• 정보처리학회논문지C
• /
• 제12C권5호
• /
• pp.643-648
• /
• 2005

기업들이 많이 사용하고 있는 인트라넷 시스템은 기본적으로 사용자인증을 거치지만, 인가된 사용자임을 가장한 악의의 사용자들에 의해, 또는 웹 브라우저의 다양한 기능을 통한 사용자들의 실수로 정보가 유출, 편집, 삭제될 수 있다. 따라서 이러한 정보에 대해서 비합법적인 사용. 부분적인 조작을 통한 자료의 변형 또는 도용 등의 불법적 유출을 막기 위한 방법이 필요하다. 본 논문에서는 인트라넷상의 정보를 보안하기 위해 효율적인 보안정책을 세움으로써 유연성 있는 ACM기반 웹 보안 접근제어(Web Security Access Control)시스템을 제안한다. 웹 보안 접근 제어 시스템은 인트라넷 정보에 대하여 암/복호화를 수행함으로써 보안기능을 강화하였을 뿐만 아니라 기업의 부서 간 민감한 정보의 공유에 대하여 해당 보안 페이지에 권한을 달리 함으로써 효과적이고 유용한 접근 통제를 수행한다. 또한 클라이언트 PC의 여러 가지 기능 제어를 통해 악의적인 혹은 실수로 인한 정보유출을 방지한다.

• 한국실내디자인학회논문집
• /
• 제19권5호
• /
• pp.95-104
• /
• 2010

One of 21st century's main paradigms is a 'Culture', and people started to express their 'cultural desires and demands' regarding public environments. Accordingly central and local governments are paying attention to these demands from their citizens and trying to establish the policies to meet these needs. This research is done to suggest the strategy programming model to support the executions of culture-centered public designs which are based on the local resources and identities. The entire research contains three sub-topics. First topic is setting the prototype phases of strategy programming. Second topic is analyzing the associated indices for each prototype phase. Third topic is suggesting Matrix Model in which the prototype phases and their associated indices are linked. Among three topics, this paper deals with the first one - the prototype phases of strategy programming. It studies this subject in relation with Place Marketing which emphasizes the local resources and identities. The prototype phases are comprised of 3 steps for Place Strategy and 4 steps for Marketing Strategy. Place Strategy should be considered prior to Marketing Strategy because in culture-centered public design, locality has priority over other concerns. The phases for Place Strategy includes 'Resource_analyzing of local resources', 'Mission_setting a purpose', and 'Targeting_segmenting target groups'. The phases for Marketing Strategy involves 'Organization_instituting the main body and/or partnership', 'Image Positioning_setting an unique local image', 'Point_realizing the product', and 'Channel_deciding the sales promotion tools'.

• 대한화장품학회:학술대회논문집
• /
• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
• /
• pp.192-202
• /
• 2003

The wrinkles correspond to the most obvious expression of skin ageing and are manifested by changes on the organization and dermal structure. In the extracellular matrix, decreased quantities of collagens and glycosaminoglycans as well as a deterioration of the fibrillary network is noted, result in a reduction of dermal thickness. In addition, the activity of the collagenases increases in contrast to the synthesis of collagen fibers. Nor are cells spared during the aging process. We thus studied and compared the contractile capacity as well as the synthesis capacity of normal human fibroblasts and human fibroblasts obtained from biopsies of forehead wrinkles. The capacity of the fibroblasts to be adhered to the collagen network and to maintain a three-dimensional structure of dermis was studied on a model of equivalent dermis. The metabolic activity was studied by evaluating the capacities of synthesis of collagen I, main component of dermis. Human fibroblasts resulting from the forehead wrinkle contract less the gel of collagen than the normal human fibroblasts and present an activity of biosynthesis of collagen I less important than normal human fibroblasts. These results show that fibroblasts with aging present a deceleration of their metabolic activity and lose their capacity of adhesion to collagen fibers thus limiting the possibility of organizing the dermal tissue. We investigated the potential of an active ingredient able to compensate for the reduction of the metabolic activity and to restore the contractile capacity of fibroblasts obtained from forehead wrinkles. This effect was compared with a reference molecule: the vitamin C.

