• 대한본초학회지
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• 제23권4호
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• pp.71-79
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• 2008

Objectives: SimJeok-Hwan(CP, Cardiotonic Pills) was made to treat patients with coronary arteriosclerosis, angina pectoris and hyperlipidemia. This study was designed to investigate the effects of CP on Proliferation rates neuroglia cells and protective effect of CP against oxidative stress, and also investigate the effects on regional Cerebral Blood Flow(rCBF) in normal rats. Methods: In this experiment, effects of CP on proliferation rates of neuroglia cells were measured using modified MTT methods. Oxidative stress was induced by treatment with 200 mM of hydrogen peroxide for 2 hr. rCBF and MABP were measured using Laser doppler flowmeter. Results: Treatment with CP elevated proliferation rates in C6 cells. In addition, CP protected cell death of C6 cells induced by oxidative stress. In results, rCBF was elevated by treatment with CP in normal rats. But, Mean Arterial Blood Pressure(MABP) did not affected by CP. In addition, the elevation of rCBF was blacked by pre-treatment with 1 mg/kg of indomethacin effectively. On the other hand, pre-treatment with 0.01 mg/kg of methylene blue did not affect rCBF level in normal rats. Conclusions: In conclusion, these results suggest that CP can act as anti-oxidant to protect neuroglia cells and also suggest that CP can elevate rCBF, which are involved in cyclooxygenase pathway.

• The Korean Journal of Physiology
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• 제14권1호
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• pp.1-5
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• 1980

This study was under taken to investigate the influences of predictable or unpredictable stress upon gastric ulceration, and the hippocampectomy upon the ulceration order the stressful conditions. Sixty male albino rats(Sprague-Dawley strain) were divided equally into 3 groups: One was the hippocampal group(N=20) which received hippocampal ablation by suction, another was the cortical control group(N =20) which received partial cortical ablation over the hippocampus, and a third was the normal control group(N=20). Each group was further divided into two subgroups: One was the predicted subgroup(N=10) in which animals could predict the imminent stressful stimuli by hearing a sound(1,000 Hz, 2 sec in duration) 3 sec before the onset of the stress, and the other was the unpredicted subgroup(N=10). After starvation for 24 hours, but water ad libitum, each rat received the electric stimulation(3 mA, 60 Hz, 2 sec in duration, and once per minute in average) for 6 hours via a pair of electrodes attached on the tale. The electric stimulation served as the stress causing the gastric ulcer. Five hours after completion of stimulation, the stomach filled with the physiological saline was removed under deep anesthesia and spread out on a small glass plate. The numbers of the ulcer in each stomach were counted and the shape was examined under the dissecting microscope. Results obtained were as follows: 1. The mean numbers of the ulcer of the predicted subgroups were significantly larger than those of the unpredicted subgroups in the normal control and the cortical control groups, but there was no difference between the values of the two subgroups in the hippocampal group. 2. The mean numbers of the ulcer of the predicted subgroups in the normal control and the cortical control groups were larger(but not significant) than that in the hippocampal group. It is inferred from the above results that the prediction of the stress strengthens the effect of the stress on the gastric ulceration, and the hippocampus facilitates the effect of the prediction of the stress.

• Journal of Welding and Joining
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• 제10권4호
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• pp.250-258
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• 1992

In order to clarify the mechanical behavior of welding crack and to evaluate the mechanical characteristics of welded parts in thick plate, it is very important to accurately predict the welding deformation and residual stress including transient state before welding. In this paper, the theory of a three-dimensional elasto-plastic problem for the analysis of mechanical phenomenon of welding joint on the plate is developed into an efficient and accurate method based on the finite element method, and then several examples are considered by using the proposed model. The results of numerical analyses are discussed in the viewpoint of the mechanical characteristics of the distribution of three-dimensional welding residual stresses, plastic strains and their production mechanism on the thick plate.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.227-236
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• 2018

본 연구는 심리적 스트레스 경험과 해마 용적의 차이를 체계적이고 종합적으로 검증하기 위해 메타분석을 실시하였다. 메타분석을 위해 1990년도에서 2016년도까지 출판된 국외 문헌들 중 스트레스를 경험한 개인의 해마 용적을 측정한 연구들을 대상으로, PRISMA에 따라 스트레스 경험 집단과 정상 집단 간의 해마 용적 차이를 확인하였다. MRI를 사용하여 해마용적의 평균, 표준편차, 사례수가 제시된 연구들이 분석에 사용되었고, 13편의 연구(스트레스 경험 374명, 정상 대상자 439명)가 최종 선별되었다. 스트레스원의 유형에 따라서는, 전쟁관련 연구 8편, 개인적 외상사건 관련 연구 5편으로 나눌 수 있다. 전체 메타분석에서 효과크기는 -0.70(-1.04; -0.37)이었고, 스트레스원으로 나누어 분석하였을 때, 전쟁 관련 하위집단에서의 효과크기는 -0.47(-0.78; -0.16), 개인적 외상사건 관련 하위집단에서의 효과크기는 -0.91(-1.57; -0.26)으로 나타났다. 분석 결과, 스트레스의 경험과 해마 용적 간의 유의한 부적 상관이 확인되었다. 만성적인 스트레스 요인과 그로 인한 환자 집단들의 해마 용적은 각 연구 간 이질성이 높은 편이었지만, 3개의 연구를 제외하고 모두 해마 용적이 통제집단에 비해 작게 나타났다.

