• 보건의료산업학회지
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• 제11권4호
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• pp.225-237
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• 2017

Objectives : This study reviews the feasibility of Reciprocal Health Care Agreements (RHCA) between South Korea and Australia. Methods : A literature review was conducted using government reports and media articles. Results : In Australia, the Health Insurance Act enables health care agreements with other nations, but Korea has no similar legislation in place. Therefore, Korea must build a broader consensus on the need for RHCA, based on the precedent of Australia's RHCA with 11 nations, as well as on the Korean Pension Act, which has made reciprocal pension agreements with 28 nations through an exceptive clause. The active government involvement of the Ministry of Health and the Department of Foreign Affairs and Trade in Australia, and the Ministry of Health & Welfare and Ministry of Foreign Affairs in Korea, are essential for a successful RHCA process. Conclusions : RHCA between Australia and Korea would constitute a significant step forward in strengthening people-to-people links between these two trading partners in the spirit of health diplomacy.

• Journal of Microbiology and Biotechnology
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• 제18권12호
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• pp.1884-1889
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• 2008

The ${\beta}$-lactamase inhibitory protein, BLIP-II, found in the culture supernatant of Streptomyces exfoliatus SMF19, shows no discernible sequence identity with other ${\beta}$-lactamase inhibitory proteins identified in Streptomyces spp. A null mutant of the gene encoding BLIP-II (bliB::$hyg^r$) showed a bald appearance on solid media. Although BLIP-II was initially isolated from the supernatant of submerged cultures, sites of BLIP-II accumulation were seen in the cell envelope. Mutation of bliB was also associated with changes in the formation of septa and condensation of the chromosomal DNA associated with sporulation. The bliB mutant exhibited infrequent septa, showing dispersed chromosomal DNA throughout the mycelium, whereas the condensed chromosomes of the wild-type were separated by regularly spaced septa giving the appearance of a string of beads. Therefore, on the basis of these results, it is suggested that BLIP-II is a regulator of morphological differentiation in S. exfoliatus SMF19.

• 패션비즈니스
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• 제21권2호
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• pp.1-15
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• 2017

This study aims to identify the special features of high-concept funology observed in fashion products and expressional media by exploring funology in an era of high-concept, the emotional paradigm of the 21st century. High-concept funology in today's fashion can be explained as follows: First, 'virtual reality', which is often seen in fashion shows and fashion commercials, enhances consumer participation and involvement with blurred boundaries between the real world and the virtual world. With the expansion of various forms of real-time communication with consumers, positive images of the brand are being projected to the consumers. Second, 'form transformability', which is often found in fashion products, promotes customers' purchase desire as they are able to present themselves in a more versatile way in the fashion product that is changeable in various designs. Third, 'integration of different fields', which is easily found in various fashion goods, engages consumers in a mutual interaction under an entertaining setting with the product that is made to satisfy their needs attuned to their digital lifestyle. Fourth, 'interactive responsiveness', which is mainly recognized in fashion stores and commercials, is characterized by its interactive playfulness that encourages consumer participation through entertainment contents and promotes brand intimacy, eventually adding more value to its name.

• Biomolecules & Therapeutics
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• 제14권1호
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• pp.25-29
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• 2006

We tested effects of bioactive lysophospholipids including lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), sphingosylphosphorylcholine (SPC), and sphingosine I-phosphate (S1P) on membrane potential in C6 glioma cells to understand action mechanism of the lysophospholipids. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded glioma cells. LPA largely increased membrane potential and the increase was gradually diminished. LPC also increased the membrane potential, however, the increase sustained. SPC induced smaller increase of membrane potential than LPC. SIP was not able to change the membrane potential. We tested effects of suramin and pertussis toxin on lysophospholipid-induced membrane potential increase. However, there wasn't any effect. The membrane potential increase was partially diminished in $Na^+$-free media, suggesting $Na^+$ influx as a component of membrane potential changes. Thus, involvement of $Na^+$ influx in the increase of membrane potential by lysophospholipids and independence of suramin-sensitive GPCRs and pertussis toxin-sensitive G proteins are found in this study.

