• 보건교육건강증진학회지
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• 제10권2호
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• pp.73-85
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• 1993

It is necessary to understand the relationship between socio-cultural elements and smoking, alcohol, and marijuana use behaviors in order to plan public health policy or health promotion program of Mexican Americans. Demographic, socioeconomic status, and acculturation are variables which reflect mechanisms socialization influences these behavior patterns among this population. Thus, this study investigates the prevalence of addictive behaviors and individual differences on addictive behaviors related to variables of acculturation, age, gender, education, and income. And the interrelations among addictive behaviors are also examined. The analyses used data for Mexican Americans from the U.S. Hispanic Health and Nutrition Examination Survey conducted from July 1982 through December 1984 by the National Center for Health Statistics. ANOVA and correlation coefficients were used for this study. This study found that there are gender differences among addictive behaviors in their prevalence. Both males' and females' alcohol and marijuana use behaviors are positively related to the acculturation. Females' smoking behavior is positively related to acculturation while males' smoking is negatively related to it. Income and education are negatively related to males' smoking and positively related to males' alcohol behavior. However, males' marijuana behavior is not related to income. Females' smoking behaviors is not significantly related income and education. Education and income are positively related to marijuana behavior among females. Age is related to all three addictive behaviors among both gender. Age is negatively related to both males' and females' marijuana use behavior. Interrelation between smoking and marijuana use behavior is not significant among males. However, interrelations between alcohol and marijuana use behavior and between alcohol and smoking are significant among both genders. Females' smoking and marijuana use behavior is also significantly related.

• 한국융합학회논문지
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• 제10권11호
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• pp.463-470
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• 2019

의료용 대마의 소비 프로세스가 복잡해 환자 중심의 서비스 제공이 필요한 시점이다. 본 연구는 사용자 중심의 소비 프로세스 방향성 연구를 위해 의료용 대마의 소비 과정을 세 단계와 다섯 개의 절차로 정의하고 의료용 대마 구매 경험이 있는 사용자 인터뷰를 통해 소비 여정 지도를 작성하여 소비 과정에서 발생하는 페인 포인트를 발견하였다. 그 후 미국과 캐나다의 사례연구를 바탕으로 국내에 적용 가능한 시나리오를 시행범위에 따라 세 가지를 제시하였다. 의료용 대마 소비자의 경험에 기반한 사용자 중심의 연구라는 점에 의의가 있으며 향후 소비 프로세스 개선 시 참고 자료로 활용되길 기대한다.

• Archives of Pharmacal Research
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• 제28권12호
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• pp.1365-1375
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• 2005

The antiestrogenic effects of marijuana smoke condensate (MSC) and three major cannabinoids, i.e., $\bigtriangleup^{9}$-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN), were evaluated using in vitro bioassays, viz., the human breast cancer cell proliferation assay, the recombinant human estrogen receptor (ER) competitive binding assay, and the reporter gene assay. The inhibitory effects on estrogen were also examined using the ethoxyresorufin-O­deethylase (EROD) assay, the aromatase assay, and the 17$\beta$-estradiol ($E_{2}$) metabolism assay. The results showed that MSC induced the antiestrogenic effect via the ER-mediated pathway, while THC, CBD, and CBN did not have any antiestrogenic activity. This suggests that the combined effects of the marijuana smoke components are responsible for the antiestrogenicity of marijuana use. In addition, MSC induced the CYP1A activity and the $E_{2}$ metabolism, but inhibited the aromatase activity, suggesting that the antiestrogenic activity of MSC is also related to the indirect ER-dependent pathway, as a result of the depletion of the in situ $E_{2}$ level available to bind to the ER. In conclusion, pyrogenic products including polycyclic aromatic hydrocarbons (PAHs) in the non-polar fraction, which is the most biologically active fraction among the seven fractions of MSC, might be responsible for the antiestrogenic effect.

