the aged society, and to find ways to expand the finances, manpower, methods, and facilities necessary for the welfare of the elderly. Elderly welfare services in Korea have been changed and developed in accordance with socioeconomic changes such as industrialization and urbanization. This study examines the changes in elderly welfare services in Korea by the flow of times and presents a method which utilizes artificial intelligence and Internet of Things in services for the elderly welfare consumers to improve both quality and efficiency.

Prediction and Comparison of Electrochemical Machining on Shape Memory Alloy(SMA) using Deep Neural Network(DNN)

  • Song, Woo Jae;Choi, Seung Geon;Lee, Eun-Sang
    • Journal of Electrochemical Science and Technology
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    • 제10권3호
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    • pp.276-283
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    • 2019
  • Nitinol is an alloy of nickel and titanium. Nitinol is one of the shape memory alloys(SMA) that are restored to a remembered form, changing the crystal structure at a given temperature. Because of these unique features, it is used in medical devices, high precision sensors, and aerospace industries. However, the conventional method of mechanical machining for nitinol has problems of thermal and residual stress after processing. Therefore, the electrochemical machining(ECM), which does not produce residual stress and thermal deformation, has emerged as an alternative processing technique. In addition, to replace the existing experimental planning methods, this study used deep neural network(DNN), which is the basis for AI. This method was shown to be more useful than conventional method of design of experiments(RSM, Taguchi, Regression) by applying deep neural network(DNN) to electrochemical machining(ECM) and comparing root mean square errors(RMSE). Comparison with actual experimental values has shown that DNN is a more useful method than conventional method. (DOE - RSM, Taguchi, Regression). The result of the machining was accurately and efficiently predicted by applying electrochemical machining(ECM) and deep neural network(DNN) to the shape memory alloy(SMA), which is a hard-mechinability material.

An overview of deep learning in the field of dentistry

  • Hwang, Jae-Joon;Jung, Yun-Hoa;Cho, Bong-Hae;Heo, Min-Suk
    • Imaging Science in Dentistry
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    • 제49권1호
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    • pp.1-7
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    • 2019
  • Purpose: Artificial intelligence (AI), represented by deep learning, can be used for real-life problems and is applied across all sectors of society including medical and dental field. The purpose of this study is to review articles about deep learning that were applied to the field of oral and maxillofacial radiology. Materials and Methods: A systematic review was performed using Pubmed, Scopus, and IEEE explore databases to identify articles using deep learning in English literature. The variables from 25 articles included network architecture, number of training data, evaluation result, pros and cons, study object and imaging modality. Results: Convolutional Neural network (CNN) was used as a main network component. The number of published paper and training datasets tended to increase, dealing with various field of dentistry. Conclusion: Dental public datasets need to be constructed and data standardization is necessary for clinical application of deep learning in dental field.