• Proceedings of the KSME Conference
• /
• 2001.11a
• /
• pp.258-265
• /
• 2001

Turbine blade is subject to force of three type ; torsional force by torsion-mount, centrifugal force by rotation of rotor and cyclic bending force by steam pressure. Cyclic bending force of them is main factor on fatigue fracture. In the X-ray diffraction method, the change in the values related to plastic deformation and residual stress near the fracture surface mat be determined, and information of internal structure of material can be obtained. Therefore, to find a fracture mechanism of torsion-mounted blade in nuclear plant, based on the information from the fracture surface obtained by fatigue test, the correlation of X-ray parameter and fracture mechanics parameter was determined, and then the load applied to actual broken turbine blade parts was predicted. Failure analysis is performed by finite element method and Goodman diagram on torsion-mounted blade.

• Korean Journal of Plant Resources
• /
• v.35 no.3
• /
• pp.391-398
• /
• 2022

Ulcerative colitis (UC) is a typical inflammatory colon disorder. Platycodon grandiflorum (PG) is known to exert various beneficial effects including anti-oxidative and anti-bacterial properties and improvements in liver function. However, the improving effect and mechanism of PG on intestinal inflammation are not fully understood. The present research was designed to investigate the effect of PG on the clinical signs of DSS-induced colitis in mice. The ameliorative effects of PG on inflammatory cytokine expression and the activation of hypoxia-inducible-factor (HIF)-1α in DSS-treated colon tissue were also determined. Our results showed that mice treated with DSS displayed the main clinical symptoms of colitis, including weight loss, bloody stools, decrease in colon length and diarrhea and PG treatment significantly improved the clinical features induced by DSS in mice. PG inhibited the increase in the levels of inflammatory cytokines caused by DSS in colon tissues. We also showed that the anti-inflammatory mechanism of PG involved suppressing the activation of HIF-1α in DSS-treated colon tissues. Collectively, the findings of this study indicate the prospect of developing new drugs from PG for UC treatment.

• Journal of Korea Foundry Society
• /
• v.28 no.3
• /
• pp.129-135
• /
• 2008

The reheating stage of electromagnetically stirred Al billet is a critical factor in the thixoforming process. When reheated to the solid-liquid state, the microstructure evolves to a more globular and more homogeneous structure by a coarsening mechanism, the kinetics depending on the initial microstructure. Microstructural evolution has been characterized by conventional parameters (mean size of particle and shape factor) as a function of holding time in the solid-liquid state. The aim of this study is to report experimental results concerning microstructural evolution in the solid-liquid state of electromagnetically stirred Al billet. The material was elaborated in the form of continuously cast bars solidified with electromagnetic stirring to degenerate the dendritic structure. The choice of the reheating conditions is determined by a dendritic ripening and coalescence mechanism, involving variations of both the shape and size of the particles. The reheating time has to be long enough to allow a minimum degree of spheroidizing, but has to be limited as much as possible in order to avoid excessive ripening. The optimum microstructure was obtained at the reheating temperature of near $584^{\circ}C$ and the holding time of 5 min. The only means of combining high productivity with good casting quality was to use feedstock billets whose microstructure showed rapid transformation characteristics.

• Journal of the Korea Concrete Institute
• /
• v.18 no.5 s.95
• /
• pp.639-648
• /
• 2006

A shear experiment of one-way monotonic loading was carried out with the shear span ratio as the main experimental variable for reinforced concrete beam. Using the finite element analysis as the experimental analysis tool and the analysis method to compute the shear resistance of small shear span ratio, a new macro-model composed of crooked main strut and sub strut is proposed in consideration of the effect of bond action between re-bar and concrete based on the experimental result. The experimental finding affirmed the validity of the proposed macro-model when the shear span ratio was at or below 0.75 and confirmed that the experimental result was the most consistent with the computed analysis result when the effective factor of concrete compressive strength was set at 0.75.

• Journal of the Korean earth science society
• /
• v.28 no.5
• /
• pp.613-619
• /
• 2007

Mesoscale low is often observed over the downstream region of the East Sea (or, northwest coast off the Japan Islands) during East-Asia winter monsoon. The low system causes a heavy snowfall at the region. A series of numerical experiments were conducted with the aid of a regional model (MM5 ver. 3.5) to examine the formation mechanism of the mesoscale low. The following results were obtained: 1) A well-developed mesoscale low was simulated by the regional model under real topography, NCEP reanalysis, and OISST; 2) The mesoscale low was simulated under a zonally averaged SST without topography. This implies that the meridional gradient of SST is the main factor in the formation of a mesoscale low; 3) A thermal contrast ($>10^{\circ}C$) of land-sea and topography-induced disturbance served as the second important factor for the formation; 4) Paektu Mountain caused the surface wind to decelerate downstream, which created a more favorable environment for thermodynamic modification than that was found in a flat topography; and 5) The types of cumulus parameterizations did not affect the development of the mesoscale low.

