Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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Bile acids from a Marine Sponge-Associated Fungus Penicillium sp.

  • Pil, Gam Bang (Marine Natural Products Laboratory, Korea Institute of Ocean Science & Technology) ;
  • Won, Ho Shik (Department of chemistry & Applied Chemistry, Hanyang University) ;
  • Shin, Hee Jae (Marine Natural Products Laboratory, Korea Institute of Ocean Science & Technology)
  • Received : 2016.04.06
  • Accepted : 2016.05.19
  • Published : 2016.06.20
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Abstract

Chemical investigation of a marine-derived fungus, Penicillium sp. 108YD020, resulted in the discovery of six bile acid derivatives, glycocholic acid (1), glycocholic acid methyl ester (2), cholic acid (3), glycochenodeoxycholic acid (4), glycodeoxycholic acid methyl ester (5), and cholic acid methyl ester (6). The structures of six bile acid derivatives 1-6 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis.

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References

  1. D. K. Kim, J. S. Lee, J. Y. Kim, S. J. Kang, J. H. Yoon, W. G. Kim, and C. H. Lee, J. Microbiol. Biotechnol. 17, 3 (2007)
  2. S. Maneerat, T. Nitoda, H. Kanzaki, and F. Kawai, Appl. Microbiol. Biotechnol. 67, 5 (2005)
  3. O. B. Ijare, B. S. Somashekar, Y. Jadegoud, and G. A. N. Gowda, Lipids 40, 10 (2005)
  4. R. F. Angawi, B. Calcinai, C. Cerrano, H. A. Dien, E. Fattorusso, F. Scala, and O. T. Scafati, J. Nat. Prod. 72, 12 (2009)
  5. Z. Lu, R. M. V. Wagoner, M. K. Harper, J. N. A. Hooper, and C. M. Ireland, Nat. Prod. Commum. 5, 10 (2010)
  6. S. H. Kim, Y. K. Shin, Y. C. Sohn, and H. C. Kwon, Molecules 17, 10 (2012)
  7. A. F. Hofmann, Arch. Intern. Med. 159, 22 (1999)