• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 1999년도 추계학술발표논문집
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• pp.180-186
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• 1999

Alkaline peroxide bleaching of (chemi) mechanical pulp is a very complicated system where various process factors affect the bleaching performance and pulp properties. Traditional on-factor-at a time method is ineffective and costly in finding the optimal bleaching conditions. In this study statistical experimental methods which include three steps. I. e. screening, response surface modeling and optimization, were used to find the conditions for maximal brightness development during one stage alkaline peroxide bleaching of TMP which had an initial brightness of 54.5% Elerpho. The TMP was pretreated with EDTA(0.5% on O. D. pulp. consistency, $30^{\circ}C$ for 60 minutes) and bleached in a 2L Mark V Quantum Reactor at 750rpm, 7.5% of bleaching consistency and with 0.05% magnesium sulfate addition. The ranges of other factors studied were 1~5% hydrogen peroxide on O. D plup, 1~4% sodium hydroxide on O. D pulp and 1~4% sodium silicate on O. D pulp, reaction temperature 50~$90^{\circ}C$ and reaction time 40~180minutes. A models with good predictability was established and the maximal brightness after one stage bleaching was found to be 70% Elerpho at $50^{\circ}C$, 50 minutes 5% hydrogen peroxide on O. D. pulp 3.2~3.4% sodium hydroxide on O. D. pulp 3.2~3.4% sodium hydroxide on O. D pulp and 4% silicate on O. D pulp. However further studies on other pulp properties such as strength and brightness stability shall be carried out in order to find out the optimal bleaching conditions.

• Earthquakes and Structures
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• 제14권6호
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• pp.577-587
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• 2018

The quantitative assessment of the seismic collapse risk of a structure requires the usage of an optimal intensity measure (IM) which can adequately characterise the severity of the ground motion. Research suggests that the average spectral acceleration ($Sa_{avg}$) may be an efficient and sufficient alternate IM as compared to the more traditional first mode spectral acceleration, $Sa(T_1)$, particularly during seismic collapse risk estimation. This study primarily presents a comparative evaluation of the sufficiency of the average spectral acceleration with respect to ground motion duration, and secondarily assesses the impact of ground motion duration on collapse risk estimation. By assembling a suite of 100 historical ground motions, incremental dynamic analysis of 60 different inelastic single-degree-of-freedom (SDF) oscillators with varying periods and ductility capacities were analysed, and collapse risk estimates obtained. Linear regression models are used to comparatively quantify the sufficiency of $Sa_{avg}$ and $Sa(T_1)$ using four significant duration metrics. Results suggests that an improved sufficiency may exist for $Sa_{avg}$ when the period of the SDF system increases, particularly beyond 0.5, as compare to $Sa(T_1)$. In reference to the ground motion duration measures, results indicated that the sufficiency of $Sa_{avg}$ is more sensitive to significant duration definitions that consider almost the full wave train of an accelerogram ($SD_{a5-95}$ and $SD_{v5-95}$). In order to obtain a reduced variability of the collapse risk estimate, the 5-95% significant duration metric defined using the Arias integral ($SD_{a5-95}$) should be used for seismic collapse risk estimation in conjunction with $Sa_{avg}$.

• 정보처리학회논문지D
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• 제12D권5호
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• pp.781-788
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• 2005

MTF 메시지는 C4I 체계와 같은 국방 메시지 시스템에서 필요한 정보를 상호 교환하거나 다른 시스템으로 정보를 전달하고자 할 때 사용되는 정형화되고 표준화된 메시지 포맷이며, XML은 다양한 검색 지원 및 하드웨어나 소프트웨어에 종속되지 않는 장점을 바탕으로 인터넷 기반에서 전자정보의 효율적 표현과 교환에 최적의 수단으로 평가 받고 있다. 미군은 MTF에 이러한 XML 기반 기술과 결합한 XML-MTF를 도입하여 지속적인 개량과 발전을 도모하고 있으나, 우리 군은 자체 MTF 체계를 보유하지 않고 있으며 또한, 여러 C4I 체계가 Web 기반으로 이동함에 따라 한$\cdot$미간 효율적인 연합작전 수행을 위해 MTF의 필요성이 증가하고 있다. 본 논문에서는 MTF 메시지의 기본구조 및 본문 구성, 작성규칙을 분석하며, 이러한 결과를 바탕으로 XML 변환을 위한 엘리먼트 명칭과 기본적인 매핑(Mapping) 규칙을 제안한다 또한, 제안된 매핑 규칙을 적용하여 MTF 메시지 샘플을 XML 문서로 직접 변환해 봄으로써 MTF 메시지가 XML 문서로 변환이 가능함을 보이고, 이를 기반으로 MTF 메시지를 생성하고 이를 자동으로 XML 문서로 변환하는 XML-MTF 변환 프로그램을 구현한다.