• Genomics & Informatics
• /
• 제8권1호
• /
• pp.9-18
• /
• 2010

Integrins are transmembrane receptor proteins that mediate cell-cell adhesion and cell-extracellular matrix (ECM) adhesion. The deregulation of cell-ECM adhesion and the abnormal expression of beta1 (${\beta}1$) integrins (ITGB1s) are involved in tumor development and metastasis. In the liver, the expression of integrins and ECM proteins can be a cause of hepatocellular carcinoma (HCC) development. We performed direct DNA sequencing of 24 individuals, and identified 23 sequence variants of ITGB1 polymorphisms. Among these 23 variants, 7 common variants were selected based on frequencies and linkage disequilibrium, and then genotyped in a larger-scale group of subjects (n=1,103). The genetic associations of ITGB1 polymorphisms with the clearance of HBV and HCC outcome of HBV patients were analyzed using logistic regression models and Cox relative hazard models. Although there was no significant association observed between the polymorphisms and the HCC outcome of HBV patients, the second most common haplotype (ITGB1 haplotype-2 [C-C-C-C-T-C-T]) was putatively associated with HBV clearance (OR=0.75, p=0.008 and $P^{corr}=0.05$). The minor allele frequency (MAF) of ITGB1 haplotype -2 of the spontaneously recovered (SR) group was significantly higher than that of the chronic carrier group (CC) (freq. = 0.248 vs. 0.199). The information derived from this study could be valuable for understanding the genetic factors involved in the clearance of HBV.

• 한국지역지리학회지
• /
• 제6권3호
• /
• pp.169-184
• /
• 2000

미국의 씬씨내티 대도시지역을 대상으로 인자분석 및 Hot Spot 분석에 의해 산업 군집과 그것의 경계가 확인되어졌다. 전통적 투입 산출 접근법이 비공간적 산업 군집을 추출하는 반면 이 연구는 전통적 접근을 GIS 기법과 결합하여 경계를 설정한다. 투입 산출 산업 군집의 결과를 선도산업 부문과 결합하여 5개 선도 산업 군집을 추출하였는데 그것은 음식료품, 화학, 금속, 금속제품, 기계공업 부분이다. 그리고 Hot Spot 기법을 이용하여 연구지역의 산업 군집을 Arcview에 통합하여 시각화하였다. 산업 군집의 공간적 결합정도와 공간적 한계를 결정하는 것은 경제의 공간구조의 효율성을 측정하는 부가적 접근이 될 수 있다. 산업 군집과 산업의 공간적 군집 접근은 하나의 공장이나 기업의 수준보다 집계적인 차원에서 산업의 공간적 배열의 새로운 모형 개발 기초의 가능성을 제시한다.

• Archives of Plastic Surgery
• /
• 제36권1호
• /
• pp.11-18
• /
• 2009

Purpose: Excessive scarring in the forms of keloid and hypertrophic scar could be a consquence of the accumulation of granulation tissue cells due to aberrant control of apoptosis. Verapamil retard extracelluar matrix production and inhibits VEGF production in primary cultured keloid fibroblast. The object of this study was effect of verapamil on VEGF expression and apoptosis in early wound scarring of the rabbit ear. Methods: Full thickness wounds were created on the ventral side of 6 New Zealand rabbits's ear. 16 days after initial wounding verapamil and saline were injected each scars and scars were harvested 1 week, 2 weeks, 4 weeks later. The wounds were stained with hematoxylin and eosin, TUNEL stain, immunohistochemical stain for VEGF and calculated scar elevation index. Results: Histologic analaysis demonstrated significant reduction in inflammation, vascularity and improvement in dermal collagen organization in experimental group. In TUNEL staining apotosis positive cells were increased and immunohistochemial staining of VEGF demonstrated significant reduction of VEGF expression in experimental group. No significant difference was noted in scar elevation index between two groups. Conclusion: This study suggest that intralesional injection of verapamil on early wound scarring of the rabbit ear decreased VEGF production and increased apoptosis and have a benefit on the pathophysiology of scar formation.

• 정보처리학회논문지D
• /
• 제11D권2호
• /
• pp.407-414
• /
• 2004

미군의 아키텍처프레임워크는 3원화관점에 의해서 산출물을 정의하였으나, 관점간의 전환과정이 불명확하고, 개발절차가 미흡하여, 아키텍처개발자가 아키텍처를 개발하기 어렵다. 그리고, 개발하더라도 독립적인 방법으로 산출물을 작성하여, 개발된 산출물의 수준이 상이하고 일관성이 없는 경우가 많다. 따라서, 본 논문에서는 우리 군 실정에 맞추어 산출물간의 연계성과 일관성을 유지시키기 위한 신규 산출물을 추가로 정의하였고, 아키텍처 개발절차를 보다 상세히 제시하였으며, 정보체계 수명주기별로 아키텍처 활용 용도를 제공하는 국방아키텍처프레임워크(MND AF)를 개발하였다. 이를 통하여 아키텍처산출물의 일관성과 추적성을 제공할 수 있게 되고, 체계통합 및 상호운용성 기반을 구축하게 되었으며, 아키텍처 개발자가 좀 더 쉽게 아키텍처를 개발할 수 있도록 하였다.