• 대한임상독성학회지
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• 제18권1호
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• pp.47-50
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• 2020

A 21-year-old female patient complaining of hemiparesis was diagnosed with right middle cerebral artery infarction. No risk factor was found, despite an extensive young-age stroke work-up, except her history of marijuana use. The patient had smoked marijuana for treating depression for more than five years. Magnetic resonance angiography showed multifocal intra- and extracranial stenoses, suggesting cannabinoid-induced vasculopathy. Since the use of illicit drugs has increased nationwide, physicians should consider it as a possible cause of a stroke due to an unknown etiology.

• 한국융합학회논문지
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• 제11권5호
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• pp.131-138
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• 2020

주요 선진국을 시작으로 국내 또한 부가가치가 높은 서비스 산업의 발전에 중점을 두고 있다. 산업 패러다임의 변화로 통합적 관점을 중시하는 비즈니스 환경으로 급격하게 변화하였고 다양한 이해관계자들의 이해와 참여를 균형있게 관리하며 대응하는 것이 중요해졌다. 하지만 새로운 서비스가 국내에 들어올 때 이해관계자마다 서비스에 대한 이해도가 상이하기 때문에 다양한 이해관계자들을 아우르며 공공성을 목적으로 한 전지적 시점의 아이덴티티 구축이 필요성이 제기되었다. 본 논문은 최적화 아이덴티티를 의료용 대마 서비스 사례에 적용하여 실행 방안을 제안하는 것에 대한 연구로 크게 이론적 고찰, 최적화 아이덴티티 구조도 개발, 의료용 대마 서비스에 적용 3가지 단계로 이루어져 있다. 이는 국내에 도입 된 의료용 대마 서비스에 대한 다양한 역할의 이해관계자들을 일관되게 관리하기 위한 연구란 점에 의의가 있으며 향후 의료용 대마 서비스 개선 시 참고 자료로 활용되길 기대한다.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.95-99
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• 2000

• Investigative Magnetic Resonance Imaging
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• 제22권3호
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• pp.168-171
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• 2018

Cannabis or marijuana is the most commonly used recreational drug after alcohol in the world, and usage is generally recognized as having few serious adverse effects. However, usage is restricted in South Korea. The report of ischemic stroke associated with cannabis is rare in literature. We present a case of a 47-year-old female patient with no underlying disease presenting with acute ischemic stroke after smoking cannabis in South Korea. The result for synthetic cannabinoid metabolites (delta-9 tetrahydrocannabinol) screening was positive. Absence of other vascular risk factors and drug screening results suggest a causal role of cannabis in this ischemic stroke case. The patient eventually progressed to brain death. The underlying mechanism, clinical manifestation, and imaging findings of cannabis-related stroke will be reviewed.

• 약학회지
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• 제52권3호
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• pp.172-175
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• 2008

Stable isotope ratio of carbon and nitrogen ($\delta^{13}C$ & $\delta^{15}N$), and $\Delta^{9}$-tetrahydrocannabinol (THC) contents were measured on 37 Korean cannabis and 10 commercial grade marijuana seized in Korea. Factors influencing on the measured values and their variations were investigated. $\delta^{13}C$ value of cannabis is specified mainly by water availability. Korean cannabis showed relatively low $\delta^{13}C$ values ranging -33.29$\sim$-27.01% (mean=-31.01%), which reflect geographic conditions of Korea where is rainy, especially during summer. $\delta^{15}N$ values, which reflect individual planting conditions, were relatively high up to -0.5$\sim$18.0% (mean=6.44%). It reflects characteristics of Korean cannabis growing wild in forest or cultivated in fertile soil. Tetrahydrocannabinol is the major hallucinogenic compound of cannabis. Ethanol extracts of cannabis leaves were derivatized by N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and the derivatives were analyzed by GC-MS in selected ion monitoring (SIM) mode. THC contents of Korean cannabis ranged 0.11$\sim$4.34% (mean=1.47%), which were relatively low compared with commercial grade marijuana.

• Communications for Statistical Applications and Methods
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• 제7권3호
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• pp.711-720
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• 2000

A case study of modeling ordinal categorical response data with the MARS method is done. The study is to analyze the effect of some personal characteristics and socioeconomic status on the teenage marijuana use. The MARS method gave a new insight into the data set.

• 대한약침학회지
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• 제22권4호
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• pp.225-230
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• 2019

Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future. Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria. Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone. Conclusion: We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive tool.