• Asia Pacific Journal of Business Review
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• 제1권1호
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• pp.40-55
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• 2016

Information and Communication Technology (ICT) has the potential to provide economic opportunities and help raise the social and political status of countries. For developing countries, ICT can be used as a tool for economic growth and social advancement in a short period of time. The benefits of ICT, however, are not only economic in nature. It can help improve professional skills, teaching quality, job creation, agricultural production, community involvement, and information use, personal relationships, and time use. These benefits are examples of how ICT has become an indispensable part of our lives. Myanmar is a developing country and is ranked low in the ICT Development Index. In terms of ICT development, Myanmar today is facing many issues such as a lack of telecommunication infrastructure, ICT awareness, electricity, and budget for ICT development. Among the economic reforms implemented by the recent government, the telecommunications sector has been opened up as a measure of economic reform. As a result of this reform, the telecommunications sector has been growing rapidly. Myanmar, however, remains behind other Asian countries. This paper discusses Myanmar's ICT infrastructure status, progress that has been made in the country's telecommunications over the last fifteen years, and the challenges that lie ahead.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.86-93
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• 2004

Nitric oxide (NO) has emerged as an important intracellular and intercellular messenger, controlling many physiological processes and participating in the fertilization process via the autocrine and paracrine mechanisms. This study investigated whether nitric oxide synthase (NOS) inhibitior (L-NAME) and L-arginine could regulate in vitro fertilization and early embryonic development in mice. Mouse epididymal spermatozoa, oocytes, and embryos were incubated in mediums of variable conditions with and without L-NAME or L-arginine (0.5, 1, 5 and 10mM). Fertilization rate and early embryonic development were significantly inhibited by treating sperms or oocytes with L-NAME (93.8% vs 66.3%,92.1% vs 60.3%), but not with L-arginine. In contrast, fertilization rate and early embryonic development were conspicuously reduced when L-NAME or L-arginine was added to the culture media for embryos. Early embryonic development was inhibited by microinjection of L-NAME into the fertilized embryosin a dose-dependent manner, but only by high concentrations of L-arginine. These results suggest that a moderate amount of NO production is essential for fertilization and early embryo development in mice.

• Journal of Contemporary Eastern Asia
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• 제20권2호
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• pp.19-34
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• 2021

The purpose of this study is to introduce a synergetic configuration of stakeholders, especially government and university, into the corporate social responsibility strategy. The alignment of a company's CSR efforts with its business practices and values must be communicated strategically for effective and successful business outcomes. Therefore, the proposed process of CSR evaluation takes into account the three helices of the Triple-Helix perspective, university, industry, and government (UIG), and investigates how involvement in the Triple Helix actors influence corporations with CSR initiatives. Specifically, whether the public's awareness of a corporation's CSR activities is heightened by the concurrent support of the three helixes will be examined. We propose a methodology that enables corporations to determine effective levels of integration with government and educational institutions. The intensity of Triple-Helix indicators will be examined.

• 벤처창업연구
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• 제16권1호
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• pp.147-159
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• 2021

2020년 코로나19 팬데믹 현상 이후에 소비자들의 온라인 소비가 급증하고 있으며 무점포 온라인 소매판매채널이 높은 성장세를 보이고 있다. 특히 소셜미디어가 기업의 브랜드와 제품을 알리는 홍보수단에서 직접적인 거래가 발생하는 SNS마켓으로서 위상이 높아지고 있다. 본 연구에서는 코로나19 팬데믹 현상 이후 달라진 소비자들의 행동변화가 온라인에서 농식품을 구매하는 경우 기존 인터넷 쇼핑몰과 개방형 SNS마켓과 폐쇄형 SNS마켓 등의 온라인 쇼핑매체를 선택하는데 어떠한 차이를 보이는지, 또한 농식품 제품 선택에 있어서 어떠한 유형의 제품을 선호하는지를 알아보고자 하였다. 본 연구를 위해 독립변수로 소비자의 인구통계학적 특성, 소비자 지각위험, 식생활 라이프스타일로 설정하여 온라인 구매채널 유형과 농식품 제품 선택에 미치는 영향을 알아보았다. 실증분석 결과를 요약하면 다음과 같다. 소비자들이 온라인에서 농식품을 구매하는 경우 인터넷 쇼핑몰과 개방형 SNS마켓, 폐쇄형 SNS마켓 등의 쇼핑채널을 선택하는데 있어 인구통계학적 특성과 소비자지각위험, 식생활 라이프스타일의 세부요인에서 다음과 같은 유의미한 차이가 있는 것으로 나타났다. 개방형 SNS마켓을 선택하는 소비자는 여성보다 남성이 높고, 가구소득이 낮으며 건강과 맛을 추구하는 소비자들이 높게 나타났다. 폐쇄형 SNS마켓을 선택하는 소비자는 지방에 거주하며 배송에 대한 위험인지도가 높은 소비자들로 분석되었다. 기존 인터넷 쇼핑몰을 선택하는 소비자는 학력이 높고 개인소득이 높으며 맛과 경제성을 추구하는 소비자들이 높은 것으로 나타났다. 본 연구를 통해 자신의 제품특성에 적합한 온라인쇼핑매체를 선택하는데 어려움을 겪는 농업인들에게 판단의 단초를 제공하여 실무적인 도움을 주고자 하였으며, 농식품 쇼핑채널로서 소셜미디어를 단순 홍보채널이 아닌 직접적인 거래가 발생하는 마켓으로서 접근하였다는 점에서 기존 연구들과 차별화 할 수 있다.