• Radiation Oncology Journal
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• 제37권4호
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• pp.302-308
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• 2019

The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain's distinctive immune microenvironment, extracranial abscopal responses following cranial radiation therapy have rarely been reported. In this report, we describe the case of 42-year-old female patient with metastatic melanoma who experienced an abscopal response following her cranial radiation therapy for her brain metastasis. The patient initially presented with a stage III melanoma of the right upper skin of her back. Approximately 5 years after her diagnosis, the patient developed a large metastatic lesion in her upper right pectoral region of her chest wall and axilla. Since the patient's tumor was positive for BRAF and MEK, targeted therapy with dabrafenib and trametinib was initiated. However, the patient experienced central nervous system (CNS) symptoms of headache and disequilibrium and developed brain metastases prior to the start of targeted therapy. The patient received radiation therapy to a dose of 30 Gy delivered in 15 fractions to her brain lesions while the patient was on dabrafenib and trametinib therapy. The patient's CNS metastases improved significantly within weeks of her therapy. The patient's non-irradiated large extracranial chest mass and axilla mass also shrank substantially demonstrating the abscopal effect during her CNS radiation therapy. Following radiation therapy of her residual chest lesions, the patient was disease free clinically and her CNS lesions had regressed. However, when the radiation therapy ended and the patient continued her targeted therapy alone, recurrence outside of her previously treated fields was noted. The disease recurrence could be due to the possibility of developing BRAF resistance clones to the BRAF targeted therapy. The patient died eventually due to wide spread systemic disease recurrence despite targeted therapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권2호
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• pp.85-99
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• 2004

Purpose: This study observed the changes in the telomerase activity, it's developmental regulation, PCNA expression, and their correlation in rat's upper digestive organs during growth and aging. Materials and Methods: Upper digestive organs(buccal mucosa, gingiva, palate, submandibular and parotid glands, and tongue) were aseptically removed from Sprague-Dawley rats of fetal(gestational 20 days), growing(1, 2, 3, 5, and 7 weeks after birth) and adult(12 week old). Samples for telomerase activity were frozen on liquid nitrogen immediately after sacrifice, and stored until the use at $-75^{\circ}C$ in order to measure it. Telomerase activity was measured by a PCR-based telomeric repeat amplication protoco(TRAP) assay and quantitated with Photometric Telo TAGGG Telomerase PCR ELISA plus(Roche Diagnostics GmbH. Mannheim. Germany). PCNA expression were measured immunohistochemistry with anti PCNA Ab-1, Clone PC10(NeoMark. California. USA). Results: 1. Telomerase activities in buccal mucosa, palate and gingiva were the highest in fetus and decreased gradually or rapidly after birth and then diminished, but In salivary gland and tongue were the highest in fetus and also high at 1 week and then decreased rapidly. 2. PCNA expression in buccal mucosa, gingiva, Tongue and salivary gland was the highest in fetus and decreased gradually and then diminished. but only in palate decreased rapidly after birth and then diminished. Conclusion: The highest telomerase activity of embryonic stage decreased rapidly after birth in rat's upper digestive organs. There may be a developmental regulation of telomerase activity, but not a tissue-specific. This telomerase activity seems correlated closely with PCNA expression in rat's upper digestive system.

• 보건행정학회지
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• 제29권4호
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• pp.394-398
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• 2019

Education on the physician continues with undergraduate medical education, graduate medical education, and continuous medical education. The countries such as the United States, Japan, the United Kingdom, German, and others are required to undergo training in the clinical field for 2 years after completing the national medical examination, and to become doctors after passing the clinical practice license test. Korea can obtain a medical license and become a clinical doctor at the same time if it passes written and practical tests after completing 6 years of undergraduate medical education or 4 years of graduate school. About 90% of medical school graduates replace clinical practice with 4-5 years of training to acquire professional qualifications, but this is an option for individual doctors rather than an extension of the licensing system under law. The medical professional qualification system is implemented by the Ministry of Health and Welfare on the regulation. In fact, under the supervision of the government, the Korean Hospital Association, the Korean Medical Association, and the Korean Academy of Medical Sciences progress most procedures. After training and becoming a specialist, the only thing that is given to a specialist is the right to mark him or her as a specialist in marking a medical institution and advertising. The government's guidelines for professional training are too restrictive, such as the recruitment method of residents, annual training courses of residents, dispatch rule of the residents, and the quota of residents of training hospitals. Although professional training systems are operated in the United States, the United Kingdom, France, and Germany, most of them are organized and operated by public professional organizations and widely recognize the autonomy of academic institutions and hospitals. Korea should also introduce a compulsory education system after graduating from medical education and organize and initiate by autonomic public professional organization that meets global standards.