• 예술인문사회 융합 멀티미디어 논문지
• /
• 제9권1호
• /
• pp.815-824
• /
• 2019

스포츠이벤트의 운영 환경은 크기, 종류, 지역에 따라 다양하고, 단위업무별 업무가 독립적이지 않고 상호 유기적인 관계를 이루고 있으며, 복잡한 이해관계자가 매트릭스구조로 이루어져 있어 일반화된 운영 모델을 구축하는 것은 결코 쉬운 일은 아니다. 이 연구에서는 이러한 문제를 해결하기 위해 스포츠이벤트 관리의 개념 및 프로세스의 지침을 제공하는 '표준'을 제안한다. 표준개발을 위해 산업분야 및 활동의 품질경영을 위한 국제 표준 규격인 ISO 9001:2015에서 제시하는 프레임을 따라 표준화를 진행하였다. 이 연구에서 제안하는 표준의 구성은 적용범위, 인용표준, 용어와 정의, 조직의 상황, 리더십, 계획수립, 지원, 운용, 성과평가, 개선으로 구성되어 있다. 이 연구에서 제시하는 스포츠이벤트 프로세스 관리 시스템 표준은 스포츠이벤트의 형태 또는 규모에 관계없이 스포츠이벤트를 유치하고, 준비하여, 운영하고자 하는 모든 조직에 적용될 수 있다. 또한, 스포츠이벤트의 생애주기 단계별 프로세스 관리에 초점을 맞춘 접근방법을 시도하여, 프로세스와 프로세스 간 상호 관련성과 의존성을 관리 할 수 있도록 하였다.

• Biomolecules & Therapeutics
• /
• 제27권3호
• /
• pp.302-310
• /
• 2019

Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and -resistant (A375P/Mdr with acquired resistance and SK-MEL-2 with intrinsic resistance) melanoma cell lines, to reveal the genes and pathways potentially involved in intrinsic and acquired resistance to BRAF inhibitors. A total of 546 differentially expressed genes (DEGs), including 239 up-regulated and 307 down-regulated genes, were identified in both intrinsic and acquired resistant cells. Gene ontology (GO) analysis revealed that the top 10 biological processes associated with these genes included angiogenesis, immune response, cell adhesion, antigen processing and presentation, extracellular matrix organization, osteoblast differentiation, collagen catabolic process, viral entry into host cell, cell migration, and positive regulation of protein kinase B signaling. In addition, using the PAN-THER GO classification system, we showed that the highest enriched GOs targeted by the 546 DEGs were responses to cellular processes (ontology: biological process), binding (ontology: molecular function), and cell subcellular localization (ontology: cellular component). Ingenuity pathway analysis (IPA) network analysis showed a network that was common to two BRAF inhibitorresistant cells. Taken together, the present study may provide a useful platform to further reveal biological processes associated with BRAF inhibitor resistance, and present areas for therapeutic tool development to overcome BRAF inhibitor resistance.

• Genomics & Informatics
• /
• 제18권4호
• /
• pp.40.1-40.8
• /
• 2020

Avian influenza (AIV) outbreaks can induce fatal human pulmonary infections in addition to economic losses to the poultry industry. In this study, we aimed to develop a rapid and sensitive point-of-care AIV test using loop-mediated isothermal amplification (LAMP) technology. We designed three sets of reverse transcription LAMP (RT-LAMP) primers targeting the matrix (M) and hemagglutinin (HA) genes of the H5 and H9 subtypes. RT-LAMP targeting the universal M gene was designed to screen for the presence of AIV and RT-LAMP assays targeting H5-HA and H9-HA were designed to discriminate between the H5 and H9 subtypes. All three RT-LAMP assays showed specific amplification results without nonspecific reactions. In terms of sensitivity, the detection limits of our RT-LAMP assays were 100 to 1,000 RNA copies per reaction, which were 10 times more sensitive than the detection limits of the reference reverse-transcription polymerase chain reaction (RT-PCR) (1,000 to 10,000 RNA copies per reaction). The reaction time of our RT-LAMP assays was less than 30 min, which was approximately four times quicker than that of conventional RT-PCR. Altogether, these assays successfully detected the existence of AIV and discriminated between the H5 or H9 subtypes with higher sensitivity and less time than the conventional RT-PCR assay.