• Archives of Pharmacal Research
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• v.28 no.9
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• pp.1042-1046
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• 2005

Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.

• Fisheries and Aquatic Sciences
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• v.5 no.2
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• pp.97-102
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• 2002

Pyricularia oryzae (P. oryzae), the cause of rice blast, is one of the most important fungal pathogens of rice. Seventy strains of marine fungi were isolated from marine algae, and it was measured antifungal activity against P. oryzae. Metabolites of marine fungus A-248 which isolated from marine algae showed strong antifungal activity against P. oryzae. The antifungal substance from the metabolites of marine fungus A-248 was extracted with ethylacetate, and then purified by preparative TLC and reverse-phase HPLC. The minimum inhibitory concentration (MIC) value was $0.18\mu g/mL$ for the antifungal activity of the substance purified from A-248 metabolites. The purified substance was similar to antifungal activity of rhizoxin, which is a commercial antifungal agent.

• Archives of Pharmacal Research
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• v.25 no.1
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• pp.77-79
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• 2002

Farnesylhydroquinone (1) has been isolated from the mycelium of a marine-derived fungus of the genus Penicillium. The structure of the compound (1) has been elucidated by spectral method. The compound 1 exhibits potent radical scavenging activity ($IC_{50}{\;}12.5{\;}{\mu}M$) against the DPPH.

• Archives of Pharmacal Research
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• v.29 no.11
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• pp.942-945
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• 2006

A novel quinone derivative, Griseusin C (1), along with a known quinone, Naphthoquinone C (2), was isolated from the lyophilized culture broth of the marine-derived fungus Penicillium sp. The structures were elucidated on the basis of extensive 1D-and 2D-NMR, as well as HRESIMS, spectroscopic analysis. The relative stereochemistries of the compounds were assessed by NOESY analysis.

• Journal of the Korean Magnetic Resonance Society
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• v.20 no.2
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• pp.41-45
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• 2016

Chemical investigation of a marine-derived fungus, Penicillium sp. 108YD020, resulted in the discovery of six bile acid derivatives, glycocholic acid (1), glycocholic acid methyl ester (2), cholic acid (3), glycochenodeoxycholic acid (4), glycodeoxycholic acid methyl ester (5), and cholic acid methyl ester (6). The structures of six bile acid derivatives 1-6 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis.

• Fisheries and Aquatic Sciences
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• v.21 no.8
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• pp.22.1-22.7
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• 2018

Background: Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to find anti-prostate cancer compounds from marine-derived fungus Microsporum sp. Results: We found that physcion isolated from the fermentation broth extract of the marine fungus Microsporum sp. strain MFS-YL decreases the cell proliferation of PC3 human prostate cancer cells. Physcion induced cell apoptosis as determined by Annexin V/propidium iodide double staining. Physcion downregulated the anti-apopotoic proteins such as Ras, Bcl-xL, and Bcl-2, whereas upregulated the pro-apoptotic Bax. Physcion also activated caspase-3, caspase-8, and caspase-9. Conclusion: These results suggest that physcion from Microsporum sp. inhibits the proliferation of PC3 human prostate cancer cells via the pathway leading to apoptotic cell death. Physcion may be a potential candidate in the field of anticancer drug discovery against human prostate cancer.

• Archives of Pharmacal Research
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• v.26 no.7
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• pp.532-534
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• 2003

Kojic acid dimethyl ether (1), and the known kojic acid mono methyl ether (2), kojic acid (3) and phomaligol A (4) have been isolated from the organic extract of the broth of the marine-derived fungus Altenaria sp. collected from the surface of the marine green alga Ulva pertusa. The structures were assigned on the basis of comprehensive spectroscopic analyses. Each isolate was tested for its tyrosinase inhibitory activity. Kojic acid (3) was found to have significant tyrosinase inhibitory activity, but compounds 1, 2, and 4 were found to be inactive.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.59-63
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• 2006

Secalonic acid D(SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.

• Natural Product Sciences
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• v.21 no.4
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• pp.227-230
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• 2015

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin ($IC_{50}=418.0{\mu}M$), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an $IC_{50}$ value of $27.7{\mu}M$. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.

• Natural Product Sciences
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• v.5 no.2
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• pp.93-96
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• 1999

A new ergosteryl myristate (1) and ergosterol (2) have been isolated from the organic extract of the mycelium of unidentified marine algicolous fungus, isolate MF001. The structure of a new compound was assigned on the basis of comprehensive spectroscopic analyses and chemical synthesis.