• Communications for Statistical Applications and Methods
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• v.6 no.2
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• pp.543-564
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• 1999

The principal aim of a sequential phase I clinical trial in which the toxicity reponses of a group of patient(s) determine the dose level of the next patient(s) group is to estimate the maximal tolerated dose(MTD) of a new drug, In this paper we compared with a simulation study the performance of the MTD estimates that are determined by a stopping rule in a design and also those that are determined by analyzing the data after a clinical trial is terminated. To the latter belong the mean median mode and maximum likelihood estimates. For the Standard Methods the stopping rule MTD is quite inefficient but the median MTD has a best efficiency and is robust with respect to the three different toxicity curves. The problem of non-convergence of MLE MTD is severe. A more improved MTD estimate is produced by combining the advantages of the various MTD estimates and its efficiency is better than the single median MTD estimate especially for the toxicity curve of an unlucky choice of dose levels. The simulation results suggest that simple types of phase I designs can be combined with relatively standard analytic techniques to provide a more efficient MTD estimate.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.159-163
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• 2013

Background: This study used Surveillance, Epidemiology and End Results (SEER) pancreatic cancer data to identify predictive models and potential socio-economic disparities in pancreatic cancer outcome. Materials and Methods: For risk modeling, Kaplan Meier method was used for cause specific survival analysis. The Kolmogorov-Smirnov's test was used to compare survival curves. The Cox proportional hazard method was applied for multivariate analysis. The area under the ROC curve was computed for predictors of absolute risk of death, optimized to improve efficiency. Results: This study included 58,747 patients. The mean follow up time (S.D.) was 7.6 (10.6) months. SEER stage and grade were strongly predictive univariates. Sex, race, and three socio-economic factors (county level family income, rural-urban residence status, and county level education attainment) were independent multivariate predictors. Racial and socio-economic factors were associated with about 2% difference in absolute cause specific survival. Conclusions: This study s found significant effects of socio-economic factors on pancreas cancer outcome. These data may generate hypotheses for trials to eliminate these outcome disparities.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.4
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• pp.44-50
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• 1998

The creep life fraction can be evaluated by the degree of grain deformation since the grain of Cr-Mo base metal deforms in the direction of stress. The grain deformation method using image processing technique is developed for life assessment of in-service high-temperature components. The new assessment model of grain deformation method is presented to apply to in-service components and is verified by interrupted creep test for ex-serviced material of 1Cr-0.5Mo steel. The proposed model, which is irrespective of stress direction, is to evaluate mean of the absolute deviation for the measured ratios which are diametrical maximum to minimum dimensions for grains.

• Journal of The Korean Astronomical Society
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• v.23 no.2
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• pp.97-105
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• 1990

The tidal radii of globular clusters reflect the tidal field of the Galaxy. The mass distribution of the Galaxy thus may be obtained if the tidal fields of clusters are well known. Although large amounts of uncertainties in the determination of tidal radii have been obstacles in utilizing this method, analysis of tidal density could give independent check for the Galactic mass distribution. Recent theoretical modeling of dynamical evolution including steady Galactic tidal field shows that the observationally determined tidal radii could be systematically larger by about a factor of 1.5 compared to the theoretical values. From the analysis of entire sample of 148 globular clusters and 7 dwarf spheroidal systems compiled by Webbink (1985), we find that such reduction from observed values would make the tidal density (the mean density within the tidal radius) distribution consistent with the flat rotation curve of our Galaxy out to large distances if the velocity distribution of clusters and dwarf spheroidals with respect to the Galactic center is isotropic.

• Proceedings of the KIEE Conference
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• 2001.05a
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• pp.89-91
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• 2001

This paper presents the result of pattern classification of load demand for distribution transformer in domestic. The field data of load demand is measured using the load acquisition device and the measurement data is used for the database system for load management of distribution transformed. For the pattern classification, the load data and the customer information data are also used. The K-MEAN method is used for the pattern classification algorithm. The result of pattern classification is used for the 2-step format of load demand curve.

• Journal of the Korean Data and Information Science Society
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• v.26 no.3
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• pp.749-754
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• 2015

This article presents Bayesian approach to regression splines with knots on a grid of equally spaced sample quantiles of the independent variables under functional measurement error model.We consider small area model by using penalized splines of non-linear pattern. Specifically, in a basis functions of the regression spline, we use radial basis functions. To fit the model and estimate parameters we suggest a hierarchical Bayesian framework using Markov Chain Monte Carlo methodology. Furthermore, we illustrate the method in an application data. We check the convergence by a potential scale reduction factor and we use the posterior predictive p-value and the mean logarithmic conditional predictive ordinate to compar models.

• 유체기계공업학회:학술대회논문집
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• 2000.12a
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• pp.65-74
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• 2000

A five path ultrasonic and/or magnetic flowmeter were installed after valve. Five path ultrasonic flowmeter were tested to obtain it's performance in a water flow standard system and magnetic flowmeter. It's varied with straight pipe length(nD), install direction and valve position. All the results are summerized. The multi-path flowmeters(MUF) showed up to $\pm0.5{\%}$ at a 2, 4, 8, 15D spacing : the MUF was significantly better than magnetic flowmeter at disturbed flow conditions.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.12
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• pp.1375-1382
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• 2009

The objective of this paper is to apply the load ratio method to the measurement of the crack length of the real scale pipe specimen. The load ratio method was modified and finite element analyses were performed to derive the relationship between the normalized compliance and the normalized crack length for the pipe specimen. In order to measure the crack length, the direct current potential drop method and the modified load ratio method were applied to the pipe test. The applicability of the modified load ratio method was confirmed by comparing the calculated crack length with the measured crack length from the pipe experiment.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.9
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• pp.71-81
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• 2001

This paper analyzes the effectiveness of minimizing vibration and sound transmission on/through a thin rectangular plate by both feedback control and hybrid control which combines adaptive feedforward control with a feedback loop. An experimental system identification technique using the matrix-fractional curve-fitting of the frequency response data is introduced for complex shaped structures. This identification technique reduces the model order o the MIMO(Multi-Input Multi-Output) system which simplifies the practical implementation. The adaptive feedforward control uses a Multiple filtered-x LMS(Least Mean Square) algorithm and the feedback control uses a multivariable digital LQG(Linear Quadratic Gaussian) algorithm. Experimental results show that an effective reduction of sound transmission is achieved by the hybrid control scheme when both vibration and noise measurement signals are incorporated in the controller.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.10
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• pp.1712-1719
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• 2003

This paper concerns on application of active magnetic bearing(AMB) system to levitate the elevation axis of an electro-optical sight mounted on moving vehicles. In such a system, it is desirable to retain the elevation axis within the predetermined air-gap while the vehicle is moving. An optimal base acceleration feedforward control is proposed to reduce the base motion response. In the consideration of the uncertainty of the system model, a filtered-x least-mean-square(FXLMS) algorithm is used to estimate the frequency response function of the feedforward control which cancels base motions. The frequency response function is fitted to an optimal feedforward control. Experimental results demonstrate that the proposed control reduces the air-gap deviation to 27.7% that by feedback control alone.