• Title/Summary/Keyword: Mastic

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In vitro and In vivo Activities Studies of Chois Mastic Using Self-microemulsifying Drug Delivery System (SMEDDS) against Helicobactor pylori (자가미세유화시스템을 이용한 매스틱의 헬리코박터파일로리 대한 In vitro 및 In vivo 활성 연구)

  • Kim, Su-Ji;Jeong, Sang-Young;Gil, Young-Sig;Shin, Byung-Cheol;Hwang, Sung-Joo;Cho, Sun-Hang
    • YAKHAK HOEJI
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    • v.55 no.1
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    • pp.1-10
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    • 2011
  • Mastic is a bleed resin formed in pistacia lentiscus tree extract form the anacatdiaceae family. Mastic is used as a food ingredient in the Mediteraanean resin, and has been used by local inhabitants as a traditional medicine for relief of upper abdominal discomfort, dyspepsiaand peptic ulcer. Clinically, mastic has been effective in the treatment of benign gastric and duodenal, ulcers, giving symptomatic relief and endoscopically proven healing. In this study, to enhance activiteies of poorly water soluble Mastic with oils, surfactants and cosurfactants and then the mixure was microemulsified in aqueous media under condition of gentle agitation and digestive motility that would be encountered in the gastrointestinal tract. Formulation development and screening were based on phase diagrams and characteristics of resultant microemulsion. For optimum mastic formulation, microemulsions with various ratio (w/w%) of mastics, oils, surfactants and cosurfactants were prepared and their solubility was evaluated by monitoring particles size in their buffer through visual asessment and electrophoretic light scattering spectrophotomerter (ELS). In vitro activity of self microemulsified mastic (SME mastic) was determined by minimum ingibition concentration (MIC) test against a panel of Helicobacter pylori (H. pylori) clinical strains. Additionally, in vivo activity of SME masitc was investigated us mouse infected by CH275 of H. pylori. The mean diameter of SME mastic was less then 100 nm in water and SME mastic was showed similar antiboisis effect compared to tometronidazole, clarithromycin and omeproazole. Consequently, SME mastic would be effective system to exterminate H. pylori. If mastic were dose with combined treatment, mastic might augur well for effect of H. pylori eradication as good remedy.

Antibacterial Effects of Tea Tree Oil and Mastic Oil to Streptococcus mutans

  • Song-Yi Yang;So-Hyun Lee;On-Bi Park;Hee-Rang An;Yeong-Hyeon Yu;Eun-Bi Hong;Kyung-Hee Kang;Hwa-Soo Koong
    • Journal of dental hygiene science
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    • v.23 no.1
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    • pp.51-59
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    • 2023
  • Background: Tea tree oil has antiviral, antimicrobial and antifungal effects and Mastic oil has antifungal and anticancer effects. For synergistic effects of oils, blending oil containing a mixture of two to three oils is recommended. This study aimed to determine the antibacterial effects of Tea tree oil, Mastic oil, and Blending oil containing the two oils in a mixture, to verify and suggest the potential use of these oils as a substance to prevent dental caries. Methods: Tea tree oil, Mastic oil, and Blending oil with a 1:1 blend of the two oils were diluted in liquid medium to 0% (negative control), 0.5%, 1.0%, and 2.0%. Streptococcus mutans was applied to each experimental group of the three diluted oils and after 8 h culture, the optical density (OD) was measured and the growth inhibition rate for S. mutans was estimated. Results: Tea tree oil had significantly low OD values across all concentrations (p<0.05) without significant variation among different concentrations (p>0.05). Mastic oil did not significantly vary in OD compared to the negative control across all concentrations (p>0.05) without significant variation among different concentrations (p>0.05). Blending oil, compared to the negative control, did not significantly vary in OD at 0.5% (p>0.05) but significant variation was found as the concentration increased (p<0.05). Additionally, for Tea tree oil and Mastic oil, the growth inhibition rate showed no significant variation according to concentration (p>0.05), whereas for Blending oil, the growth inhibition rate for S. mutans showed a significant difference at 1.0% (p<0.05) and at higher concentrations. Conclusion: Blending oil containing a Tea tree oil and Mastic oil demonstrated a significant growth inhibition effect on S. mutans from the concentration of 1.0%, which suggested its potential use as an effective antibacterial agent for dental caries.

Application for a Composite Waterproof Method of Asphalt Mastic Film and Sheet on Concrete Structures. (콘크리트 구조물 방소에 ASPHALT MASTIC 도막 및 SHEET 복합방수공법의 적용에 대한 연구)

  • 임채중;배문옥
    • Proceedings of the Korea Concrete Institute Conference
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    • 2000.10a
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    • pp.793-800
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    • 2000
  • This is a double Composite Waterproofing Method of Mastic Asphalt Film ad Sheet(MAS) on concrete structure and its working method. MAS is characterized as having excellent strength and adhesion to concrete. To make a good waterproofing system, it is needed the information on the performance tests. The designer should choose a material that can be applied in almost all conditions. During their service life, Underground spaces have been keeping to dry enough for habitable or utilitarian used. This method is of use for waterproofness in various spaces.