• The Korean Journal of Physiology and Pharmacology
• /
• v.5 no.1
• /
• pp.47-53
• /
• 2001

Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as a stress factor on vasculature and indirectly modulates vascular contractility. After end of exposure to 1, 2.5 and 5% ethanol for 45 min, rat aortic strips were subjected to contractile responses, immunoblot for Hsp70 and the measurement of levels of myosin light chain phosphorylation. Exposure to 5% ethanol not only augmented contractions to KCl or phenylephrine, but also increased expression of Hsp70 and the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by $1\;{\mu}mol/L$ phorbol 12,13-dibutyrate, a protein kinase C activator, whether the tissues were exposed to 5% ethanol or not. This is the first report to show that even short exposure to ethanol has a delayed effect to increase vascular smooth muscle contractility through a modulation of thick filament regulation. It may be a mechanism by which ingestion of alcohol induces hypertension.

• Journal of Microbiology
• /
• v.39 no.1
• /
• pp.67-73
• /
• 2001

A validation study was conducted to evaluate the efficacy and mechanism of the cryo-precipitation, monoclonal anti-FVIIIc antibody (mAb) chromatography, Q-Sepharose chromatography, and lyophilization steps involved in the manufacture of high purity factor VIII (GreenMono) from human plasma, in the removal and/or inactivation of hepatitis A virus (HAV). Samples from the relevant stages of the production process were spiked with HAV and subjected to scale-down processes mimicking the manufacture of the high purity factor VIII concentrate. Samples were collected at each step and immediately titrated using a 50% tissue culture infectious dose (TCID$\_$50/) and then the virus reduction factors were evaluated. HAV was effectively partitioned from factor VⅢ during cryo-precipitation with the log reduction factor of 3.2. The mAb chromatography was the most effective step far removal of HAV with the log reduction factor of $\geq$4.3. HAV infectivity was not detected in the fraction of factor VⅢ, while most of HAV infectivity was recovered in the fractions of flow through and wash during mAb chromatography. Q-Sepharose chromatography showed the lowest efficacy for partitioning HAV with the log reduction factor of 0.7. Lyophilization was an effective step in inactivating HAV with the log reduction factor of 2.3. The cumulative lag reduction factor, $\geq$10.5, achieved for tile entire manufacturing process was several magnitudes greater than the potential HAV load of current plasma pools.

• Korean Chemical Engineering Research
• /
• v.44 no.6
• /
• pp.555-562
• /
• 2006

Recently, liquid chromatography (LC) has been used more frequently to separate drugs and natural substances. Especially, to selection of the solutes from the products, the operation condition of analytical chromatography should be necessarily determined. So accurate computer modeling and simulation of chromatographic performances has become a necessary part of the development and design of processes. High-Purity Separation Lab. Inha University developed the resulting HCI software for the purpose of the optimization of chromatographic performances. The HCI program was utilized to find the optimum operating condition more accurately and rapidly, reducing the number of many possible experiments. The elution profiles were calculated by the plate theory based on the three retention mechanism of capacity factor.

• Journal of Satellite, Information and Communications
• /
• v.8 no.2
• /
• pp.36-43
• /
• 2013

In this study, the high current behaviors and double snapback mechanism of gate grounded_extended drain n-type MOSFET(GG_EDNMOS) device were analyzed in order to realize the robust electrostatic discharge(ESD) protection performances of high voltage operating display driver IC(DDIC) chips. Both the transmission line pulse(TLP) data and the thermal incorporated 2-dimensional simulation analysis as a function of ion implant conditions demonstrate a characteristic double snapback phenomenon after triggering of bipolar junction transistor(BJT) operation. Also, the background carrier density is proven to be a critical factor to affect the high current behavior of the GG_EDNMOS devices.

• ETRI Journal
• /
• v.40 no.5
• /
• pp.604-612
• /
• 2018

To solve the problem of unbalanced loads and the short network lifetime of heterogeneous wireless sensor networks, this paper proposes a node-selection algorithm based on energy balance and dynamic adjustment. The spacing and energy of the nodes are calculated according to the proximity to the network nodes and the characteristics of the link structure. The direction factor and the energy-adjustment factor are introduced to optimize the node-selection probability in order to realize the dynamic selection of network nodes. On this basis, the target path is selected by the relevance of the nodes, and nodes with insufficient energy values are excluded in real time by the establishment of the node-selection mechanism, which guarantees the normal operation of the network and a balanced energy consumption. Simulation results show that this algorithm can effectively extend the network lifetime, and it has better stability, higher accuracy, and an enhanced data-receiving rate in sufficient time.