• Membrane and Water Treatment
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• v.9 no.6
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• pp.421-434
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• 2018

Decision-makers have different and sometimes conflicting goals with utilities in operating dam reservoirs. As repeated interactions exist between decision-makers in the long-term, and the utility of each decision-making organization is affected not only by its selected strategy, but also by other rivals' strategies; selecting and prioritizing optimum strategies from a decision maker's point of view are of great importance while interacting with others. In this paper, a model based on a fuzzy set theory, for determining the priority of decision-makers' strategies in optimal qualitative-quantitative operation management of dam reservoir is presented. The fuzzy priority matrix is developed via defining membership functions of a fuzzy set for each decision maker's strategies, so that all uncertainties are taken into account. This matrix includes priorities assigned to possible combination for other decision makers' strategies in bargaining with each player's viewpoint. Here, the 15-Khordad Dam located in the central part of Iran, suffering from low water quality, was studied in order to evaluate the effectiveness of the model. Then, the range of quality of water withdrawal agreed by all decision-makers was determined using the prioritization matrix based on fuzzy logic. The results showed that the model proposed in the study had high effectiveness model.

• Journal of the Korea Society of Computer and Information
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• v.16 no.12
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• pp.139-155
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• 2011

In recent years, parents of students and government have been taking a growing interest in education for the gifted students and there are many research reports about the gifted education. Most of the reports, however, focuses on the conceptional feature of the gifted education program such as organization, operation, management, evaluation, etc,. In other words, there are very few researches on instructional materials for gifted students even though the materials is a critical factor for successful education programs. So, this paper introduces a lecture notes used in a personal education for gifted students to contribute in developing education contents in computer science area. The instructional materials titled as "The Necessity and Application of Matrix in Computer Science" is based on linear equation to usher the students into creative problem recognition and groping for solutions. Also, the instructional materials is useful for students to understand the tight mathematics-computer science relationship and the basic concept of liner algebra.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2019.11a
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• pp.134-136
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• 2019

The International Maritime Organization (IMO) issued 2017 Guidelines on maritime cyber risk management. In accordance with IMO's maritime cyber risk management guidelines, each flag State is required to comply with the Safety Management System (SMS) of the International Safety Management Code (ISM) that the cyber risks should be integrated and managed before the first annual audit following January 1, 2021. In this paper, to identify cyber security management targets and risk factors in the maritime sector and to conduct vulnerability analysis, we catagorized the cyber security sector in management, technical and physical sector in maritime sector based on the industry guidelines and international standards proposed by IMO. In addition, the Risk Matrix was used to conduct a qualitative risk assessment according to risk factors by cyber security sector.

• Atmosphere
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• v.30 no.2
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• pp.195-207
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• 2020

This study aims to introduce the structure of the impact-based heat health warning system on 165 counties in South Korea developed by the National Institute of Meteorological Sciences. This system was developed using the daily maximum perceived temperature (PTmax), which is a human physiology-based thermal comfort index, and the Local ENSemble prediction system for the probability forecasts. Also, A risk matrix proposed by the World Meteorological Organization was employed for the impact-based forecasts of this system. The threshold value of the risk matrix was separately set depending on regions. In this system, the risk level was issued as four levels (GREEN, YELLOW, ORANGE, RED) for first, second, and third forecast lead-day (LD1, LD2, and LD3). The daily risk level issued by the system was evaluated using emergency heat-related patients obtained at six cities, including Seoul, Incheon, Daejeon, Gwangju, Daegu, and Busan, for LD1 to LD3. The high-risks level occurred more consistently in the shorter lead time (LD3 → LD1) and the performance (r_s) was increased from 0.42 (LD3) to 0.45 (LD1) in all cities. Especially, it showed good performance (r_s = 0.51) in July and August, when heat stress is highest in South Korea. From an impact-based forecasting perspective, PTmax is one of the most suitable temperature indicators for issuing the health risk warnings by heat in South Korea.

• Journal of Veterinary Science
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• v.21 no.2
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• pp.33.1-33.15
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• 2020

Bovine ephemeral fever virus (BEFV) causes bovine ephemeral fever, which can produce considerable economic damage to the cattle industry. However, there is limited experimental evidence regarding the underlying mechanisms of BEFV. Annexin A2 (AnxA2) is a calcium and lipid-conjugated protein that binds phospholipids and the cytoskeleton in a Ca²⁺-dependent manner, and it participates in various cellular functions, including vesicular trafficking, organization of membrane domains, and virus proliferation. The role of the AnxA2 gene during virus infection has not yet been reported. In this study, we observed that AnxA2 gene expression was up-regulated in BHK-21 cells infected with the virus. Additionally, overexpression of the AnxA2 gene promoted the release of mature virus particles, whereas BEFV replication was remarkably inhibited after reducing AnxA2 gene expression by using the small interfering RNA (siRNA). For viral proteins, overexpression of the Matrix (M) gene promotes the release of mature virus particles. Moreover, the AnxA2 protein interaction with the M protein of BEFV was confirmed by GST pull-down and co-immunoprecipitation assays. Experimental results indicate that the C-terminal domain (268-334 aa) of AxnA2 contributes to this interaction. An additional mechanistic study showed that AnxA2 protein interacts with M protein and mediates the localization of the M protein at the plasma membrane. Furthermore, the absence of the AnxA2-V domain could attenuate the effect of AnxA2 on BEFV replication. These findings can contribute to elucidating the regulation of BEFV replication and may have implications for antiviral strategy development.