• 대한지역사회영양학회지
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• 제14권2호
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• pp.175-181
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• 2009

The purpose of this study was to investigate the relationships of stress, depression, binge eating and food behavior of high school girls with their degree of BMI. One hundred twenty high school girls from the Seoul metropolitan area participated in this study. Self-administrated questionnaires to search for degree of stress, depression, binge eating, and food behavior were distributed. Anthropometric assessment was carried out to calculate the body mass index(BMI). The results are as follows: The mean of age and BMI of the subjects were $17.6{\pm}0.6$ years and $21.0{\pm}2.9kg/m^2$(ranged from 15.4 to $31.7kg/m^2$), respectively. 16.7%, 65.8% and 17.5% of the subjects were classified as under weight, normal weight and overweight, respectively. The average scores of stress, depression and binge eating were $124.9{\pm}31.4$, $15.2{\pm}9.8$, $29.5{\pm}7.8$ points, respectively. The food behavior score was $11.5{\pm}2.4$ points. Their degree of stress, depression, binge eating was significantly higher in overweight high school girls compared to underweight or normal weight high school girls. There were significant correlations of BMI with stress(p<0.05), depression(p<0.001), and binge eating(p<0.01). Also there were significant correlations of food behavior with stress(p<0.05), depression(p<0.05) and binge eating(p<0.001). These results indicate that the high school girls who have higher BMI seem to have more stress, depression, and binge eating habits. Also the high school girls who have more stress, depression and binge eating habits have poor food behaviors. Therefore proper control of emotions is required to maintain desirable food behaviors in high school girls.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.585-590
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• 2001

Turbine blade is subject to torsional load by torsion-mount, centrifugal load by rotation of rotor and repeated bending load by steam pressure. Turbine with partially cracked blade has normal working condition at initial repair time but vibratory working condition at middle repair time due to crack growth. Finite element analysis on turbine blade indicates that repeated bending load out of all loads is the most important factor on fatigue strength of turbine blade. Therefore, this study shows root mean square roughness has linear relation with stress intensity factor range in 12% Cr steel and can predict loading condition of fractured turbine blade.

• 한국자동차공학회논문집
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• 제9권6호
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• pp.170-177
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• 2001

Turbine blade is subject to torsional load by torsion-mount, centrifugal load by rotation of rotor and repeated bending load by steam pressure. Turbine with partially cracked blade has normal working condition at initial repair time but vibratory working condition at middle repair time due to crack growth. Finite element analysis on turbine blade indicates that repeated bending load out of all loads is the most important factor on fatigue strength of turbine blade. Therefore, this study shows root mean square roughness has linear relation with stress intensity factor range in 12% Cr steel and can predict loading condition of fractured turbine blade.

• Steel and Composite Structures
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• 제38권5호
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• pp.563-582
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• 2021

The present study experimentally and analytically investigated the push-out behaviour of H-shaped steel section embedded in ultrahigh-performance fibre-reinforced concrete (UHPFRC). The effect of significant parameters such as the concrete types, fibre content, embedded steel length, transverse reinforcement ratio and concrete cover on the bond stress, development of bond stress along the embedded length and failure mechanism has been reported. The test results show that the bond slip behaviour of steel-UHPFRC is different from the bond slip behaviour of steel-normal concrete and steel-high strength concrete. The bond-slip curves of steel-normal concrete and steel-high strength concrete exhibit brittle behaviour, and the bond strength decreases rapidly after reaching the peak load, with a residual bond strength of approximately one-half of the peak bond strength. The bond-slip curves of steel-UHPFRC show an obvious ductility, which exhibits a unique displacement pseudoplastic effect. The residual bond strength can still reach from 80% to 90% of the peak bond strength. Compared to steel-normal concrete, the transverse confinement of stirrups has a limited effect on the bond strength in the steel-UHPFRC substrate, but a higher stirrup ratio can improve cracking resistance. The experimental campaign quantifies the local bond stress development and finds that the strain distribution in steel follows an exponential rule along the steel embedded length. Based on the theory of mean bond and local bond stress, the present study proposes empirical approaches to predict the ultimate and residual bond resistance with satisfactory precision. The research findings serve to explain the interface bond mechanism between UHPFRC and steel, which is significant for the design of steel-UHPFRC composite structures and verify the feasibility of eliminating longitudinal rebars and stirrups by using UHPFRC in composite columns.

• Journal of Advanced Marine Engineering and Technology
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• 제29권8호
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• pp.923-928
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• 2005

The estimation of fatigue life at the design stage of the compressed air tank on board is very important in order to arrive at feasible and reliable solutions considering the total lifetime of the tank. In this paper the compressed air tank on board was selected as a model and the change of inside pressure of the tank during normal navigation period was measured and the cycle of fluctuation stress was presumed statistically based on this. Also the effect of stress concentration with the FEM analysis on the longitudinal weld and the mean stress effect on the fatigue strength of compressed air tank were discussed.

• 한국지반공학회지:지반
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• 제6권4호
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• pp.33-42
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• 1990

정적관입저항 또는 선단지지말뚝의 선단지지력을 해석함에 있어서는 유효수직응력이 기준음력으로 사용되어 왔다. 그러나 정적관입저항은 유효수직응력보다 원위치 유효수평응력에 관계된다는 것이 많은 실험연구결과로부터 보고 되었다. 이와같은 문제점을 규명하기 위하여 기 보고된 실험결과를 다시 분석하였으며 실험실에서의 관입시험이 실시되었다. 연구결과 정적관입저항은 유효수직 응력과 유효수평응력 모두에 영향을 받는 것으로 나타나고 있으며 해석시에는 평균주응력이 기준응력으로 사용되어야 함을 결론 지을 수 있었다.