• Journal of Microbiology and Biotechnology
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• v.31 no.7
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• pp.1022-1027
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• 2021

Three compounds were isolated from marine-derived Streptomyces sp. CNQ-031, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) were evaluated. Compound 1 (5,7-dihydroxy-2-isopropyl-4H-chromen-4-one) was a potent and selective inhibitor of MAO-A, with a 50% inhibitory concentration (IC₅₀) of 2.70 µM and a selectivity index (SI) of 10.0 versus MAO-B. Compound 2 [5,7-dihydroxy-2-(1-methylpropyl)-4H-chromen-4-one] was a potent and low-selective inhibitor of MAO-B, with an IC₅₀ of 3.42 µM and an SI value of 2.02 versus MAO-A. Compound 3 (1-methoxyphenazine) did not inhibit MAO-A or MAO-B. All three compounds showed little inhibitory activity against AChE, BChE, and BACE-1. The K_i value of compound 1 for MAO-A was 0.94 ± 0.28 µM, and the K_i values of compound 2 for MAO-A and MAO-B were 3.57 ± 0.60 and 1.89 ± 0.014 µM, respectively, with competitive inhibition. The 1-methylpropyl group in compound 2 increased the MAO-B inhibitory activity compared with the isopropyl group in compound 1. Inhibition of MAO-A and MAO-B by compounds 1 and 2 was recovered by dialysis experiments. These results suggest that compounds 1 and 2 are reversible, competitive inhibitors of MAOs and can be considered potential therapies for neurological disorders such as depression and Alzheimer's disease.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.192-193
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• 2003

• Earthquakes and Structures
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• v.11 no.5
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• pp.861-871
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• 2016

The Groningen gas field shows exponential growth in earthquake event counts around a magnitude M1 with a doubling time of 6-9 years since 2001. This behavior is identified with dimensionless curvature in land subsidence, which has been evolving at a constant rate over the last few decades essentially uncorrelated to gas production. We demonstrate our mechanism by a tabletop crack formation experiment. The observed skewed distribution of event magnitudes is matched by that of maxima of event clusters with a normal distribution. It predicts about one event < M5 per day in 2025, pointing to increasing stress to human living conditions.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.98-98
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• 2003

We will present various MR findings of hyperacute ischemic stroke with our own experiences in the management of the patients according to the findings. 대상 및 방법： A total of 441 patients were underwent 'acute stroke MR' imaging protocol between Mar. 2001 and Jun. 2003. The protocol included initial T2-weighted image (WI), diffusion WI (DWI, b=2000), time-of-flight (TOF) MR angiography (MRA), and pefusion WI(PWI), and follow-up T2WI, DWI, TOF MRA, and neck vessel contrast-enhanced MRA obtained three to five days after the insult. Among them, we retrospectively reviewed the MR findings and clinical courses of 193 patients with anterior circulation territorial infarction. Those ICA and MCA lesions were divided into six and five groups respectively according to the level and mechanism of the occlusion. PWI findings can be another factor in the management planning.

• Journal of Korean Academy of Nursing Administration
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• v.15 no.3
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• pp.355-364
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• 2009

Purpose: The purpose of the research is to investigate the effect of self-image on work performance and controlling ability of self-leadership in relationship in between self-image and work performance. Methods: The data were collected from Mar 16th to April 15th 2009, a descriptive survey study was conducted with 140 nurses. Results: The hypothesis "Self image of nurse would affect on work performance" is supported ($R^2$=.335, p<.001). In the hypothesis of "Self-leadership would have controlling ability on self-image and work performance", as a result of regression analysis in independent variables of self-image(A) and self-leadership(B), adding relation of both variable($A{\times}B$) would increase in 36.6% (p<.05). Conclusion: Self-image of nurse was confirmed that it had positive effect on work performance and that it had moderating ability on relationship between self-image and work performance. The shaping and strategic operation are required to increase self-leadership and positive development on self-image of nursed.

• The Korean Journal of Food And Nutrition
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• v.28 no.4
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• pp.517-526
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• 2015

This study was carried out to determine the depression symptoms and nutritional status of elderly females that ate congregate meals at lunch in rural Pocheon. The subjects were 18 elderly females aged over 65 ($75.7{\pm}4.6$ years) and information on smoking, subjective health status, depression symptoms and malnutrition risk were collected using a questionnaire administered with the help of trained research assistants. Measurements included mid-arm circumference and calf circumference. Food consumption for 3 days during breakfast and supper were determined by 24-hour recall and food consumption at lunch was determined as the difference between the amounts served and the plate waste. All data were compared between two age groups (${\leq}75$ and > 75). The subjects had the lowest nutrient adequacy ratio (NAR) for vitamin $B_6$ (0.523), followed by calcium and niacin and the lowest index of nutrient quality (INQ) for calcium (0.738). The older elderly had significantly lower NAR for vitamin $B_1$, vitamin $B_2$, vitamin $B_6$ and niacin as well as significantly lower mean adequacy ratio (MAR) compared to the young elderly. They also had significantly lower INQ for vitamin $B_1$ and vitamin C and significantly thinner arm circumference (28.3 cm vs. 31.3 cm). They consumed more than 40% of their daily intake for each nutrient at lunch. Higher proportions of nutrient intake from lunch provided evidence of the importance of congregate meals, suggesting that the government and society should support congregate meals to improve nutritional status.