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Double Waterproof Method of Asphalt Mastic Membrane and Sheet on Concrete Structures. (ASPHALT MASTIC 도막 및 SHEET에 의한 이중방수공법)

  • 임채중;배문옥
    • Proceedings of the Korea Concrete Institute Conference
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    • 1999.10a
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    • pp.845-852
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    • 1999
  • Nealy, A large amount of underground spaces is constructed the form of deep basement in construction work. During their service life, Underground spaces have been keeping to dry enough for habitable or utilitarian used. This method is of use for waterproofness in underground spaces.

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Development of Newly Formulated High-strength Wash Primer for Membrane LNG Carrier (멤브레인형 LNG 운반선용 고강도 워시프라이머 개발)

  • Song, Eun-Ha;Lee, Sung-Kyun;Chung, Mong-Kyu;Baek, Kwang-Ki
    • Special Issue of the Society of Naval Architects of Korea
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    • 2007.09a
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    • pp.48-56
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    • 2007
  • Wash primer was applied to cargo tank of Membrane-LNG Carrier (M-LNGC) for corrosion resistance and high bond-strength with the mastic. However, a lack of bond-strength verification at high thickness wash primer coating resulted in strict coating thickness control. Therefore wash primer was controlled below DFT(Dry Film Thickness) $30{\mu}m$. In order to develop the wash primer satisfying GTT (GAZ TRANSPORTAION TECHNIGAZ) standard even at high thickness, we evaluated coating properties such as wash primer/mastic bond-strength, corrosion resistance, as well as workability for the newly formulated wash primer materials. The newly formulated wash primer had high bonding-strength to mastic even at high thickness and had proper corrosion resistance and workability suitable to yard condition.

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Results Of Mathematical Modeling Of Organizational And Technological Solutions Of Effective Use Of Available Resource Of Modern Roofs

  • Arutiunian, Iryna;Mishuk, Katerina;Dankevych, Natalia;Yukhymenko, Artem;Anin, Victor;Poltavets, Maryna;Sharapova, Tetiana
    • International Journal of Computer Science & Network Security
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    • v.21 no.1
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    • pp.49-54
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    • 2021
  • Relative to the outer surface of the mastic coating, the reliability of the available waterproofing resource is determined by the ability to stabilize the structural characteristics in difficult climatic conditions. Organic components of mastic as a result of solar radiation, elevated temperatures and their alternating change, atmospheric oxidants, especially in industrial areas, have a tendency to self-polymerization and loss of low molecular weight components. This is the gradual loss of deformability and the transition to brittleness with its tendency to crack as the reasons for the gradual transition from normal to emergency operating condition.The presented mechanism of functioning of the coating surface indicates the expediency of increasing its components, able to stabilize the structure and prevent changes in deformability.Durability, hydrophobicity, water displacement, water absorption are accepted as estimating indicators. The main dependences of the influence of the lost additional components of mastic on the operational properties of the formed coating characterize the ability to provide successful resistance to environmental influences and longer stability. As a result, mastic acquires additional service life.

Development of an analytical method for the quantification of oleanonic acid from mastic gum using HPLC/PDA

  • Hak-Dong Lee;Chang-Dae Lee;So Yeon Choi;Sanghyun Lee
    • Journal of Applied Biological Chemistry
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    • v.66
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    • pp.67-72
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    • 2023
  • A simple and accurate method was developed for the quantitative analysis of oleanonic acid (OA) from mastic gum. The analysis was carried out using reverse-phase high-performance liquid chromatography combined with a photodiode array detector (HPLC/PDA). Our optimized method was validated by measuring various parameters, using an INNO C18 column fitted with a gradient elution system. The results revealed limits of detection and quantification of 0.34 and 1.042 ㎍/mL, respectively. The OA calibration curve exhibited excellent linearity over the concentration range of 0.0625 to 2.0 mg/mL, with r2 =0.9996. Accuracy tests revealed a high recovery rate of 99.44-103.66%, with precision values below 0.15%. These results suggest that the present analytical method can identify and quantify OA in mastic gum with high precision. The HPLC approach developed in this study might be applied to routine analyses and large-scale extraction procedures for OA content quantification.

Oil Leakage Characteristics of Asphalt Mastic Waterproofing Membrane Coating According to Particle Size and Content of Organic/Mineral Extender (유·무기질 체질안료 입도 및 함량에 따른 아스팔트 매스틱 도막방수재의 누유 특성)

  • Park, Jin-Sang;Kim, Dong-Bum;Park, Wan-Goo;Kim, Young-Sam;Shin, Hong-Chol;Oh, Sang-Keun
    • Journal of the Korea Institute of Building Construction
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    • v.21 no.1
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    • pp.51-59
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    • 2021
  • In this study, the purpose of this study was to quantitatively grasp the specific correlation between the raw material and the occurrence of leakage by analyzing the characteristics of leakage by adjusting the type and content of the raw material constituting the asphalt mastic coating waterproofing material. To this end, two raw materials, CA (calcium carbonate) and ASE (anti-sedimentation), which are organic and mineral extender for asphalt mastic waterproofing membrane coating, were selected. viscosity and oil leakage stability (20 ℃, 40 ℃) was evaluated. As a result of the evaluation, the oil leakage stability and viscosity were inversely proportional to the CA average particle size, and it was quantitatively proven that a correlation in proportion to the ASE content was established. The results of this study are expected to be used as core data for basic mixing design in the future mixing studies to improve leakage of asphalt mastic waterproofing membrane coating.