• Current Optics and Photonics
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• 제1권4호
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• pp.351-357
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• 2017

This paper proposes a LED bicycle headlamp with a wide viewing angle to help bicyclists see the front effectively and because of its high visibility to reduce the risks of accidents around intersections or blind spots. The wide viewing angle was determined to be $28^{\circ}$ because it can illuminate a 5 m wide area 10 m away. Therefore, the road conditions of the intersection can be observed with the bicycle handlebar tilted slightly to the left or right. The headlamp has a compact reflector with a width of 30 mm, height of 27 mm, and length of 17 mm. Owing to its size, a change in the position of a light source leads to severe changes in light distribution. Therefore, the tolerance of the source position was analyzed by a simulation. The tolerance was ${\pm}0.5mm$ at the X, Y and Z axes within a less centered aiming range of ${\pm}1^{\circ}$. Finally, the prototype of the bicycle headlamp was made and the light distribution was measured by an automotive headlamp light measurement system. The experimental results indicate that the headlamp illuminates a 5 m wide area with an edge light of 3.2 lx as well as meeting the K-mark regulation.

• 생태와환경
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• 제45권3호
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• pp.322-328
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• 2012

금강수계 백곡천 상류에 서식하는 미호종개(국가 천연기념물)를 대상으로 형광물질 주입에 의한 다중표지-재포획법(졸리-시바모델적용)으로 개체군 크기를 추정하였다. 총 어류조사지점은 335개였고, 그 중 미호종개가 출현 지점은 217개 였다. 본 연구에서 추정한 미호종개 평균 개체군 크기는 6,143개체였다. 이는 2009년 환경부에서 수행한 미호종개 개체군 규모와 비교 했을때보다 41% 감소된 것이다. 백곡천에서 본 종의 감소는 미소서식지 훼손, 퇴적물, 서식환경의 악화 등의 영향으로 판단된다. 따라서 백곡천 본 종의 개체군 회복 미소서식지 보호를 위해 서식지복원 프로그램이 요구된다.

• 한국화재소방학회논문지
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• 제34권2호
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• pp.141-146
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• 2020

본 연구의 궁극적 목적은 소방활동 현장지휘관의 대응역량 강화이며, 그 일환으로 훈련용 콘텐츠 시나리오를 개발하였다. 현장지휘관의 상황판단력, 커뮤니케이션, 의사결정력을 3가지 핵심역량으로 설정하였다. 이 3가지 핵심역량이 시나리오 체계구성시 적극 반영될 수 있도록 구축하였다. 본 시나리오의 모든 내용은 재난현장 표준작전절차 SOP를 기반으로 구성하였다. 시나리오의 체계는 전체 14단계로 구성되며, 훈련의 시작과 마지막인 1단계와 14단계를 제외하면, 크게 4단계로 구분된다. 상황설정 단계와 1, 2, 3차 의사결정 단계로 구성되며, 특히 상황판단과 커뮤니케이션은 각 단계마다 중요한 요인이다.

• The Journal of Advanced Prosthodontics
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• 제6권1호
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• pp.46-52
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• 2014

PURPOSE. The aim of this study was to evaluate the interface accuracy of computer-assisted designed and manufactured (CAD/CAM) titanium abutments and implant fixture compared to gold-cast UCLA abutments. MATERIALS AND METHODS. An external connection implant system (Mark III, n=10) and an internal connection implant system (Replace Select, n=10) were used, 5 of each group were connected to milled titanium abutment and the rest were connected to the gold-cast UCLA abutments. The implant fixture and abutment were tightened to torque of 35 Ncm using a digital torque gauge, and initial detorque values were measured 10 minutes after tightening. To mimic the mastication, a cyclic loading was applied at 14 Hz for one million cycles, with the stress amplitude range being within 0 N to 100 N. After the cyclic loading, detorque values were measured again. The fixture-abutment gaps were measured under a microscope and recorded with an accuracy of ${\pm}0.1{\mu}m$ at 50 points. RESULTS. Initial detorque values of milled abutment were significantly higher than those of cast abutment (P<.05). Detorque values after one million dynamic cyclic loadings were not significantly different (P>.05). After cyclic loading, detorque values of cast abutment increased, but those of milled abutment decreased (P<.05). There was no significant difference of gap dimension between the milled abutment group and the cast abutment group after cyclic loading. CONCLUSION. In conclusion, CAD/CAM milled titanium abutment can be fabricated with sufficient accuracy to permit screw joint stability between abutment and fixture comparable to that of the traditional gold cast UCLA abutment.