• Korean Journal of Community Nutrition
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• v.8 no.1
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• pp.33-40
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• 2003

This study was investigated the differences in the dietary habits and quality of diet among 148 university students in Daejeon between 1993 (71 subjects) and 2000 (77 subjects). Among male students, there were increases in height and decreases in weight, but the number in the normal weight group assessed by the BMI, increased. Significant increases in meal regularity and the rate of considering a balanced diet at meal time and significant decreases in the rate of eating unbalanced meals were noted over time among the male students. The number of male students drinking alcohol and those drinking alcohol frequently decreased significantly. When considering differences in the nutrient intake of males according to the Korean RBA, the percentages of energy, iron, and Vitamin B$_2$ decreased, while those of Vitamin C, calcium, and phosphorus increased over time. The NAR (Nutrient Adequacy Ratio) of most nutrients, especially in iron and Vitamin C were higher, than those of 1993, but the NAR of calcium, iron, Vitamin B$_2$, niacin and MAR (Mean Adequacy Ratio) were lower than 0.75 in the males. The INQ (Index of nutritional quality) of Vitamin C was higher than that of 1993, and the mQ of calcium and Vitamin $B_2$ were lower than 1 among the males. Among the females, there was no change in height and weight between 1993 and 2000, but the normal weight group, as assessed by the BMI, increased as among the males. However, unlike among the males, significant decreases in meal regularity and significant increases in the rate of alcohol drinking were noted over time. The intake of energy and nutrients showed trends similar to those among the males. The NARs of most nutrients were lower than those of 1993 among in the females. The INQs of protein, calcium, Vitamin $B_1$ and Vitamin C increased significantly, but the INQs of calcium, iron, and Vitamin $B_2$ were lower than 1 among the females. From these results, we found that male students showed relatively desirable changes over time in their dietary and health-related habits and the quality of their diets, while female students showed undesirable changes in their dietary and alcohol drinking habits and the quality of their diets.

• Korean Journal of Community Nutrition
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• v.8 no.1
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• pp.112-119
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• 2003

We studied the nutritional status of on mentally handicapped children living at home or in institutions since early teenage years are nutritionally important. The subjects of 7 to 12 year old mentally retarded children attenending a special education school in Seoul were surveyed with questionnaires as well as 2-day dietary recall records, with the help of persons of their care-giver when needed. Among the 64 children,54.7% are living in institutions and the rest of them are living at home. They were ranged from the trainable (64.1%) , the educable (26.6%) , and the non-trainable (9.4%) . Their average daily intake of energy intakes (%RDA) was 2,070.1 kcal (94.1%) , Ca 603.9 mg (75.5%) , Fe 11.1 mg (92.5%), Vt.A 507.5 RE (84.6%) , Vt. B$_2$.1g (88.2%), niacin 14.1 g (93.6%) and Vt. C 58.2 g (83.1%) . Their average intakes of these nutrients were significantly higher in subjects of institutions than at home. The nutrients consumed at a much higher level than the RDh of the normal children were Vt. B, (1.6 g,146.8%) and protein (75.3g, 136.9%) . The higher percentage of children at home were under consumed of several nutrients (< 75% RDA) than ones in institutions. When comparing the degree of handicap, energy and nutrient intakes except Vt. C were highest in educable children than trainable ones or Dawn's children. MAR of the diets of the subjects was 0.84. Children at home showed lower MAR as well as NAR of each nutrients, whereas children belonged to INQ < 1 were less at home. Handicapped children at home were snacking higher amount relative to their calorie intake and too frequently, that may lead to their poor nutrition. There was positive correlations between factors of nutrition and physical and dietary behaviors, but there were no correlations between factors of nutrition and health-related habits. Nutritional caring mentally handicapped children in institutions seemed to be more effectively managed.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.3
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• pp.181-186
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• 2014

The purpose of this study is to report a clinical progress of sudden hearing loss through korean medicine. Between 26th Mar. 2014 and 19th Apr. 2014, she was treated with Chuna manual therapy every day and observed by Pure Tone Audiometry (before and after) and visual analogue pain scale (VAS). A patient was diagnosed with sudden hearing loss on 23th Dec. 2013 in Severance Hospital, she had sudden hearing loss on left side. She had 19 times treatments. At the first of treatment, her audibility was 20 dB on right side, 74 dB on left side and she had tinitus and ear fullness (VAS 8 / VAS 9). At the middle of treatment (2nd Apr. 2014), symptoms of tinitus and ear fullness started improving. State was tinitus VAS 6, ear fullness VAS 6. At the end of treatment (21th Apr. 2014), state was tinitus VAS 4, ear fullness VAS 4, and recorded 35 dB on right side, 80 dB on left side in pure tone audiometry. Chuna manual therapy is estimated to be good for sudden hearing loss especially on tinitus and ear fullness. More cases are required to develop treatment of sudden hearing loss.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.209-213
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• 1986

To study the therapeutic effect of ribavirin, a broad spectrum antiviral agent, for chronic hepatitis B in pediatric patients, 24 patients who were diagnosed as chronic hepatitis B (elevated SGOT and SGPT and positive HBsAg and HBeAg for more than 6 months) at the pediatric department of Yeungnam University Hospital from Mar. 1, 1985 to Sep. 30, 1986 were randomly divided into two groups. Ribavirin was administered to 11 patients in dose of 15mg/kg/day and 13 patients were control group and both groups were followed for 12 months. Serum HBsAg and HBeAg were measured with RIA(Ausria-1I and Abbott-HBe, respectively) and compared in PIN ratio (counts per minute of patient's sample/counts per minute of normal serum). There were no statistically significant reductions in PIN ratios of HBsAg and HBeAg in both groups between prior to the therapy and 12 months follow-up period. It seems that ribavirin does not have the therapeutic effect on chronic hepatis B in children. Also, there were no noticeable side effects from ribavirin therapy.