• Genomics & Informatics
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• v.21 no.1
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• pp.9.1-9.13
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• 2023

Matrix metalloproteinase-9 (MMP-9) is a zinc and calcium-dependent proteolytic enzyme involved in extracellular matrix degradation. Overexpression of MMP-9 has been confirmed in several disorders, including cancers, Alzheimer's disease, autoimmune diseases, cardiovascular diseases, and dental caries. Therefore, MMP-9 inhibition is recommended as a therapeutic strategy for combating various diseases. Cinnamic acid derivatives have shown therapeutic effects in different cancers, Alzheimer's disease, cardiovascular diseases, and dental caries. A computational drug discovery approach was performed to evaluate the binding affinity of selected cinnamic acid derivatives to the MMP-9 active site. The stability of docked poses for top-ranked compounds was also examined. Twelve herbal cinnamic acid derivatives were tested for possible MMP-9 inhibition using the AutoDock 4.0 tool. The stability of the docked poses for the most potent MMP-9 inhibitors was assessed by molecular dynamics (MD) in 10 nanosecond simulations. Interactions between the best MMP-9 inhibitors in this study and residues incorporated in the MMP-9 active site were studied before and after MD simulations. Cynarin, chlorogenic acid, and rosmarinic acid revealed a considerable binding affinity to the MMP-9 catalytic domain (ΔG_binding < -10 kcal/ mol). The inhibition constant value for cynarin and chlorogenic acid were calculated at the picomolar scale and assigned as the most potent MMP-9 inhibitor from the cinnamic acid derivatives. The root-mean-square deviations for cynarin and chlorogenic acid were below 2 Å in the 10 ns simulation. Cynarin, chlorogenic acid, and rosmarinic acid might be considered drug candidates for MMP-9 inhibition.

• Proceedings of the KIEE Conference
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• 2008.11a
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• pp.360-362
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• 2008

Based on classification systems of power and IT standard dictionaries, scientific and technological standard, SPARK, power IT fields of IEC and organization units of corporations, we propose a new classification system for the standardization of power of terminologies. The classification system consists of a hierarchical structure with general classification, application fields and specific technologies while keeping the conventional matrix-type classification system. Interpretation work of the power of terminologies confirms that the proposed classification system is efficient.

• Korean Management Science Review
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• v.17 no.3
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• pp.5-17
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• 2000

The needs of strategic approach toward the usage of the Internet in corporate context are increasingly important as digital economy changes the way of doing business. However, companies are not easily taking the opportunity since the strategic use of the Internet is difficult because of the conflicts in distribution, business process, organization structure, etc. The Internet strategy applicable to companies in a generic context is proposed by identifying the CSFs (Critical Sucess Factors) in exploiting the potential of the internet. CSFs are derived by the previous study and case analysis, from which two most important factors are chosen based on a survey. In the survey, the ranking of the significance of the 8 CFSs from the 25 cases is questioned to the internet experts. Then a $2{\times}$2$ matrix is designed to find the optimal area for a company to be successful in the Internet usage. The strategy suggested here appears to be the shifting strategy in order to be in the optimal area in using the Internet strategically.

• Journal of Applied Reliability
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• v.10 no.1
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• pp.73-91
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• 2010

All activities relate to railway traffic involve risk and that these arise from a combination of the nature of operating activities. Proper management system is required to provide the organizational capability to reveal, analyse and address these weaknesses over time and in reasonably practicable ways, which will determine the rate at which risks can be further reduced. This paper presents a systematic risk analysis approach to safety planning and decision making, informed by a range of risk assessment techniques. An railway organization's safety management system is also presented that shows the approaches taken to minimize the external risks, and identify the shared risks and explain how they will be controlled through collaboration with others.

• The Mathematical Education
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• v.42 no.2
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• pp.111-119
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• 2003

This research discussed a general concept on the qualitative research methods in mathematics education. It provided a classification of research methods in mathematics education. It also described research trends in mathematics education. It addressed how research design facilitates formulating a research problem, selecting a research design, choosing who and what to study, deciding how to approach Participants, selecting means to collect data choosing how to analyzing data, and interpreting data and applying the analysis. This study addressed the issues involved in choosing relevant populations and in selecting and sampling qualitative data. It described how populations are conceptualized and distinguished between probability sampling and criterion based selection. It discussed not only data arrangement such as, cross-sectional and categorical indexing, non-cross- sectional data organization, but also diagram flow chart matrix, cognitive map, family tree to facilitate analyzing data.