• Archives of Pharmacal Research
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• 제28권8호
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• pp.948-955
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• 2005

Glomerular mesangial cells (GMCs) in diverse renal diseases undergo cell proliferation and/or hypertrophy, and gangliosides have been reported to play an important role in modulating cell structure and function. This study compared the effects of transforming growth $factor-\beta\; (TGF­\beta1)$ and the effects of the application of exogenous gangliosides on GMCs and investigated whether the application of exogenous gangliosides regulated cellular proliferation and hypertrophy. Human GMCs were cultured with exogenous gangliosides and $TGF-\beta1$ in a media containing $10\%$ fetal bovine serum and in a media without the fetal bovine serum. Exogenous gangliosides biphasically changed the proliferation of human GMCs (0.1-1.0 mg/mL). A low concentration (0.1 mg/mL) of gangliosides mainly increased the number of human GMCs, whereas cellular proliferation was significantly reduced by raising the concentration of exogenous gangliosides. $TGF-\beta1$ greatly reduced the number of human GMCs in a concentration­dependent manner (1-10 ng/mL). Serum deprivation accelerated the gangliosides- and $TGF­\beta1-induced$ inhibition of mesangial cell proliferation to a greater extent. Gangliosides (1.0 mg/ mL) and $TGF-\beta1$ (10 ng/mL) both caused a significant increase in the incorporation of $[^3H]leucine$ per cell in the serum-deprived condition, whereas it was completely reversed in serum­supplemented condition. Similar results to the $[^3H]leucine$ incorporation were also observed in the changes in cell size measured by flow cytometric analysis. These results show that exogenous gangliosides modulate cell proliferation and hypertrophy in cultured human GMCs, and these cellular responses were regulated differently based on whether the media contained serum or not. Results from the present study raise new possibilities about the potential involvement of gangliosides in the development of mesangial cell proliferation and hypertrophy.

• 대한수의학회지
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• 제36권2호
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• pp.305-312
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• 1996

Cell volume regulatory mechanisms are usually disclosed by exposure of cell to anisotonic media. If a cell is suddenly exposed to hypotonic media, it swells initially like an osmometer but within minutes regains its original cell volume. This behavior has been labelled as regulatory cell volume decrease(RVD). RVD is believed to result from the loss of permeable ions through the membrane. In this study, we examined hypotonically induced changes in the membrance currents involved in RVD by using whole cell voltage clamp technique in the unfertilized hamster egg. At -40mV of the holding potential, the stationary current was maintained in the hamster egg exposed to isotonic solution composed of, mainly, 115mM NaCl and 40mM mannitol. Hypotonic solution was prepared by removing mannitol. Therefore, the concentrations of $Na^+$ and $Cl^-$ in this hypotonic media were the same as those in the isotonic solution. Following 30 to 60 sec after applying the hypotonic media to the egg, the inward current was evoked. This inward current was eliminated by $100{\mu}M$ 4-acetamido-4'-isothiocyanostil-bene-2,2'-disulfonic acid(SITS), an anion channel blocker, leaving the small outward current component. Further addition of 2mM $Ba^{2+}$, a broad $K^+$ channel blocker, completely abolished the small outward current left even in the presence of SITS during hypotonic stress. These results suggest that $K^+$ and $Cl^-$ move out of cells, resulting in RVD. To test the involvement of $Na^+$ in RVD, 20mM Na-isethionate was substituted for mannitol in isotonic media(135mM $Na^+$) and Na-isethionate (20mM) was freed the hypotonic solution. Only $Cl^-$ concentration in both isotonic and hypotonic media was kept constant at 115mM, whereas concentration of $Na^+$ was lowered in hypotonic solution to 115mM from 135mM in isotonic solution. Hypotonic medium induced the outward current in the egg equilibrated isotonically. This current was reduced by $100{\mu}M$ SITS but was augmented by 2 mM $Ba^{2+}$. In terms of RVD, these results imply that $Cl^-$ efflux is coupled with $K^+$, maybe for electroneutrality during hypotonic stress and/or with $Na^+$ via unknown transport mechanism(s). From the overall results, the hypotonic stress facilitates the movement of $Cl^-$ and $K^+$ out of the hamster egg to regain cellular volume with electroneutrality. If there exist a difference in $[Na^+]_0$ between isotonic and hypotonic solution, another transport mechanism concerned with $Na^+$ may, at least partly, participate in regulatory volume decrease.